Replication protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Replication protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3W3_LEIMA

TriTrypDb:

LmjF.33.2240 , LMJLV39_330032900 , LMJSD75_330032500

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3W3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3W3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	181	183	PF00675	0.522
CLV_NRD_NRD_1	4	6	PF00675	0.597
CLV_NRD_NRD_1	55	57	PF00675	0.397
CLV_PCSK_KEX2_1	181	183	PF00082	0.496
CLV_PCSK_KEX2_1	34	36	PF00082	0.383
CLV_PCSK_KEX2_1	4	6	PF00082	0.628
CLV_PCSK_KEX2_1	55	57	PF00082	0.397
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.484
CLV_PCSK_PC7_1	51	57	PF00082	0.390
CLV_PCSK_SKI1_1	124	128	PF00082	0.411
CLV_PCSK_SKI1_1	51	55	PF00082	0.449
DEG_APCC_DBOX_1	188	196	PF00400	0.521
DEG_Nend_UBRbox_3	1	3	PF02207	0.606
DEG_SCF_FBW7_1	66	72	PF00400	0.415
DOC_ANK_TNKS_1	204	211	PF00023	0.558
DOC_CKS1_1	66	71	PF01111	0.479
DOC_MAPK_gen_1	103	110	PF00069	0.335
DOC_MAPK_gen_1	169	177	PF00069	0.589
DOC_PP1_RVXF_1	159	166	PF00149	0.581
DOC_USP7_MATH_1	281	285	PF00917	0.675
DOC_WW_Pin1_4	65	70	PF00397	0.586
LIG_14-3-3_CanoR_1	136	140	PF00244	0.585
LIG_BRCT_BRCA1_1	22	26	PF00533	0.375
LIG_BRCT_BRCA1_1	230	234	PF00533	0.522
LIG_FHA_1	140	146	PF00498	0.560
LIG_FHA_1	155	161	PF00498	0.457
LIG_FHA_1	301	307	PF00498	0.635
LIG_FHA_1	70	76	PF00498	0.485
LIG_FHA_1	78	84	PF00498	0.402
LIG_FHA_2	130	136	PF00498	0.619
LIG_KLC1_Yacidic_2	257	262	PF13176	0.566
LIG_LIR_Apic_2	142	147	PF02991	0.514
LIG_LIR_Gen_1	16	27	PF02991	0.473
LIG_LIR_Gen_1	162	173	PF02991	0.545
LIG_LIR_Nem_3	122	126	PF02991	0.405
LIG_LIR_Nem_3	162	168	PF02991	0.607
LIG_LIR_Nem_3	23	29	PF02991	0.423
LIG_LIR_Nem_3	231	237	PF02991	0.561
LIG_LIR_Nem_3	255	261	PF02991	0.517
LIG_LIR_Nem_3	52	57	PF02991	0.370
LIG_LYPXL_S_1	26	30	PF13949	0.495
LIG_PDZ_Class_1	306	311	PF00595	0.620
LIG_Pex14_2	123	127	PF04695	0.367
LIG_Pex14_2	26	30	PF04695	0.471
LIG_Pex14_2	73	77	PF04695	0.488
LIG_PTB_Apo_2	56	63	PF02174	0.395
LIG_PTB_Phospho_1	56	62	PF10480	0.386
LIG_SH2_CRK	93	97	PF00017	0.377
LIG_SH2_NCK_1	42	46	PF00017	0.431
LIG_SH2_PTP2	144	147	PF00017	0.587
LIG_SH2_STAT5	144	147	PF00017	0.553
LIG_SH2_STAT5	260	263	PF00017	0.475
LIG_SH3_1	63	69	PF00018	0.433
LIG_SH3_3	63	69	PF00018	0.532
LIG_SH3_3	9	15	PF00018	0.595
LIG_SH3_3	98	104	PF00018	0.519
LIG_SH3_4	218	225	PF00018	0.531
LIG_SUMO_SIM_anti_2	84	90	PF11976	0.311
LIG_SUMO_SIM_par_1	78	84	PF11976	0.555
LIG_TRAF2_1	238	241	PF00917	0.513
MOD_CK1_1	125	131	PF00069	0.516
MOD_CK1_1	167	173	PF00069	0.565
MOD_CK1_1	296	302	PF00069	0.594
MOD_CK2_1	129	135	PF00069	0.551
MOD_CK2_1	281	287	PF00069	0.726
MOD_GlcNHglycan	115	118	PF01048	0.619
MOD_GSK3_1	125	132	PF00069	0.434
MOD_GSK3_1	135	142	PF00069	0.569
MOD_GSK3_1	159	166	PF00069	0.531
MOD_GSK3_1	209	216	PF00069	0.625
MOD_GSK3_1	296	303	PF00069	0.608
MOD_GSK3_1	65	72	PF00069	0.402
MOD_N-GLC_1	306	311	PF02516	0.620
MOD_NEK2_1	195	200	PF00069	0.686
MOD_NEK2_1	213	218	PF00069	0.445
MOD_NEK2_1	44	49	PF00069	0.552
MOD_PIKK_1	187	193	PF00454	0.570
MOD_PKA_2	135	141	PF00069	0.584
MOD_PKA_2	214	220	PF00069	0.587
MOD_Plk_1	154	160	PF00069	0.585
MOD_Plk_1	163	169	PF00069	0.550
MOD_Plk_2-3	148	154	PF00069	0.626
MOD_Plk_4	135	141	PF00069	0.478
MOD_Plk_4	264	270	PF00069	0.483
MOD_Plk_4	84	90	PF00069	0.395
MOD_ProDKin_1	65	71	PF00069	0.582
MOD_SUMO_for_1	175	178	PF00179	0.456
TRG_DiLeu_BaEn_1	84	89	PF01217	0.503
TRG_ENDOCYTIC_2	27	30	PF00928	0.356
TRG_ENDOCYTIC_2	93	96	PF00928	0.363
TRG_ER_diArg_1	54	56	PF00400	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE06	Leptomonas seymouri	64%	100%
A0A0S4JDA2	Bodo saltans	25%	97%
A0A1X0P3S3	Trypanosomatidae	43%	100%
A0A3S7X717	Leishmania donovani	95%	100%
A0A422NI03	Trypanosoma rangeli	41%	100%
A4HLT7	Leishmania braziliensis	79%	100%
D0A689	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AHP3	Leishmania infantum	95%	100%
E9B463	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5DQC4	Trypanosoma cruzi	40%	100%