Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q3V4_LEIMA

TriTrypDb:

LmjF.33.2330 , LMJLV39_330034000 , LMJSD75_330033400

Length:

1067

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3V4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3V4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	524	528	PF00656	0.609
CLV_C14_Caspase3-7	758	762	PF00656	0.579
CLV_C14_Caspase3-7	959	963	PF00656	0.552
CLV_MEL_PAP_1	438	444	PF00089	0.555
CLV_NRD_NRD_1	115	117	PF00675	0.551
CLV_NRD_NRD_1	130	132	PF00675	0.426
CLV_NRD_NRD_1	197	199	PF00675	0.499
CLV_NRD_NRD_1	207	209	PF00675	0.427
CLV_NRD_NRD_1	218	220	PF00675	0.422
CLV_NRD_NRD_1	261	263	PF00675	0.627
CLV_NRD_NRD_1	515	517	PF00675	0.604
CLV_NRD_NRD_1	807	809	PF00675	0.648
CLV_NRD_NRD_1	889	891	PF00675	0.610
CLV_NRD_NRD_1	945	947	PF00675	0.559
CLV_NRD_NRD_1	991	993	PF00675	0.528
CLV_PCSK_KEX2_1	115	117	PF00082	0.551
CLV_PCSK_KEX2_1	130	132	PF00082	0.426
CLV_PCSK_KEX2_1	197	199	PF00082	0.508
CLV_PCSK_KEX2_1	207	209	PF00082	0.461
CLV_PCSK_KEX2_1	218	220	PF00082	0.415
CLV_PCSK_KEX2_1	515	517	PF00082	0.604
CLV_PCSK_KEX2_1	809	811	PF00082	0.630
CLV_PCSK_KEX2_1	889	891	PF00082	0.610
CLV_PCSK_KEX2_1	945	947	PF00082	0.560
CLV_PCSK_KEX2_1	991	993	PF00082	0.530
CLV_PCSK_PC1ET2_1	809	811	PF00082	0.647
CLV_PCSK_SKI1_1	150	154	PF00082	0.548
CLV_PCSK_SKI1_1	308	312	PF00082	0.642
CLV_PCSK_SKI1_1	432	436	PF00082	0.694
CLV_PCSK_SKI1_1	451	455	PF00082	0.443
CLV_PCSK_SKI1_1	458	462	PF00082	0.681
CLV_PCSK_SKI1_1	702	706	PF00082	0.523
CLV_PCSK_SKI1_1	903	907	PF00082	0.521
CLV_PCSK_SKI1_1	991	995	PF00082	0.498
CLV_Separin_Fungi	486	492	PF03568	0.601
DEG_APCC_DBOX_1	114	122	PF00400	0.517
DEG_APCC_DBOX_1	196	204	PF00400	0.493
DEG_APCC_DBOX_1	431	439	PF00400	0.672
DEG_SPOP_SBC_1	360	364	PF00917	0.569
DOC_ANK_TNKS_1	1055	1062	PF00023	0.612
DOC_CYCLIN_yCln2_LP_2	400	406	PF00134	0.633
DOC_CYCLIN_yCln2_LP_2	79	85	PF00134	0.661
DOC_MAPK_gen_1	115	122	PF00069	0.394
DOC_MAPK_gen_1	515	521	PF00069	0.603
DOC_MAPK_gen_1	965	974	PF00069	0.537
DOC_MAPK_MEF2A_6	115	124	PF00069	0.398
DOC_MAPK_MEF2A_6	432	439	PF00069	0.595
DOC_MAPK_MEF2A_6	74	83	PF00069	0.571
DOC_PP1_RVXF_1	910	916	PF00149	0.577
DOC_PP1_SILK_1	702	707	PF00149	0.600
DOC_PP2B_LxvP_1	400	403	PF13499	0.560
DOC_PP2B_LxvP_1	627	630	PF13499	0.496
DOC_PP2B_LxvP_1	79	82	PF13499	0.662
DOC_PP4_FxxP_1	687	690	PF00568	0.483
DOC_USP7_MATH_1	280	284	PF00917	0.600
DOC_USP7_MATH_1	30	34	PF00917	0.649
DOC_USP7_MATH_1	360	364	PF00917	0.564
DOC_USP7_MATH_1	440	444	PF00917	0.535
DOC_USP7_MATH_1	62	66	PF00917	0.634
DOC_USP7_MATH_1	72	76	PF00917	0.707
DOC_USP7_MATH_1	795	799	PF00917	0.646
DOC_USP7_MATH_1	8	12	PF00917	0.645
DOC_USP7_MATH_1	847	851	PF00917	0.687
DOC_USP7_MATH_1	861	865	PF00917	0.643
DOC_USP7_MATH_1	891	895	PF00917	0.628
DOC_USP7_MATH_1	897	901	PF00917	0.536
DOC_USP7_MATH_1	96	100	PF00917	0.547
DOC_WW_Pin1_4	317	322	PF00397	0.551
DOC_WW_Pin1_4	366	371	PF00397	0.685
DOC_WW_Pin1_4	50	55	PF00397	0.631
DOC_WW_Pin1_4	57	62	PF00397	0.714
DOC_WW_Pin1_4	686	691	PF00397	0.568
DOC_WW_Pin1_4	746	751	PF00397	0.558
DOC_WW_Pin1_4	791	796	PF00397	0.713
DOC_WW_Pin1_4	838	843	PF00397	0.647
DOC_WW_Pin1_4	866	871	PF00397	0.665
DOC_WW_Pin1_4	872	877	PF00397	0.713
LIG_14-3-3_CanoR_1	145	153	PF00244	0.552
LIG_14-3-3_CanoR_1	207	212	PF00244	0.507
LIG_14-3-3_CanoR_1	218	225	PF00244	0.445
LIG_14-3-3_CanoR_1	366	370	PF00244	0.614
LIG_14-3-3_CanoR_1	441	449	PF00244	0.673
LIG_14-3-3_CanoR_1	515	520	PF00244	0.648
LIG_14-3-3_CanoR_1	582	587	PF00244	0.538
LIG_14-3-3_CanoR_1	635	643	PF00244	0.628
LIG_14-3-3_CanoR_1	74	80	PF00244	0.691
LIG_14-3-3_CanoR_1	785	791	PF00244	0.570
LIG_14-3-3_CanoR_1	808	817	PF00244	0.649
LIG_14-3-3_CanoR_1	889	898	PF00244	0.628
LIG_Actin_WH2_2	567	584	PF00022	0.598
LIG_Actin_WH2_2	875	891	PF00022	0.593
LIG_Actin_WH2_2	911	928	PF00022	0.523
LIG_BIR_III_4	410	414	PF00653	0.630
LIG_BRCT_BRCA1_1	13	17	PF00533	0.544
LIG_BRCT_BRCA1_1	322	326	PF00533	0.675
LIG_BRCT_BRCA1_1	357	361	PF00533	0.629
LIG_BRCT_BRCA1_1	799	803	PF00533	0.685
LIG_CaM_IQ_9	200	216	PF13499	0.469
LIG_CtBP_PxDLS_1	82	86	PF00389	0.512
LIG_FHA_1	1052	1058	PF00498	0.534
LIG_FHA_1	252	258	PF00498	0.493
LIG_FHA_1	290	296	PF00498	0.593
LIG_FHA_1	320	326	PF00498	0.538
LIG_FHA_1	344	350	PF00498	0.529
LIG_FHA_1	399	405	PF00498	0.603
LIG_FHA_1	507	513	PF00498	0.618
LIG_FHA_1	521	527	PF00498	0.546
LIG_FHA_1	585	591	PF00498	0.538
LIG_FHA_1	593	599	PF00498	0.527
LIG_FHA_1	64	70	PF00498	0.608
LIG_FHA_1	673	679	PF00498	0.631
LIG_FHA_1	727	733	PF00498	0.508
LIG_FHA_1	74	80	PF00498	0.608
LIG_FHA_1	869	875	PF00498	0.539
LIG_FHA_1	920	926	PF00498	0.615
LIG_FHA_2	369	375	PF00498	0.646
LIG_FHA_2	587	593	PF00498	0.533
LIG_LIR_Gen_1	443	453	PF02991	0.614
LIG_LIR_Gen_1	693	700	PF02991	0.541
LIG_LIR_Gen_1	721	726	PF02991	0.608
LIG_LIR_Nem_3	443	449	PF02991	0.605
LIG_LIR_Nem_3	693	697	PF02991	0.542
LIG_LIR_Nem_3	721	725	PF02991	0.608
LIG_MYND_1	403	407	PF01753	0.634
LIG_NRBOX	117	123	PF00104	0.493
LIG_PDZ_Class_2	1062	1067	PF00595	0.661
LIG_RPA_C_Fungi	540	552	PF08784	0.479
LIG_SH2_CRK	446	450	PF00017	0.581
LIG_SH2_CRK	722	726	PF00017	0.611
LIG_SH2_SRC	553	556	PF00017	0.606
LIG_SH2_STAP1	168	172	PF00017	0.487
LIG_SH2_STAP1	46	50	PF00017	0.560
LIG_SH2_STAP1	553	557	PF00017	0.608
LIG_SH2_STAP1	586	590	PF00017	0.670
LIG_SH2_STAT3	168	171	PF00017	0.488
LIG_SH2_STAT5	46	49	PF00017	0.558
LIG_SH2_STAT5	570	573	PF00017	0.670
LIG_SH2_STAT5	586	589	PF00017	0.448
LIG_SH2_STAT5	877	880	PF00017	0.582
LIG_SH2_STAT5	881	884	PF00017	0.589
LIG_SH3_2	1037	1042	PF14604	0.620
LIG_SH3_3	1034	1040	PF00018	0.645
LIG_SH3_3	400	406	PF00018	0.767
LIG_SH3_3	528	534	PF00018	0.598
LIG_SH3_3	879	885	PF00018	0.589
LIG_SUMO_SIM_anti_2	969	976	PF11976	0.543
LIG_SUMO_SIM_par_1	151	156	PF11976	0.544
LIG_TRAF2_1	167	170	PF00917	0.413
LIG_TRAF2_1	921	924	PF00917	0.563
LIG_WRC_WIRS_1	391	396	PF05994	0.528
MOD_CDK_SPK_2	746	751	PF00069	0.558
MOD_CDK_SPxxK_3	57	64	PF00069	0.654
MOD_CK1_1	1045	1051	PF00069	0.676
MOD_CK1_1	11	17	PF00069	0.641
MOD_CK1_1	283	289	PF00069	0.680
MOD_CK1_1	320	326	PF00069	0.535
MOD_CK1_1	327	333	PF00069	0.512
MOD_CK1_1	368	374	PF00069	0.783
MOD_CK1_1	384	390	PF00069	0.647
MOD_CK1_1	52	58	PF00069	0.645
MOD_CK1_1	580	586	PF00069	0.571
MOD_CK1_1	60	66	PF00069	0.656
MOD_CK1_1	749	755	PF00069	0.578
MOD_CK1_1	75	81	PF00069	0.780
MOD_CK1_1	796	802	PF00069	0.607
MOD_CK1_1	804	810	PF00069	0.616
MOD_CK1_1	828	834	PF00069	0.638
MOD_CK1_1	838	844	PF00069	0.570
MOD_CK1_1	869	875	PF00069	0.635
MOD_CK2_1	368	374	PF00069	0.775
MOD_CK2_1	586	592	PF00069	0.555
MOD_DYRK1A_RPxSP_1	366	370	PF00069	0.542
MOD_GlcNHglycan	1005	1008	PF01048	0.591
MOD_GlcNHglycan	1051	1054	PF01048	0.599
MOD_GlcNHglycan	349	352	PF01048	0.632
MOD_GlcNHglycan	357	360	PF01048	0.679
MOD_GlcNHglycan	381	384	PF01048	0.774
MOD_GlcNHglycan	407	410	PF01048	0.636
MOD_GlcNHglycan	55	58	PF01048	0.715
MOD_GlcNHglycan	714	717	PF01048	0.498
MOD_GlcNHglycan	746	749	PF01048	0.602
MOD_GlcNHglycan	757	760	PF01048	0.626
MOD_GlcNHglycan	803	806	PF01048	0.648
MOD_GlcNHglycan	827	830	PF01048	0.581
MOD_GlcNHglycan	853	856	PF01048	0.782
MOD_GlcNHglycan	863	866	PF01048	0.628
MOD_GlcNHglycan	899	902	PF01048	0.673
MOD_GSK3_1	1045	1052	PF00069	0.685
MOD_GSK3_1	181	188	PF00069	0.410
MOD_GSK3_1	320	327	PF00069	0.711
MOD_GSK3_1	343	350	PF00069	0.671
MOD_GSK3_1	355	362	PF00069	0.581
MOD_GSK3_1	377	384	PF00069	0.784
MOD_GSK3_1	49	56	PF00069	0.711
MOD_GSK3_1	577	584	PF00069	0.582
MOD_GSK3_1	60	67	PF00069	0.617
MOD_GSK3_1	7	14	PF00069	0.679
MOD_GSK3_1	739	746	PF00069	0.654
MOD_GSK3_1	749	756	PF00069	0.611
MOD_GSK3_1	791	798	PF00069	0.681
MOD_GSK3_1	804	811	PF00069	0.557
MOD_GSK3_1	836	843	PF00069	0.658
MOD_GSK3_1	847	854	PF00069	0.792
MOD_GSK3_1	868	875	PF00069	0.647
MOD_GSK3_1	897	904	PF00069	0.697
MOD_GSK3_1	993	1000	PF00069	0.496
MOD_N-GLC_1	327	332	PF02516	0.522
MOD_N-GLC_1	384	389	PF02516	0.704
MOD_N-GLC_1	666	671	PF02516	0.652
MOD_N-GLC_1	866	871	PF02516	0.663
MOD_NEK2_1	1029	1034	PF00069	0.581
MOD_NEK2_1	1051	1056	PF00069	0.539
MOD_NEK2_1	13	18	PF00069	0.663
MOD_NEK2_1	181	186	PF00069	0.402
MOD_NEK2_1	361	366	PF00069	0.603
MOD_NEK2_1	379	384	PF00069	0.623
MOD_NEK2_1	477	482	PF00069	0.594
MOD_NEK2_1	581	586	PF00069	0.719
MOD_NEK2_1	594	599	PF00069	0.487
MOD_NEK2_1	666	671	PF00069	0.672
MOD_NEK2_1	726	731	PF00069	0.534
MOD_NEK2_1	732	737	PF00069	0.561
MOD_NEK2_1	755	760	PF00069	0.704
MOD_NEK2_1	825	830	PF00069	0.657
MOD_NEK2_1	835	840	PF00069	0.630
MOD_PIKK_1	280	286	PF00454	0.549
MOD_PIKK_1	327	333	PF00454	0.521
MOD_PIKK_1	361	367	PF00454	0.653
MOD_PIKK_1	393	399	PF00454	0.634
MOD_PIKK_1	477	483	PF00454	0.546
MOD_PIKK_1	506	512	PF00454	0.597
MOD_PIKK_1	749	755	PF00454	0.699
MOD_PIKK_1	776	782	PF00454	0.574
MOD_PIKK_1	8	14	PF00454	0.662
MOD_PIKK_1	869	875	PF00454	0.660
MOD_PIKK_1	919	925	PF00454	0.615
MOD_PK_1	515	521	PF00069	0.603
MOD_PKA_1	207	213	PF00069	0.402
MOD_PKA_1	218	224	PF00069	0.362
MOD_PKA_1	515	521	PF00069	0.603
MOD_PKA_1	808	814	PF00069	0.652
MOD_PKA_2	1045	1051	PF00069	0.644
MOD_PKA_2	207	213	PF00069	0.518
MOD_PKA_2	218	224	PF00069	0.405
MOD_PKA_2	365	371	PF00069	0.618
MOD_PKA_2	440	446	PF00069	0.682
MOD_PKA_2	514	520	PF00069	0.648
MOD_PKA_2	581	587	PF00069	0.621
MOD_PKA_2	672	678	PF00069	0.612
MOD_PKA_2	73	79	PF00069	0.689
MOD_PKA_2	861	867	PF00069	0.585
MOD_Plk_1	289	295	PF00069	0.597
MOD_Plk_1	566	572	PF00069	0.591
MOD_Plk_1	666	672	PF00069	0.606
MOD_Plk_1	739	745	PF00069	0.527
MOD_Plk_4	1060	1066	PF00069	0.620
MOD_Plk_4	390	396	PF00069	0.584
MOD_Plk_4	508	514	PF00069	0.609
MOD_Plk_4	586	592	PF00069	0.546
MOD_Plk_4	700	706	PF00069	0.564
MOD_Plk_4	714	720	PF00069	0.553
MOD_Plk_4	970	976	PF00069	0.570
MOD_ProDKin_1	317	323	PF00069	0.549
MOD_ProDKin_1	366	372	PF00069	0.686
MOD_ProDKin_1	50	56	PF00069	0.632
MOD_ProDKin_1	57	63	PF00069	0.714
MOD_ProDKin_1	686	692	PF00069	0.562
MOD_ProDKin_1	746	752	PF00069	0.556
MOD_ProDKin_1	791	797	PF00069	0.712
MOD_ProDKin_1	838	844	PF00069	0.646
MOD_ProDKin_1	866	872	PF00069	0.660
MOD_SUMO_for_1	245	248	PF00179	0.538
MOD_SUMO_for_1	389	392	PF00179	0.535
MOD_SUMO_for_1	460	463	PF00179	0.619
MOD_SUMO_rev_2	143	153	PF00179	0.532
MOD_SUMO_rev_2	307	317	PF00179	0.581
MOD_SUMO_rev_2	463	473	PF00179	0.600
TRG_DiLeu_BaEn_1	820	825	PF01217	0.605
TRG_DiLeu_BaEn_3	169	175	PF01217	0.464
TRG_DiLeu_BaLyEn_6	687	692	PF01217	0.571
TRG_ENDOCYTIC_2	446	449	PF00928	0.579
TRG_ENDOCYTIC_2	722	725	PF00928	0.611
TRG_ENDOCYTIC_2	818	821	PF00928	0.561
TRG_ER_diArg_1	114	116	PF00400	0.472
TRG_ER_diArg_1	130	132	PF00400	0.452
TRG_ER_diArg_1	196	198	PF00400	0.539
TRG_ER_diArg_1	473	476	PF00400	0.612
TRG_ER_diArg_1	651	654	PF00400	0.492
TRG_ER_diArg_1	888	890	PF00400	0.602
TRG_ER_diArg_1	990	992	PF00400	0.528
TRG_NES_CRM1_1	112	127	PF08389	0.465
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	432	436	PF00026	0.666
TRG_Pf-PMV_PEXEL_1	562	567	PF00026	0.681
TRG_Pf-PMV_PEXEL_1	618	622	PF00026	0.545
TRG_PTS2	1	13	PF00400	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD26	Leptomonas seymouri	29%	79%
A0A3S5H7V0	Leishmania donovani	84%	100%
A4HLU6	Leishmania braziliensis	58%	92%
E9AHQ1	Leishmania infantum	85%	100%
E9B472	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%