Putative recombinase rad51

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

recombinase rad51, putative

Species:

Leishmania major

UniProt:

Q4Q3T8_LEIMA

TriTrypDb:

LmjF.33.2490 , LMJLV39_330035700 , LMJSD75_330035000

Length:

687

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005657	replication fork	2	2
GO:0032991	protein-containing complex	1	2
GO:0033061	DNA recombinase mediator complex	2	2
GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex	3	2
GO:0033065	Rad51C-XRCC3 complex	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	2

Expansion

Sequence features

Q4Q3T8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3T8

Function

Biological processes
Term	Name	Level	Count
GO:0000707	meiotic DNA recombinase assembly	4	2
GO:0000730	DNA recombinase assembly	7	2
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006259	DNA metabolic process	4	10
GO:0006310	DNA recombination	5	2
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0007131	reciprocal meiotic recombination	3	2
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	2
GO:0022402	cell cycle process	2	2
GO:0022414	reproductive process	1	2
GO:0022607	cellular component assembly	4	2
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0035825	homologous recombination	6	2
GO:0043170	macromolecule metabolic process	3	10
GO:0043933	protein-containing complex organization	4	2
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0046483	heterocycle metabolic process	3	10
GO:0061982	meiosis I cell cycle process	3	2
GO:0065003	protein-containing complex assembly	5	2
GO:0065004	protein-DNA complex assembly	6	2
GO:0071704	organic substance metabolic process	2	10
GO:0071824	protein-DNA complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090304	nucleic acid metabolic process	4	10
GO:0090735	DNA repair complex assembly	6	2
GO:0140527	reciprocal homologous recombination	7	2
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1903046	meiotic cell cycle process	2	2
GO:0006281	DNA repair	5	8
GO:0006950	response to stress	2	8
GO:0006974	DNA damage response	4	8
GO:0033554	cellular response to stress	3	8
GO:0050896	response to stimulus	1	8
GO:0051716	cellular response to stimulus	2	8

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	10
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0008094	ATP-dependent activity, acting on DNA	2	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0140097	catalytic activity, acting on DNA	3	10
GO:0140299	small molecule sensor activity	1	10
GO:0140612	DNA damage sensor activity	2	10
GO:0140640	catalytic activity, acting on a nucleic acid	2	10
GO:0140657	ATP-dependent activity	1	10
GO:0140664	ATP-dependent DNA damage sensor activity	3	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	42	46	PF00656	0.769
CLV_C14_Caspase3-7	464	468	PF00656	0.695
CLV_NRD_NRD_1	107	109	PF00675	0.687
CLV_NRD_NRD_1	192	194	PF00675	0.478
CLV_NRD_NRD_1	343	345	PF00675	0.577
CLV_NRD_NRD_1	501	503	PF00675	0.385
CLV_NRD_NRD_1	566	568	PF00675	0.509
CLV_NRD_NRD_1	634	636	PF00675	0.449
CLV_NRD_NRD_1	652	654	PF00675	0.483
CLV_NRD_NRD_1	668	670	PF00675	0.640
CLV_NRD_NRD_1	72	74	PF00675	0.790
CLV_NRD_NRD_1	75	77	PF00675	0.804
CLV_PCSK_FUR_1	73	77	PF00082	0.640
CLV_PCSK_KEX2_1	192	194	PF00082	0.478
CLV_PCSK_KEX2_1	334	336	PF00082	0.734
CLV_PCSK_KEX2_1	501	503	PF00082	0.385
CLV_PCSK_KEX2_1	566	568	PF00082	0.509
CLV_PCSK_KEX2_1	634	636	PF00082	0.581
CLV_PCSK_KEX2_1	652	654	PF00082	0.582
CLV_PCSK_KEX2_1	668	670	PF00082	0.662
CLV_PCSK_KEX2_1	72	74	PF00082	0.796
CLV_PCSK_KEX2_1	75	77	PF00082	0.813
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.734
CLV_PCSK_SKI1_1	303	307	PF00082	0.477
CLV_PCSK_SKI1_1	504	508	PF00082	0.388
CLV_PCSK_SKI1_1	586	590	PF00082	0.338
CLV_PCSK_SKI1_1	643	647	PF00082	0.440
CLV_PCSK_SKI1_1	675	679	PF00082	0.587
CLV_PCSK_SKI1_1	83	87	PF00082	0.556
DOC_CYCLIN_RxL_1	109	123	PF00134	0.684
DOC_CYCLIN_RxL_1	501	511	PF00134	0.471
DOC_MAPK_gen_1	501	507	PF00069	0.386
DOC_MAPK_gen_1	566	572	PF00069	0.468
DOC_MAPK_MEF2A_6	253	262	PF00069	0.444
DOC_PP1_RVXF_1	502	508	PF00149	0.388
DOC_USP7_MATH_1	152	156	PF00917	0.571
DOC_USP7_MATH_1	297	301	PF00917	0.477
DOC_USP7_MATH_1	340	344	PF00917	0.809
DOC_USP7_MATH_1	346	350	PF00917	0.695
DOC_USP7_MATH_1	417	421	PF00917	0.713
DOC_USP7_MATH_1	446	450	PF00917	0.390
DOC_USP7_MATH_1	481	485	PF00917	0.737
DOC_USP7_MATH_1	544	548	PF00917	0.660
DOC_USP7_MATH_1	549	553	PF00917	0.745
DOC_USP7_MATH_1	597	601	PF00917	0.655
DOC_USP7_MATH_1	658	662	PF00917	0.546
DOC_USP7_MATH_1	93	97	PF00917	0.711
DOC_WW_Pin1_4	328	333	PF00397	0.623
DOC_WW_Pin1_4	335	340	PF00397	0.664
DOC_WW_Pin1_4	413	418	PF00397	0.620
DOC_WW_Pin1_4	486	491	PF00397	0.552
DOC_WW_Pin1_4	604	609	PF00397	0.614
DOC_WW_Pin1_4	61	66	PF00397	0.600
LIG_14-3-3_CanoR_1	326	332	PF00244	0.629
LIG_14-3-3_CanoR_1	379	387	PF00244	0.434
LIG_14-3-3_CanoR_1	53	63	PF00244	0.662
LIG_14-3-3_CanoR_1	566	571	PF00244	0.656
LIG_14-3-3_CanoR_1	586	592	PF00244	0.310
LIG_Actin_WH2_2	630	648	PF00022	0.527
LIG_BIR_II_1	1	5	PF00653	0.527
LIG_BIR_III_4	577	581	PF00653	0.402
LIG_BIR_III_4	77	81	PF00653	0.601
LIG_BRCT_BRCA1_1	449	453	PF00533	0.434
LIG_FHA_1	252	258	PF00498	0.473
LIG_FHA_1	294	300	PF00498	0.573
LIG_FHA_1	517	523	PF00498	0.435
LIG_FHA_1	529	535	PF00498	0.533
LIG_FHA_1	583	589	PF00498	0.342
LIG_FHA_1	613	619	PF00498	0.551
LIG_FHA_2	118	124	PF00498	0.537
LIG_FHA_2	200	206	PF00498	0.453
LIG_FHA_2	509	515	PF00498	0.440
LIG_Integrin_RGD_1	189	191	PF01839	0.503
LIG_LIR_Gen_1	114	124	PF02991	0.700
LIG_LIR_Nem_3	114	119	PF02991	0.707
LIG_LIR_Nem_3	590	594	PF02991	0.560
LIG_MAD2	643	651	PF02301	0.522
LIG_NRBOX	382	388	PF00104	0.426
LIG_PCNA_yPIPBox_3	634	645	PF02747	0.424
LIG_Rb_LxCxE_1	1	14	PF01857	0.603
LIG_SH2_CRK	594	598	PF00017	0.708
LIG_SH2_NCK_1	594	598	PF00017	0.597
LIG_SH2_PTP2	377	380	PF00017	0.405
LIG_SH2_STAT5	25	28	PF00017	0.558
LIG_SH2_STAT5	377	380	PF00017	0.371
LIG_SH3_2	68	73	PF14604	0.613
LIG_SH3_3	164	170	PF00018	0.700
LIG_SH3_3	307	313	PF00018	0.552
LIG_SH3_3	567	573	PF00018	0.505
LIG_SH3_3	602	608	PF00018	0.594
LIG_SH3_3	62	68	PF00018	0.620
LIG_SUMO_SIM_anti_2	27	36	PF11976	0.528
LIG_SUMO_SIM_par_1	27	36	PF11976	0.528
LIG_SUMO_SIM_par_1	436	442	PF11976	0.307
LIG_TRAF2_1	548	551	PF00917	0.527
LIG_TYR_ITIM	375	380	PF00017	0.490
LIG_WRC_WIRS_1	222	227	PF05994	0.484
LIG_WRC_WIRS_1	588	593	PF05994	0.444
LIG_WW_3	165	169	PF00397	0.635
MOD_CDC14_SPxK_1	331	334	PF00782	0.624
MOD_CDC14_SPxK_1	489	492	PF00782	0.532
MOD_CDK_SPK_2	328	333	PF00069	0.623
MOD_CDK_SPxK_1	328	334	PF00069	0.625
MOD_CDK_SPxK_1	413	419	PF00069	0.533
MOD_CDK_SPxK_1	486	492	PF00069	0.545
MOD_CDK_SPxxK_3	328	335	PF00069	0.627
MOD_CK1_1	176	182	PF00069	0.762
MOD_CK1_1	31	37	PF00069	0.417
MOD_CK1_1	328	334	PF00069	0.670
MOD_CK1_1	392	398	PF00069	0.461
MOD_CK1_1	407	413	PF00069	0.652
MOD_CK1_1	427	433	PF00069	0.556
MOD_CK1_1	461	467	PF00069	0.716
MOD_CK1_1	552	558	PF00069	0.706
MOD_CK1_1	609	615	PF00069	0.572
MOD_CK1_1	621	627	PF00069	0.656
MOD_CK1_1	9	15	PF00069	0.533
MOD_CK1_1	98	104	PF00069	0.687
MOD_CK2_1	117	123	PF00069	0.529
MOD_CK2_1	176	182	PF00069	0.580
MOD_CK2_1	199	205	PF00069	0.437
MOD_CK2_1	392	398	PF00069	0.434
MOD_CK2_1	508	514	PF00069	0.442
MOD_CK2_1	544	550	PF00069	0.669
MOD_DYRK1A_RPxSP_1	604	608	PF00069	0.572
MOD_GlcNHglycan	150	153	PF01048	0.776
MOD_GlcNHglycan	175	178	PF01048	0.754
MOD_GlcNHglycan	193	196	PF01048	0.467
MOD_GlcNHglycan	225	228	PF01048	0.194
MOD_GlcNHglycan	244	248	PF01048	0.325
MOD_GlcNHglycan	410	413	PF01048	0.747
MOD_GlcNHglycan	420	423	PF01048	0.676
MOD_GlcNHglycan	429	432	PF01048	0.635
MOD_GlcNHglycan	464	467	PF01048	0.679
MOD_GlcNHglycan	478	481	PF01048	0.527
MOD_GlcNHglycan	49	52	PF01048	0.568
MOD_GlcNHglycan	547	550	PF01048	0.734
MOD_GlcNHglycan	551	554	PF01048	0.775
MOD_GlcNHglycan	608	611	PF01048	0.485
MOD_GlcNHglycan	647	650	PF01048	0.506
MOD_GSK3_1	148	155	PF00069	0.580
MOD_GSK3_1	176	183	PF00069	0.768
MOD_GSK3_1	216	223	PF00069	0.401
MOD_GSK3_1	24	31	PF00069	0.596
MOD_GSK3_1	293	300	PF00069	0.578
MOD_GSK3_1	315	322	PF00069	0.650
MOD_GSK3_1	340	347	PF00069	0.586
MOD_GSK3_1	404	411	PF00069	0.627
MOD_GSK3_1	413	420	PF00069	0.690
MOD_GSK3_1	423	430	PF00069	0.599
MOD_GSK3_1	43	50	PF00069	0.451
MOD_GSK3_1	457	464	PF00069	0.620
MOD_GSK3_1	524	531	PF00069	0.382
MOD_GSK3_1	540	547	PF00069	0.685
MOD_GSK3_1	552	559	PF00069	0.770
MOD_GSK3_1	6	13	PF00069	0.576
MOD_GSK3_1	91	98	PF00069	0.712
MOD_GSK3_1	99	106	PF00069	0.731
MOD_N-GLC_1	117	122	PF02516	0.660
MOD_N-GLC_1	145	150	PF02516	0.621
MOD_N-GLC_1	540	545	PF02516	0.695
MOD_NEK2_1	10	15	PF00069	0.590
MOD_NEK2_1	260	265	PF00069	0.539
MOD_NEK2_1	32	37	PF00069	0.638
MOD_NEK2_1	389	394	PF00069	0.495
MOD_NEK2_1	439	444	PF00069	0.404
MOD_NEK2_1	458	463	PF00069	0.502
MOD_NEK2_1	473	478	PF00069	0.451
MOD_NEK2_1	507	512	PF00069	0.456
MOD_NEK2_1	516	521	PF00069	0.401
MOD_NEK2_1	535	540	PF00069	0.662
MOD_NEK2_1	587	592	PF00069	0.457
MOD_NEK2_1	645	650	PF00069	0.468
MOD_NEK2_1	657	662	PF00069	0.368
MOD_NEK2_2	154	159	PF00069	0.605
MOD_NEK2_2	199	204	PF00069	0.501
MOD_NEK2_2	481	486	PF00069	0.491
MOD_PIKK_1	251	257	PF00454	0.442
MOD_PIKK_1	305	311	PF00454	0.549
MOD_PIKK_1	325	331	PF00454	0.550
MOD_PIKK_1	621	627	PF00454	0.526
MOD_PIKK_1	670	676	PF00454	0.566
MOD_PK_1	566	572	PF00069	0.468
MOD_PKA_1	108	114	PF00069	0.495
MOD_PKA_1	344	350	PF00069	0.637
MOD_PKA_1	566	572	PF00069	0.468
MOD_PKA_1	652	658	PF00069	0.406
MOD_PKA_2	132	138	PF00069	0.606
MOD_PKA_2	191	197	PF00069	0.467
MOD_PKA_2	325	331	PF00069	0.774
MOD_PKA_2	378	384	PF00069	0.442
MOD_PKA_2	418	424	PF00069	0.561
MOD_PKA_2	447	453	PF00069	0.511
MOD_PKA_2	500	506	PF00069	0.392
MOD_PKA_2	566	572	PF00069	0.490
MOD_PKA_2	603	609	PF00069	0.573
MOD_PKA_2	652	658	PF00069	0.456
MOD_Plk_1	111	117	PF00069	0.594
MOD_Plk_1	315	321	PF00069	0.654
MOD_Plk_1	364	370	PF00069	0.543
MOD_Plk_1	424	430	PF00069	0.502
MOD_Plk_4	28	34	PF00069	0.390
MOD_Plk_4	282	288	PF00069	0.442
MOD_Plk_4	297	303	PF00069	0.501
MOD_Plk_4	367	373	PF00069	0.476
MOD_Plk_4	392	398	PF00069	0.463
MOD_Plk_4	481	487	PF00069	0.535
MOD_Plk_4	508	514	PF00069	0.520
MOD_Plk_4	566	572	PF00069	0.609
MOD_ProDKin_1	328	334	PF00069	0.625
MOD_ProDKin_1	335	341	PF00069	0.664
MOD_ProDKin_1	413	419	PF00069	0.621
MOD_ProDKin_1	486	492	PF00069	0.545
MOD_ProDKin_1	604	610	PF00069	0.610
MOD_ProDKin_1	61	67	PF00069	0.603
MOD_SUMO_rev_2	398	408	PF00179	0.524
MOD_SUMO_rev_2	42	49	PF00179	0.564
TRG_DiLeu_BaEn_1	28	33	PF01217	0.469
TRG_DiLeu_BaEn_2	111	117	PF01217	0.569
TRG_DiLeu_BaLyEn_6	489	494	PF01217	0.574
TRG_DiLeu_BaLyEn_6	501	506	PF01217	0.361
TRG_DiLeu_BaLyEn_6	583	588	PF01217	0.371
TRG_ENDOCYTIC_2	377	380	PF00928	0.394
TRG_ER_diArg_1	500	502	PF00400	0.390
TRG_ER_diArg_1	633	635	PF00400	0.684
TRG_ER_diArg_1	651	653	PF00400	0.547
TRG_ER_diArg_1	680	683	PF00400	0.572
TRG_ER_diArg_1	71	73	PF00400	0.781
TRG_ER_diArg_1	74	76	PF00400	0.803
TRG_NLS_MonoExtC_3	332	337	PF00514	0.728
TRG_NLS_MonoExtN_4	332	338	PF00514	0.730
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.713
TRG_Pf-PMV_PEXEL_1	504	508	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	72	77	PF00026	0.661

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE01	Leptomonas seymouri	42%	100%
A0A1X0P3T9	Trypanosomatidae	33%	100%
A0A3Q8IGS3	Leishmania donovani	89%	100%
A4HLW0	Leishmania braziliensis	67%	100%
D0A661	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AHR7	Leishmania infantum	89%	100%
E9B488	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
V5BTS0	Trypanosoma cruzi	36%	100%