Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP synthase regulation protein NCA2, putative

Species:

Leishmania major

UniProt:

Q4Q3V1_LEIMA

TriTrypDb:

LmjF.33.2360 , LMJLV39_330034300 , LMJSD75_330033600

Length:

928

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	7
GO:0005741	mitochondrial outer membrane	5	2
GO:0016020	membrane	2	7
GO:0019867	outer membrane	3	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2
GO:0031968	organelle outer membrane	4	2
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q3V1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3V1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	477	481	PF00656	0.558
CLV_C14_Caspase3-7	840	844	PF00656	0.818
CLV_C14_Caspase3-7	9	13	PF00656	0.681
CLV_NRD_NRD_1	106	108	PF00675	0.578
CLV_NRD_NRD_1	116	118	PF00675	0.417
CLV_NRD_NRD_1	342	344	PF00675	0.805
CLV_NRD_NRD_1	374	376	PF00675	0.712
CLV_NRD_NRD_1	506	508	PF00675	0.634
CLV_NRD_NRD_1	525	527	PF00675	0.743
CLV_NRD_NRD_1	553	555	PF00675	0.614
CLV_NRD_NRD_1	589	591	PF00675	0.546
CLV_NRD_NRD_1	792	794	PF00675	0.588
CLV_NRD_NRD_1	798	800	PF00675	0.601
CLV_NRD_NRD_1	910	912	PF00675	0.363
CLV_PCSK_KEX2_1	105	107	PF00082	0.593
CLV_PCSK_KEX2_1	116	118	PF00082	0.414
CLV_PCSK_KEX2_1	342	344	PF00082	0.775
CLV_PCSK_KEX2_1	374	376	PF00082	0.712
CLV_PCSK_KEX2_1	506	508	PF00082	0.634
CLV_PCSK_KEX2_1	525	527	PF00082	0.738
CLV_PCSK_KEX2_1	589	591	PF00082	0.546
CLV_PCSK_KEX2_1	618	620	PF00082	0.619
CLV_PCSK_KEX2_1	629	631	PF00082	0.489
CLV_PCSK_KEX2_1	791	793	PF00082	0.573
CLV_PCSK_KEX2_1	798	800	PF00082	0.549
CLV_PCSK_KEX2_1	910	912	PF00082	0.397
CLV_PCSK_PC1ET2_1	618	620	PF00082	0.619
CLV_PCSK_PC1ET2_1	629	631	PF00082	0.489
CLV_PCSK_PC7_1	787	793	PF00082	0.466
CLV_PCSK_SKI1_1	200	204	PF00082	0.680
CLV_PCSK_SKI1_1	385	389	PF00082	0.610
CLV_PCSK_SKI1_1	492	496	PF00082	0.595
CLV_PCSK_SKI1_1	506	510	PF00082	0.555
CLV_PCSK_SKI1_1	525	529	PF00082	0.671
CLV_PCSK_SKI1_1	555	559	PF00082	0.569
CLV_PCSK_SKI1_1	561	565	PF00082	0.598
CLV_PCSK_SKI1_1	626	630	PF00082	0.563
CLV_PCSK_SKI1_1	657	661	PF00082	0.619
CLV_PCSK_SKI1_1	666	670	PF00082	0.546
CLV_PCSK_SKI1_1	736	740	PF00082	0.346
CLV_PCSK_SKI1_1	913	917	PF00082	0.330
DEG_APCC_DBOX_1	491	499	PF00400	0.416
DEG_APCC_DBOX_1	575	583	PF00400	0.419
DEG_APCC_DBOX_1	665	673	PF00400	0.346
DEG_APCC_DBOX_1	910	918	PF00400	0.563
DOC_CKS1_1	336	341	PF01111	0.559
DOC_CYCLIN_RxL_1	730	743	PF00134	0.619
DOC_MAPK_gen_1	506	512	PF00069	0.502
DOC_MAPK_gen_1	721	729	PF00069	0.531
DOC_MAPK_HePTP_8	695	707	PF00069	0.419
DOC_MAPK_JIP1_4	725	731	PF00069	0.619
DOC_MAPK_MEF2A_6	698	707	PF00069	0.524
DOC_MAPK_MEF2A_6	723	731	PF00069	0.619
DOC_MAPK_MEF2A_6	74	82	PF00069	0.765
DOC_MAPK_RevD_3	93	107	PF00069	0.741
DOC_PP1_RVXF_1	559	566	PF00149	0.336
DOC_PP1_RVXF_1	655	662	PF00149	0.346
DOC_PP1_RVXF_1	730	736	PF00149	0.546
DOC_PP1_RVXF_1	738	745	PF00149	0.546
DOC_PP2B_LxvP_1	444	447	PF13499	0.473
DOC_PP2B_LxvP_1	751	754	PF13499	0.732
DOC_PP4_FxxP_1	295	298	PF00568	0.503
DOC_USP7_MATH_1	17	21	PF00917	0.763
DOC_USP7_MATH_1	260	264	PF00917	0.534
DOC_USP7_MATH_1	329	333	PF00917	0.618
DOC_USP7_MATH_1	422	426	PF00917	0.596
DOC_USP7_MATH_1	455	459	PF00917	0.618
DOC_USP7_MATH_1	613	617	PF00917	0.363
DOC_USP7_MATH_1	655	659	PF00917	0.346
DOC_USP7_MATH_1	67	71	PF00917	0.777
DOC_USP7_MATH_1	76	80	PF00917	0.792
DOC_USP7_MATH_1	854	858	PF00917	0.536
DOC_WW_Pin1_4	18	23	PF00397	0.758
DOC_WW_Pin1_4	239	244	PF00397	0.457
DOC_WW_Pin1_4	264	269	PF00397	0.595
DOC_WW_Pin1_4	294	299	PF00397	0.547
DOC_WW_Pin1_4	318	323	PF00397	0.533
DOC_WW_Pin1_4	335	340	PF00397	0.640
DOC_WW_Pin1_4	467	472	PF00397	0.501
DOC_WW_Pin1_4	514	519	PF00397	0.456
DOC_WW_Pin1_4	542	547	PF00397	0.316
DOC_WW_Pin1_4	94	99	PF00397	0.821
LIG_14-3-3_CanoR_1	105	114	PF00244	0.794
LIG_14-3-3_CanoR_1	117	127	PF00244	0.490
LIG_14-3-3_CanoR_1	200	206	PF00244	0.461
LIG_14-3-3_CanoR_1	375	384	PF00244	0.503
LIG_14-3-3_CanoR_1	506	511	PF00244	0.511
LIG_14-3-3_CanoR_1	554	560	PF00244	0.391
LIG_14-3-3_CanoR_1	649	653	PF00244	0.346
LIG_14-3-3_CanoR_1	740	745	PF00244	0.619
LIG_14-3-3_CanoR_1	757	765	PF00244	0.662
LIG_14-3-3_CanoR_1	799	808	PF00244	0.755
LIG_14-3-3_CanoR_1	913	918	PF00244	0.542
LIG_14-3-3_CanoR_1	919	928	PF00244	0.622
LIG_Actin_WH2_2	616	634	PF00022	0.336
LIG_APCC_ABBA_1	765	770	PF00400	0.736
LIG_APCC_ABBAyCdc20_2	342	348	PF00400	0.589
LIG_BIR_II_1	1	5	PF00653	0.678
LIG_BIR_III_2	333	337	PF00653	0.480
LIG_BRCT_BRCA1_1	174	178	PF00533	0.437
LIG_BRCT_BRCA1_1	657	661	PF00533	0.346
LIG_BRCT_BRCA1_1	78	82	PF00533	0.820
LIG_BRCT_BRCA1_1	888	892	PF00533	0.619
LIG_CaM_NSCaTE_8	524	531	PF13499	0.516
LIG_CSL_BTD_1	295	298	PF09270	0.614
LIG_EH1_1	696	704	PF00400	0.346
LIG_FHA_1	119	125	PF00498	0.464
LIG_FHA_1	22	28	PF00498	0.796
LIG_FHA_1	421	427	PF00498	0.595
LIG_FHA_1	507	513	PF00498	0.505
LIG_FHA_1	554	560	PF00498	0.381
LIG_FHA_1	712	718	PF00498	0.499
LIG_FHA_1	770	776	PF00498	0.742
LIG_FHA_1	98	104	PF00498	0.763
LIG_FHA_2	219	225	PF00498	0.378
LIG_FHA_2	378	384	PF00498	0.335
LIG_FHA_2	7	13	PF00498	0.707
LIG_FHA_2	858	864	PF00498	0.452
LIG_GBD_Chelix_1	682	690	PF00786	0.619
LIG_Integrin_RGD_1	324	326	PF01839	0.683
LIG_IRF3_LxIS_1	752	759	PF10401	0.592
LIG_LIR_Apic_2	293	298	PF02991	0.498
LIG_LIR_Apic_2	578	584	PF02991	0.346
LIG_LIR_Gen_1	207	216	PF02991	0.461
LIG_LIR_Gen_1	236	245	PF02991	0.364
LIG_LIR_Gen_1	673	682	PF02991	0.339
LIG_LIR_Gen_1	889	897	PF02991	0.539
LIG_LIR_Gen_1	898	906	PF02991	0.539
LIG_LIR_LC3C_4	772	776	PF02991	0.794
LIG_LIR_Nem_3	177	182	PF02991	0.409
LIG_LIR_Nem_3	207	212	PF02991	0.464
LIG_LIR_Nem_3	293	299	PF02991	0.538
LIG_LIR_Nem_3	625	631	PF02991	0.413
LIG_LIR_Nem_3	658	664	PF02991	0.346
LIG_LIR_Nem_3	673	677	PF02991	0.339
LIG_LIR_Nem_3	714	718	PF02991	0.411
LIG_LIR_Nem_3	737	742	PF02991	0.520
LIG_LIR_Nem_3	777	781	PF02991	0.646
LIG_LIR_Nem_3	889	893	PF02991	0.546
LIG_LIR_Nem_3	898	903	PF02991	0.546
LIG_LYPXL_S_1	611	615	PF13949	0.539
LIG_LYPXL_yS_3	612	615	PF13949	0.339
LIG_NRBOX	225	231	PF00104	0.316
LIG_PDZ_Class_2	923	928	PF00595	0.687
LIG_Pex14_1	153	157	PF04695	0.400
LIG_Pex14_1	283	287	PF04695	0.482
LIG_Pex14_1	735	739	PF04695	0.546
LIG_Pex14_2	718	722	PF04695	0.563
LIG_Pex14_2	82	86	PF04695	0.824
LIG_SH2_CRK	724	728	PF00017	0.546
LIG_SH2_GRB2like	273	276	PF00017	0.561
LIG_SH2_PTP2	581	584	PF00017	0.346
LIG_SH2_STAP1	119	123	PF00017	0.411
LIG_SH2_STAT5	215	218	PF00017	0.381
LIG_SH2_STAT5	220	223	PF00017	0.391
LIG_SH2_STAT5	542	545	PF00017	0.419
LIG_SH2_STAT5	567	570	PF00017	0.346
LIG_SH2_STAT5	581	584	PF00017	0.346
LIG_SH2_STAT5	886	889	PF00017	0.520
LIG_SH3_3	333	339	PF00018	0.560
LIG_SH3_3	565	571	PF00018	0.419
LIG_SH3_3	632	638	PF00018	0.346
LIG_SH3_3	649	655	PF00018	0.346
LIG_SH3_3	773	779	PF00018	0.807
LIG_SUMO_SIM_par_1	870	876	PF11976	0.546
LIG_SxIP_EBH_1	96	107	PF03271	0.747
LIG_TRAF2_1	380	383	PF00917	0.332
LIG_TYR_ITIM	672	677	PF00017	0.402
LIG_WRC_WIRS_1	741	746	PF05994	0.513
MOD_CDC14_SPxK_1	321	324	PF00782	0.717
MOD_CDK_SPxK_1	318	324	PF00069	0.725
MOD_CDK_SPxxK_3	335	342	PF00069	0.752
MOD_CK1_1	109	115	PF00069	0.720
MOD_CK1_1	20	26	PF00069	0.748
MOD_CK1_1	262	268	PF00069	0.642
MOD_CK1_1	309	315	PF00069	0.777
MOD_CK1_1	353	359	PF00069	0.754
MOD_CK1_1	517	523	PF00069	0.594
MOD_CK1_1	815	821	PF00069	0.815
MOD_CK1_1	844	850	PF00069	0.774
MOD_CK1_1	857	863	PF00069	0.308
MOD_CK1_1	905	911	PF00069	0.402
MOD_CK1_1	97	103	PF00069	0.708
MOD_CK2_1	218	224	PF00069	0.493
MOD_CK2_1	353	359	PF00069	0.754
MOD_CK2_1	377	383	PF00069	0.395
MOD_CK2_1	483	489	PF00069	0.685
MOD_CK2_1	542	548	PF00069	0.390
MOD_CK2_1	844	850	PF00069	0.796
MOD_CK2_1	857	863	PF00069	0.208
MOD_CMANNOS	132	135	PF00535	0.590
MOD_CMANNOS	153	156	PF00535	0.495
MOD_Cter_Amidation	789	792	PF01082	0.583
MOD_DYRK1A_RPxSP_1	318	322	PF00069	0.724
MOD_DYRK1A_RPxSP_1	514	518	PF00069	0.567
MOD_GlcNHglycan	108	111	PF01048	0.679
MOD_GlcNHglycan	143	147	PF01048	0.490
MOD_GlcNHglycan	153	156	PF01048	0.495
MOD_GlcNHglycan	174	177	PF01048	0.642
MOD_GlcNHglycan	326	330	PF01048	0.720
MOD_GlcNHglycan	40	43	PF01048	0.832
MOD_GlcNHglycan	416	419	PF01048	0.791
MOD_GlcNHglycan	458	461	PF01048	0.780
MOD_GlcNHglycan	471	474	PF01048	0.577
MOD_GlcNHglycan	475	479	PF01048	0.711
MOD_GlcNHglycan	58	61	PF01048	0.624
MOD_GlcNHglycan	62	65	PF01048	0.719
MOD_GlcNHglycan	74	77	PF01048	0.702
MOD_GlcNHglycan	758	761	PF01048	0.544
MOD_GlcNHglycan	825	828	PF01048	0.747
MOD_GlcNHglycan	839	842	PF01048	0.672
MOD_GlcNHglycan	852	855	PF01048	0.574
MOD_GlcNHglycan	856	859	PF01048	0.381
MOD_GSK3_1	105	112	PF00069	0.696
MOD_GSK3_1	17	24	PF00069	0.619
MOD_GSK3_1	256	263	PF00069	0.738
MOD_GSK3_1	290	297	PF00069	0.659
MOD_GSK3_1	325	332	PF00069	0.756
MOD_GSK3_1	540	547	PF00069	0.521
MOD_GSK3_1	56	63	PF00069	0.710
MOD_GSK3_1	68	75	PF00069	0.706
MOD_GSK3_1	76	83	PF00069	0.704
MOD_GSK3_1	808	815	PF00069	0.805
MOD_GSK3_1	831	838	PF00069	0.717
MOD_GSK3_1	841	848	PF00069	0.726
MOD_GSK3_1	850	857	PF00069	0.831
MOD_GSK3_1	902	909	PF00069	0.411
MOD_GSK3_1	93	100	PF00069	0.554
MOD_N-GLC_1	35	40	PF02516	0.837
MOD_NEK2_1	1	6	PF00069	0.749
MOD_NEK2_1	174	179	PF00069	0.405
MOD_NEK2_1	211	216	PF00069	0.463
MOD_NEK2_1	51	56	PF00069	0.583
MOD_NEK2_1	575	580	PF00069	0.344
MOD_NEK2_1	677	682	PF00069	0.411
MOD_NEK2_1	711	716	PF00069	0.411
MOD_NEK2_1	734	739	PF00069	0.411
MOD_NEK2_1	756	761	PF00069	0.710
MOD_NEK2_1	80	85	PF00069	0.721
MOD_NEK2_1	812	817	PF00069	0.815
MOD_NEK2_1	837	842	PF00069	0.780
MOD_NEK2_1	873	878	PF00069	0.411
MOD_NEK2_1	920	925	PF00069	0.508
MOD_NEK2_2	648	653	PF00069	0.411
MOD_PIKK_1	22	28	PF00454	0.606
MOD_PIKK_1	309	315	PF00454	0.745
MOD_PIKK_1	498	504	PF00454	0.474
MOD_PIKK_1	613	619	PF00454	0.319
MOD_PKA_1	105	111	PF00069	0.783
MOD_PKA_1	506	512	PF00069	0.629
MOD_PKA_1	791	797	PF00069	0.642
MOD_PKA_2	105	111	PF00069	0.785
MOD_PKA_2	306	312	PF00069	0.722
MOD_PKA_2	350	356	PF00069	0.675
MOD_PKA_2	506	512	PF00069	0.629
MOD_PKA_2	553	559	PF00069	0.424
MOD_PKA_2	575	581	PF00069	0.515
MOD_PKA_2	648	654	PF00069	0.411
MOD_PKA_2	756	762	PF00069	0.705
MOD_PKA_2	791	797	PF00069	0.655
MOD_PKA_2	818	824	PF00069	0.718
MOD_PKA_2	841	847	PF00069	0.758
MOD_PKA_2	920	926	PF00069	0.514
MOD_PKB_1	305	313	PF00069	0.648
MOD_PKB_1	911	919	PF00069	0.436
MOD_Plk_1	325	331	PF00069	0.829
MOD_Plk_1	353	359	PF00069	0.676
MOD_Plk_1	624	630	PF00069	0.389
MOD_Plk_1	677	683	PF00069	0.411
MOD_Plk_1	769	775	PF00069	0.655
MOD_Plk_2-3	43	49	PF00069	0.695
MOD_Plk_2-3	845	851	PF00069	0.803
MOD_Plk_4	174	180	PF00069	0.629
MOD_Plk_4	204	210	PF00069	0.512
MOD_Plk_4	211	217	PF00069	0.426
MOD_Plk_4	225	231	PF00069	0.501
MOD_Plk_4	290	296	PF00069	0.763
MOD_Plk_4	383	389	PF00069	0.575
MOD_Plk_4	506	512	PF00069	0.594
MOD_Plk_4	530	536	PF00069	0.496
MOD_Plk_4	575	581	PF00069	0.453
MOD_Plk_4	922	928	PF00069	0.613
MOD_ProDKin_1	18	24	PF00069	0.707
MOD_ProDKin_1	239	245	PF00069	0.570
MOD_ProDKin_1	264	270	PF00069	0.758
MOD_ProDKin_1	294	300	PF00069	0.692
MOD_ProDKin_1	318	324	PF00069	0.675
MOD_ProDKin_1	335	341	PF00069	0.826
MOD_ProDKin_1	467	473	PF00069	0.628
MOD_ProDKin_1	514	520	PF00069	0.574
MOD_ProDKin_1	542	548	PF00069	0.369
MOD_ProDKin_1	94	100	PF00069	0.798
MOD_SUMO_rev_2	379	387	PF00179	0.523
TRG_DiLeu_BaEn_1	639	644	PF01217	0.389
TRG_DiLeu_BaEn_1	770	775	PF01217	0.682
TRG_DiLeu_BaLyEn_6	46	51	PF01217	0.740
TRG_ENDOCYTIC_2	220	223	PF00928	0.474
TRG_ENDOCYTIC_2	612	615	PF00928	0.342
TRG_ENDOCYTIC_2	674	677	PF00928	0.402
TRG_ENDOCYTIC_2	724	727	PF00928	0.411
TRG_ENDOCYTIC_2	890	893	PF00928	0.411
TRG_ER_diArg_1	104	107	PF00400	0.735
TRG_ER_diArg_1	373	375	PF00400	0.644
TRG_ER_diArg_1	505	507	PF00400	0.528
TRG_ER_diArg_1	524	526	PF00400	0.602
TRG_ER_diArg_1	727	730	PF00400	0.454
TRG_ER_diArg_1	791	793	PF00400	0.656
TRG_ER_diArg_1	910	913	PF00400	0.436
TRG_NES_CRM1_1	122	136	PF08389	0.411
TRG_NLS_Bipartite_1	618	633	PF00514	0.319
TRG_NLS_MonoExtN_4	626	633	PF00514	0.319
TRG_Pf-PMV_PEXEL_1	343	347	PF00026	0.752
TRG_Pf-PMV_PEXEL_1	492	496	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	618	622	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I755	Leptomonas seymouri	52%	67%
A0A3Q8IKC8	Leishmania donovani	89%	100%
A4HHX9	Leishmania braziliensis	71%	67%
E9AHQ4	Leishmania infantum	89%	69%
E9B475	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%