PH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3W4_LEIMA

TriTrypDb:

LmjF.33.2230 , LMJLV39_330032800 , LMJSD75_330032400

Length:

266

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3W4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3W4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.511
CLV_C14_Caspase3-7	18	22	PF00656	0.743
DEG_Nend_UBRbox_1	1	4	PF02207	0.610
DEG_SCF_FBW7_2	230	237	PF00400	0.637
DEG_SPOP_SBC_1	222	226	PF00917	0.619
DOC_ANK_TNKS_1	176	183	PF00023	0.652
DOC_MAPK_gen_1	101	110	PF00069	0.566
DOC_MAPK_gen_1	214	222	PF00069	0.512
DOC_USP7_MATH_1	15	19	PF00917	0.699
DOC_WW_Pin1_4	146	151	PF00397	0.621
DOC_WW_Pin1_4	158	163	PF00397	0.305
DOC_WW_Pin1_4	230	235	PF00397	0.755
LIG_14-3-3_CanoR_1	217	223	PF00244	0.514
LIG_14-3-3_CterR_2	262	266	PF00244	0.605
LIG_APCC_ABBA_1	155	160	PF00400	0.630
LIG_BIR_III_2	136	140	PF00653	0.475
LIG_BIR_III_2	21	25	PF00653	0.751
LIG_BRCT_BRCA1_1	184	188	PF00533	0.580
LIG_BRCT_BRCA1_1	8	12	PF00533	0.632
LIG_deltaCOP1_diTrp_1	210	216	PF00928	0.583
LIG_eIF4E_1	70	76	PF01652	0.610
LIG_FHA_2	124	130	PF00498	0.631
LIG_LIR_Nem_3	100	105	PF02991	0.412
LIG_LIR_Nem_3	152	158	PF02991	0.508
LIG_LIR_Nem_3	185	191	PF02991	0.605
LIG_LIR_Nem_3	213	219	PF02991	0.477
LIG_LIR_Nem_3	74	79	PF02991	0.486
LIG_MYND_3	156	160	PF01753	0.523
LIG_Pex14_1	212	216	PF04695	0.576
LIG_Pex14_2	184	188	PF04695	0.580
LIG_Rb_LxCxE_1	161	181	PF01857	0.686
LIG_REV1ctd_RIR_1	100	108	PF16727	0.600
LIG_SH2_NCK_1	189	193	PF00017	0.650
LIG_SH2_STAT5	60	63	PF00017	0.462
LIG_SH2_STAT5	79	82	PF00017	0.421
LIG_SH3_3	21	27	PF00018	0.571
LIG_SUMO_SIM_anti_2	129	136	PF11976	0.537
LIG_SUMO_SIM_anti_2	198	203	PF11976	0.589
LIG_SUMO_SIM_par_1	123	130	PF11976	0.509
LIG_SUMO_SIM_par_1	218	226	PF11976	0.606
LIG_TYR_ITIM	77	82	PF00017	0.585
LIG_UBA3_1	134	142	PF00899	0.332
MOD_CDK_SPK_2	158	163	PF00069	0.538
MOD_CK1_1	161	167	PF00069	0.454
MOD_CK1_1	221	227	PF00069	0.627
MOD_CK2_1	123	129	PF00069	0.618
MOD_CK2_1	8	14	PF00069	0.630
MOD_GlcNHglycan	129	132	PF01048	0.673
MOD_GlcNHglycan	17	20	PF01048	0.707
MOD_GlcNHglycan	92	95	PF01048	0.632
MOD_GSK3_1	123	130	PF00069	0.609
MOD_GSK3_1	218	225	PF00069	0.436
MOD_N-GLC_1	222	227	PF02516	0.628
MOD_N-GLC_1	6	11	PF02516	0.485
MOD_NEK2_1	123	128	PF00069	0.611
MOD_NEK2_2	212	217	PF00069	0.507
MOD_PK_1	195	201	PF00069	0.496
MOD_Plk_1	222	228	PF00069	0.644
MOD_Plk_1	6	12	PF00069	0.607
MOD_Plk_2-3	8	14	PF00069	0.630
MOD_Plk_4	161	167	PF00069	0.573
MOD_Plk_4	223	229	PF00069	0.672
MOD_ProDKin_1	146	152	PF00069	0.618
MOD_ProDKin_1	158	164	PF00069	0.302
MOD_ProDKin_1	230	236	PF00069	0.754
MOD_SUMO_rev_2	200	209	PF00179	0.504
TRG_DiLeu_BaEn_2	84	90	PF01217	0.599
TRG_ENDOCYTIC_2	64	67	PF00928	0.508
TRG_ENDOCYTIC_2	79	82	PF00928	0.491
TRG_ER_diArg_1	103	106	PF00400	0.587
TRG_ER_diArg_1	175	178	PF00400	0.712
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.643
TRG_Pf-PMV_PEXEL_1	65	69	PF00026	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HLT6	Leishmania braziliensis	79%	67%
E9B462	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	79%