TBC1 domain family member 23

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rab-GTPase-TBC domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q3V2_LEIMA

TriTrypDb:

LmjF.33.2350 , LMJLV39_330034200 , LMJSD75_300008500

Length:

850

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005802	trans-Golgi network	4	3
GO:0005829	cytosol	2	16
GO:0031984	organelle subcompartment	2	3
GO:0098791	Golgi apparatus subcompartment	3	3
GO:0110165	cellular anatomical entity	1	16
GO:0005794	Golgi apparatus	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11

Expansion

Sequence features

Q4Q3V2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3V2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	16
GO:0009987	cellular process	1	16
GO:0016043	cellular component organization	3	3
GO:0016192	vesicle-mediated transport	4	16
GO:0016197	endosomal transport	4	16
GO:0016482	cytosolic transport	4	16
GO:0042147	retrograde transport, endosome to Golgi	5	16
GO:0046907	intracellular transport	3	16
GO:0051179	localization	1	16
GO:0051234	establishment of localization	2	16
GO:0051641	cellular localization	2	16
GO:0051649	establishment of localization in cell	3	16
GO:0071840	cellular component organization or biogenesis	2	3
GO:0099022	vesicle tethering	4	3
GO:0099041	vesicle tethering to Golgi	5	3

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	356	360	PF00656	0.604
CLV_C14_Caspase3-7	81	85	PF00656	0.492
CLV_NRD_NRD_1	282	284	PF00675	0.342
CLV_NRD_NRD_1	322	324	PF00675	0.438
CLV_NRD_NRD_1	489	491	PF00675	0.522
CLV_NRD_NRD_1	768	770	PF00675	0.696
CLV_NRD_NRD_1	90	92	PF00675	0.582
CLV_PCSK_KEX2_1	282	284	PF00082	0.342
CLV_PCSK_KEX2_1	322	324	PF00082	0.427
CLV_PCSK_KEX2_1	434	436	PF00082	0.626
CLV_PCSK_KEX2_1	489	491	PF00082	0.525
CLV_PCSK_KEX2_1	568	570	PF00082	0.583
CLV_PCSK_KEX2_1	633	635	PF00082	0.652
CLV_PCSK_KEX2_1	768	770	PF00082	0.698
CLV_PCSK_KEX2_1	90	92	PF00082	0.582
CLV_PCSK_PC1ET2_1	434	436	PF00082	0.626
CLV_PCSK_PC1ET2_1	568	570	PF00082	0.583
CLV_PCSK_PC1ET2_1	633	635	PF00082	0.648
CLV_PCSK_SKI1_1	150	154	PF00082	0.619
CLV_PCSK_SKI1_1	216	220	PF00082	0.500
CLV_PCSK_SKI1_1	252	256	PF00082	0.377
CLV_PCSK_SKI1_1	282	286	PF00082	0.321
CLV_PCSK_SKI1_1	331	335	PF00082	0.531
CLV_PCSK_SKI1_1	372	376	PF00082	0.496
CLV_PCSK_SKI1_1	525	529	PF00082	0.483
CLV_PCSK_SKI1_1	769	773	PF00082	0.655
DEG_APCC_DBOX_1	117	125	PF00400	0.495
DEG_APCC_DBOX_1	321	329	PF00400	0.399
DEG_Nend_UBRbox_2	1	3	PF02207	0.653
DEG_SCF_FBW7_1	384	389	PF00400	0.435
DEG_SPOP_SBC_1	245	249	PF00917	0.485
DEG_SPOP_SBC_1	792	796	PF00917	0.752
DOC_CYCLIN_RxL_1	320	330	PF00134	0.366
DOC_CYCLIN_yClb5_NLxxxL_5	509	518	PF00134	0.408
DOC_CYCLIN_yCln2_LP_2	304	310	PF00134	0.443
DOC_MAPK_gen_1	322	328	PF00069	0.424
DOC_MAPK_gen_1	732	740	PF00069	0.523
DOC_MAPK_MEF2A_6	525	533	PF00069	0.487
DOC_MAPK_RevD_3	308	323	PF00069	0.361
DOC_PP1_RVXF_1	294	301	PF00149	0.443
DOC_PP1_RVXF_1	389	396	PF00149	0.504
DOC_PP2B_LxvP_1	771	774	PF13499	0.703
DOC_PP4_FxxP_1	257	260	PF00568	0.443
DOC_PP4_FxxP_1	343	346	PF00568	0.393
DOC_USP7_MATH_1	237	241	PF00917	0.393
DOC_USP7_MATH_1	246	250	PF00917	0.385
DOC_USP7_MATH_1	445	449	PF00917	0.591
DOC_USP7_MATH_1	50	54	PF00917	0.662
DOC_USP7_MATH_1	623	627	PF00917	0.597
DOC_USP7_MATH_1	649	653	PF00917	0.682
DOC_USP7_MATH_1	681	685	PF00917	0.789
DOC_USP7_MATH_1	755	759	PF00917	0.681
DOC_USP7_MATH_1	761	765	PF00917	0.621
DOC_USP7_MATH_1	78	82	PF00917	0.527
DOC_USP7_MATH_1	783	787	PF00917	0.702
DOC_USP7_MATH_1	793	797	PF00917	0.756
DOC_USP7_MATH_1	833	837	PF00917	0.657
DOC_USP7_UBL2_3	582	586	PF12436	0.458
DOC_WW_Pin1_4	23	28	PF00397	0.661
DOC_WW_Pin1_4	363	368	PF00397	0.612
DOC_WW_Pin1_4	382	387	PF00397	0.290
DOC_WW_Pin1_4	415	420	PF00397	0.433
DOC_WW_Pin1_4	552	557	PF00397	0.538
DOC_WW_Pin1_4	57	62	PF00397	0.769
DOC_WW_Pin1_4	739	744	PF00397	0.664
DOC_WW_Pin1_4	774	779	PF00397	0.765
DOC_WW_Pin1_4	788	793	PF00397	0.658
DOC_WW_Pin1_4	828	833	PF00397	0.626
LIG_14-3-3_CanoR_1	212	220	PF00244	0.432
LIG_14-3-3_CanoR_1	322	326	PF00244	0.457
LIG_14-3-3_CanoR_1	361	365	PF00244	0.489
LIG_14-3-3_CanoR_1	569	576	PF00244	0.674
LIG_14-3-3_CanoR_1	768	774	PF00244	0.654
LIG_14-3-3_CanoR_1	806	811	PF00244	0.714
LIG_14-3-3_CanoR_1	91	97	PF00244	0.531
LIG_Actin_WH2_2	390	407	PF00022	0.458
LIG_Actin_WH2_2	719	737	PF00022	0.617
LIG_APCC_ABBA_1	395	400	PF00400	0.493
LIG_BIR_III_2	444	448	PF00653	0.548
LIG_Clathr_ClatBox_1	124	128	PF01394	0.524
LIG_deltaCOP1_diTrp_1	299	302	PF00928	0.420
LIG_EH1_1	547	555	PF00400	0.397
LIG_FHA_1	168	174	PF00498	0.469
LIG_FHA_1	203	209	PF00498	0.435
LIG_FHA_1	24	30	PF00498	0.531
LIG_FHA_1	245	251	PF00498	0.395
LIG_FHA_1	333	339	PF00498	0.378
LIG_FHA_1	416	422	PF00498	0.559
LIG_FHA_1	5	11	PF00498	0.617
LIG_FHA_1	539	545	PF00498	0.436
LIG_FHA_1	662	668	PF00498	0.782
LIG_FHA_1	735	741	PF00498	0.662
LIG_FHA_2	172	178	PF00498	0.508
LIG_FHA_2	262	268	PF00498	0.443
LIG_FHA_2	405	411	PF00498	0.558
LIG_FHA_2	54	60	PF00498	0.702
LIG_LIR_Apic_2	190	195	PF02991	0.480
LIG_LIR_Gen_1	299	308	PF02991	0.318
LIG_LIR_Gen_1	461	471	PF02991	0.440
LIG_LIR_Gen_1	818	828	PF02991	0.562
LIG_LIR_Nem_3	143	148	PF02991	0.543
LIG_LIR_Nem_3	222	227	PF02991	0.370
LIG_LIR_Nem_3	299	303	PF02991	0.318
LIG_LIR_Nem_3	461	467	PF02991	0.436
LIG_LIR_Nem_3	818	824	PF02991	0.559
LIG_NRBOX	120	126	PF00104	0.490
LIG_PCNA_PIPBox_1	270	279	PF02747	0.443
LIG_PCNA_yPIPBox_3	212	224	PF02747	0.497
LIG_PCNA_yPIPBox_3	270	283	PF02747	0.443
LIG_PCNA_yPIPBox_3	71	80	PF02747	0.564
LIG_Pex14_2	821	825	PF04695	0.558
LIG_PTAP_UEV_1	750	755	PF05743	0.542
LIG_SH2_CRK	122	126	PF00017	0.380
LIG_SH2_CRK	224	228	PF00017	0.427
LIG_SH2_CRK	464	468	PF00017	0.424
LIG_SH2_GRB2like	192	195	PF00017	0.524
LIG_SH2_NCK_1	243	247	PF00017	0.484
LIG_SH2_SRC	243	246	PF00017	0.491
LIG_SH2_SRC	451	454	PF00017	0.492
LIG_SH2_STAP1	148	152	PF00017	0.568
LIG_SH2_STAP1	291	295	PF00017	0.438
LIG_SH2_STAT3	148	151	PF00017	0.371
LIG_SH2_STAT3	258	261	PF00017	0.434
LIG_SH2_STAT3	597	600	PF00017	0.688
LIG_SH2_STAT5	122	125	PF00017	0.409
LIG_SH2_STAT5	148	151	PF00017	0.567
LIG_SH2_STAT5	192	195	PF00017	0.512
LIG_SH2_STAT5	206	209	PF00017	0.377
LIG_SH2_STAT5	276	279	PF00017	0.396
LIG_SH2_STAT5	312	315	PF00017	0.335
LIG_SH2_STAT5	317	320	PF00017	0.322
LIG_SH2_STAT5	451	454	PF00017	0.366
LIG_SH2_STAT5	521	524	PF00017	0.421
LIG_SH2_STAT5	597	600	PF00017	0.688
LIG_SH3_2	730	735	PF14604	0.625
LIG_SH3_3	130	136	PF00018	0.570
LIG_SH3_3	416	422	PF00018	0.520
LIG_SH3_3	58	64	PF00018	0.691
LIG_SH3_3	727	733	PF00018	0.675
LIG_SH3_3	748	754	PF00018	0.759
LIG_SH3_3	786	792	PF00018	0.756
LIG_SUMO_SIM_anti_2	324	330	PF11976	0.442
LIG_SUMO_SIM_anti_2	720	728	PF11976	0.612
LIG_SUMO_SIM_par_1	123	129	PF11976	0.552
LIG_SUMO_SIM_par_1	283	290	PF11976	0.385
LIG_SUMO_SIM_par_1	736	742	PF11976	0.567
LIG_SxIP_EBH_1	535	546	PF03271	0.460
LIG_TRAF2_1	140	143	PF00917	0.677
LIG_TRFH_1	395	399	PF08558	0.476
LIG_UBA3_1	226	232	PF00899	0.415
LIG_UBA3_1	325	331	PF00899	0.462
MOD_CK1_1	211	217	PF00069	0.515
MOD_CK1_1	458	464	PF00069	0.465
MOD_CK1_1	53	59	PF00069	0.794
MOD_CK1_1	60	66	PF00069	0.728
MOD_CK1_1	640	646	PF00069	0.604
MOD_CK1_1	651	657	PF00069	0.652
MOD_CK1_1	670	676	PF00069	0.704
MOD_CK1_1	679	685	PF00069	0.682
MOD_CK1_1	791	797	PF00069	0.802
MOD_CK1_1	95	101	PF00069	0.559
MOD_CK2_1	171	177	PF00069	0.485
MOD_CK2_1	404	410	PF00069	0.564
MOD_CK2_1	53	59	PF00069	0.709
MOD_CK2_1	63	69	PF00069	0.704
MOD_CK2_1	635	641	PF00069	0.736
MOD_CK2_1	710	716	PF00069	0.707
MOD_CK2_1	761	767	PF00069	0.813
MOD_CK2_1	839	845	PF00069	0.693
MOD_Cter_Amidation	566	569	PF01082	0.489
MOD_GlcNHglycan	429	432	PF01048	0.604
MOD_GlcNHglycan	587	590	PF01048	0.713
MOD_GlcNHglycan	593	597	PF01048	0.705
MOD_GlcNHglycan	653	656	PF01048	0.718
MOD_GlcNHglycan	667	670	PF01048	0.630
MOD_GlcNHglycan	673	676	PF01048	0.619
MOD_GlcNHglycan	678	681	PF01048	0.765
MOD_GlcNHglycan	751	754	PF01048	0.735
MOD_GlcNHglycan	758	761	PF01048	0.652
MOD_GlcNHglycan	763	766	PF01048	0.547
MOD_GlcNHglycan	795	798	PF01048	0.726
MOD_GlcNHglycan	808	811	PF01048	0.564
MOD_GlcNHglycan	841	844	PF01048	0.723
MOD_GSK3_1	107	114	PF00069	0.389
MOD_GSK3_1	167	174	PF00069	0.511
MOD_GSK3_1	23	30	PF00069	0.709
MOD_GSK3_1	286	293	PF00069	0.434
MOD_GSK3_1	317	324	PF00069	0.463
MOD_GSK3_1	36	43	PF00069	0.815
MOD_GSK3_1	382	389	PF00069	0.356
MOD_GSK3_1	423	430	PF00069	0.495
MOD_GSK3_1	5	12	PF00069	0.791
MOD_GSK3_1	53	60	PF00069	0.846
MOD_GSK3_1	635	642	PF00069	0.589
MOD_GSK3_1	645	652	PF00069	0.584
MOD_GSK3_1	661	668	PF00069	0.646
MOD_GSK3_1	679	686	PF00069	0.834
MOD_GSK3_1	769	776	PF00069	0.742
MOD_GSK3_1	788	795	PF00069	0.685
MOD_GSK3_1	91	98	PF00069	0.528
MOD_N-GLC_1	4	9	PF02516	0.555
MOD_N-GLC_1	404	409	PF02516	0.564
MOD_N-GLC_1	563	568	PF02516	0.503
MOD_NEK2_1	202	207	PF00069	0.464
MOD_NEK2_1	219	224	PF00069	0.473
MOD_NEK2_1	278	283	PF00069	0.443
MOD_NEK2_1	326	331	PF00069	0.558
MOD_NEK2_1	341	346	PF00069	0.377
MOD_NEK2_1	404	409	PF00069	0.368
MOD_NEK2_1	501	506	PF00069	0.489
MOD_NEK2_1	538	543	PF00069	0.493
MOD_NEK2_1	662	667	PF00069	0.719
MOD_NEK2_1	725	730	PF00069	0.558
MOD_NEK2_1	734	739	PF00069	0.610
MOD_NEK2_2	187	192	PF00069	0.421
MOD_NEK2_2	92	97	PF00069	0.661
MOD_PIKK_1	332	338	PF00454	0.490
MOD_PIKK_1	386	392	PF00454	0.443
MOD_PIKK_1	69	75	PF00454	0.560
MOD_PKA_2	211	217	PF00069	0.443
MOD_PKA_2	321	327	PF00069	0.474
MOD_PKA_2	360	366	PF00069	0.595
MOD_PKA_2	458	464	PF00069	0.410
MOD_PKA_2	635	641	PF00069	0.593
MOD_PKA_2	702	708	PF00069	0.693
MOD_PKA_2	734	740	PF00069	0.726
MOD_Plk_1	143	149	PF00069	0.559
MOD_Plk_1	187	193	PF00069	0.540
MOD_Plk_1	826	832	PF00069	0.770
MOD_Plk_4	187	193	PF00069	0.538
MOD_Plk_4	202	208	PF00069	0.308
MOD_Plk_4	246	252	PF00069	0.392
MOD_Plk_4	272	278	PF00069	0.433
MOD_Plk_4	370	376	PF00069	0.447
MOD_Plk_4	734	740	PF00069	0.696
MOD_Plk_4	78	84	PF00069	0.396
MOD_ProDKin_1	23	29	PF00069	0.660
MOD_ProDKin_1	363	369	PF00069	0.612
MOD_ProDKin_1	382	388	PF00069	0.288
MOD_ProDKin_1	415	421	PF00069	0.425
MOD_ProDKin_1	552	558	PF00069	0.534
MOD_ProDKin_1	57	63	PF00069	0.766
MOD_ProDKin_1	739	745	PF00069	0.665
MOD_ProDKin_1	774	780	PF00069	0.767
MOD_ProDKin_1	788	794	PF00069	0.675
MOD_ProDKin_1	828	834	PF00069	0.626
MOD_SUMO_rev_2	63	72	PF00179	0.650
TRG_DiLeu_BaEn_1	510	515	PF01217	0.403
TRG_DiLeu_BaEn_1	721	726	PF01217	0.682
TRG_DiLeu_BaEn_4	510	516	PF01217	0.403
TRG_DiLeu_BaLyEn_6	280	285	PF01217	0.443
TRG_DiLeu_BaLyEn_6	540	545	PF01217	0.394
TRG_ENDOCYTIC_2	122	125	PF00928	0.380
TRG_ENDOCYTIC_2	224	227	PF00928	0.364
TRG_ENDOCYTIC_2	464	467	PF00928	0.456
TRG_ER_diArg_1	282	284	PF00400	0.343
TRG_ER_diArg_1	488	490	PF00400	0.529
TRG_Pf-PMV_PEXEL_1	283	288	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	506	510	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P357	Leptomonas seymouri	57%	99%
A0A1X0P274	Trypanosomatidae	30%	100%
A0A3Q8IGR4	Leishmania donovani	92%	99%
A0A3R7MQU5	Trypanosoma rangeli	35%	100%
A0A3S7X2Z8	Leishmania donovani	92%	96%
A4HHY0	Leishmania braziliensis	76%	100%
A4HLU8	Leishmania braziliensis	76%	100%
A4I560	Leishmania infantum	92%	77%
C9ZQI6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AHQ3	Leishmania infantum	92%	99%
E9B0F7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
E9B474	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4Q7S6	Leishmania major	100%	100%
V5DD41	Trypanosoma cruzi	38%	100%