MYND-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q3U5_LEIMA

TriTrypDb:

LmjF.33.2420 , LMJLV39_330035000 , LMJSD75_330034300

Length:

603

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3U5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3U5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	310	314	PF00656	0.793
CLV_NRD_NRD_1	345	347	PF00675	0.830
CLV_NRD_NRD_1	547	549	PF00675	0.561
CLV_NRD_NRD_1	80	82	PF00675	0.818
CLV_PCSK_KEX2_1	345	347	PF00082	0.837
CLV_PCSK_KEX2_1	564	566	PF00082	0.604
CLV_PCSK_KEX2_1	80	82	PF00082	0.818
CLV_PCSK_PC1ET2_1	564	566	PF00082	0.608
CLV_PCSK_PC7_1	560	566	PF00082	0.701
CLV_PCSK_SKI1_1	21	25	PF00082	0.770
CLV_PCSK_SKI1_1	543	547	PF00082	0.616
DEG_SCF_FBW7_1	100	105	PF00400	0.627
DEG_SCF_SKP2-CKS1_1	335	342	PF00560	0.608
DOC_CKS1_1	28	33	PF01111	0.611
DOC_CYCLIN_yCln2_LP_2	51	57	PF00134	0.803
DOC_PP2B_LxvP_1	197	200	PF13499	0.451
DOC_USP7_MATH_1	102	106	PF00917	0.619
DOC_USP7_MATH_1	123	127	PF00917	0.717
DOC_USP7_MATH_1	19	23	PF00917	0.626
DOC_USP7_MATH_1	331	335	PF00917	0.752
DOC_USP7_MATH_1	457	461	PF00917	0.641
DOC_USP7_MATH_1	476	480	PF00917	0.569
DOC_USP7_MATH_1	500	504	PF00917	0.587
DOC_WW_Pin1_4	206	211	PF00397	0.454
DOC_WW_Pin1_4	21	26	PF00397	0.749
DOC_WW_Pin1_4	27	32	PF00397	0.662
DOC_WW_Pin1_4	336	341	PF00397	0.750
DOC_WW_Pin1_4	375	380	PF00397	0.768
DOC_WW_Pin1_4	389	394	PF00397	0.610
DOC_WW_Pin1_4	459	464	PF00397	0.787
DOC_WW_Pin1_4	98	103	PF00397	0.639
LIG_14-3-3_CanoR_1	12	20	PF00244	0.626
LIG_14-3-3_CanoR_1	152	158	PF00244	0.570
LIG_14-3-3_CanoR_1	327	331	PF00244	0.767
LIG_14-3-3_CanoR_1	34	40	PF00244	0.782
LIG_14-3-3_CanoR_1	351	360	PF00244	0.803
LIG_14-3-3_CanoR_1	391	400	PF00244	0.800
LIG_14-3-3_CanoR_1	420	424	PF00244	0.801
LIG_14-3-3_CanoR_1	464	471	PF00244	0.766
LIG_14-3-3_CanoR_1	96	101	PF00244	0.804
LIG_BRCT_BRCA1_1	365	369	PF00533	0.815
LIG_BRCT_BRCA1_1	502	506	PF00533	0.587
LIG_FHA_1	22	28	PF00498	0.809
LIG_FHA_1	249	255	PF00498	0.540
LIG_FHA_1	427	433	PF00498	0.818
LIG_FHA_1	524	530	PF00498	0.459
LIG_FHA_2	287	293	PF00498	0.675
LIG_FHA_2	302	308	PF00498	0.703
LIG_FHA_2	56	62	PF00498	0.722
LIG_Integrin_RGD_1	284	286	PF01839	0.801
LIG_LIR_Apic_2	161	167	PF02991	0.489
LIG_LIR_Apic_2	383	388	PF02991	0.775
LIG_LIR_Gen_1	233	240	PF02991	0.407
LIG_LIR_Gen_1	577	588	PF02991	0.531
LIG_LIR_Nem_3	141	145	PF02991	0.747
LIG_LIR_Nem_3	233	239	PF02991	0.407
LIG_LIR_Nem_3	366	372	PF02991	0.814
LIG_LIR_Nem_3	577	583	PF02991	0.535
LIG_PCNA_PIPBox_1	521	530	PF02747	0.669
LIG_PCNA_yPIPBox_3	519	528	PF02747	0.684
LIG_SH2_CRK	164	168	PF00017	0.576
LIG_SH2_CRK	236	240	PF00017	0.407
LIG_SH2_NCK_1	385	389	PF00017	0.774
LIG_SH2_SRC	385	388	PF00017	0.773
LIG_SH2_STAT5	173	176	PF00017	0.463
LIG_SH2_STAT5	224	227	PF00017	0.357
LIG_SH3_1	86	92	PF00018	0.754
LIG_SH3_2	341	346	PF14604	0.619
LIG_SH3_3	22	28	PF00018	0.610
LIG_SH3_3	275	281	PF00018	0.738
LIG_SH3_3	338	344	PF00018	0.603
LIG_SH3_3	510	516	PF00018	0.622
LIG_SH3_3	86	92	PF00018	0.754
LIG_Sin3_3	109	116	PF02671	0.576
LIG_WRC_WIRS_1	524	529	PF05994	0.483
MOD_CDC14_SPxK_1	343	346	PF00782	0.776
MOD_CDK_SPK_2	340	345	PF00069	0.755
MOD_CDK_SPK_2	459	464	PF00069	0.639
MOD_CDK_SPxK_1	336	342	PF00069	0.726
MOD_CDK_SPxK_1	98	104	PF00069	0.639
MOD_CDK_SPxxK_3	27	34	PF00069	0.795
MOD_CK1_1	103	109	PF00069	0.640
MOD_CK1_1	126	132	PF00069	0.661
MOD_CK1_1	135	141	PF00069	0.510
MOD_CK1_1	242	248	PF00069	0.490
MOD_CK1_1	375	381	PF00069	0.620
MOD_CK1_1	419	425	PF00069	0.767
MOD_CK1_1	488	494	PF00069	0.822
MOD_CK2_1	286	292	PF00069	0.701
MOD_CK2_1	301	307	PF00069	0.733
MOD_CK2_1	311	317	PF00069	0.563
MOD_CK2_1	331	337	PF00069	0.481
MOD_CK2_1	498	504	PF00069	0.698
MOD_CK2_1	55	61	PF00069	0.649
MOD_Cter_Amidation	562	565	PF01082	0.697
MOD_Cter_Amidation	78	81	PF01082	0.809
MOD_DYRK1A_RPxSP_1	21	25	PF00069	0.620
MOD_GlcNHglycan	109	112	PF01048	0.768
MOD_GlcNHglycan	114	117	PF01048	0.680
MOD_GlcNHglycan	125	128	PF01048	0.602
MOD_GlcNHglycan	137	140	PF01048	0.676
MOD_GlcNHglycan	17	20	PF01048	0.702
MOD_GlcNHglycan	321	324	PF01048	0.664
MOD_GlcNHglycan	363	366	PF01048	0.812
MOD_GlcNHglycan	41	44	PF01048	0.727
MOD_GlcNHglycan	440	443	PF01048	0.826
MOD_GlcNHglycan	510	513	PF01048	0.567
MOD_GlcNHglycan	538	543	PF01048	0.627
MOD_GlcNHglycan	65	68	PF01048	0.741
MOD_GlcNHglycan	76	80	PF01048	0.704
MOD_GlcNHglycan	93	96	PF01048	0.686
MOD_GSK3_1	126	133	PF00069	0.679
MOD_GSK3_1	15	22	PF00069	0.733
MOD_GSK3_1	206	213	PF00069	0.416
MOD_GSK3_1	239	246	PF00069	0.515
MOD_GSK3_1	307	314	PF00069	0.824
MOD_GSK3_1	319	326	PF00069	0.541
MOD_GSK3_1	336	343	PF00069	0.622
MOD_GSK3_1	35	42	PF00069	0.795
MOD_GSK3_1	351	358	PF00069	0.664
MOD_GSK3_1	389	396	PF00069	0.693
MOD_GSK3_1	428	435	PF00069	0.785
MOD_GSK3_1	459	466	PF00069	0.767
MOD_GSK3_1	484	491	PF00069	0.828
MOD_GSK3_1	87	94	PF00069	0.710
MOD_GSK3_1	96	103	PF00069	0.738
MOD_LATS_1	309	315	PF00433	0.814
MOD_LATS_1	349	355	PF00433	0.779
MOD_N-GLC_1	135	140	PF02516	0.754
MOD_N-GLC_1	292	297	PF02516	0.809
MOD_N-GLC_1	438	443	PF02516	0.736
MOD_N-GLC_2	151	153	PF02516	0.533
MOD_NEK2_1	112	117	PF00069	0.671
MOD_NEK2_1	301	306	PF00069	0.812
MOD_NEK2_1	321	326	PF00069	0.776
MOD_NEK2_1	432	437	PF00069	0.731
MOD_NEK2_1	506	511	PF00069	0.611
MOD_NEK2_1	528	533	PF00069	0.546
MOD_NEK2_2	210	215	PF00069	0.504
MOD_NEK2_2	428	433	PF00069	0.820
MOD_PIKK_1	208	214	PF00454	0.504
MOD_PIKK_1	264	270	PF00454	0.576
MOD_PIKK_1	355	361	PF00454	0.696
MOD_PIKK_1	393	399	PF00454	0.820
MOD_PIKK_1	457	463	PF00454	0.702
MOD_PIKK_1	498	504	PF00454	0.787
MOD_PK_1	96	102	PF00069	0.796
MOD_PKA_1	345	351	PF00069	0.839
MOD_PKA_2	103	109	PF00069	0.777
MOD_PKA_2	151	157	PF00069	0.482
MOD_PKA_2	279	285	PF00069	0.684
MOD_PKA_2	307	313	PF00069	0.691
MOD_PKA_2	326	332	PF00069	0.775
MOD_PKA_2	345	351	PF00069	0.741
MOD_PKA_2	419	425	PF00069	0.784
MOD_PKA_2	463	469	PF00069	0.839
MOD_Plk_4	35	41	PF00069	0.819
MOD_Plk_4	428	434	PF00069	0.837
MOD_Plk_4	485	491	PF00069	0.822
MOD_Plk_4	523	529	PF00069	0.508
MOD_ProDKin_1	206	212	PF00069	0.454
MOD_ProDKin_1	21	27	PF00069	0.745
MOD_ProDKin_1	336	342	PF00069	0.756
MOD_ProDKin_1	375	381	PF00069	0.772
MOD_ProDKin_1	389	395	PF00069	0.610
MOD_ProDKin_1	459	465	PF00069	0.788
MOD_ProDKin_1	98	104	PF00069	0.639
MOD_SUMO_for_1	574	577	PF00179	0.596
TRG_DiLeu_BaEn_3	568	574	PF01217	0.647
TRG_ENDOCYTIC_2	224	227	PF00928	0.279
TRG_ENDOCYTIC_2	236	239	PF00928	0.373
TRG_ER_diArg_1	259	262	PF00400	0.740
TRG_ER_diArg_1	344	346	PF00400	0.826
TRG_Pf-PMV_PEXEL_1	532	536	PF00026	0.646

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMA3	Leptomonas seymouri	35%	82%
A0A3Q8IHZ5	Leishmania donovani	84%	85%
E9AHR0	Leishmania infantum	84%	85%
E9B481	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	86%