Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3T9_LEIMA

TriTrypDb:

LmjF.33.2480 , LMJLV39_330035600 , LMJSD75_330034900

Length:

585

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3T9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3T9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.480
CLV_C14_Caspase3-7	267	271	PF00656	0.566
CLV_C14_Caspase3-7	310	314	PF00656	0.641
CLV_NRD_NRD_1	171	173	PF00675	0.427
CLV_NRD_NRD_1	29	31	PF00675	0.430
CLV_NRD_NRD_1	445	447	PF00675	0.615
CLV_NRD_NRD_1	482	484	PF00675	0.472
CLV_PCSK_FUR_1	11	15	PF00082	0.592
CLV_PCSK_KEX2_1	13	15	PF00082	0.702
CLV_PCSK_KEX2_1	171	173	PF00082	0.348
CLV_PCSK_KEX2_1	29	31	PF00082	0.360
CLV_PCSK_KEX2_1	370	372	PF00082	0.485
CLV_PCSK_KEX2_1	445	447	PF00082	0.615
CLV_PCSK_KEX2_1	482	484	PF00082	0.468
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.595
CLV_PCSK_PC1ET2_1	370	372	PF00082	0.485
CLV_PCSK_SKI1_1	337	341	PF00082	0.423
CLV_PCSK_SKI1_1	581	585	PF00082	0.587
CLV_PCSK_SKI1_1	99	103	PF00082	0.361
DOC_CYCLIN_yCln2_LP_2	116	122	PF00134	0.513
DOC_PP1_RVXF_1	335	342	PF00149	0.463
DOC_SPAK_OSR1_1	470	474	PF12202	0.356
DOC_USP7_MATH_1	127	131	PF00917	0.567
DOC_USP7_MATH_1	134	138	PF00917	0.649
DOC_USP7_MATH_1	159	163	PF00917	0.525
DOC_USP7_MATH_1	226	230	PF00917	0.600
DOC_USP7_MATH_1	254	258	PF00917	0.606
DOC_USP7_MATH_1	369	373	PF00917	0.514
DOC_USP7_MATH_1	378	382	PF00917	0.586
DOC_USP7_MATH_1	508	512	PF00917	0.684
DOC_USP7_MATH_1	514	518	PF00917	0.636
DOC_USP7_MATH_1	565	569	PF00917	0.374
DOC_USP7_MATH_1	69	73	PF00917	0.473
DOC_WW_Pin1_4	268	273	PF00397	0.582
DOC_WW_Pin1_4	402	407	PF00397	0.442
LIG_14-3-3_CanoR_1	147	152	PF00244	0.503
LIG_14-3-3_CanoR_1	225	233	PF00244	0.441
LIG_14-3-3_CanoR_1	29	33	PF00244	0.477
LIG_14-3-3_CanoR_1	298	304	PF00244	0.533
LIG_14-3-3_CanoR_1	324	329	PF00244	0.542
LIG_14-3-3_CanoR_1	361	366	PF00244	0.409
LIG_14-3-3_CanoR_1	371	376	PF00244	0.489
LIG_14-3-3_CanoR_1	482	490	PF00244	0.511
LIG_14-3-3_CanoR_1	93	101	PF00244	0.395
LIG_BRCT_BRCA1_1	176	180	PF00533	0.399
LIG_BRCT_BRCA1_1	223	227	PF00533	0.462
LIG_CaM_IQ_9	40	56	PF13499	0.419
LIG_EVH1_1	573	577	PF00568	0.583
LIG_FHA_1	148	154	PF00498	0.554
LIG_FHA_1	31	37	PF00498	0.458
LIG_FHA_1	323	329	PF00498	0.580
LIG_FHA_1	41	47	PF00498	0.426
LIG_FHA_1	410	416	PF00498	0.443
LIG_FHA_1	454	460	PF00498	0.429
LIG_FHA_1	545	551	PF00498	0.510
LIG_FHA_1	552	558	PF00498	0.400
LIG_FHA_2	1	7	PF00498	0.545
LIG_FHA_2	218	224	PF00498	0.643
LIG_FHA_2	308	314	PF00498	0.604
LIG_FHA_2	40	46	PF00498	0.383
LIG_LIR_Apic_2	572	576	PF02991	0.517
LIG_LIR_Gen_1	177	187	PF02991	0.405
LIG_LIR_Gen_1	412	422	PF02991	0.413
LIG_LIR_Gen_1	424	434	PF02991	0.394
LIG_LIR_Gen_1	49	55	PF02991	0.466
LIG_LIR_Gen_1	546	553	PF02991	0.441
LIG_LIR_Nem_3	177	183	PF02991	0.352
LIG_LIR_Nem_3	412	417	PF02991	0.413
LIG_LIR_Nem_3	424	430	PF02991	0.398
LIG_LIR_Nem_3	49	53	PF02991	0.389
LIG_LIR_Nem_3	546	551	PF02991	0.477
LIG_LIR_Nem_3	55	60	PF02991	0.406
LIG_NRBOX	471	477	PF00104	0.363
LIG_PCNA_APIM_2	468	474	PF02747	0.353
LIG_PCNA_PIPBox_1	465	474	PF02747	0.420
LIG_PCNA_yPIPBox_3	465	474	PF02747	0.420
LIG_Pex14_1	176	180	PF04695	0.399
LIG_Pex14_2	202	206	PF04695	0.481
LIG_SH2_CRK	427	431	PF00017	0.441
LIG_SH2_NCK_1	243	247	PF00017	0.459
LIG_SH2_NCK_1	427	431	PF00017	0.441
LIG_SH2_STAP1	32	36	PF00017	0.466
LIG_SH2_STAP1	349	353	PF00017	0.400
LIG_SH2_STAT5	163	166	PF00017	0.379
LIG_SH2_STAT5	299	302	PF00017	0.522
LIG_SH2_STAT5	32	35	PF00017	0.462
LIG_SH2_STAT5	64	67	PF00017	0.493
LIG_SH3_3	116	122	PF00018	0.599
LIG_SH3_3	493	499	PF00018	0.573
LIG_SH3_3	571	577	PF00018	0.588
LIG_SUMO_SIM_anti_2	186	191	PF11976	0.391
LIG_SUMO_SIM_par_1	361	368	PF11976	0.497
LIG_SxIP_EBH_1	506	519	PF03271	0.529
LIG_TRAF2_1	374	377	PF00917	0.634
LIG_TRAF2_1	42	45	PF00917	0.385
LIG_TRAF2_1	78	81	PF00917	0.558
LIG_TYR_ITIM	241	246	PF00017	0.523
MOD_CK1_1	110	116	PF00069	0.598
MOD_CK1_1	143	149	PF00069	0.756
MOD_CK1_1	327	333	PF00069	0.548
MOD_CK1_1	388	394	PF00069	0.656
MOD_CK1_1	455	461	PF00069	0.507
MOD_CK1_1	543	549	PF00069	0.518
MOD_CK1_1	7	13	PF00069	0.521
MOD_CK2_1	233	239	PF00069	0.497
MOD_CK2_1	361	367	PF00069	0.452
MOD_CK2_1	371	377	PF00069	0.474
MOD_CK2_1	39	45	PF00069	0.383
MOD_CK2_1	74	80	PF00069	0.587
MOD_CK2_1	86	92	PF00069	0.352
MOD_Cter_Amidation	443	446	PF01082	0.576
MOD_GlcNHglycan	112	115	PF01048	0.476
MOD_GlcNHglycan	126	130	PF01048	0.555
MOD_GlcNHglycan	190	193	PF01048	0.440
MOD_GlcNHglycan	228	231	PF01048	0.643
MOD_GlcNHglycan	294	297	PF01048	0.467
MOD_GlcNHglycan	331	334	PF01048	0.577
MOD_GlcNHglycan	355	360	PF01048	0.499
MOD_GlcNHglycan	448	451	PF01048	0.599
MOD_GlcNHglycan	5	9	PF01048	0.523
MOD_GlcNHglycan	510	513	PF01048	0.579
MOD_GlcNHglycan	76	79	PF01048	0.573
MOD_GlcNHglycan	88	91	PF01048	0.497
MOD_GSK3_1	143	150	PF00069	0.581
MOD_GSK3_1	188	195	PF00069	0.399
MOD_GSK3_1	217	224	PF00069	0.490
MOD_GSK3_1	242	249	PF00069	0.458
MOD_GSK3_1	28	35	PF00069	0.451
MOD_GSK3_1	307	314	PF00069	0.646
MOD_GSK3_1	324	331	PF00069	0.635
MOD_GSK3_1	361	368	PF00069	0.456
MOD_GSK3_1	378	385	PF00069	0.507
MOD_GSK3_1	525	532	PF00069	0.664
MOD_GSK3_1	536	543	PF00069	0.555
MOD_GSK3_1	93	100	PF00069	0.445
MOD_LATS_1	66	72	PF00433	0.533
MOD_N-GLC_1	514	519	PF02516	0.499
MOD_NEK2_1	140	145	PF00069	0.489
MOD_NEK2_1	190	195	PF00069	0.427
MOD_NEK2_1	233	238	PF00069	0.537
MOD_NEK2_1	28	33	PF00069	0.457
MOD_NEK2_1	290	295	PF00069	0.474
MOD_NEK2_1	328	333	PF00069	0.544
MOD_NEK2_1	347	352	PF00069	0.323
MOD_NEK2_1	551	556	PF00069	0.393
MOD_PIKK_1	217	223	PF00454	0.490
MOD_PIKK_1	40	46	PF00454	0.434
MOD_PIKK_1	536	542	PF00454	0.630
MOD_PIKK_1	551	557	PF00454	0.249
MOD_PIKK_1	93	99	PF00454	0.378
MOD_PK_1	361	367	PF00069	0.452
MOD_PK_1	371	377	PF00069	0.474
MOD_PKA_2	110	116	PF00069	0.453
MOD_PKA_2	221	227	PF00069	0.468
MOD_PKA_2	28	34	PF00069	0.485
MOD_PKA_2	297	303	PF00069	0.589
MOD_PKA_2	40	46	PF00069	0.408
MOD_PKA_2	444	450	PF00069	0.633
MOD_PKA_2	528	534	PF00069	0.598
MOD_Plk_1	79	85	PF00069	0.448
MOD_Plk_4	159	165	PF00069	0.456
MOD_Plk_4	347	353	PF00069	0.521
MOD_Plk_4	361	367	PF00069	0.411
MOD_Plk_4	409	415	PF00069	0.388
MOD_ProDKin_1	268	274	PF00069	0.583
MOD_ProDKin_1	402	408	PF00069	0.429
MOD_SUMO_for_1	101	104	PF00179	0.355
MOD_SUMO_for_1	319	322	PF00179	0.649
TRG_DiLeu_BaLyEn_6	358	363	PF01217	0.433
TRG_DiLeu_BaLyEn_6	471	476	PF01217	0.389
TRG_ENDOCYTIC_2	243	246	PF00928	0.495
TRG_ENDOCYTIC_2	349	352	PF00928	0.389
TRG_ENDOCYTIC_2	427	430	PF00928	0.396
TRG_ER_diArg_1	171	173	PF00400	0.348
TRG_ER_diArg_1	28	30	PF00400	0.420
TRG_ER_diArg_1	481	483	PF00400	0.469
TRG_ER_diArg_1	519	522	PF00400	0.632
TRG_NES_CRM1_1	186	199	PF08389	0.448
TRG_Pf-PMV_PEXEL_1	474	478	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8S0	Leptomonas seymouri	36%	98%
A0A3S7X715	Leishmania donovani	87%	100%
A4HLV9	Leishmania braziliensis	63%	100%
E9AHR6	Leishmania infantum	88%	100%
E9B487	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%