Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3U4_LEIMA

TriTrypDb:

LmjF.33.2430 , LMJLV39_330035100 , LMJSD75_330034400

Length:

650

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	2
GO:0020015	glycosome	7	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q3U4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3U4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	174	178	PF00656	0.549
CLV_C14_Caspase3-7	9	13	PF00656	0.326
CLV_NRD_NRD_1	279	281	PF00675	0.401
CLV_NRD_NRD_1	309	311	PF00675	0.704
CLV_NRD_NRD_1	537	539	PF00675	0.512
CLV_NRD_NRD_1	541	543	PF00675	0.517
CLV_NRD_NRD_1	575	577	PF00675	0.456
CLV_NRD_NRD_1	627	629	PF00675	0.346
CLV_NRD_NRD_1	99	101	PF00675	0.473
CLV_PCSK_FUR_1	277	281	PF00082	0.435
CLV_PCSK_FUR_1	535	539	PF00082	0.479
CLV_PCSK_KEX2_1	279	281	PF00082	0.435
CLV_PCSK_KEX2_1	309	311	PF00082	0.621
CLV_PCSK_KEX2_1	537	539	PF00082	0.520
CLV_PCSK_KEX2_1	541	543	PF00082	0.527
CLV_PCSK_KEX2_1	575	577	PF00082	0.456
CLV_PCSK_KEX2_1	627	629	PF00082	0.614
CLV_PCSK_KEX2_1	99	101	PF00082	0.473
CLV_PCSK_PC7_1	537	543	PF00082	0.480
CLV_PCSK_SKI1_1	197	201	PF00082	0.484
CLV_PCSK_SKI1_1	280	284	PF00082	0.377
CLV_PCSK_SKI1_1	309	313	PF00082	0.581
CLV_PCSK_SKI1_1	375	379	PF00082	0.462
CLV_PCSK_SKI1_1	455	459	PF00082	0.431
CLV_PCSK_SKI1_1	519	523	PF00082	0.343
CLV_PCSK_SKI1_1	537	541	PF00082	0.488
CLV_PCSK_SKI1_1	67	71	PF00082	0.356
DEG_APCC_DBOX_1	279	287	PF00400	0.402
DEG_APCC_DBOX_1	536	544	PF00400	0.479
DEG_Nend_Nbox_1	1	3	PF02207	0.330
DOC_CKS1_1	16	21	PF01111	0.365
DOC_CYCLIN_RxL_1	450	461	PF00134	0.425
DOC_CYCLIN_yCln2_LP_2	409	415	PF00134	0.336
DOC_MAPK_gen_1	161	171	PF00069	0.634
DOC_MAPK_gen_1	185	193	PF00069	0.363
DOC_MAPK_gen_1	99	107	PF00069	0.441
DOC_MAPK_MEF2A_6	99	107	PF00069	0.393
DOC_MAPK_NFAT4_5	100	108	PF00069	0.386
DOC_PP1_RVXF_1	517	524	PF00149	0.287
DOC_PP1_SILK_1	286	291	PF00149	0.438
DOC_PP2B_LxvP_1	362	365	PF13499	0.457
DOC_PP2B_LxvP_1	409	412	PF13499	0.313
DOC_USP7_MATH_1	394	398	PF00917	0.690
DOC_USP7_MATH_1	559	563	PF00917	0.621
DOC_USP7_MATH_1	613	617	PF00917	0.572
DOC_USP7_MATH_1	65	69	PF00917	0.333
DOC_WW_Pin1_4	15	20	PF00397	0.379
DOC_WW_Pin1_4	240	245	PF00397	0.424
DOC_WW_Pin1_4	29	34	PF00397	0.346
DOC_WW_Pin1_4	304	309	PF00397	0.559
DOC_WW_Pin1_4	385	390	PF00397	0.621
DOC_WW_Pin1_4	475	480	PF00397	0.597
DOC_WW_Pin1_4	642	647	PF00397	0.560
DOC_WW_Pin1_4	82	87	PF00397	0.574
LIG_14-3-3_CanoR_1	148	156	PF00244	0.586
LIG_14-3-3_CanoR_1	217	222	PF00244	0.349
LIG_14-3-3_CanoR_1	280	289	PF00244	0.448
LIG_14-3-3_CanoR_1	39	48	PF00244	0.329
LIG_14-3-3_CanoR_1	462	467	PF00244	0.542
LIG_14-3-3_CanoR_1	614	621	PF00244	0.626
LIG_Actin_WH2_2	44	59	PF00022	0.423
LIG_APCC_ABBA_1	515	520	PF00400	0.499
LIG_BRCT_BRCA1_1	31	35	PF00533	0.469
LIG_BRCT_BRCA1_1	416	420	PF00533	0.406
LIG_BRCT_BRCA1_1	439	443	PF00533	0.346
LIG_BRCT_BRCA1_2	439	445	PF00533	0.365
LIG_deltaCOP1_diTrp_1	467	474	PF00928	0.557
LIG_DLG_GKlike_1	217	225	PF00625	0.336
LIG_DLG_GKlike_1	563	570	PF00625	0.455
LIG_eIF4E_1	331	337	PF01652	0.410
LIG_FHA_1	151	157	PF00498	0.468
LIG_FHA_1	376	382	PF00498	0.598
LIG_FHA_1	51	57	PF00498	0.456
LIG_FHA_1	544	550	PF00498	0.535
LIG_FHA_1	602	608	PF00498	0.452
LIG_FHA_2	172	178	PF00498	0.437
LIG_FHA_2	184	190	PF00498	0.306
LIG_FHA_2	299	305	PF00498	0.568
LIG_FHA_2	50	56	PF00498	0.347
LIG_FHA_2	509	515	PF00498	0.415
LIG_FHA_2	620	626	PF00498	0.482
LIG_FHA_2	634	640	PF00498	0.473
LIG_FHA_2	7	13	PF00498	0.409
LIG_FHA_2	70	76	PF00498	0.210
LIG_GBD_Chelix_1	403	411	PF00786	0.379
LIG_Integrin_isoDGR_2	23	25	PF01839	0.466
LIG_KLC1_Yacidic_2	189	194	PF13176	0.452
LIG_LIR_Gen_1	215	226	PF02991	0.449
LIG_LIR_Gen_1	440	448	PF02991	0.439
LIG_LIR_Gen_1	520	529	PF02991	0.460
LIG_LIR_Gen_1	566	574	PF02991	0.527
LIG_LIR_Nem_3	189	195	PF02991	0.319
LIG_LIR_Nem_3	220	225	PF02991	0.347
LIG_LIR_Nem_3	3	8	PF02991	0.437
LIG_LIR_Nem_3	32	38	PF02991	0.376
LIG_LIR_Nem_3	440	446	PF02991	0.421
LIG_LIR_Nem_3	516	521	PF02991	0.410
LIG_LIR_Nem_3	522	526	PF02991	0.372
LIG_LIR_Nem_3	566	570	PF02991	0.526
LIG_LIR_Nem_3	583	589	PF02991	0.484
LIG_LIR_Nem_3	60	66	PF02991	0.383
LIG_LIR_Nem_3	623	629	PF02991	0.448
LIG_LIR_Nem_3	72	76	PF02991	0.455
LIG_MLH1_MIPbox_1	416	420	PF16413	0.406
LIG_NRBOX	358	364	PF00104	0.414
LIG_NRBOX	453	459	PF00104	0.471
LIG_NRBOX	602	608	PF00104	0.472
LIG_Pex14_1	271	275	PF04695	0.340
LIG_Pex14_1	470	474	PF04695	0.565
LIG_Pex14_2	416	420	PF04695	0.327
LIG_PTB_Apo_2	585	592	PF02174	0.421
LIG_PTB_Phospho_1	585	591	PF10480	0.428
LIG_SH2_CRK	499	503	PF00017	0.404
LIG_SH2_NCK_1	609	613	PF00017	0.385
LIG_SH2_SRC	26	29	PF00017	0.484
LIG_SH2_SRC	293	296	PF00017	0.488
LIG_SH2_STAP1	127	131	PF00017	0.384
LIG_SH2_STAP1	233	237	PF00017	0.333
LIG_SH2_STAP1	331	335	PF00017	0.445
LIG_SH2_STAP1	513	517	PF00017	0.425
LIG_SH2_STAP1	567	571	PF00017	0.482
LIG_SH2_STAP1	609	613	PF00017	0.385
LIG_SH2_STAT3	331	334	PF00017	0.467
LIG_SH2_STAT5	108	111	PF00017	0.364
LIG_SH2_STAT5	192	195	PF00017	0.400
LIG_SH2_STAT5	228	231	PF00017	0.351
LIG_SH2_STAT5	26	29	PF00017	0.372
LIG_SH2_STAT5	275	278	PF00017	0.413
LIG_SH2_STAT5	293	296	PF00017	0.349
LIG_SH2_STAT5	300	303	PF00017	0.496
LIG_SH2_STAT5	419	422	PF00017	0.388
LIG_SH2_STAT5	456	459	PF00017	0.353
LIG_SH2_STAT5	591	594	PF00017	0.360
LIG_SH2_STAT5	76	79	PF00017	0.447
LIG_SH3_1	383	389	PF00018	0.477
LIG_SH3_3	238	244	PF00018	0.427
LIG_SH3_3	260	266	PF00018	0.488
LIG_SH3_3	383	389	PF00018	0.619
LIG_SH3_3	553	559	PF00018	0.587
LIG_SH3_3	59	65	PF00018	0.338
LIG_SUMO_SIM_par_1	103	109	PF11976	0.318
LIG_SUMO_SIM_par_1	243	249	PF11976	0.477
LIG_TRAF2_1	72	75	PF00917	0.366
LIG_TYR_ITIM	226	231	PF00017	0.443
LIG_UBA3_1	246	252	PF00899	0.424
LIG_WRC_WIRS_1	355	360	PF05994	0.352
LIG_WRC_WIRS_1	66	71	PF05994	0.284
LIG_WW_3	96	100	PF00397	0.508
MOD_CDK_SPK_2	304	309	PF00069	0.476
MOD_CDK_SPK_2	477	482	PF00069	0.559
MOD_CDK_SPxK_1	15	21	PF00069	0.356
MOD_CDK_SPxK_1	304	310	PF00069	0.504
MOD_CDK_SPxxK_3	475	482	PF00069	0.625
MOD_CDK_SPxxK_3	642	649	PF00069	0.572
MOD_CK1_1	106	112	PF00069	0.340
MOD_CK1_1	150	156	PF00069	0.532
MOD_CK1_1	387	393	PF00069	0.636
MOD_CK1_1	449	455	PF00069	0.388
MOD_CK1_1	548	554	PF00069	0.465
MOD_CK2_1	183	189	PF00069	0.397
MOD_CK2_1	508	514	PF00069	0.440
MOD_CK2_1	563	569	PF00069	0.487
MOD_CK2_1	619	625	PF00069	0.526
MOD_CK2_1	69	75	PF00069	0.444
MOD_GlcNHglycan	128	131	PF01048	0.479
MOD_GlcNHglycan	157	161	PF01048	0.701
MOD_GlcNHglycan	177	180	PF01048	0.230
MOD_GlcNHglycan	200	203	PF01048	0.487
MOD_GlcNHglycan	390	393	PF01048	0.732
MOD_GlcNHglycan	576	579	PF01048	0.541
MOD_GSK3_1	11	18	PF00069	0.327
MOD_GSK3_1	171	178	PF00069	0.417
MOD_GSK3_1	375	382	PF00069	0.527
MOD_GSK3_1	384	391	PF00069	0.578
MOD_GSK3_1	437	444	PF00069	0.391
MOD_GSK3_1	559	566	PF00069	0.575
MOD_GSK3_1	570	577	PF00069	0.540
MOD_GSK3_1	65	72	PF00069	0.460
MOD_GSK3_1	82	89	PF00069	0.566
MOD_N-GLC_2	47	49	PF02516	0.295
MOD_NEK2_1	103	108	PF00069	0.294
MOD_NEK2_1	11	16	PF00069	0.322
MOD_NEK2_1	147	152	PF00069	0.470
MOD_NEK2_1	246	251	PF00069	0.598
MOD_NEK2_1	543	548	PF00069	0.531
MOD_NEK2_1	570	575	PF00069	0.537
MOD_NEK2_1	601	606	PF00069	0.453
MOD_NEK2_1	69	74	PF00069	0.425
MOD_NEK2_2	513	518	PF00069	0.407
MOD_OFUCOSY	170	175	PF10250	0.367
MOD_PIKK_1	212	218	PF00454	0.427
MOD_PIKK_1	310	316	PF00454	0.649
MOD_PIKK_1	484	490	PF00454	0.450
MOD_PIKK_1	527	533	PF00454	0.529
MOD_PIKK_1	543	549	PF00454	0.503
MOD_PK_1	462	468	PF00069	0.517
MOD_PK_1	545	551	PF00069	0.438
MOD_PKA_2	147	153	PF00069	0.566
MOD_PKA_2	574	580	PF00069	0.492
MOD_PKA_2	613	619	PF00069	0.556
MOD_Plk_1	375	381	PF00069	0.618
MOD_Plk_1	513	519	PF00069	0.406
MOD_Plk_4	103	109	PF00069	0.375
MOD_Plk_4	11	17	PF00069	0.342
MOD_Plk_4	117	123	PF00069	0.330
MOD_Plk_4	150	156	PF00069	0.473
MOD_Plk_4	217	223	PF00069	0.500
MOD_Plk_4	251	257	PF00069	0.534
MOD_Plk_4	354	360	PF00069	0.323
MOD_Plk_4	437	443	PF00069	0.382
MOD_Plk_4	513	519	PF00069	0.406
MOD_ProDKin_1	15	21	PF00069	0.384
MOD_ProDKin_1	240	246	PF00069	0.428
MOD_ProDKin_1	29	35	PF00069	0.344
MOD_ProDKin_1	304	310	PF00069	0.562
MOD_ProDKin_1	385	391	PF00069	0.621
MOD_ProDKin_1	475	481	PF00069	0.599
MOD_ProDKin_1	642	648	PF00069	0.567
MOD_ProDKin_1	82	88	PF00069	0.584
MOD_SUMO_rev_2	265	273	PF00179	0.515
MOD_SUMO_rev_2	302	307	PF00179	0.600
TRG_DiLeu_BaEn_1	324	329	PF01217	0.441
TRG_DiLeu_BaEn_1	625	630	PF01217	0.326
TRG_DiLeu_BaLyEn_6	241	246	PF01217	0.431
TRG_ENDOCYTIC_2	218	221	PF00928	0.308
TRG_ENDOCYTIC_2	228	231	PF00928	0.314
TRG_ENDOCYTIC_2	26	29	PF00928	0.353
TRG_ENDOCYTIC_2	499	502	PF00928	0.433
TRG_ENDOCYTIC_2	5	8	PF00928	0.424
TRG_ENDOCYTIC_2	567	570	PF00928	0.531
TRG_ENDOCYTIC_2	63	66	PF00928	0.333
TRG_ER_diArg_1	184	187	PF00400	0.367
TRG_ER_diArg_1	276	279	PF00400	0.441
TRG_ER_diArg_1	308	310	PF00400	0.496
TRG_ER_diArg_1	535	538	PF00400	0.486
TRG_ER_diArg_1	540	542	PF00400	0.509
TRG_ER_diArg_1	574	576	PF00400	0.466
TRG_ER_diArg_1	626	628	PF00400	0.346
TRG_ER_diArg_1	98	100	PF00400	0.499
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.606
TRG_Pf-PMV_PEXEL_1	555	560	PF00026	0.395
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.379
TRG_PTS1	647	650	PF00515	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF78	Leptomonas seymouri	64%	100%
A0A0S4IPL3	Bodo saltans	30%	100%
A0A1X0P3T8	Trypanosomatidae	35%	100%
A0A3Q8IHN4	Leishmania donovani	93%	100%
A0A3R7MTT7	Trypanosoma rangeli	36%	100%
A4HLV4	Leishmania braziliensis	75%	100%
D0A669	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AHR1	Leishmania infantum	93%	100%
E9B482	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%