Putative Golgi reassembly stacking protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Golgi reassembly stacking protein (GRASP homologue), putative

Species:

Leishmania major

UniProt:

Q4Q3U9_LEIMA

TriTrypDb:

LmjF.33.2380 , LMJLV39_330034600 , LMJSD75_330033900

Length:

541

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	6
GO:0016020	membrane	2	5
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q3U9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3U9

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0007030	Golgi organization	5	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.385
CLV_NRD_NRD_1	207	209	PF00675	0.385
CLV_PCSK_KEX2_1	537	539	PF00082	0.671
CLV_PCSK_PC1ET2_1	537	539	PF00082	0.649
CLV_PCSK_SKI1_1	203	207	PF00082	0.385
CLV_PCSK_SKI1_1	209	213	PF00082	0.365
CLV_PCSK_SKI1_1	75	79	PF00082	0.434
CLV_PCSK_SKI1_1	83	87	PF00082	0.402
DEG_SPOP_SBC_1	462	466	PF00917	0.568
DOC_CKS1_1	289	294	PF01111	0.509
DOC_CYCLIN_yCln2_LP_2	525	531	PF00134	0.664
DOC_MAPK_DCC_7	216	224	PF00069	0.276
DOC_MAPK_MEF2A_6	216	224	PF00069	0.276
DOC_MAPK_MEF2A_6	520	527	PF00069	0.654
DOC_PP2B_LxvP_1	335	338	PF13499	0.555
DOC_PP4_MxPP_1	521	524	PF00568	0.646
DOC_USP7_MATH_1	158	162	PF00917	0.342
DOC_USP7_MATH_1	277	281	PF00917	0.427
DOC_USP7_MATH_1	331	335	PF00917	0.678
DOC_USP7_MATH_1	363	367	PF00917	0.708
DOC_USP7_MATH_1	462	466	PF00917	0.652
DOC_USP7_MATH_1	469	473	PF00917	0.644
DOC_USP7_MATH_1	494	498	PF00917	0.637
DOC_WW_Pin1_4	153	158	PF00397	0.492
DOC_WW_Pin1_4	288	293	PF00397	0.500
DOC_WW_Pin1_4	306	311	PF00397	0.620
DOC_WW_Pin1_4	347	352	PF00397	0.791
DOC_WW_Pin1_4	426	431	PF00397	0.698
DOC_WW_Pin1_4	471	476	PF00397	0.744
DOC_WW_Pin1_4	53	58	PF00397	0.442
LIG_APCC_ABBA_1	421	426	PF00400	0.566
LIG_APCC_ABBA_1	63	68	PF00400	0.406
LIG_BIR_III_2	140	144	PF00653	0.385
LIG_BIR_III_4	404	408	PF00653	0.583
LIG_CtBP_PxDLS_1	38	42	PF00389	0.434
LIG_deltaCOP1_diTrp_1	196	204	PF00928	0.385
LIG_EH_1	421	425	PF12763	0.696
LIG_EH1_1	46	54	PF00400	0.430
LIG_EVH1_2	523	527	PF00568	0.652
LIG_FHA_1	103	109	PF00498	0.385
LIG_FHA_1	254	260	PF00498	0.385
LIG_FHA_1	265	271	PF00498	0.416
LIG_FHA_1	307	313	PF00498	0.786
LIG_FHA_2	110	116	PF00498	0.342
LIG_FHA_2	135	141	PF00498	0.527
LIG_FHA_2	174	180	PF00498	0.356
LIG_FHA_2	232	238	PF00498	0.385
LIG_FHA_2	242	248	PF00498	0.274
LIG_FHA_2	69	75	PF00498	0.464
LIG_GBD_Chelix_1	69	77	PF00786	0.302
LIG_LIR_Apic_2	115	120	PF02991	0.385
LIG_LIR_Apic_2	497	501	PF02991	0.637
LIG_LIR_Gen_1	190	197	PF02991	0.385
LIG_LIR_Gen_1	280	290	PF02991	0.490
LIG_LIR_Gen_1	429	440	PF02991	0.695
LIG_LIR_Gen_1	45	54	PF02991	0.390
LIG_LIR_Nem_3	104	109	PF02991	0.311
LIG_LIR_Nem_3	110	116	PF02991	0.316
LIG_LIR_Nem_3	190	195	PF02991	0.527
LIG_LIR_Nem_3	280	285	PF02991	0.445
LIG_LIR_Nem_3	429	435	PF02991	0.671
LIG_LIR_Nem_3	45	50	PF02991	0.381
LIG_LIR_Nem_3	464	470	PF02991	0.657
LIG_LIR_Nem_3	87	92	PF02991	0.375
LIG_LYPXL_yS_3	467	470	PF13949	0.631
LIG_PCNA_yPIPBox_3	178	189	PF02747	0.385
LIG_REV1ctd_RIR_1	86	94	PF16727	0.453
LIG_SH2_CRK	117	121	PF00017	0.385
LIG_SH2_CRK	387	391	PF00017	0.608
LIG_SH2_CRK	498	502	PF00017	0.564
LIG_SH2_NCK_1	387	391	PF00017	0.608
LIG_SH2_NCK_1	498	502	PF00017	0.565
LIG_SH2_SRC	170	173	PF00017	0.342
LIG_SH2_STAP1	109	113	PF00017	0.342
LIG_SH2_STAP1	463	467	PF00017	0.666
LIG_SH2_STAT5	117	120	PF00017	0.474
LIG_SH2_STAT5	170	173	PF00017	0.385
LIG_SH2_STAT5	192	195	PF00017	0.254
LIG_SH2_STAT5	92	95	PF00017	0.378
LIG_SH3_1	498	504	PF00018	0.621
LIG_SH3_1	51	57	PF00018	0.444
LIG_SH3_3	214	220	PF00018	0.385
LIG_SH3_3	286	292	PF00018	0.557
LIG_SH3_3	330	336	PF00018	0.691
LIG_SH3_3	345	351	PF00018	0.676
LIG_SH3_3	356	362	PF00018	0.623
LIG_SH3_3	367	373	PF00018	0.586
LIG_SH3_3	394	400	PF00018	0.663
LIG_SH3_3	417	423	PF00018	0.654
LIG_SH3_3	498	504	PF00018	0.806
LIG_SH3_3	51	57	PF00018	0.444
LIG_SH3_3	525	531	PF00018	0.664
LIG_SUMO_SIM_anti_2	179	187	PF11976	0.342
LIG_SUMO_SIM_par_1	148	154	PF11976	0.527
LIG_TRAF2_1	176	179	PF00917	0.356
LIG_TRAF2_1	234	237	PF00917	0.342
LIG_UBA3_1	181	189	PF00899	0.385
LIG_WRC_WIRS_1	103	108	PF05994	0.342
LIG_WRC_WIRS_1	392	397	PF05994	0.647
LIG_WRC_WIRS_1	513	518	PF05994	0.624
LIG_WW_3	371	375	PF00397	0.639
LIG_WW_3	399	403	PF00397	0.651
MOD_CDK_SPxK_1	288	294	PF00069	0.506
MOD_CDK_SPxxK_3	53	60	PF00069	0.447
MOD_CK1_1	253	259	PF00069	0.385
MOD_CK1_1	26	32	PF00069	0.652
MOD_CK1_1	264	270	PF00069	0.398
MOD_CK1_1	288	294	PF00069	0.506
MOD_CK1_1	322	328	PF00069	0.672
MOD_CK1_1	388	394	PF00069	0.572
MOD_CK1_1	471	477	PF00069	0.602
MOD_CK2_1	173	179	PF00069	0.356
MOD_CK2_1	231	237	PF00069	0.513
MOD_CK2_1	241	247	PF00069	0.316
MOD_GlcNHglycan	25	28	PF01048	0.601
MOD_GlcNHglycan	30	33	PF01048	0.600
MOD_GlcNHglycan	327	330	PF01048	0.593
MOD_GlcNHglycan	477	480	PF01048	0.714
MOD_GlcNHglycan	498	501	PF01048	0.637
MOD_GSK3_1	130	137	PF00069	0.487
MOD_GSK3_1	173	180	PF00069	0.406
MOD_GSK3_1	227	234	PF00069	0.385
MOD_GSK3_1	277	284	PF00069	0.527
MOD_GSK3_1	319	326	PF00069	0.666
MOD_GSK3_1	471	478	PF00069	0.576
MOD_GSK3_1	490	497	PF00069	0.614
MOD_GSK3_1	508	515	PF00069	0.716
MOD_GSK3_1	84	91	PF00069	0.456
MOD_N-GLC_1	485	490	PF02516	0.699
MOD_N-GLC_2	365	367	PF02516	0.590
MOD_NEK2_1	184	189	PF00069	0.342
MOD_NEK2_1	477	482	PF00069	0.617
MOD_NEK2_1	485	490	PF00069	0.634
MOD_NEK2_1	508	513	PF00069	0.663
MOD_NEK2_1	88	93	PF00069	0.454
MOD_NEK2_2	84	89	PF00069	0.407
MOD_NMyristoyl	1	7	PF02799	0.663
MOD_PIKK_1	184	190	PF00454	0.342
MOD_PIKK_1	319	325	PF00454	0.660
MOD_PIKK_1	469	475	PF00454	0.636
MOD_PIKK_1	515	521	PF00454	0.802
MOD_PK_1	281	287	PF00069	0.544
MOD_Plk_1	21	27	PF00069	0.675
MOD_Plk_1	304	310	PF00069	0.643
MOD_Plk_2-3	231	237	PF00069	0.385
MOD_Plk_4	177	183	PF00069	0.342
MOD_Plk_4	285	291	PF00069	0.597
MOD_Plk_4	84	90	PF00069	0.448
MOD_ProDKin_1	153	159	PF00069	0.492
MOD_ProDKin_1	288	294	PF00069	0.506
MOD_ProDKin_1	306	312	PF00069	0.623
MOD_ProDKin_1	347	353	PF00069	0.791
MOD_ProDKin_1	426	432	PF00069	0.697
MOD_ProDKin_1	471	477	PF00069	0.747
MOD_ProDKin_1	53	59	PF00069	0.442
MOD_SUMO_rev_2	201	211	PF00179	0.342
MOD_SUMO_rev_2	79	85	PF00179	0.424
TRG_DiLeu_BaLyEn_6	48	53	PF01217	0.428
TRG_ENDOCYTIC_2	113	116	PF00928	0.385
TRG_ENDOCYTIC_2	192	195	PF00928	0.527
TRG_ENDOCYTIC_2	432	435	PF00928	0.673
TRG_ENDOCYTIC_2	467	470	PF00928	0.653
TRG_NES_CRM1_1	68	81	PF08389	0.425
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.347

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IU65	Leishmania donovani	87%	100%
A4HLV0	Leishmania braziliensis	66%	100%
E9AHQ6	Leishmania infantum	88%	100%
E9B477	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%