PH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3U3_LEIMA

TriTrypDb:

LmjF.33.2440 , LMJLV39_330035200 , LMJSD75_330034500

Length:

506

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3U3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3U3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.495
CLV_C14_Caspase3-7	28	32	PF00656	0.633
CLV_NRD_NRD_1	18	20	PF00675	0.592
CLV_NRD_NRD_1	225	227	PF00675	0.705
CLV_NRD_NRD_1	266	268	PF00675	0.509
CLV_NRD_NRD_1	351	353	PF00675	0.554
CLV_NRD_NRD_1	427	429	PF00675	0.696
CLV_PCSK_KEX2_1	18	20	PF00082	0.592
CLV_PCSK_KEX2_1	205	207	PF00082	0.471
CLV_PCSK_KEX2_1	222	224	PF00082	0.541
CLV_PCSK_KEX2_1	266	268	PF00082	0.541
CLV_PCSK_KEX2_1	427	429	PF00082	0.699
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.471
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.541
CLV_PCSK_SKI1_1	104	108	PF00082	0.644
CLV_PCSK_SKI1_1	227	231	PF00082	0.603
CLV_PCSK_SKI1_1	346	350	PF00082	0.567
CLV_PCSK_SKI1_1	355	359	PF00082	0.591
CLV_PCSK_SKI1_1	393	397	PF00082	0.754
CLV_PCSK_SKI1_1	98	102	PF00082	0.598
DEG_Nend_UBRbox_1	1	4	PF02207	0.721
DOC_MAPK_gen_1	465	473	PF00069	0.540
DOC_MAPK_gen_1	98	108	PF00069	0.584
DOC_USP7_MATH_1	414	418	PF00917	0.719
DOC_USP7_MATH_1	437	441	PF00917	0.724
DOC_USP7_MATH_1	453	457	PF00917	0.663
DOC_USP7_MATH_1	493	497	PF00917	0.719
DOC_USP7_UBL2_3	283	287	PF12436	0.629
DOC_WW_Pin1_4	10	15	PF00397	0.761
DOC_WW_Pin1_4	29	34	PF00397	0.802
DOC_WW_Pin1_4	59	64	PF00397	0.811
LIG_14-3-3_CanoR_1	121	129	PF00244	0.564
LIG_14-3-3_CanoR_1	2	10	PF00244	0.711
LIG_14-3-3_CanoR_1	206	211	PF00244	0.548
LIG_14-3-3_CanoR_1	226	236	PF00244	0.418
LIG_14-3-3_CanoR_1	371	378	PF00244	0.776
LIG_14-3-3_CanoR_1	381	385	PF00244	0.731
LIG_14-3-3_CanoR_1	427	435	PF00244	0.748
LIG_14-3-3_CanoR_1	439	444	PF00244	0.729
LIG_14-3-3_CanoR_1	479	484	PF00244	0.648
LIG_Actin_WH2_2	195	213	PF00022	0.478
LIG_BIR_III_2	239	243	PF00653	0.490
LIG_BRCT_BRCA1_1	4	8	PF00533	0.713
LIG_CtBP_PxDLS_1	489	493	PF00389	0.547
LIG_FHA_1	231	237	PF00498	0.759
LIG_FHA_1	297	303	PF00498	0.510
LIG_FHA_1	343	349	PF00498	0.638
LIG_FHA_2	181	187	PF00498	0.593
LIG_FHA_2	360	366	PF00498	0.651
LIG_FHA_2	50	56	PF00498	0.799
LIG_LIR_Gen_1	420	426	PF02991	0.635
LIG_LIR_Gen_1	482	492	PF02991	0.666
LIG_LIR_Nem_3	482	487	PF02991	0.671
LIG_LYPXL_SIV_4	168	176	PF13949	0.498
LIG_MYND_3	111	115	PF01753	0.488
LIG_PCNA_yPIPBox_3	188	199	PF02747	0.553
LIG_PTB_Apo_2	163	170	PF02174	0.381
LIG_PTB_Phospho_1	163	169	PF10480	0.380
LIG_SH2_GRB2like	384	387	PF00017	0.724
LIG_SH2_SRC	169	172	PF00017	0.500
LIG_SH2_SRC	384	387	PF00017	0.724
LIG_SH2_STAT5	198	201	PF00017	0.474
LIG_SH2_STAT5	79	82	PF00017	0.587
LIG_SH3_3	484	490	PF00018	0.581
LIG_TRAF2_1	113	116	PF00917	0.600
LIG_TRAF2_1	183	186	PF00917	0.570
LIG_TRAF2_1	215	218	PF00917	0.637
LIG_TRAF2_1	418	421	PF00917	0.655
MOD_CK1_1	110	116	PF00069	0.631
MOD_CK1_1	374	380	PF00069	0.679
MOD_CK1_1	387	393	PF00069	0.614
MOD_CK1_1	402	408	PF00069	0.612
MOD_CK1_1	415	421	PF00069	0.565
MOD_CK1_1	451	457	PF00069	0.675
MOD_CK1_1	459	465	PF00069	0.670
MOD_CK1_1	482	488	PF00069	0.662
MOD_CK1_1	496	502	PF00069	0.728
MOD_CK1_1	74	80	PF00069	0.621
MOD_CK2_1	110	116	PF00069	0.613
MOD_CK2_1	180	186	PF00069	0.593
MOD_CK2_1	188	194	PF00069	0.462
MOD_CK2_1	414	420	PF00069	0.687
MOD_CK2_1	49	55	PF00069	0.767
MOD_GlcNHglycan	282	286	PF01048	0.540
MOD_GlcNHglycan	374	377	PF01048	0.626
MOD_GlcNHglycan	55	58	PF01048	0.646
MOD_GlcNHglycan	73	76	PF01048	0.590
MOD_GSK3_1	25	32	PF00069	0.791
MOD_GSK3_1	270	277	PF00069	0.511
MOD_GSK3_1	380	387	PF00069	0.649
MOD_GSK3_1	427	434	PF00069	0.666
MOD_GSK3_1	435	442	PF00069	0.711
MOD_GSK3_1	469	476	PF00069	0.682
MOD_GSK3_1	49	56	PF00069	0.807
MOD_GSK3_1	57	64	PF00069	0.739
MOD_N-GLC_1	2	7	PF02516	0.711
MOD_NEK2_1	372	377	PF00069	0.575
MOD_NEK2_1	399	404	PF00069	0.761
MOD_NEK2_1	448	453	PF00069	0.728
MOD_PIKK_1	213	219	PF00454	0.632
MOD_PIKK_1	248	254	PF00454	0.579
MOD_PIKK_1	25	31	PF00454	0.594
MOD_PIKK_1	322	328	PF00454	0.584
MOD_PIKK_1	384	390	PF00454	0.734
MOD_PIKK_1	437	443	PF00454	0.769
MOD_PIKK_1	453	459	PF00454	0.676
MOD_PIKK_1	496	502	PF00454	0.654
MOD_PKA_1	427	433	PF00069	0.705
MOD_PKA_2	122	128	PF00069	0.569
MOD_PKA_2	380	386	PF00069	0.719
MOD_PKA_2	415	421	PF00069	0.626
MOD_PKA_2	427	433	PF00069	0.635
MOD_PKA_2	459	465	PF00069	0.711
MOD_Plk_1	102	108	PF00069	0.634
MOD_Plk_1	172	178	PF00069	0.561
MOD_Plk_1	180	186	PF00069	0.580
MOD_Plk_1	469	475	PF00069	0.689
MOD_Plk_2-3	43	49	PF00069	0.707
MOD_Plk_4	479	485	PF00069	0.714
MOD_ProDKin_1	10	16	PF00069	0.762
MOD_ProDKin_1	29	35	PF00069	0.801
MOD_ProDKin_1	59	65	PF00069	0.812
MOD_SUMO_rev_2	238	248	PF00179	0.561
MOD_SUMO_rev_2	350	354	PF00179	0.520
MOD_SUMO_rev_2	99	106	PF00179	0.624
TRG_DiLeu_BaEn_3	420	426	PF01217	0.518
TRG_DiLeu_BaEn_4	185	191	PF01217	0.497
TRG_ENDOCYTIC_2	369	372	PF00928	0.706
TRG_ER_diArg_1	121	124	PF00400	0.504
TRG_ER_diArg_1	265	267	PF00400	0.529
TRG_ER_diArg_1	426	428	PF00400	0.683
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	2	6	PF00026	0.673
TRG_Pf-PMV_PEXEL_1	346	350	PF00026	0.644
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMH4	Leptomonas seymouri	66%	100%
A0A1X0P3T7	Trypanosomatidae	38%	100%
A0A3S7X729	Leishmania donovani	91%	100%
A0A422P039	Trypanosoma rangeli	36%	100%
A4HLV5	Leishmania braziliensis	57%	99%
E9AHR2	Leishmania infantum	91%	100%
E9B483	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%