RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3W2_LEIMA

TriTrypDb:

LmjF.33.2250 , LMJLV39_330033000 , LMJSD75_330032600

Length:

452

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3W2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3W2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	392	396	PF00656	0.700
CLV_C14_Caspase3-7	425	429	PF00656	0.672
CLV_NRD_NRD_1	127	129	PF00675	0.523
CLV_NRD_NRD_1	304	306	PF00675	0.669
CLV_NRD_NRD_1	316	318	PF00675	0.560
CLV_PCSK_KEX2_1	118	120	PF00082	0.643
CLV_PCSK_KEX2_1	306	308	PF00082	0.615
CLV_PCSK_KEX2_1	316	318	PF00082	0.668
CLV_PCSK_KEX2_1	320	322	PF00082	0.707
CLV_PCSK_KEX2_1	440	442	PF00082	0.538
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.643
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.615
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.707
CLV_PCSK_PC1ET2_1	440	442	PF00082	0.538
CLV_PCSK_PC7_1	316	322	PF00082	0.623
CLV_PCSK_SKI1_1	138	142	PF00082	0.594
CLV_PCSK_SKI1_1	19	23	PF00082	0.465
CLV_PCSK_SKI1_1	309	313	PF00082	0.702
CLV_PCSK_SKI1_1	352	356	PF00082	0.607
CLV_PCSK_SKI1_1	407	411	PF00082	0.496
DEG_COP1_1	375	385	PF00400	0.563
DEG_Nend_UBRbox_2	1	3	PF02207	0.459
DOC_MAPK_HePTP_8	318	330	PF00069	0.610
DOC_MAPK_MEF2A_6	321	330	PF00069	0.607
DOC_PP2B_LxvP_1	427	430	PF13499	0.682
DOC_PP2B_LxvP_1	72	75	PF13499	0.662
DOC_SPAK_OSR1_1	247	251	PF12202	0.406
DOC_USP7_MATH_1	14	18	PF00917	0.447
DOC_USP7_MATH_1	172	176	PF00917	0.810
DOC_USP7_MATH_1	202	206	PF00917	0.615
DOC_USP7_MATH_1	256	260	PF00917	0.613
DOC_USP7_MATH_1	310	314	PF00917	0.661
DOC_USP7_MATH_1	341	345	PF00917	0.719
DOC_USP7_MATH_1	364	368	PF00917	0.744
DOC_USP7_MATH_1	374	378	PF00917	0.599
DOC_USP7_MATH_1	75	79	PF00917	0.789
DOC_WW_Pin1_4	166	171	PF00397	0.612
DOC_WW_Pin1_4	183	188	PF00397	0.452
DOC_WW_Pin1_4	400	405	PF00397	0.725
LIG_14-3-3_CanoR_1	111	117	PF00244	0.423
LIG_14-3-3_CanoR_1	173	183	PF00244	0.698
LIG_14-3-3_CanoR_1	19	24	PF00244	0.467
LIG_14-3-3_CanoR_1	234	242	PF00244	0.501
LIG_14-3-3_CanoR_1	309	319	PF00244	0.573
LIG_14-3-3_CanoR_1	332	337	PF00244	0.720
LIG_14-3-3_CanoR_1	352	361	PF00244	0.578
LIG_14-3-3_CanoR_1	415	424	PF00244	0.605
LIG_14-3-3_CanoR_1	44	52	PF00244	0.454
LIG_BRCT_BRCA1_1	204	208	PF00533	0.668
LIG_FHA_1	111	117	PF00498	0.423
LIG_FHA_1	149	155	PF00498	0.535
LIG_FHA_1	30	36	PF00498	0.583
LIG_FHA_1	353	359	PF00498	0.712
LIG_FHA_2	28	34	PF00498	0.459
LIG_FHA_2	379	385	PF00498	0.704
LIG_LIR_Gen_1	108	116	PF02991	0.427
LIG_LIR_Gen_1	17	26	PF02991	0.463
LIG_LIR_Gen_1	236	244	PF02991	0.422
LIG_LIR_Nem_3	108	112	PF02991	0.437
LIG_LIR_Nem_3	17	23	PF02991	0.462
LIG_MYND_1	70	74	PF01753	0.692
LIG_SH2_CRK	109	113	PF00017	0.433
LIG_SH2_CRK	7	11	PF00017	0.418
LIG_SH2_NCK_1	255	259	PF00017	0.569
LIG_SH2_STAT5	20	23	PF00017	0.458
LIG_SH3_2	171	176	PF14604	0.667
LIG_SH3_3	165	171	PF00018	0.742
LIG_SH3_3	181	187	PF00018	0.518
LIG_SH3_3	20	26	PF00018	0.618
LIG_SH3_3	323	329	PF00018	0.671
LIG_SH3_3	382	388	PF00018	0.562
LIG_SH3_3	67	73	PF00018	0.641
LIG_SUMO_SIM_par_1	112	117	PF11976	0.418
LIG_TRAF2_1	237	240	PF00917	0.475
LIG_TYR_ITIM	5	10	PF00017	0.410
LIG_UBA3_1	207	212	PF00899	0.698
LIG_WW_3	170	174	PF00397	0.659
MOD_CDK_SPxxK_3	166	173	PF00069	0.697
MOD_CDK_SPxxK_3	400	407	PF00069	0.642
MOD_CK1_1	149	155	PF00069	0.630
MOD_CK1_1	166	172	PF00069	0.573
MOD_CK1_1	276	282	PF00069	0.564
MOD_CK1_1	375	381	PF00069	0.673
MOD_CK1_1	77	83	PF00069	0.664
MOD_CK2_1	124	130	PF00069	0.534
MOD_CK2_1	233	239	PF00069	0.554
MOD_CK2_1	254	260	PF00069	0.443
MOD_GlcNHglycan	148	151	PF01048	0.665
MOD_GlcNHglycan	16	19	PF01048	0.457
MOD_GlcNHglycan	165	168	PF01048	0.654
MOD_GlcNHglycan	176	179	PF01048	0.620
MOD_GlcNHglycan	235	238	PF01048	0.432
MOD_GlcNHglycan	256	259	PF01048	0.434
MOD_GlcNHglycan	276	279	PF01048	0.557
MOD_GlcNHglycan	290	293	PF01048	0.644
MOD_GlcNHglycan	343	346	PF01048	0.763
MOD_GlcNHglycan	366	369	PF01048	0.765
MOD_GlcNHglycan	374	377	PF01048	0.631
MOD_GlcNHglycan	389	392	PF01048	0.625
MOD_GlcNHglycan	433	436	PF01048	0.586
MOD_GlcNHglycan	65	68	PF01048	0.664
MOD_GlcNHglycan	76	80	PF01048	0.740
MOD_GlcNHglycan	84	87	PF01048	0.637
MOD_GSK3_1	110	117	PF00069	0.422
MOD_GSK3_1	250	257	PF00069	0.397
MOD_GSK3_1	276	283	PF00069	0.572
MOD_GSK3_1	284	291	PF00069	0.658
MOD_GSK3_1	364	371	PF00069	0.640
MOD_GSK3_1	374	381	PF00069	0.654
MOD_N-GLC_1	45	50	PF02516	0.455
MOD_NEK2_1	112	117	PF00069	0.428
MOD_NEK2_1	148	153	PF00069	0.532
MOD_NEK2_1	82	87	PF00069	0.764
MOD_OFUCOSY	249	254	PF10250	0.378
MOD_PIKK_1	202	208	PF00454	0.524
MOD_PK_1	332	338	PF00069	0.685
MOD_PKA_2	110	116	PF00069	0.426
MOD_PKA_2	172	178	PF00069	0.711
MOD_PKA_2	233	239	PF00069	0.503
MOD_PKA_2	331	337	PF00069	0.685
MOD_PKA_2	341	347	PF00069	0.573
MOD_Plk_1	299	305	PF00069	0.711
MOD_Plk_1	45	51	PF00069	0.455
MOD_Plk_4	422	428	PF00069	0.663
MOD_ProDKin_1	166	172	PF00069	0.610
MOD_ProDKin_1	183	189	PF00069	0.449
MOD_ProDKin_1	400	406	PF00069	0.717
MOD_SUMO_for_1	311	314	PF00179	0.707
TRG_DiLeu_BaEn_1	53	58	PF01217	0.437
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.410
TRG_ENDOCYTIC_2	109	112	PF00928	0.448
TRG_ENDOCYTIC_2	20	23	PF00928	0.458
TRG_ENDOCYTIC_2	7	10	PF00928	0.409
TRG_ER_diArg_1	304	307	PF00400	0.670
TRG_ER_diArg_1	316	318	PF00400	0.560
TRG_NES_CRM1_1	414	428	PF08389	0.650
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILE8	Leptomonas seymouri	48%	100%
A0A3Q8IH00	Leishmania donovani	92%	99%
A4HLT8	Leishmania braziliensis	74%	100%
E9AHP4	Leishmania infantum	92%	99%
E9B464	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%