UDP-glucose 4-epimerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

udp-glc 4'-epimerase, putative

Species:

Leishmania major

UniProt:

Q4Q3V7_LEIMA

TriTrypDb:

LmjF.33.2300 , LMJLV39_330033700 , LMJSD75_330033100

Length:

391

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3V7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3V7

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	12
GO:0005996	monosaccharide metabolic process	3	12
GO:0006012	galactose metabolic process	5	12
GO:0008152	metabolic process	1	12
GO:0019318	hexose metabolic process	4	12
GO:0044238	primary metabolic process	2	12
GO:0044281	small molecule metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003978	UDP-glucose 4-epimerase activity	5	12
GO:0016853	isomerase activity	2	12
GO:0016854	racemase and epimerase activity	3	12
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	328	330	PF00675	0.407
CLV_NRD_NRD_1	342	344	PF00675	0.471
CLV_PCSK_KEX2_1	328	330	PF00082	0.427
CLV_PCSK_KEX2_1	341	343	PF00082	0.419
CLV_PCSK_KEX2_1	63	65	PF00082	0.420
CLV_PCSK_PC1ET2_1	341	343	PF00082	0.517
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.299
CLV_PCSK_PC7_1	338	344	PF00082	0.597
CLV_PCSK_SKI1_1	137	141	PF00082	0.310
CLV_PCSK_SKI1_1	18	22	PF00082	0.293
CLV_PCSK_SKI1_1	328	332	PF00082	0.437
CLV_PCSK_SKI1_1	68	72	PF00082	0.491
CLV_Separin_Metazoa	19	23	PF03568	0.372
DEG_Nend_UBRbox_1	1	4	PF02207	0.320
DEG_SCF_FBW7_1	268	273	PF00400	0.293
DOC_CKS1_1	267	272	PF01111	0.278
DOC_CYCLIN_RxL_1	15	24	PF00134	0.293
DOC_MAPK_gen_1	132	140	PF00069	0.353
DOC_MAPK_gen_1	253	262	PF00069	0.423
DOC_MAPK_MEF2A_6	342	351	PF00069	0.439
DOC_PP1_RVXF_1	76	83	PF00149	0.367
DOC_PP2B_LxvP_1	234	237	PF13499	0.312
DOC_PP4_FxxP_1	147	150	PF00568	0.278
DOC_USP7_MATH_1	167	171	PF00917	0.417
DOC_USP7_UBL2_3	379	383	PF12436	0.343
DOC_WW_Pin1_4	175	180	PF00397	0.325
DOC_WW_Pin1_4	21	26	PF00397	0.299
DOC_WW_Pin1_4	266	271	PF00397	0.309
DOC_WW_Pin1_4	296	301	PF00397	0.516
LIG_14-3-3_CanoR_1	155	165	PF00244	0.211
LIG_14-3-3_CanoR_1	305	311	PF00244	0.433
LIG_BIR_III_4	214	218	PF00653	0.405
LIG_CaM_IQ_9	124	139	PF13499	0.423
LIG_deltaCOP1_diTrp_1	375	380	PF00928	0.393
LIG_EH1_1	14	22	PF00400	0.278
LIG_eIF4E_1	133	139	PF01652	0.343
LIG_eIF4E_1	180	186	PF01652	0.293
LIG_FHA_1	12	18	PF00498	0.334
LIG_FHA_1	141	147	PF00498	0.336
LIG_FHA_1	180	186	PF00498	0.315
LIG_FHA_1	307	313	PF00498	0.476
LIG_FHA_2	297	303	PF00498	0.513
LIG_IBAR_NPY_1	149	151	PF08397	0.343
LIG_LIR_Apic_2	265	270	PF02991	0.278
LIG_LIR_Gen_1	277	284	PF02991	0.324
LIG_LIR_Gen_1	304	312	PF02991	0.359
LIG_LIR_Gen_1	364	374	PF02991	0.376
LIG_LIR_Nem_3	277	281	PF02991	0.290
LIG_LIR_Nem_3	304	310	PF02991	0.415
LIG_LIR_Nem_3	364	370	PF02991	0.408
LIG_Pex14_1	363	367	PF04695	0.351
LIG_Pex14_2	306	310	PF04695	0.372
LIG_SH2_CRK	245	249	PF00017	0.332
LIG_SH2_GRB2like	116	119	PF00017	0.294
LIG_SH2_GRB2like	207	210	PF00017	0.278
LIG_SH2_NCK_1	367	371	PF00017	0.348
LIG_SH2_PTP2	259	262	PF00017	0.343
LIG_SH2_PTP2	278	281	PF00017	0.278
LIG_SH2_SRC	278	281	PF00017	0.278
LIG_SH2_STAP1	116	120	PF00017	0.352
LIG_SH2_STAT5	11	14	PF00017	0.307
LIG_SH2_STAT5	207	210	PF00017	0.278
LIG_SH2_STAT5	259	262	PF00017	0.343
LIG_SH2_STAT5	278	281	PF00017	0.278
LIG_SH2_STAT5	294	297	PF00017	0.278
LIG_SH3_1	173	179	PF00018	0.293
LIG_SH3_2	164	169	PF14604	0.211
LIG_SH3_3	106	112	PF00018	0.278
LIG_SH3_3	161	167	PF00018	0.317
LIG_SH3_3	173	179	PF00018	0.258
LIG_SH3_3	245	251	PF00018	0.343
LIG_SUMO_SIM_par_1	346	353	PF11976	0.418
LIG_TRAF2_1	353	356	PF00917	0.450
LIG_TYR_ITIM	365	370	PF00017	0.380
LIG_UBA3_1	123	132	PF00899	0.346
LIG_WRC_WIRS_1	307	312	PF05994	0.478
MOD_CDK_SPxxK_3	296	303	PF00069	0.514
MOD_CK2_1	155	161	PF00069	0.426
MOD_CK2_1	316	322	PF00069	0.350
MOD_CK2_1	350	356	PF00069	0.425
MOD_GlcNHglycan	285	288	PF01048	0.372
MOD_GlcNHglycan	352	355	PF01048	0.462
MOD_GlcNHglycan	375	378	PF01048	0.375
MOD_GlcNHglycan	64	67	PF01048	0.357
MOD_GSK3_1	175	182	PF00069	0.365
MOD_GSK3_1	258	265	PF00069	0.283
MOD_GSK3_1	266	273	PF00069	0.270
MOD_GSK3_1	30	37	PF00069	0.284
MOD_GSK3_1	312	319	PF00069	0.426
MOD_LATS_1	280	286	PF00433	0.343
MOD_N-GLC_2	209	211	PF02516	0.290
MOD_NEK2_1	138	143	PF00069	0.285
MOD_NEK2_1	306	311	PF00069	0.422
MOD_NEK2_1	312	317	PF00069	0.384
MOD_NEK2_1	34	39	PF00069	0.389
MOD_NEK2_2	258	263	PF00069	0.211
MOD_PK_1	316	322	PF00069	0.397
MOD_PKA_1	328	334	PF00069	0.398
MOD_PKA_2	328	334	PF00069	0.415
MOD_PKB_1	153	161	PF00069	0.211
MOD_Plk_2-3	366	372	PF00069	0.474
MOD_Plk_4	258	264	PF00069	0.262
MOD_ProDKin_1	175	181	PF00069	0.325
MOD_ProDKin_1	21	27	PF00069	0.299
MOD_ProDKin_1	266	272	PF00069	0.309
MOD_ProDKin_1	296	302	PF00069	0.510
MOD_SUMO_for_1	70	73	PF00179	0.343
MOD_SUMO_rev_2	60	65	PF00179	0.299
TRG_DiLeu_BaLyEn_6	228	233	PF01217	0.337
TRG_ENDOCYTIC_2	151	154	PF00928	0.299
TRG_ENDOCYTIC_2	245	248	PF00928	0.335
TRG_ENDOCYTIC_2	259	262	PF00928	0.220
TRG_ENDOCYTIC_2	278	281	PF00928	0.278
TRG_ENDOCYTIC_2	367	370	PF00928	0.352
TRG_ER_diArg_1	328	330	PF00400	0.431

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6X4	Leptomonas seymouri	83%	100%
A0A0S4JG28	Bodo saltans	53%	100%
A0A1X0NTG2	Trypanosomatidae	23%	90%
A0A1X0P4J8	Trypanosomatidae	68%	100%
A0A3Q8IH81	Leishmania donovani	24%	87%
A0A3Q8IHM5	Leishmania donovani	96%	100%
A0A3R7MTU6	Trypanosoma rangeli	67%	100%
A0QSK6	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	25%	100%
A4HLU3	Leishmania braziliensis	88%	100%
A4I2F0	Leishmania infantum	25%	87%
B0M3E8	Pisum sativum	32%	100%
D0A685	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	99%
E8MF10	Bifidobacterium longum subsp. longum (strain ATCC 15707 / DSM 20219 / JCM 1217 / NCTC 11818 / E194b)	35%	100%
E9AHP8	Leishmania infantum	97%	100%
E9B469	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
F8C4X8	Thermodesulfobacterium geofontis (strain OPF15)	25%	100%
O54067	Rhizobium meliloti (strain 1021)	22%	100%
O64749	Arabidopsis thaliana	33%	94%
O65780	Cyamopsis tetragonoloba	34%	100%
O65781	Cyamopsis tetragonoloba	35%	100%
O84903	Lactobacillus casei	40%	100%
P09147	Escherichia coli (strain K12)	34%	100%
P13226	Streptomyces lividans	37%	100%
P18645	Rattus norvegicus	32%	100%
P21977	Streptococcus thermophilus	39%	100%
P22715	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	35%	100%
P24325	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	32%	100%
P26391	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	25%	100%
P26503	Rhizobium meliloti (strain 1021)	38%	100%
P27830	Escherichia coli (strain K12)	25%	100%
P33119	Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)	36%	100%
P35673	Erwinia amylovora	34%	100%
P37759	Escherichia coli (strain K12)	24%	100%
P37777	Shigella flexneri	25%	100%
P39630	Bacillus subtilis (strain 168)	22%	100%
P39858	Staphylococcus aureus	22%	100%
P44914	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	25%	100%
P47364	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	29%	100%
P55180	Bacillus subtilis (strain 168)	33%	100%
P55293	Escherichia coli	23%	100%
P55294	Neisseria meningitidis serogroup B (strain MC58)	25%	100%
P55462	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	26%	100%
P56985	Neisseria meningitidis serogroup B (strain MC58)	32%	100%
P56986	Neisseria meningitidis serogroup C	33%	100%
P56997	Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)	32%	100%
P75517	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	31%	100%
P95780	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	24%	100%
P96995	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	41%	100%
P9WN64	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	27%	100%
P9WN65	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	27%	100%
Q04871	Escherichia coli O111:H-	23%	100%
Q05026	Neisseria gonorrhoeae	32%	100%
Q14376	Homo sapiens	32%	100%
Q3T105	Bos taurus	32%	100%
Q42605	Arabidopsis thaliana	32%	100%
Q43070	Pisum sativum	32%	100%
Q45291	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	39%	100%
Q4Q8W9	Leishmania major	24%	88%
Q54WS6	Dictyostelium discoideum	22%	90%
Q553X7	Dictyostelium discoideum	32%	100%
Q56093	Salmonella typhi	35%	100%
Q564Q1	Caenorhabditis elegans	31%	100%
Q57301	Yersinia enterocolitica	34%	100%
Q57664	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	28%	100%
Q58455	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	24%	100%
Q59083	Azospirillum brasilense	36%	100%
Q59678	Mannheimia haemolytica	31%	100%
Q59745	Rhizobium leguminosarum bv. trifolii	36%	100%
Q5R8D0	Pongo abelii	33%	100%
Q652A8	Oryza sativa subsp. japonica	35%	100%
Q6E7F4	Escherichia coli	24%	100%
Q6K2E1	Oryza sativa subsp. japonica	34%	100%
Q6ZDJ7	Oryza sativa subsp. japonica	34%	96%
Q7WTB1	Lactobacillus helveticus	40%	100%
Q8H0B2	Oryza sativa subsp. japonica	34%	96%
Q8H0B6	Oryza sativa subsp. japonica	34%	100%
Q8H930	Oryza sativa subsp. japonica	33%	93%
Q8LDN8	Arabidopsis thaliana	34%	100%
Q8LNZ3	Oryza sativa subsp. japonica	34%	100%
Q8R059	Mus musculus	33%	100%
Q9C7W7	Arabidopsis thaliana	33%	100%
Q9CNY5	Pasteurella multocida (strain Pm70)	33%	100%
Q9F7D4	Yersinia pestis	34%	100%
Q9FI17	Arabidopsis thaliana	34%	90%
Q9KDV3	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	43%	100%
Q9LPC1	Arabidopsis thaliana	22%	90%
Q9S642	Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)	25%	100%
Q9SA77	Arabidopsis thaliana	34%	93%
Q9SN58	Arabidopsis thaliana	34%	100%
Q9SUN3	Arabidopsis thaliana	35%	95%
Q9T0A7	Arabidopsis thaliana	34%	100%
Q9W0P5	Drosophila melanogaster	34%	100%
Q9Y7X5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
Q9ZAE8	Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110)	26%	100%
V5BEL1	Trypanosoma cruzi	22%	69%
V5DQC0	Trypanosoma cruzi	68%	93%