Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellum attachment zone protein 12

Species:

Leishmania major

UniProt:

Q4Q3U1_LEIMA

TriTrypDb:

LmjF.33.2460 , LMJLV39_330035400 , LMJSD75_330034700

Length:

1051

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3U1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3U1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1013	1017	PF00656	0.723
CLV_C14_Caspase3-7	184	188	PF00656	0.533
CLV_C14_Caspase3-7	200	204	PF00656	0.488
CLV_C14_Caspase3-7	489	493	PF00656	0.754
CLV_C14_Caspase3-7	660	664	PF00656	0.611
CLV_C14_Caspase3-7	683	687	PF00656	0.578
CLV_C14_Caspase3-7	707	711	PF00656	0.595
CLV_C14_Caspase3-7	988	992	PF00656	0.668
CLV_NRD_NRD_1	206	208	PF00675	0.553
CLV_NRD_NRD_1	215	217	PF00675	0.658
CLV_NRD_NRD_1	42	44	PF00675	0.711
CLV_NRD_NRD_1	52	54	PF00675	0.606
CLV_NRD_NRD_1	557	559	PF00675	0.587
CLV_NRD_NRD_1	589	591	PF00675	0.528
CLV_NRD_NRD_1	613	615	PF00675	0.539
CLV_NRD_NRD_1	764	766	PF00675	0.621
CLV_NRD_NRD_1	791	793	PF00675	0.472
CLV_PCSK_KEX2_1	112	114	PF00082	0.553
CLV_PCSK_KEX2_1	206	208	PF00082	0.564
CLV_PCSK_KEX2_1	214	216	PF00082	0.662
CLV_PCSK_KEX2_1	420	422	PF00082	0.695
CLV_PCSK_KEX2_1	52	54	PF00082	0.639
CLV_PCSK_KEX2_1	589	591	PF00082	0.528
CLV_PCSK_KEX2_1	764	766	PF00082	0.621
CLV_PCSK_KEX2_1	791	793	PF00082	0.472
CLV_PCSK_KEX2_1	857	859	PF00082	0.507
CLV_PCSK_KEX2_1	870	872	PF00082	0.658
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.599
CLV_PCSK_PC1ET2_1	420	422	PF00082	0.695
CLV_PCSK_PC1ET2_1	857	859	PF00082	0.507
CLV_PCSK_PC1ET2_1	870	872	PF00082	0.658
CLV_PCSK_SKI1_1	151	155	PF00082	0.450
CLV_PCSK_SKI1_1	289	293	PF00082	0.719
CLV_PCSK_SKI1_1	599	603	PF00082	0.626
CLV_PCSK_SKI1_1	615	619	PF00082	0.377
CLV_PCSK_SKI1_1	791	795	PF00082	0.487
CLV_PCSK_SKI1_1	803	807	PF00082	0.553
DEG_APCC_DBOX_1	213	221	PF00400	0.602
DEG_APCC_DBOX_1	42	50	PF00400	0.709
DEG_APCC_DBOX_1	790	798	PF00400	0.461
DEG_COP1_1	496	506	PF00400	0.593
DOC_CKS1_1	240	245	PF01111	0.514
DOC_MAPK_DCC_7	225	233	PF00069	0.714
DOC_MAPK_DCC_7	840	848	PF00069	0.598
DOC_MAPK_gen_1	366	374	PF00069	0.498
DOC_MAPK_gen_1	791	797	PF00069	0.486
DOC_MAPK_MEF2A_6	225	233	PF00069	0.714
DOC_MAPK_MEF2A_6	53	62	PF00069	0.511
DOC_MAPK_MEF2A_6	840	848	PF00069	0.637
DOC_PP1_RVXF_1	287	294	PF00149	0.724
DOC_PP2B_LxvP_1	309	312	PF13499	0.711
DOC_PP2B_PxIxI_1	228	234	PF00149	0.698
DOC_PP2B_PxIxI_1	314	320	PF00149	0.686
DOC_PP4_FxxP_1	445	448	PF00568	0.662
DOC_PP4_FxxP_1	972	975	PF00568	0.521
DOC_PP4_MxPP_1	848	851	PF00568	0.535
DOC_USP7_MATH_1	1041	1045	PF00917	0.734
DOC_USP7_MATH_1	235	239	PF00917	0.542
DOC_USP7_MATH_1	279	283	PF00917	0.677
DOC_USP7_MATH_1	448	452	PF00917	0.724
DOC_USP7_MATH_1	45	49	PF00917	0.589
DOC_USP7_MATH_1	507	511	PF00917	0.786
DOC_USP7_MATH_1	640	644	PF00917	0.614
DOC_USP7_MATH_1	692	696	PF00917	0.588
DOC_USP7_MATH_1	739	743	PF00917	0.620
DOC_USP7_MATH_1	760	764	PF00917	0.719
DOC_USP7_MATH_1	771	775	PF00917	0.434
DOC_USP7_MATH_1	776	780	PF00917	0.411
DOC_USP7_MATH_1	935	939	PF00917	0.635
DOC_WW_Pin1_4	1037	1042	PF00397	0.729
DOC_WW_Pin1_4	239	244	PF00397	0.514
DOC_WW_Pin1_4	523	528	PF00397	0.761
DOC_WW_Pin1_4	62	67	PF00397	0.537
DOC_WW_Pin1_4	641	646	PF00397	0.594
DOC_WW_Pin1_4	754	759	PF00397	0.590
DOC_WW_Pin1_4	927	932	PF00397	0.682
DOC_WW_Pin1_4	971	976	PF00397	0.472
LIG_14-3-3_CanoR_1	1028	1036	PF00244	0.747
LIG_14-3-3_CanoR_1	151	161	PF00244	0.484
LIG_14-3-3_CanoR_1	21	25	PF00244	0.525
LIG_14-3-3_CanoR_1	215	221	PF00244	0.648
LIG_14-3-3_CanoR_1	37	46	PF00244	0.678
LIG_14-3-3_CanoR_1	52	56	PF00244	0.537
LIG_14-3-3_CanoR_1	573	582	PF00244	0.493
LIG_14-3-3_CanoR_1	812	820	PF00244	0.487
LIG_14-3-3_CanoR_1	964	970	PF00244	0.622
LIG_14-3-3_CanoR_1	983	988	PF00244	0.641
LIG_Actin_WH2_2	7	23	PF00022	0.563
LIG_APCC_ABBA_1	430	435	PF00400	0.631
LIG_BIR_II_1	1	5	PF00653	0.657
LIG_BIR_III_2	775	779	PF00653	0.664
LIG_BRCT_BRCA1_1	220	224	PF00533	0.684
LIG_Clathr_ClatBox_1	797	801	PF01394	0.572
LIG_deltaCOP1_diTrp_1	138	148	PF00928	0.478
LIG_DLG_GKlike_1	680	688	PF00625	0.496
LIG_EH1_1	581	589	PF00400	0.425
LIG_FHA_1	1028	1034	PF00498	0.733
LIG_FHA_1	264	270	PF00498	0.480
LIG_FHA_1	320	326	PF00498	0.536
LIG_FHA_1	427	433	PF00498	0.609
LIG_FHA_1	447	453	PF00498	0.455
LIG_FHA_1	5	11	PF00498	0.594
LIG_FHA_1	57	63	PF00498	0.525
LIG_FHA_1	575	581	PF00498	0.434
LIG_FHA_1	671	677	PF00498	0.608
LIG_FHA_1	712	718	PF00498	0.750
LIG_FHA_1	832	838	PF00498	0.556
LIG_FHA_1	937	943	PF00498	0.518
LIG_FHA_2	1011	1017	PF00498	0.724
LIG_FHA_2	171	177	PF00498	0.581
LIG_FHA_2	180	186	PF00498	0.513
LIG_FHA_2	240	246	PF00498	0.650
LIG_FHA_2	536	542	PF00498	0.685
LIG_FHA_2	561	567	PF00498	0.593
LIG_FHA_2	601	607	PF00498	0.482
LIG_FHA_2	69	75	PF00498	0.544
LIG_FHA_2	705	711	PF00498	0.600
LIG_FHA_2	904	910	PF00498	0.550
LIG_FHA_2	914	920	PF00498	0.514
LIG_LIR_Apic_2	237	243	PF02991	0.510
LIG_LIR_Apic_2	79	83	PF02991	0.634
LIG_LIR_Gen_1	133	143	PF02991	0.448
LIG_LIR_Gen_1	400	408	PF02991	0.504
LIG_LIR_Gen_1	663	672	PF02991	0.580
LIG_LIR_Nem_3	105	110	PF02991	0.490
LIG_LIR_Nem_3	133	139	PF02991	0.411
LIG_LIR_Nem_3	400	405	PF02991	0.501
LIG_LIR_Nem_3	425	430	PF02991	0.599
LIG_LIR_Nem_3	431	436	PF02991	0.643
LIG_LIR_Nem_3	499	503	PF02991	0.705
LIG_LIR_Nem_3	663	668	PF02991	0.580
LIG_LIR_Nem_3	874	880	PF02991	0.682
LIG_MAD2	667	675	PF02301	0.611
LIG_MYND_2	645	649	PF01753	0.477
LIG_NRP_CendR_1	1050	1051	PF00754	0.768
LIG_PCNA_yPIPBox_3	337	350	PF02747	0.616
LIG_Pex14_1	402	406	PF04695	0.368
LIG_PTB_Apo_2	541	548	PF02174	0.590
LIG_PTB_Phospho_1	541	547	PF10480	0.588
LIG_SH2_CRK	375	379	PF00017	0.475
LIG_SH2_CRK	547	551	PF00017	0.580
LIG_SH2_CRK	582	586	PF00017	0.544
LIG_SH2_CRK	665	669	PF00017	0.517
LIG_SH2_CRK	751	755	PF00017	0.528
LIG_SH2_NCK_1	136	140	PF00017	0.578
LIG_SH2_PTP2	80	83	PF00017	0.631
LIG_SH2_SRC	136	139	PF00017	0.581
LIG_SH2_SRC	80	83	PF00017	0.631
LIG_SH2_SRC	880	883	PF00017	0.559
LIG_SH2_STAP1	136	140	PF00017	0.476
LIG_SH2_STAP1	399	403	PF00017	0.475
LIG_SH2_STAP1	547	551	PF00017	0.580
LIG_SH2_STAP1	665	669	PF00017	0.471
LIG_SH2_STAP1	877	881	PF00017	0.669
LIG_SH2_STAT3	247	250	PF00017	0.644
LIG_SH2_STAT5	170	173	PF00017	0.510
LIG_SH2_STAT5	240	243	PF00017	0.502
LIG_SH2_STAT5	28	31	PF00017	0.627
LIG_SH2_STAT5	302	305	PF00017	0.725
LIG_SH2_STAT5	671	674	PF00017	0.375
LIG_SH2_STAT5	788	791	PF00017	0.362
LIG_SH2_STAT5	80	83	PF00017	0.631
LIG_SH2_STAT5	826	829	PF00017	0.591
LIG_SH3_1	80	86	PF00018	0.620
LIG_SH3_3	309	315	PF00018	0.709
LIG_SH3_3	495	501	PF00018	0.728
LIG_SH3_3	52	58	PF00018	0.503
LIG_SH3_3	521	527	PF00018	0.784
LIG_SH3_3	63	69	PF00018	0.555
LIG_SH3_3	653	659	PF00018	0.510
LIG_SH3_3	669	675	PF00018	0.381
LIG_SH3_3	78	84	PF00018	0.637
LIG_SH3_3	866	872	PF00018	0.626
LIG_SUMO_SIM_anti_2	197	205	PF11976	0.431
LIG_SUMO_SIM_par_1	265	271	PF11976	0.529
LIG_TRAF2_1	182	185	PF00917	0.557
LIG_TRAF2_1	242	245	PF00917	0.548
LIG_TRAF2_1	335	338	PF00917	0.459
LIG_TRAF2_1	534	537	PF00917	0.672
LIG_TRAF2_1	603	606	PF00917	0.507
LIG_TYR_ITIM	580	585	PF00017	0.426
LIG_UBA3_1	339	345	PF00899	0.539
LIG_UBA3_1	414	420	PF00899	0.647
LIG_UBA3_1	797	803	PF00899	0.515
LIG_WW_1	77	80	PF00397	0.631
MOD_CDK_SPK_2	927	932	PF00069	0.682
MOD_CDK_SPxxK_3	239	246	PF00069	0.513
MOD_CDK_SPxxK_3	971	978	PF00069	0.530
MOD_CK1_1	1004	1010	PF00069	0.782
MOD_CK1_1	310	316	PF00069	0.748
MOD_CK1_1	38	44	PF00069	0.570
MOD_CK1_1	380	386	PF00069	0.502
MOD_CK1_1	419	425	PF00069	0.622
MOD_CK1_1	493	499	PF00069	0.640
MOD_CK1_1	502	508	PF00069	0.579
MOD_CK1_1	510	516	PF00069	0.560
MOD_CK1_1	526	532	PF00069	0.641
MOD_CK1_1	560	566	PF00069	0.591
MOD_CK1_1	644	650	PF00069	0.567
MOD_CK1_1	695	701	PF00069	0.616
MOD_CK1_1	814	820	PF00069	0.554
MOD_CK1_1	927	933	PF00069	0.555
MOD_CK2_1	179	185	PF00069	0.542
MOD_CK2_1	239	245	PF00069	0.534
MOD_CK2_1	279	285	PF00069	0.686
MOD_CK2_1	357	363	PF00069	0.585
MOD_CK2_1	535	541	PF00069	0.653
MOD_CK2_1	560	566	PF00069	0.700
MOD_CK2_1	600	606	PF00069	0.568
MOD_CK2_1	68	74	PF00069	0.529
MOD_CK2_1	913	919	PF00069	0.506
MOD_CK2_1	982	988	PF00069	0.653
MOD_Cter_Amidation	612	615	PF01082	0.543
MOD_GlcNHglycan	1043	1046	PF01048	0.746
MOD_GlcNHglycan	121	124	PF01048	0.565
MOD_GlcNHglycan	273	276	PF01048	0.621
MOD_GlcNHglycan	285	288	PF01048	0.737
MOD_GlcNHglycan	358	362	PF01048	0.640
MOD_GlcNHglycan	40	43	PF01048	0.636
MOD_GlcNHglycan	421	424	PF01048	0.710
MOD_GlcNHglycan	488	491	PF01048	0.749
MOD_GlcNHglycan	492	495	PF01048	0.693
MOD_GlcNHglycan	504	507	PF01048	0.521
MOD_GlcNHglycan	512	515	PF01048	0.580
MOD_GlcNHglycan	532	535	PF01048	0.580
MOD_GlcNHglycan	591	595	PF01048	0.448
MOD_GlcNHglycan	695	698	PF01048	0.622
MOD_GlcNHglycan	707	710	PF01048	0.664
MOD_GlcNHglycan	722	725	PF01048	0.426
MOD_GlcNHglycan	741	744	PF01048	0.316
MOD_GlcNHglycan	926	929	PF01048	0.597
MOD_GlcNHglycan	965	968	PF01048	0.518
MOD_GSK3_1	1006	1013	PF00069	0.816
MOD_GSK3_1	1023	1030	PF00069	0.723
MOD_GSK3_1	1035	1042	PF00069	0.679
MOD_GSK3_1	152	159	PF00069	0.457
MOD_GSK3_1	175	182	PF00069	0.506
MOD_GSK3_1	197	204	PF00069	0.499
MOD_GSK3_1	227	234	PF00069	0.654
MOD_GSK3_1	235	242	PF00069	0.602
MOD_GSK3_1	279	286	PF00069	0.660
MOD_GSK3_1	303	310	PF00069	0.776
MOD_GSK3_1	319	326	PF00069	0.483
MOD_GSK3_1	422	429	PF00069	0.597
MOD_GSK3_1	482	489	PF00069	0.720
MOD_GSK3_1	526	533	PF00069	0.720
MOD_GSK3_1	616	623	PF00069	0.545
MOD_GSK3_1	640	647	PF00069	0.599
MOD_GSK3_1	735	742	PF00069	0.627
MOD_GSK3_1	899	906	PF00069	0.571
MOD_GSK3_1	948	955	PF00069	0.749
MOD_GSK3_1	997	1004	PF00069	0.749
MOD_N-GLC_1	1001	1006	PF02516	0.706
MOD_N-GLC_1	253	258	PF02516	0.522
MOD_N-GLC_1	263	268	PF02516	0.483
MOD_N-GLC_1	832	837	PF02516	0.588
MOD_N-GLC_1	884	889	PF02516	0.439
MOD_N-GLC_1	935	940	PF02516	0.591
MOD_NEK2_1	121	126	PF00069	0.606
MOD_NEK2_1	130	135	PF00069	0.462
MOD_NEK2_1	154	159	PF00069	0.481
MOD_NEK2_1	20	25	PF00069	0.523
MOD_NEK2_1	263	268	PF00069	0.497
MOD_NEK2_1	292	297	PF00069	0.741
MOD_NEK2_1	357	362	PF00069	0.645
MOD_NEK2_1	621	626	PF00069	0.532
MOD_NEK2_1	910	915	PF00069	0.616
MOD_NEK2_2	235	240	PF00069	0.638
MOD_NEK2_2	428	433	PF00069	0.612
MOD_NEK2_2	475	480	PF00069	0.603
MOD_PIKK_1	1004	1010	PF00454	0.830
MOD_PIKK_1	121	127	PF00454	0.623
MOD_PIKK_1	128	134	PF00454	0.489
MOD_PIKK_1	292	298	PF00454	0.719
MOD_PIKK_1	4	10	PF00454	0.608
MOD_PK_1	216	222	PF00069	0.610
MOD_PK_1	952	958	PF00069	0.694
MOD_PKA_1	112	118	PF00069	0.567
MOD_PKA_1	870	876	PF00069	0.621
MOD_PKA_2	1027	1033	PF00069	0.721
MOD_PKA_2	112	118	PF00069	0.627
MOD_PKA_2	20	26	PF00069	0.531
MOD_PKA_2	51	57	PF00069	0.636
MOD_PKA_2	557	563	PF00069	0.633
MOD_PKA_2	811	817	PF00069	0.481
MOD_PKA_2	870	876	PF00069	0.665
MOD_PKA_2	963	969	PF00069	0.662
MOD_PKA_2	982	988	PF00069	0.583
MOD_PKB_1	214	222	PF00069	0.610
MOD_Plk_1	141	147	PF00069	0.463
MOD_Plk_1	175	181	PF00069	0.485
MOD_Plk_1	263	269	PF00069	0.509
MOD_Plk_1	380	386	PF00069	0.494
MOD_Plk_1	571	577	PF00069	0.505
MOD_Plk_1	814	820	PF00069	0.584
MOD_Plk_1	832	838	PF00069	0.451
MOD_Plk_1	884	890	PF00069	0.437
MOD_Plk_4	1007	1013	PF00069	0.839
MOD_Plk_4	197	203	PF00069	0.423
MOD_Plk_4	263	269	PF00069	0.530
MOD_Plk_4	380	386	PF00069	0.533
MOD_Plk_4	398	404	PF00069	0.364
MOD_Plk_4	428	434	PF00069	0.601
MOD_Plk_4	448	454	PF00069	0.458
MOD_Plk_4	545	551	PF00069	0.369
MOD_Plk_4	644	650	PF00069	0.587
MOD_Plk_4	680	686	PF00069	0.470
MOD_Plk_4	76	82	PF00069	0.536
MOD_Plk_4	833	839	PF00069	0.538
MOD_Plk_4	913	919	PF00069	0.608
MOD_ProDKin_1	1037	1043	PF00069	0.731
MOD_ProDKin_1	239	245	PF00069	0.511
MOD_ProDKin_1	523	529	PF00069	0.761
MOD_ProDKin_1	62	68	PF00069	0.535
MOD_ProDKin_1	641	647	PF00069	0.587
MOD_ProDKin_1	754	760	PF00069	0.589
MOD_ProDKin_1	927	933	PF00069	0.679
MOD_ProDKin_1	971	977	PF00069	0.466
MOD_SUMO_rev_2	238	248	PF00179	0.539
MOD_SUMO_rev_2	26	34	PF00179	0.734
MOD_SUMO_rev_2	799	805	PF00179	0.524
MOD_SUMO_rev_2	855	863	PF00179	0.491
MOD_SUMO_rev_2	919	927	PF00179	0.560
TRG_DiLeu_BaEn_1	257	262	PF01217	0.529
TRG_DiLeu_BaEn_1	801	806	PF01217	0.502
TRG_DiLeu_BaLyEn_6	972	977	PF01217	0.513
TRG_ENDOCYTIC_2	136	139	PF00928	0.443
TRG_ENDOCYTIC_2	150	153	PF00928	0.501
TRG_ENDOCYTIC_2	249	252	PF00928	0.532
TRG_ENDOCYTIC_2	375	378	PF00928	0.470
TRG_ENDOCYTIC_2	547	550	PF00928	0.469
TRG_ENDOCYTIC_2	582	585	PF00928	0.543
TRG_ENDOCYTIC_2	665	668	PF00928	0.522
TRG_ENDOCYTIC_2	826	829	PF00928	0.591
TRG_ER_diArg_1	214	216	PF00400	0.599
TRG_ER_diArg_1	456	459	PF00400	0.743
TRG_ER_diArg_1	51	53	PF00400	0.576
TRG_ER_diArg_1	588	590	PF00400	0.507
TRG_ER_diArg_1	764	766	PF00400	0.621
TRG_ER_diArg_1	791	793	PF00400	0.450
TRG_NES_CRM1_1	257	271	PF08389	0.558
TRG_NES_CRM1_1	381	394	PF08389	0.504
TRG_Pf-PMV_PEXEL_1	99	104	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9F7	Leptomonas seymouri	56%	100%
A0A3S5H7V1	Leishmania donovani	93%	100%
A4HLV7	Leishmania braziliensis	71%	100%
E9AHR4	Leishmania infantum	93%	100%
E9B485	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%