Putative ras-like small GTPases

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ras-like small GTPases, putative

Species:

Leishmania major

UniProt:

Q4Q3U7_LEIMA

TriTrypDb:

LmjF.33.2400 , LMJLV39_330034800 , LMJSD75_330034100

Length:

567

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q3U7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3U7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	5
GO:0003924	GTPase activity	7	5
GO:0003925	G protein activity	2	5
GO:0005488	binding	1	11
GO:0005525	GTP binding	5	11
GO:0016462	pyrophosphatase activity	5	5
GO:0016787	hydrolase activity	2	5
GO:0016817	hydrolase activity, acting on acid anhydrides	3	5
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	5
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	5
GO:0019001	guanyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032561	guanyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0098772	molecular function regulator activity	1	5
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	248	252	PF00656	0.357
CLV_C14_Caspase3-7	466	470	PF00656	0.343
CLV_C14_Caspase3-7	556	560	PF00656	0.581
CLV_NRD_NRD_1	132	134	PF00675	0.515
CLV_NRD_NRD_1	178	180	PF00675	0.486
CLV_NRD_NRD_1	230	232	PF00675	0.442
CLV_NRD_NRD_1	286	288	PF00675	0.365
CLV_NRD_NRD_1	299	301	PF00675	0.439
CLV_NRD_NRD_1	323	325	PF00675	0.249
CLV_NRD_NRD_1	444	446	PF00675	0.389
CLV_NRD_NRD_1	53	55	PF00675	0.606
CLV_PCSK_KEX2_1	131	133	PF00082	0.518
CLV_PCSK_KEX2_1	178	180	PF00082	0.486
CLV_PCSK_KEX2_1	286	288	PF00082	0.365
CLV_PCSK_KEX2_1	323	325	PF00082	0.249
CLV_PCSK_KEX2_1	444	446	PF00082	0.389
CLV_PCSK_KEX2_1	53	55	PF00082	0.656
CLV_PCSK_KEX2_1	546	548	PF00082	0.604
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.249
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.656
CLV_PCSK_SKI1_1	133	137	PF00082	0.499
CLV_PCSK_SKI1_1	187	191	PF00082	0.482
CLV_PCSK_SKI1_1	247	251	PF00082	0.535
CLV_PCSK_SKI1_1	29	33	PF00082	0.571
CLV_PCSK_SKI1_1	461	465	PF00082	0.337
DEG_Kelch_Keap1_1	294	299	PF01344	0.505
DOC_CYCLIN_yCln2_LP_2	378	384	PF00134	0.356
DOC_MAPK_DCC_7	413	422	PF00069	0.478
DOC_MAPK_gen_1	131	140	PF00069	0.480
DOC_MAPK_gen_1	21	30	PF00069	0.705
DOC_MAPK_gen_1	231	238	PF00069	0.321
DOC_MAPK_gen_1	300	307	PF00069	0.388
DOC_MAPK_gen_1	323	330	PF00069	0.418
DOC_MAPK_gen_1	53	61	PF00069	0.627
DOC_MAPK_HePTP_8	128	140	PF00069	0.588
DOC_MAPK_MEF2A_6	131	140	PF00069	0.589
DOC_MAPK_MEF2A_6	231	238	PF00069	0.319
DOC_MAPK_MEF2A_6	300	307	PF00069	0.360
DOC_MAPK_NFAT4_5	133	141	PF00069	0.593
DOC_MIT_MIM_1	210	219	PF04212	0.351
DOC_PP2B_LxvP_1	35	38	PF13499	0.625
DOC_PP2B_LxvP_1	59	62	PF13499	0.647
DOC_USP7_MATH_1	272	276	PF00917	0.510
DOC_USP7_MATH_1	494	498	PF00917	0.650
DOC_USP7_MATH_1	505	509	PF00917	0.587
DOC_USP7_MATH_1	70	74	PF00917	0.673
DOC_USP7_MATH_1	75	79	PF00917	0.624
DOC_USP7_UBL2_3	29	33	PF12436	0.554
DOC_USP7_UBL2_3	545	549	PF12436	0.637
DOC_WW_Pin1_4	356	361	PF00397	0.442
LIG_14-3-3_CanoR_1	141	149	PF00244	0.576
LIG_14-3-3_CanoR_1	215	223	PF00244	0.375
LIG_14-3-3_CanoR_1	224	228	PF00244	0.399
LIG_14-3-3_CanoR_1	286	292	PF00244	0.480
LIG_14-3-3_CanoR_1	374	382	PF00244	0.555
LIG_14-3-3_CanoR_1	493	501	PF00244	0.632
LIG_14-3-3_CanoR_1	53	59	PF00244	0.568
LIG_14-3-3_CanoR_1	547	555	PF00244	0.578
LIG_Actin_WH2_2	28	43	PF00022	0.583
LIG_APCC_ABBA_1	530	535	PF00400	0.423
LIG_deltaCOP1_diTrp_1	251	257	PF00928	0.320
LIG_Dynein_DLC8_1	44	50	PF01221	0.560
LIG_EH_1	379	383	PF12763	0.423
LIG_FHA_1	135	141	PF00498	0.501
LIG_FHA_1	527	533	PF00498	0.378
LIG_FHA_1	53	59	PF00498	0.641
LIG_FHA_2	125	131	PF00498	0.582
LIG_FHA_2	215	221	PF00498	0.374
LIG_FHA_2	224	230	PF00498	0.411
LIG_FHA_2	339	345	PF00498	0.418
LIG_FHA_2	508	514	PF00498	0.708
LIG_LIR_Apic_2	148	152	PF02991	0.632
LIG_LIR_Apic_2	552	558	PF02991	0.584
LIG_LIR_Gen_1	191	196	PF02991	0.344
LIG_LIR_Nem_3	191	195	PF02991	0.334
LIG_LIR_Nem_3	251	256	PF02991	0.327
LIG_LIR_Nem_3	282	288	PF02991	0.356
LIG_LIR_Nem_3	489	495	PF02991	0.686
LIG_LRP6_Inhibitor_1	368	374	PF00058	0.312
LIG_LYPXL_yS_3	310	313	PF13949	0.418
LIG_PDZ_Class_3	562	567	PF00595	0.705
LIG_Pex14_1	253	257	PF04695	0.311
LIG_Pex14_2	188	192	PF04695	0.359
LIG_REV1ctd_RIR_1	186	194	PF16727	0.472
LIG_SH2_CRK	475	479	PF00017	0.327
LIG_SH2_CRK	492	496	PF00017	0.498
LIG_SH2_NCK_1	555	559	PF00017	0.698
LIG_SH2_SRC	555	558	PF00017	0.583
LIG_SH2_STAT3	256	259	PF00017	0.400
LIG_SH2_STAT5	256	259	PF00017	0.475
LIG_SH2_STAT5	280	283	PF00017	0.333
LIG_SH2_STAT5	475	478	PF00017	0.344
LIG_SH3_3	354	360	PF00018	0.425
LIG_SH3_3	378	384	PF00018	0.356
LIG_TYR_ITIM	308	313	PF00017	0.256
LIG_UBA3_1	318	325	PF00899	0.299
LIG_WRC_WIRS_1	527	532	PF05994	0.354
MOD_CK1_1	294	300	PF00069	0.534
MOD_CK1_1	5	11	PF00069	0.712
MOD_CK1_1	57	63	PF00069	0.583
MOD_CK1_1	73	79	PF00069	0.596
MOD_CK2_1	214	220	PF00069	0.362
MOD_CK2_1	223	229	PF00069	0.397
MOD_CK2_1	338	344	PF00069	0.272
MOD_CK2_1	356	362	PF00069	0.279
MOD_CK2_1	507	513	PF00069	0.710
MOD_GlcNHglycan	362	366	PF01048	0.392
MOD_GlcNHglycan	414	417	PF01048	0.435
MOD_GlcNHglycan	497	500	PF01048	0.646
MOD_GlcNHglycan	515	518	PF01048	0.467
MOD_GlcNHglycan	7	10	PF01048	0.728
MOD_GlcNHglycan	77	80	PF01048	0.699
MOD_GlcNHglycan	99	102	PF01048	0.766
MOD_GSK3_1	272	279	PF00069	0.483
MOD_GSK3_1	287	294	PF00069	0.372
MOD_GSK3_1	334	341	PF00069	0.275
MOD_GSK3_1	70	77	PF00069	0.640
MOD_GSK3_1	97	104	PF00069	0.569
MOD_N-GLC_1	495	500	PF02516	0.555
MOD_N-GLC_1	88	93	PF02516	0.481
MOD_NEK2_1	276	281	PF00069	0.380
MOD_NEK2_1	412	417	PF00069	0.469
MOD_NEK2_1	47	52	PF00069	0.502
MOD_NEK2_1	97	102	PF00069	0.514
MOD_PIKK_1	101	107	PF00454	0.599
MOD_PIKK_1	214	220	PF00454	0.350
MOD_PIKK_1	424	430	PF00454	0.421
MOD_PIKK_1	45	51	PF00454	0.613
MOD_PIKK_1	507	513	PF00454	0.559
MOD_PK_1	54	60	PF00069	0.590
MOD_PKA_2	140	146	PF00069	0.612
MOD_PKA_2	214	220	PF00069	0.362
MOD_PKA_2	223	229	PF00069	0.397
MOD_PKA_2	373	379	PF00069	0.547
MOD_PKA_2	390	396	PF00069	0.312
MOD_PKA_2	412	418	PF00069	0.524
MOD_PKA_2	446	452	PF00069	0.574
MOD_PKA_2	45	51	PF00069	0.603
MOD_PKA_2	52	58	PF00069	0.579
MOD_PKA_2	73	79	PF00069	0.696
MOD_Plk_1	124	130	PF00069	0.573
MOD_Plk_1	167	173	PF00069	0.592
MOD_Plk_1	181	187	PF00069	0.402
MOD_Plk_4	167	173	PF00069	0.482
MOD_Plk_4	276	282	PF00069	0.352
MOD_Plk_4	314	320	PF00069	0.286
MOD_Plk_4	54	60	PF00069	0.625
MOD_ProDKin_1	356	362	PF00069	0.289
MOD_SUMO_rev_2	225	234	PF00179	0.396
MOD_SUMO_rev_2	294	303	PF00179	0.536
MOD_SUMO_rev_2	34	43	PF00179	0.499
TRG_DiLeu_BaEn_3	229	235	PF01217	0.495
TRG_DiLeu_BaLyEn_6	384	389	PF01217	0.326
TRG_ENDOCYTIC_2	310	313	PF00928	0.256
TRG_ENDOCYTIC_2	492	495	PF00928	0.673
TRG_ER_diArg_1	131	133	PF00400	0.623
TRG_ER_diArg_1	285	287	PF00400	0.380
TRG_ER_diArg_1	443	445	PF00400	0.389
TRG_NES_CRM1_1	27	39	PF08389	0.447
TRG_NES_CRM1_1	525	538	PF08389	0.516
TRG_NLS_MonoExtC_3	544	549	PF00514	0.622
TRG_NLS_MonoExtN_4	543	550	PF00514	0.634

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P303	Leptomonas seymouri	33%	94%
A0A0N0P6X1	Leptomonas seymouri	76%	100%
A0A1X0P4K3	Trypanosomatidae	57%	100%
A0A3R7M8S7	Trypanosoma rangeli	55%	100%
A0A3S7X732	Leishmania donovani	95%	100%
A4HLV2	Leishmania braziliensis	84%	100%
D0A671	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AHQ8	Leishmania infantum	95%	100%
E9B479	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q3T0J9	Bos taurus	34%	99%
Q7SHR8	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	31%	92%
Q9SHS8	Arabidopsis thaliana	26%	100%
Q9SJF1	Arabidopsis thaliana	27%	96%
V5B8N5	Trypanosoma cruzi	60%	100%