Mitochondrial RNA binding complex 1 subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial SSU ribosomal protein, putative

Species:

Leishmania major

UniProt:

Q4Q3T6_LEIMA

TriTrypDb:

LmjF.33.2510 , LMJLV39_330035900 , LMJSD75_330035200

Length:

677

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3T6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3T6

PDB structure(s): 7ane_l

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009892	negative regulation of metabolic process	4	2
GO:0009893	positive regulation of metabolic process	4	2
GO:0009894	regulation of catabolic process	4	2
GO:0009895	negative regulation of catabolic process	5	2
GO:0009987	cellular process	1	2
GO:0010468	regulation of gene expression	5	2
GO:0010604	positive regulation of macromolecule metabolic process	5	2
GO:0010605	negative regulation of macromolecule metabolic process	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0010628	positive regulation of gene expression	6	2
GO:0016070	RNA metabolic process	5	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031324	negative regulation of cellular metabolic process	5	2
GO:0031329	regulation of cellular catabolic process	5	2
GO:0031330	negative regulation of cellular catabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043487	regulation of RNA stability	3	2
GO:0043488	regulation of mRNA stability	4	2
GO:0043489	RNA stabilization	4	2
GO:0043631	RNA polyadenylation	6	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	2
GO:0046483	heterocycle metabolic process	3	2
GO:0048255	mRNA stabilization	5	2
GO:0048518	positive regulation of biological process	3	2
GO:0048519	negative regulation of biological process	3	2
GO:0048523	negative regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051172	negative regulation of nitrogen compound metabolic process	5	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0051253	negative regulation of RNA metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0061013	regulation of mRNA catabolic process	6	2
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2
GO:0071704	organic substance metabolic process	2	2
GO:0080090	regulation of primary metabolic process	4	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1902369	negative regulation of RNA catabolic process	7	2
GO:1902373	negative regulation of mRNA catabolic process	7	2
GO:1903311	regulation of mRNA metabolic process	6	2
GO:1903312	negative regulation of mRNA metabolic process	7	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.675
CLV_C14_Caspase3-7	376	380	PF00656	0.750
CLV_C14_Caspase3-7	483	487	PF00656	0.556
CLV_NRD_NRD_1	228	230	PF00675	0.484
CLV_NRD_NRD_1	33	35	PF00675	0.545
CLV_NRD_NRD_1	388	390	PF00675	0.785
CLV_NRD_NRD_1	435	437	PF00675	0.494
CLV_NRD_NRD_1	601	603	PF00675	0.410
CLV_NRD_NRD_1	641	643	PF00675	0.463
CLV_NRD_NRD_1	78	80	PF00675	0.453
CLV_NRD_NRD_1	85	87	PF00675	0.439
CLV_PCSK_KEX2_1	228	230	PF00082	0.484
CLV_PCSK_KEX2_1	388	390	PF00082	0.785
CLV_PCSK_KEX2_1	411	413	PF00082	0.462
CLV_PCSK_KEX2_1	435	437	PF00082	0.494
CLV_PCSK_KEX2_1	601	603	PF00082	0.410
CLV_PCSK_KEX2_1	641	643	PF00082	0.443
CLV_PCSK_KEX2_1	78	80	PF00082	0.452
CLV_PCSK_KEX2_1	85	87	PF00082	0.440
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.481
CLV_PCSK_PC7_1	637	643	PF00082	0.545
CLV_PCSK_PC7_1	74	80	PF00082	0.621
CLV_PCSK_SKI1_1	146	150	PF00082	0.364
CLV_PCSK_SKI1_1	151	155	PF00082	0.362
CLV_PCSK_SKI1_1	166	170	PF00082	0.439
CLV_PCSK_SKI1_1	485	489	PF00082	0.509
CLV_PCSK_SKI1_1	590	594	PF00082	0.511
CLV_PCSK_SKI1_1	617	621	PF00082	0.474
CLV_Separin_Metazoa	265	269	PF03568	0.602
DEG_Nend_Nbox_1	1	3	PF02207	0.558
DEG_ODPH_VHL_1	416	427	PF01847	0.567
DOC_CYCLIN_RxL_1	329	338	PF00134	0.411
DOC_MAPK_gen_1	119	128	PF00069	0.407
DOC_MAPK_gen_1	544	551	PF00069	0.406
DOC_MAPK_gen_1	601	610	PF00069	0.439
DOC_MAPK_gen_1	641	649	PF00069	0.423
DOC_MAPK_HePTP_8	105	117	PF00069	0.430
DOC_MAPK_MEF2A_6	108	117	PF00069	0.411
DOC_MAPK_MEF2A_6	544	551	PF00069	0.406
DOC_PP1_RVXF_1	330	337	PF00149	0.373
DOC_PP1_RVXF_1	506	512	PF00149	0.546
DOC_PP2B_LxvP_1	212	215	PF13499	0.565
DOC_PP2B_LxvP_1	415	418	PF13499	0.583
DOC_PP2B_PxIxI_1	112	118	PF00149	0.406
DOC_PP4_FxxP_1	255	258	PF00568	0.469
DOC_SPAK_OSR1_1	122	126	PF12202	0.300
DOC_USP7_MATH_1	179	183	PF00917	0.644
DOC_USP7_MATH_1	196	200	PF00917	0.558
DOC_USP7_MATH_1	23	27	PF00917	0.536
DOC_USP7_MATH_1	248	252	PF00917	0.547
DOC_USP7_MATH_1	361	365	PF00917	0.588
DOC_USP7_MATH_1	371	375	PF00917	0.612
DOC_USP7_MATH_1	547	551	PF00917	0.500
DOC_USP7_MATH_1	569	573	PF00917	0.616
DOC_USP7_MATH_1	629	633	PF00917	0.608
DOC_USP7_MATH_1	673	677	PF00917	0.607
DOC_USP7_MATH_1	73	77	PF00917	0.574
DOC_USP7_MATH_2	179	185	PF00917	0.612
DOC_WW_Pin1_4	10	15	PF00397	0.430
DOC_WW_Pin1_4	362	367	PF00397	0.629
LIG_14-3-3_CanoR_1	151	161	PF00244	0.388
LIG_14-3-3_CanoR_1	310	316	PF00244	0.586
LIG_14-3-3_CanoR_1	360	366	PF00244	0.595
LIG_14-3-3_CanoR_1	490	494	PF00244	0.586
LIG_14-3-3_CanoR_1	617	625	PF00244	0.432
LIG_14-3-3_CanoR_1	72	78	PF00244	0.517
LIG_Actin_RPEL_3	115	134	PF02755	0.404
LIG_Actin_WH2_2	13	31	PF00022	0.570
LIG_APCC_ABBA_1	126	131	PF00400	0.427
LIG_APCC_ABBA_1	333	338	PF00400	0.356
LIG_APCC_ABBAyCdc20_2	332	338	PF00400	0.376
LIG_deltaCOP1_diTrp_1	135	144	PF00928	0.534
LIG_deltaCOP1_diTrp_1	471	475	PF00928	0.437
LIG_EH_1	345	349	PF12763	0.432
LIG_FHA_1	209	215	PF00498	0.594
LIG_FHA_2	496	502	PF00498	0.490
LIG_FHA_2	589	595	PF00498	0.368
LIG_GBD_Chelix_1	580	588	PF00786	0.491
LIG_LIR_Apic_2	252	258	PF02991	0.474
LIG_LIR_Apic_2	379	384	PF02991	0.728
LIG_LIR_Apic_2	471	477	PF02991	0.416
LIG_LIR_Gen_1	217	227	PF02991	0.488
LIG_LIR_Gen_1	345	356	PF02991	0.449
LIG_LIR_Gen_1	446	457	PF02991	0.509
LIG_LIR_Gen_1	470	480	PF02991	0.429
LIG_LIR_LC3C_4	578	582	PF02991	0.515
LIG_LIR_Nem_3	164	168	PF02991	0.425
LIG_LIR_Nem_3	18	24	PF02991	0.413
LIG_LIR_Nem_3	217	223	PF02991	0.378
LIG_LIR_Nem_3	313	318	PF02991	0.467
LIG_LIR_Nem_3	345	351	PF02991	0.425
LIG_LIR_Nem_3	38	44	PF02991	0.313
LIG_LIR_Nem_3	470	475	PF02991	0.455
LIG_LYPXL_yS_3	315	318	PF13949	0.428
LIG_MAD2	652	660	PF02301	0.529
LIG_PCNA_PIPBox_1	99	108	PF02747	0.560
LIG_PCNA_yPIPBox_3	323	334	PF02747	0.470
LIG_PCNA_yPIPBox_3	92	106	PF02747	0.573
LIG_SH2_CRK	150	154	PF00017	0.359
LIG_SH2_CRK	165	169	PF00017	0.517
LIG_SH2_CRK	381	385	PF00017	0.728
LIG_SH2_GRB2like	474	477	PF00017	0.397
LIG_SH2_NCK_1	499	503	PF00017	0.421
LIG_SH2_NCK_1	561	565	PF00017	0.661
LIG_SH2_SRC	499	502	PF00017	0.479
LIG_SH2_STAP1	668	672	PF00017	0.406
LIG_SH2_STAT5	16	19	PF00017	0.409
LIG_SH2_STAT5	167	170	PF00017	0.391
LIG_SH2_STAT5	222	225	PF00017	0.342
LIG_SH2_STAT5	231	234	PF00017	0.366
LIG_SH2_STAT5	30	33	PF00017	0.476
LIG_SH2_STAT5	357	360	PF00017	0.591
LIG_SH2_STAT5	474	477	PF00017	0.400
LIG_SH2_STAT5	532	535	PF00017	0.449
LIG_SH2_STAT5	646	649	PF00017	0.482
LIG_SH3_3	107	113	PF00018	0.405
LIG_SH3_3	306	312	PF00018	0.596
LIG_SH3_3	346	352	PF00018	0.426
LIG_SH3_3	531	537	PF00018	0.451
LIG_SH3_3	552	558	PF00018	0.450
LIG_SH3_3	59	65	PF00018	0.555
LIG_SH3_3	625	631	PF00018	0.554
LIG_SUMO_SIM_par_1	101	107	PF11976	0.427
LIG_TYR_ITIM	148	153	PF00017	0.358
MOD_CK1_1	182	188	PF00069	0.721
MOD_CK1_1	189	195	PF00069	0.725
MOD_CK1_1	199	205	PF00069	0.637
MOD_CK1_1	208	214	PF00069	0.624
MOD_CK1_1	362	368	PF00069	0.575
MOD_CK1_1	403	409	PF00069	0.522
MOD_CK1_1	467	473	PF00069	0.470
MOD_CK1_1	489	495	PF00069	0.559
MOD_CK1_1	550	556	PF00069	0.442
MOD_CK2_1	195	201	PF00069	0.791
MOD_CK2_1	495	501	PF00069	0.473
MOD_CK2_1	588	594	PF00069	0.383
MOD_GlcNHglycan	181	184	PF01048	0.748
MOD_GlcNHglycan	192	195	PF01048	0.753
MOD_GlcNHglycan	201	204	PF01048	0.779
MOD_GlcNHglycan	283	287	PF01048	0.694
MOD_GlcNHglycan	300	303	PF01048	0.724
MOD_GlcNHglycan	361	364	PF01048	0.513
MOD_GlcNHglycan	455	458	PF01048	0.638
MOD_GlcNHglycan	466	469	PF01048	0.522
MOD_GlcNHglycan	517	520	PF01048	0.563
MOD_GlcNHglycan	571	574	PF01048	0.435
MOD_GlcNHglycan	655	659	PF01048	0.495
MOD_GSK3_1	157	164	PF00069	0.429
MOD_GSK3_1	182	189	PF00069	0.732
MOD_GSK3_1	195	202	PF00069	0.673
MOD_GSK3_1	272	279	PF00069	0.640
MOD_GSK3_1	298	305	PF00069	0.755
MOD_GSK3_1	528	535	PF00069	0.532
MOD_GSK3_1	654	661	PF00069	0.479
MOD_N-GLC_1	199	204	PF02516	0.607
MOD_N-GLC_1	248	253	PF02516	0.514
MOD_N-GLC_1	47	52	PF02516	0.505
MOD_NEK2_1	253	258	PF00069	0.461
MOD_NEK2_1	426	431	PF00069	0.579
MOD_NEK2_1	44	49	PF00069	0.708
MOD_NEK2_1	453	458	PF00069	0.526
MOD_NEK2_1	588	593	PF00069	0.361
MOD_NEK2_1	654	659	PF00069	0.455
MOD_NEK2_2	67	72	PF00069	0.570
MOD_NEK2_2	73	78	PF00069	0.544
MOD_PIKK_1	276	282	PF00454	0.770
MOD_PKA_2	179	185	PF00069	0.697
MOD_PKA_2	196	202	PF00069	0.586
MOD_PKA_2	298	304	PF00069	0.715
MOD_PKA_2	359	365	PF00069	0.603
MOD_PKA_2	453	459	PF00069	0.525
MOD_PKA_2	489	495	PF00069	0.490
MOD_PKA_2	73	79	PF00069	0.572
MOD_PKB_1	308	316	PF00069	0.617
MOD_Plk_1	208	214	PF00069	0.482
MOD_Plk_1	470	476	PF00069	0.433
MOD_Plk_4	208	214	PF00069	0.594
MOD_Plk_4	403	409	PF00069	0.530
MOD_Plk_4	528	534	PF00069	0.518
MOD_Plk_4	547	553	PF00069	0.274
MOD_Plk_4	610	616	PF00069	0.410
MOD_ProDKin_1	10	16	PF00069	0.426
MOD_ProDKin_1	362	368	PF00069	0.643
MOD_SUMO_for_1	260	263	PF00179	0.536
MOD_SUMO_rev_2	32	37	PF00179	0.494
TRG_DiLeu_BaEn_1	326	331	PF01217	0.458
TRG_DiLeu_BaEn_1	338	343	PF01217	0.495
TRG_DiLeu_BaEn_4	460	466	PF01217	0.640
TRG_DiLeu_BaEn_4	483	489	PF01217	0.462
TRG_ENDOCYTIC_2	150	153	PF00928	0.346
TRG_ENDOCYTIC_2	165	168	PF00928	0.521
TRG_ENDOCYTIC_2	220	223	PF00928	0.357
TRG_ENDOCYTIC_2	315	318	PF00928	0.428
TRG_ENDOCYTIC_2	646	649	PF00928	0.432
TRG_ER_diArg_1	227	229	PF00400	0.483
TRG_ER_diArg_1	308	311	PF00400	0.631
TRG_ER_diArg_1	434	436	PF00400	0.487
TRG_ER_diArg_1	600	602	PF00400	0.407
TRG_ER_diArg_1	641	643	PF00400	0.464
TRG_ER_diArg_1	71	74	PF00400	0.516
TRG_ER_diArg_1	77	79	PF00400	0.434
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	435	439	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	652	656	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Z6	Leptomonas seymouri	71%	92%
A0A0S4IW89	Bodo saltans	35%	100%
A0A1X0P3U7	Trypanosomatidae	50%	93%
A0A3S7X701	Leishmania donovani	95%	100%
A0A422P030	Trypanosoma rangeli	52%	96%
A4HLW2	Leishmania braziliensis	87%	100%
D0A659	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	91%
E9AHR9	Leishmania infantum	95%	100%
E9B490	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BP67	Trypanosoma cruzi	51%	98%