Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3V6_LEIMA

TriTrypDb:

LmjF.33.2310 , LMJLV39_330033800 , LMJSD75_330033200

Length:

525

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3V6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3V6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.608
CLV_C14_Caspase3-7	255	259	PF00656	0.617
CLV_C14_Caspase3-7	479	483	PF00656	0.674
CLV_NRD_NRD_1	1	3	PF00675	0.535
CLV_NRD_NRD_1	193	195	PF00675	0.516
CLV_NRD_NRD_1	324	326	PF00675	0.537
CLV_NRD_NRD_1	458	460	PF00675	0.352
CLV_PCSK_FUR_1	190	194	PF00082	0.557
CLV_PCSK_KEX2_1	192	194	PF00082	0.471
CLV_PCSK_KEX2_1	324	326	PF00082	0.537
CLV_PCSK_KEX2_1	458	460	PF00082	0.352
CLV_PCSK_SKI1_1	193	197	PF00082	0.458
CLV_PCSK_SKI1_1	327	331	PF00082	0.743
CLV_PCSK_SKI1_1	365	369	PF00082	0.495
CLV_PCSK_SKI1_1	395	399	PF00082	0.383
DEG_APCC_DBOX_1	364	372	PF00400	0.488
DEG_Nend_UBRbox_1	1	4	PF02207	0.597
DEG_SCF_FBW7_1	310	315	PF00400	0.598
DEG_SPOP_SBC_1	304	308	PF00917	0.608
DEG_SPOP_SBC_1	312	316	PF00917	0.504
DEG_SPOP_SBC_1	337	341	PF00917	0.610
DOC_ANK_TNKS_1	469	476	PF00023	0.452
DOC_ANK_TNKS_1	483	490	PF00023	0.399
DOC_CYCLIN_RxL_1	190	197	PF00134	0.524
DOC_CYCLIN_RxL_1	392	401	PF00134	0.374
DOC_CYCLIN_RxL_1	46	55	PF00134	0.495
DOC_CYCLIN_yCln2_LP_2	519	525	PF00134	0.493
DOC_MAPK_gen_1	2	9	PF00069	0.536
DOC_USP7_MATH_1	113	117	PF00917	0.503
DOC_USP7_MATH_1	156	160	PF00917	0.734
DOC_USP7_MATH_1	168	172	PF00917	0.632
DOC_USP7_MATH_1	225	229	PF00917	0.577
DOC_USP7_MATH_1	250	254	PF00917	0.562
DOC_USP7_MATH_1	304	308	PF00917	0.740
DOC_USP7_MATH_1	312	316	PF00917	0.658
DOC_USP7_MATH_1	344	348	PF00917	0.718
DOC_USP7_MATH_1	350	354	PF00917	0.668
DOC_USP7_MATH_1	413	417	PF00917	0.545
DOC_WW_Pin1_4	308	313	PF00397	0.719
DOC_WW_Pin1_4	340	345	PF00397	0.737
DOC_WW_Pin1_4	346	351	PF00397	0.785
DOC_WW_Pin1_4	77	82	PF00397	0.630
LIG_14-3-3_CanoR_1	130	135	PF00244	0.498
LIG_14-3-3_CanoR_1	136	140	PF00244	0.504
LIG_14-3-3_CanoR_1	198	204	PF00244	0.520
LIG_14-3-3_CanoR_1	2	8	PF00244	0.636
LIG_14-3-3_CanoR_1	324	332	PF00244	0.675
LIG_14-3-3_CanoR_1	379	385	PF00244	0.529
LIG_14-3-3_CanoR_1	395	400	PF00244	0.518
LIG_14-3-3_CanoR_1	88	92	PF00244	0.671
LIG_AP2alpha_2	83	85	PF02296	0.551
LIG_BRCT_BRCA1_1	69	73	PF00533	0.679
LIG_BRCT_BRCA1_2	69	75	PF00533	0.588
LIG_deltaCOP1_diTrp_1	127	131	PF00928	0.506
LIG_deltaCOP1_diTrp_1	411	418	PF00928	0.534
LIG_EVH1_2	288	292	PF00568	0.602
LIG_EVH1_2	445	449	PF00568	0.456
LIG_FHA_1	294	300	PF00498	0.675
LIG_FHA_1	350	356	PF00498	0.714
LIG_FHA_1	381	387	PF00498	0.434
LIG_FHA_1	388	394	PF00498	0.345
LIG_FHA_1	514	520	PF00498	0.387
LIG_FHA_2	178	184	PF00498	0.596
LIG_FHA_2	203	209	PF00498	0.410
LIG_FHA_2	317	323	PF00498	0.825
LIG_FHA_2	396	402	PF00498	0.499
LIG_FHA_2	422	428	PF00498	0.578
LIG_FHA_2	477	483	PF00498	0.582
LIG_FHA_2	88	94	PF00498	0.642
LIG_Integrin_RGD_1	234	236	PF01839	0.615
LIG_LIR_Apic_2	89	94	PF02991	0.599
LIG_LIR_Gen_1	127	134	PF02991	0.500
LIG_LIR_Gen_1	201	211	PF02991	0.583
LIG_LIR_Gen_1	248	257	PF02991	0.627
LIG_LIR_Gen_1	38	44	PF02991	0.605
LIG_LIR_Gen_1	415	425	PF02991	0.531
LIG_LIR_Gen_1	62	72	PF02991	0.484
LIG_LIR_Nem_3	127	131	PF02991	0.521
LIG_LIR_Nem_3	197	203	PF02991	0.479
LIG_LIR_Nem_3	248	254	PF02991	0.625
LIG_LIR_Nem_3	38	43	PF02991	0.704
LIG_LIR_Nem_3	62	67	PF02991	0.488
LIG_Pex14_2	124	128	PF04695	0.507
LIG_SH2_NCK_1	242	246	PF00017	0.626
LIG_SH2_STAP1	203	207	PF00017	0.471
LIG_SH2_STAP1	40	44	PF00017	0.573
LIG_SH3_3	26	32	PF00018	0.637
LIG_SH3_3	282	288	PF00018	0.661
LIG_SH3_3	439	445	PF00018	0.486
LIG_SH3_3	78	84	PF00018	0.546
LIG_SUMO_SIM_par_1	403	408	PF11976	0.516
LIG_TRAF2_1	180	183	PF00917	0.531
LIG_WRC_WIRS_1	203	208	PF05994	0.405
LIG_WW_3	444	448	PF00397	0.478
MOD_CDC14_SPxK_1	343	346	PF00782	0.537
MOD_CDK_SPxK_1	340	346	PF00069	0.541
MOD_CK1_1	202	208	PF00069	0.402
MOD_CK1_1	243	249	PF00069	0.620
MOD_CK1_1	308	314	PF00069	0.757
MOD_CK1_1	315	321	PF00069	0.570
MOD_CK1_1	349	355	PF00069	0.773
MOD_CK1_1	416	422	PF00069	0.605
MOD_CK2_1	177	183	PF00069	0.536
MOD_CK2_1	198	204	PF00069	0.573
MOD_CK2_1	249	255	PF00069	0.559
MOD_CK2_1	316	322	PF00069	0.709
MOD_CK2_1	395	401	PF00069	0.488
MOD_CK2_1	52	58	PF00069	0.593
MOD_CK2_1	86	92	PF00069	0.671
MOD_DYRK1A_RPxSP_1	77	81	PF00069	0.630
MOD_GlcNHglycan	153	156	PF01048	0.652
MOD_GlcNHglycan	170	173	PF01048	0.579
MOD_GlcNHglycan	242	245	PF01048	0.631
MOD_GlcNHglycan	248	251	PF01048	0.625
MOD_GlcNHglycan	315	318	PF01048	0.705
MOD_GlcNHglycan	332	335	PF01048	0.698
MOD_GlcNHglycan	340	343	PF01048	0.709
MOD_GlcNHglycan	346	349	PF01048	0.795
MOD_GlcNHglycan	352	355	PF01048	0.551
MOD_GlcNHglycan	415	418	PF01048	0.626
MOD_GSK3_1	168	175	PF00069	0.658
MOD_GSK3_1	198	205	PF00069	0.402
MOD_GSK3_1	246	253	PF00069	0.560
MOD_GSK3_1	304	311	PF00069	0.747
MOD_GSK3_1	312	319	PF00069	0.567
MOD_GSK3_1	323	330	PF00069	0.754
MOD_GSK3_1	336	343	PF00069	0.656
MOD_GSK3_1	344	351	PF00069	0.751
MOD_GSK3_1	412	419	PF00069	0.578
MOD_GSK3_1	421	428	PF00069	0.511
MOD_GSK3_1	476	483	PF00069	0.541
MOD_GSK3_1	73	80	PF00069	0.678
MOD_N-GLC_1	111	116	PF02516	0.558
MOD_N-GLC_1	198	203	PF02516	0.566
MOD_N-GLC_1	308	313	PF02516	0.697
MOD_N-GLC_1	330	335	PF02516	0.545
MOD_NEK2_1	1	6	PF00069	0.674
MOD_NEK2_1	305	310	PF00069	0.768
MOD_NEK2_1	421	426	PF00069	0.442
MOD_NEK2_1	67	72	PF00069	0.637
MOD_NEK2_1	73	78	PF00069	0.631
MOD_NEK2_2	135	140	PF00069	0.502
MOD_PIKK_1	113	119	PF00454	0.520
MOD_PIKK_1	158	164	PF00454	0.762
MOD_PIKK_1	172	178	PF00454	0.530
MOD_PKA_2	1	7	PF00069	0.598
MOD_PKA_2	129	135	PF00069	0.506
MOD_PKA_2	272	278	PF00069	0.745
MOD_PKA_2	323	329	PF00069	0.582
MOD_PKA_2	35	41	PF00069	0.610
MOD_PKA_2	67	73	PF00069	0.637
MOD_PKA_2	87	93	PF00069	0.669
MOD_Plk_1	144	150	PF00069	0.678
MOD_Plk_1	198	204	PF00069	0.569
MOD_Plk_1	330	336	PF00069	0.535
MOD_Plk_1	421	427	PF00069	0.431
MOD_Plk_1	86	92	PF00069	0.612
MOD_Plk_2-3	87	93	PF00069	0.610
MOD_Plk_4	202	208	PF00069	0.402
MOD_Plk_4	359	365	PF00069	0.350
MOD_Plk_4	38	44	PF00069	0.596
MOD_Plk_4	395	401	PF00069	0.489
MOD_Plk_4	435	441	PF00069	0.404
MOD_Plk_4	513	519	PF00069	0.448
MOD_ProDKin_1	308	314	PF00069	0.720
MOD_ProDKin_1	340	346	PF00069	0.739
MOD_ProDKin_1	77	83	PF00069	0.626
TRG_DiLeu_BaLyEn_6	191	196	PF01217	0.564
TRG_ENDOCYTIC_2	203	206	PF00928	0.562
TRG_ENDOCYTIC_2	40	43	PF00928	0.600
TRG_ER_diArg_1	189	192	PF00400	0.623
TRG_ER_diArg_1	193	195	PF00400	0.545
TRG_ER_diArg_1	323	325	PF00400	0.546
TRG_ER_diArg_1	457	459	PF00400	0.490
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	510	515	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	77	82	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF55	Leptomonas seymouri	52%	98%
A0A3S7X722	Leishmania donovani	88%	100%
A4HLU4	Leishmania braziliensis	70%	100%
D0A684	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AHP9	Leishmania infantum	89%	100%
E9B470	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5B8P3	Trypanosoma cruzi	33%	100%