Putative UDP-N-acetylglucosamine pyrophosphorylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UDP-N-acetylglucosamine pyrophosphorylase, putative

Species:

Leishmania major

UniProt:

Q4Q3T5_LEIMA

TriTrypDb:

LmjF.33.2520 , LMJLV39_330036000 , LMJSD75_330035300

Length:

571

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q3T5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3T5

Function

Biological processes
Term	Name	Level	Count
GO:0006040	amino sugar metabolic process	4	2
GO:0006047	UDP-N-acetylglucosamine metabolic process	4	2
GO:0006048	UDP-N-acetylglucosamine biosynthetic process	5	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009225	nucleotide-sugar metabolic process	4	2
GO:0009226	nucleotide-sugar biosynthetic process	5	2
GO:0009987	cellular process	1	2
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019438	aromatic compound biosynthetic process	4	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034654	nucleobase-containing compound biosynthetic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0044281	small molecule metabolic process	2	2
GO:0046349	amino sugar biosynthetic process	5	2
GO:0046483	heterocycle metabolic process	3	2
GO:0055086	nucleobase-containing small molecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901137	carbohydrate derivative biosynthetic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003977	UDP-N-acetylglucosamine diphosphorylase activity	6	8
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016779	nucleotidyltransferase activity	4	12
GO:0070569	uridylyltransferase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	301	307	PF00089	0.354
CLV_NRD_NRD_1	160	162	PF00675	0.355
CLV_NRD_NRD_1	356	358	PF00675	0.359
CLV_NRD_NRD_1	401	403	PF00675	0.290
CLV_PCSK_KEX2_1	356	358	PF00082	0.322
CLV_PCSK_KEX2_1	98	100	PF00082	0.516
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.516
CLV_PCSK_SKI1_1	150	154	PF00082	0.363
CLV_PCSK_SKI1_1	212	216	PF00082	0.258
CLV_PCSK_SKI1_1	4	8	PF00082	0.506
CLV_PCSK_SKI1_1	426	430	PF00082	0.290
CLV_PCSK_SKI1_1	485	489	PF00082	0.248
CLV_PCSK_SKI1_1	551	555	PF00082	0.506
DEG_APCC_DBOX_1	53	61	PF00400	0.493
DEG_SPOP_SBC_1	500	504	PF00917	0.492
DOC_CDC14_PxL_1	89	97	PF14671	0.512
DOC_MAPK_gen_1	288	298	PF00069	0.535
DOC_MAPK_MEF2A_6	194	201	PF00069	0.389
DOC_MAPK_NFAT4_5	194	202	PF00069	0.449
DOC_USP7_MATH_1	125	129	PF00917	0.405
DOC_USP7_MATH_1	170	174	PF00917	0.471
DOC_USP7_MATH_1	250	254	PF00917	0.527
DOC_USP7_MATH_1	269	273	PF00917	0.474
DOC_USP7_MATH_1	327	331	PF00917	0.477
DOC_USP7_MATH_1	499	503	PF00917	0.651
DOC_USP7_MATH_1	532	536	PF00917	0.360
DOC_USP7_MATH_1	553	557	PF00917	0.518
DOC_USP7_UBL2_3	324	328	PF12436	0.449
DOC_WW_Pin1_4	24	29	PF00397	0.573
DOC_WW_Pin1_4	468	473	PF00397	0.508
DOC_WW_Pin1_4	528	533	PF00397	0.372
DOC_WW_Pin1_4	79	84	PF00397	0.539
LIG_14-3-3_CanoR_1	232	237	PF00244	0.527
LIG_14-3-3_CanoR_1	356	363	PF00244	0.529
LIG_14-3-3_CanoR_1	514	521	PF00244	0.493
LIG_BIR_II_1	1	5	PF00653	0.402
LIG_BRCT_BRCA1_1	380	384	PF00533	0.467
LIG_BRCT_BRCA1_1	454	458	PF00533	0.469
LIG_FHA_1	194	200	PF00498	0.449
LIG_FHA_1	241	247	PF00498	0.467
LIG_FHA_1	34	40	PF00498	0.463
LIG_FHA_1	363	369	PF00498	0.474
LIG_FHA_1	482	488	PF00498	0.474
LIG_FHA_1	495	501	PF00498	0.450
LIG_FHA_2	200	206	PF00498	0.499
LIG_FHA_2	388	394	PF00498	0.544
LIG_FHA_2	508	514	PF00498	0.533
LIG_LIR_Gen_1	21	28	PF02991	0.510
LIG_LIR_Gen_1	342	353	PF02991	0.475
LIG_LIR_Gen_1	381	392	PF02991	0.474
LIG_LIR_Gen_1	506	517	PF02991	0.339
LIG_LIR_Nem_3	21	26	PF02991	0.512
LIG_LIR_Nem_3	217	223	PF02991	0.459
LIG_LIR_Nem_3	307	313	PF02991	0.463
LIG_LIR_Nem_3	342	348	PF02991	0.455
LIG_LIR_Nem_3	349	353	PF02991	0.442
LIG_LIR_Nem_3	381	387	PF02991	0.464
LIG_LIR_Nem_3	455	461	PF02991	0.446
LIG_LIR_Nem_3	506	512	PF02991	0.512
LIG_PTB_Apo_2	223	230	PF02174	0.388
LIG_REV1ctd_RIR_1	227	236	PF16727	0.547
LIG_SH2_CRK	23	27	PF00017	0.560
LIG_SH2_GRB2like	41	44	PF00017	0.534
LIG_SH2_NCK_1	239	243	PF00017	0.554
LIG_SH2_NCK_1	350	354	PF00017	0.449
LIG_SH2_NCK_1	41	45	PF00017	0.524
LIG_SH2_NCK_1	498	502	PF00017	0.453
LIG_SH2_PTP2	292	295	PF00017	0.453
LIG_SH2_SRC	239	242	PF00017	0.535
LIG_SH2_STAP1	265	269	PF00017	0.510
LIG_SH2_STAP1	427	431	PF00017	0.554
LIG_SH2_STAT3	155	158	PF00017	0.480
LIG_SH2_STAT3	544	547	PF00017	0.447
LIG_SH2_STAT5	292	295	PF00017	0.453
LIG_SH2_STAT5	309	312	PF00017	0.346
LIG_SH2_STAT5	350	353	PF00017	0.449
LIG_SH2_STAT5	41	44	PF00017	0.534
LIG_SH2_STAT5	509	512	PF00017	0.552
LIG_SH2_STAT5	544	547	PF00017	0.454
LIG_SH3_3	184	190	PF00018	0.464
LIG_SH3_3	302	308	PF00018	0.490
LIG_SUMO_SIM_par_1	196	205	PF11976	0.495
LIG_SUMO_SIM_par_1	294	299	PF11976	0.535
LIG_SUMO_SIM_par_1	478	484	PF11976	0.510
LIG_TRAF2_1	14	17	PF00917	0.464
LIG_TRFH_1	221	225	PF08558	0.527
LIG_TYR_ITIM	290	295	PF00017	0.453
LIG_TYR_ITIM	348	353	PF00017	0.449
MOD_CK1_1	148	154	PF00069	0.466
MOD_CK1_1	175	181	PF00069	0.573
MOD_CK1_1	231	237	PF00069	0.523
MOD_CK1_1	272	278	PF00069	0.558
MOD_CK1_1	29	35	PF00069	0.420
MOD_CK1_1	358	364	PF00069	0.443
MOD_CK1_1	374	380	PF00069	0.343
MOD_CK1_1	502	508	PF00069	0.661
MOD_CK2_1	11	17	PF00069	0.464
MOD_CK2_1	24	30	PF00069	0.435
MOD_CK2_1	327	333	PF00069	0.468
MOD_CK2_1	387	393	PF00069	0.471
MOD_CK2_1	430	436	PF00069	0.554
MOD_CK2_1	507	513	PF00069	0.531
MOD_GlcNHglycan	115	118	PF01048	0.407
MOD_GlcNHglycan	127	130	PF01048	0.417
MOD_GlcNHglycan	13	16	PF01048	0.457
MOD_GlcNHglycan	147	150	PF01048	0.198
MOD_GlcNHglycan	177	180	PF01048	0.636
MOD_GlcNHglycan	271	274	PF01048	0.317
MOD_GlcNHglycan	275	278	PF01048	0.319
MOD_GlcNHglycan	329	332	PF01048	0.302
MOD_GlcNHglycan	357	360	PF01048	0.306
MOD_GlcNHglycan	505	508	PF01048	0.600
MOD_GlcNHglycan	551	554	PF01048	0.500
MOD_GlcNHglycan	555	558	PF01048	0.536
MOD_GSK3_1	228	235	PF00069	0.499
MOD_GSK3_1	26	33	PF00069	0.506
MOD_GSK3_1	269	276	PF00069	0.523
MOD_GSK3_1	358	365	PF00069	0.517
MOD_GSK3_1	374	381	PF00069	0.444
MOD_GSK3_1	387	394	PF00069	0.483
MOD_GSK3_1	481	488	PF00069	0.425
MOD_GSK3_1	499	506	PF00069	0.620
MOD_GSK3_1	528	535	PF00069	0.370
MOD_GSK3_1	549	556	PF00069	0.516
MOD_LATS_1	483	489	PF00433	0.441
MOD_N-GLC_1	206	211	PF02516	0.271
MOD_N-GLC_1	60	65	PF02516	0.462
MOD_N-GLC_1	79	84	PF02516	0.350
MOD_NEK2_1	11	16	PF00069	0.482
MOD_NEK2_1	132	137	PF00069	0.500
MOD_NEK2_1	199	204	PF00069	0.464
MOD_NEK2_1	387	392	PF00069	0.534
MOD_NEK2_1	39	44	PF00069	0.549
MOD_NEK2_1	53	58	PF00069	0.320
MOD_NEK2_1	60	65	PF00069	0.467
MOD_PIKK_1	172	178	PF00454	0.613
MOD_PIKK_1	275	281	PF00454	0.471
MOD_PIKK_1	33	39	PF00454	0.482
MOD_PKA_1	98	104	PF00069	0.424
MOD_PKA_2	193	199	PF00069	0.416
MOD_PKA_2	231	237	PF00069	0.503
MOD_PKA_2	250	256	PF00069	0.563
MOD_PKA_2	355	361	PF00069	0.520
MOD_PKA_2	401	407	PF00069	0.549
MOD_PKA_2	513	519	PF00069	0.499
MOD_PKA_2	53	59	PF00069	0.424
MOD_PKA_2	98	104	PF00069	0.476
MOD_Plk_1	29	35	PF00069	0.419
MOD_Plk_1	392	398	PF00069	0.547
MOD_Plk_1	452	458	PF00069	0.554
MOD_Plk_4	277	283	PF00069	0.474
MOD_Plk_4	387	393	PF00069	0.515
MOD_Plk_4	85	91	PF00069	0.478
MOD_ProDKin_1	24	30	PF00069	0.569
MOD_ProDKin_1	468	474	PF00069	0.508
MOD_ProDKin_1	528	534	PF00069	0.372
MOD_ProDKin_1	79	85	PF00069	0.538
MOD_SUMO_for_1	415	418	PF00179	0.444
TRG_DiLeu_BaEn_1	118	123	PF01217	0.462
TRG_DiLeu_BaEn_1	142	147	PF01217	0.498
TRG_DiLeu_BaLyEn_6	195	200	PF01217	0.410
TRG_DiLeu_BaLyEn_6	55	60	PF01217	0.282
TRG_ENDOCYTIC_2	23	26	PF00928	0.535
TRG_ENDOCYTIC_2	265	268	PF00928	0.449
TRG_ENDOCYTIC_2	292	295	PF00928	0.453
TRG_ENDOCYTIC_2	350	353	PF00928	0.456
TRG_ENDOCYTIC_2	509	512	PF00928	0.489
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.248

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG62	Leptomonas seymouri	64%	100%
A0A0S4IVW9	Bodo saltans	39%	100%
A0A1X0P444	Trypanosomatidae	44%	100%
A0A3S7X721	Leishmania donovani	93%	100%
A0A422P028	Trypanosoma rangeli	39%	100%
D0A658	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AHS0	Leishmania infantum	93%	100%
E9AIV6	Leishmania braziliensis	79%	100%
E9B491	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
O64765	Arabidopsis thaliana	34%	100%
O74933	Candida albicans	29%	100%
O94617	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
P43123	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
Q16222	Homo sapiens	30%	100%
Q18493	Caenorhabditis elegans	28%	100%
Q28CH3	Xenopus tropicalis	31%	100%
Q2FEW1	Staphylococcus aureus (strain USA300)	29%	100%
Q2FW81	Staphylococcus aureus (strain NCTC 8325 / PS 47)	29%	100%
Q2YYH4	Staphylococcus aureus (strain bovine RF122 / ET3-1)	29%	100%
Q3KQV9	Homo sapiens	32%	100%
Q3TW96	Mus musculus	33%	100%
Q49ZB5	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	26%	100%
Q4L846	Staphylococcus haemolyticus (strain JCSC1435)	28%	100%
Q54GN5	Dictyostelium discoideum	28%	100%
Q5HE34	Staphylococcus aureus (strain COL)	29%	100%
Q5HM59	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	30%	100%
Q6G7E3	Staphylococcus aureus (strain MSSA476)	29%	100%
Q6GEQ8	Staphylococcus aureus (strain MRSA252)	29%	100%
Q7A0A0	Staphylococcus aureus (strain MW2)	29%	100%
Q7A4A4	Staphylococcus aureus (strain N315)	29%	100%
Q7ZWD4	Danio rerio	32%	100%
Q8CNG6	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	29%	100%
Q91YN5	Mus musculus	31%	100%
Q940S3	Arabidopsis thaliana	33%	100%
Q99S95	Staphylococcus aureus (strain Mu50 / ATCC 700699)	29%	100%
V5BYI4	Trypanosoma cruzi	41%	95%