Nup54 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP59

Species:

Leishmania major

UniProt:

Q4Q3V0_LEIMA

TriTrypDb:

LmjF.33.2370 , LMJLV39_330034400 , LMJSD75_330033700

Length:

563

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3V0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3V0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	173	175	PF00675	0.417
CLV_NRD_NRD_1	364	366	PF00675	0.554
CLV_NRD_NRD_1	389	391	PF00675	0.596
CLV_NRD_NRD_1	399	401	PF00675	0.553
CLV_NRD_NRD_1	409	411	PF00675	0.461
CLV_NRD_NRD_1	505	507	PF00675	0.504
CLV_NRD_NRD_1	90	92	PF00675	0.514
CLV_PCSK_KEX2_1	173	175	PF00082	0.390
CLV_PCSK_KEX2_1	190	192	PF00082	0.366
CLV_PCSK_KEX2_1	21	23	PF00082	0.614
CLV_PCSK_KEX2_1	29	31	PF00082	0.553
CLV_PCSK_KEX2_1	363	365	PF00082	0.450
CLV_PCSK_KEX2_1	409	411	PF00082	0.409
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.468
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.594
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.526
CLV_PCSK_SKI1_1	29	33	PF00082	0.491
CLV_PCSK_SKI1_1	364	368	PF00082	0.421
CLV_PCSK_SKI1_1	390	394	PF00082	0.589
CLV_PCSK_SKI1_1	409	413	PF00082	0.240
CLV_PCSK_SKI1_1	515	519	PF00082	0.457
CLV_PCSK_SKI1_1	73	77	PF00082	0.447
CLV_PCSK_SKI1_1	91	95	PF00082	0.459
DEG_APCC_DBOX_1	362	370	PF00400	0.552
DEG_APCC_DBOX_1	409	417	PF00400	0.463
DEG_SPOP_SBC_1	217	221	PF00917	0.585
DEG_SPOP_SBC_1	229	233	PF00917	0.747
DEG_SPOP_SBC_1	254	258	PF00917	0.701
DOC_CKS1_1	260	265	PF01111	0.490
DOC_CYCLIN_RxL_1	158	169	PF00134	0.599
DOC_CYCLIN_yCln2_LP_2	208	214	PF00134	0.561
DOC_MAPK_gen_1	4	10	PF00069	0.447
DOC_PIKK_1	57	65	PF02985	0.439
DOC_PP1_RVXF_1	144	150	PF00149	0.599
DOC_PP1_RVXF_1	513	520	PF00149	0.580
DOC_PP4_FxxP_1	75	78	PF00568	0.622
DOC_USP7_MATH_1	178	182	PF00917	0.539
DOC_USP7_MATH_1	197	201	PF00917	0.553
DOC_USP7_MATH_1	217	221	PF00917	0.414
DOC_USP7_MATH_1	246	250	PF00917	0.628
DOC_USP7_MATH_1	284	288	PF00917	0.607
DOC_USP7_MATH_1	340	344	PF00917	0.704
DOC_USP7_MATH_1	440	444	PF00917	0.543
DOC_USP7_MATH_1	457	461	PF00917	0.382
DOC_USP7_MATH_1	498	502	PF00917	0.423
DOC_USP7_MATH_1	509	513	PF00917	0.552
DOC_USP7_UBL2_3	29	33	PF12436	0.585
DOC_USP7_UBL2_3	507	511	PF12436	0.444
DOC_USP7_UBL2_3	518	522	PF12436	0.478
DOC_WW_Pin1_4	207	212	PF00397	0.689
DOC_WW_Pin1_4	256	261	PF00397	0.660
DOC_WW_Pin1_4	276	281	PF00397	0.509
DOC_WW_Pin1_4	303	308	PF00397	0.626
DOC_WW_Pin1_4	312	317	PF00397	0.669
DOC_WW_Pin1_4	98	103	PF00397	0.399
LIG_14-3-3_CanoR_1	363	373	PF00244	0.443
LIG_14-3-3_CanoR_1	97	102	PF00244	0.490
LIG_BIR_II_1	1	5	PF00653	0.618
LIG_BRCT_BRCA1_1	209	213	PF00533	0.620
LIG_BRCT_BRCA1_1	291	295	PF00533	0.579
LIG_BRCT_BRCA1_1	308	312	PF00533	0.666
LIG_BRCT_BRCA1_1	459	463	PF00533	0.371
LIG_BRCT_BRCA1_2	293	299	PF00533	0.503
LIG_deltaCOP1_diTrp_1	428	437	PF00928	0.474
LIG_deltaCOP1_diTrp_1	86	90	PF00928	0.521
LIG_EH_1	555	559	PF12763	0.505
LIG_FHA_1	220	226	PF00498	0.587
LIG_FHA_1	230	236	PF00498	0.484
LIG_FHA_1	351	357	PF00498	0.555
LIG_FHA_1	368	374	PF00498	0.398
LIG_FHA_1	387	393	PF00498	0.462
LIG_FHA_1	440	446	PF00498	0.533
LIG_FHA_1	66	72	PF00498	0.545
LIG_LIR_Apic_2	74	78	PF02991	0.617
LIG_LIR_Gen_1	460	471	PF02991	0.392
LIG_LIR_Gen_1	86	94	PF02991	0.432
LIG_LIR_Nem_3	169	175	PF02991	0.322
LIG_LIR_Nem_3	460	466	PF02991	0.412
LIG_LIR_Nem_3	468	474	PF02991	0.407
LIG_LIR_Nem_3	512	517	PF02991	0.447
LIG_LIR_Nem_3	86	90	PF02991	0.430
LIG_OCRL_FandH_1	462	474	PF00620	0.424
LIG_PALB2_WD40_1	100	108	PF16756	0.405
LIG_PCNA_yPIPBox_3	33	45	PF02747	0.534
LIG_Pex14_2	265	269	PF04695	0.711
LIG_Pex14_2	293	297	PF04695	0.583
LIG_PTB_Apo_2	411	418	PF02174	0.337
LIG_SH2_CRK	471	475	PF00017	0.343
LIG_SH2_NCK_1	151	155	PF00017	0.638
LIG_SH2_NCK_1	471	475	PF00017	0.343
LIG_SH2_SRC	128	131	PF00017	0.572
LIG_SH2_STAP1	471	475	PF00017	0.469
LIG_SH2_STAT5	128	131	PF00017	0.522
LIG_SH2_STAT5	143	146	PF00017	0.348
LIG_SH3_3	144	150	PF00018	0.599
LIG_SH3_3	257	263	PF00018	0.689
LIG_SH3_3	301	307	PF00018	0.677
LIG_SH3_3	325	331	PF00018	0.671
LIG_SH3_3	543	549	PF00018	0.586
LIG_SUMO_SIM_par_1	480	487	PF11976	0.415
LIG_TRAF2_1	36	39	PF00917	0.546
LIG_UBA3_1	412	419	PF00899	0.377
LIG_UBA3_1	499	507	PF00899	0.447
LIG_WRPW_2	528	531	PF00400	0.534
LIG_WW_2	328	331	PF00397	0.586
MOD_CDK_SPK_2	98	103	PF00069	0.399
MOD_CK1_1	14	20	PF00069	0.493
MOD_CK1_1	218	224	PF00069	0.566
MOD_CK1_1	282	288	PF00069	0.655
MOD_CK1_1	3	9	PF00069	0.658
MOD_CK1_1	306	312	PF00069	0.673
MOD_CK1_1	315	321	PF00069	0.735
MOD_CK1_1	535	541	PF00069	0.568
MOD_CK2_1	149	155	PF00069	0.491
MOD_CK2_1	272	278	PF00069	0.598
MOD_GlcNHglycan	195	198	PF01048	0.588
MOD_GlcNHglycan	199	202	PF01048	0.586
MOD_GlcNHglycan	244	247	PF01048	0.617
MOD_GlcNHglycan	248	251	PF01048	0.603
MOD_GlcNHglycan	284	287	PF01048	0.691
MOD_GlcNHglycan	341	345	PF01048	0.703
MOD_GlcNHglycan	374	377	PF01048	0.438
MOD_GlcNHglycan	442	445	PF01048	0.465
MOD_GlcNHglycan	510	514	PF01048	0.523
MOD_GlcNHglycan	534	537	PF01048	0.556
MOD_GSK3_1	11	18	PF00069	0.549
MOD_GSK3_1	193	200	PF00069	0.690
MOD_GSK3_1	215	222	PF00069	0.547
MOD_GSK3_1	242	249	PF00069	0.613
MOD_GSK3_1	250	257	PF00069	0.605
MOD_GSK3_1	272	279	PF00069	0.578
MOD_GSK3_1	285	292	PF00069	0.702
MOD_GSK3_1	93	100	PF00069	0.557
MOD_N-GLC_2	432	434	PF02516	0.440
MOD_NEK2_1	215	220	PF00069	0.593
MOD_NEK2_1	240	245	PF00069	0.610
MOD_NEK2_1	293	298	PF00069	0.606
MOD_NEK2_1	386	391	PF00069	0.564
MOD_NEK2_1	462	467	PF00069	0.453
MOD_NEK2_1	65	70	PF00069	0.436
MOD_PIKK_1	315	321	PF00454	0.701
MOD_PIKK_1	498	504	PF00454	0.525
MOD_PK_1	4	10	PF00069	0.608
MOD_PKA_1	11	17	PF00069	0.519
MOD_PKA_1	364	370	PF00069	0.437
MOD_PKA_1	4	10	PF00069	0.585
MOD_PKA_2	364	370	PF00069	0.437
MOD_PKA_2	484	490	PF00069	0.530
MOD_Plk_2-3	121	127	PF00069	0.494
MOD_Plk_4	426	432	PF00069	0.491
MOD_ProDKin_1	207	213	PF00069	0.690
MOD_ProDKin_1	256	262	PF00069	0.661
MOD_ProDKin_1	276	282	PF00069	0.509
MOD_ProDKin_1	303	309	PF00069	0.631
MOD_ProDKin_1	312	318	PF00069	0.668
MOD_ProDKin_1	98	104	PF00069	0.396
MOD_SUMO_rev_2	341	348	PF00179	0.688
MOD_SUMO_rev_2	501	509	PF00179	0.427
TRG_DiLeu_BaLyEn_6	407	412	PF01217	0.467
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.553
TRG_DiLeu_BaLyEn_6	512	517	PF01217	0.444
TRG_ENDOCYTIC_2	471	474	PF00928	0.452
TRG_ER_diArg_1	172	174	PF00400	0.425
TRG_ER_diArg_1	363	365	PF00400	0.576
TRG_ER_diArg_1	409	411	PF00400	0.483
TRG_NLS_Bipartite_1	173	194	PF00514	0.416
TRG_Pf-PMV_PEXEL_1	161	166	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	364	368	PF00026	0.405
TRG_Pf-PMV_PEXEL_1	451	455	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	506	510	PF00026	0.603

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8T0	Leptomonas seymouri	66%	100%
A0A0S4J4Z2	Bodo saltans	40%	100%
A0A1X0P580	Trypanosomatidae	48%	100%
A0A3R7NSX9	Trypanosoma rangeli	51%	100%
A0A3S7X6X9	Leishmania donovani	92%	100%
A4HHX8	Leishmania braziliensis	76%	100%
D0A676	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AHQ5	Leishmania infantum	92%	100%
E9B476	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BYJ7	Trypanosoma cruzi	45%	100%