Putative aminopeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-peptidase, Clan MF, Family M17

Species:

Leishmania major

UniProt:

Q4Q3T0_LEIMA

TriTrypDb:

LmjF.33.2570 , LMJLV39_330036600 , LMJSD75_330035900

Length:

528

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	yes	yes: 4
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

Q4Q3T0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3T0

PDB structure(s): 5nth_A

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	16
GO:0006807	nitrogen compound metabolic process	2	16
GO:0008152	metabolic process	1	16
GO:0019538	protein metabolic process	3	16
GO:0043170	macromolecule metabolic process	3	16
GO:0044238	primary metabolic process	2	16
GO:0071704	organic substance metabolic process	2	16
GO:1901564	organonitrogen compound metabolic process	3	16

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0004177	aminopeptidase activity	5	16
GO:0005488	binding	1	16
GO:0008233	peptidase activity	3	16
GO:0008235	metalloexopeptidase activity	5	16
GO:0008237	metallopeptidase activity	4	16
GO:0008238	exopeptidase activity	4	16
GO:0016787	hydrolase activity	2	16
GO:0030145	manganese ion binding	6	16
GO:0043167	ion binding	2	16
GO:0043169	cation binding	3	16
GO:0046872	metal ion binding	4	16
GO:0046914	transition metal ion binding	5	16
GO:0070006	metalloaminopeptidase activity	6	16
GO:0140096	catalytic activity, acting on a protein	2	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	165	167	PF00675	0.511
CLV_PCSK_KEX2_1	165	167	PF00082	0.449
CLV_PCSK_KEX2_1	171	173	PF00082	0.436
CLV_PCSK_KEX2_1	5	7	PF00082	0.549
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.464
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.560
CLV_PCSK_SKI1_1	166	170	PF00082	0.482
CLV_PCSK_SKI1_1	289	293	PF00082	0.394
CLV_PCSK_SKI1_1	381	385	PF00082	0.385
CLV_PCSK_SKI1_1	41	45	PF00082	0.627
DOC_CYCLIN_yCln2_LP_2	444	450	PF00134	0.428
DOC_MAPK_gen_1	234	242	PF00069	0.488
DOC_MAPK_gen_1	364	373	PF00069	0.425
DOC_MAPK_MEF2A_6	364	373	PF00069	0.478
DOC_MAPK_MEF2A_6	95	104	PF00069	0.527
DOC_PP2B_LxvP_1	502	505	PF13499	0.500
DOC_PP2B_PxIxI_1	398	404	PF00149	0.478
DOC_USP7_MATH_1	16	20	PF00917	0.574
DOC_USP7_MATH_1	175	179	PF00917	0.534
DOC_USP7_MATH_1	42	46	PF00917	0.670
DOC_USP7_MATH_1	476	480	PF00917	0.387
DOC_USP7_MATH_2	338	344	PF00917	0.517
DOC_WW_Pin1_4	395	400	PF00397	0.415
LIG_14-3-3_CanoR_1	165	169	PF00244	0.528
LIG_14-3-3_CanoR_1	381	389	PF00244	0.501
LIG_14-3-3_CanoR_1	41	50	PF00244	0.699
LIG_14-3-3_CanoR_1	467	471	PF00244	0.413
LIG_14-3-3_CanoR_1	6	13	PF00244	0.576
LIG_Actin_WH2_2	220	238	PF00022	0.526
LIG_APCC_ABBA_1	71	76	PF00400	0.420
LIG_BIR_III_4	377	381	PF00653	0.385
LIG_BRCT_BRCA1_1	30	34	PF00533	0.355
LIG_CaM_NSCaTE_8	231	238	PF13499	0.537
LIG_CtBP_PxDLS_1	249	255	PF00389	0.428
LIG_FHA_1	193	199	PF00498	0.600
LIG_FHA_1	214	220	PF00498	0.409
LIG_FHA_1	299	305	PF00498	0.440
LIG_FHA_1	368	374	PF00498	0.385
LIG_FHA_1	396	402	PF00498	0.399
LIG_FHA_1	45	51	PF00498	0.655
LIG_FHA_1	95	101	PF00498	0.480
LIG_FHA_2	221	227	PF00498	0.385
LIG_FHA_2	374	380	PF00498	0.385
LIG_FHA_2	505	511	PF00498	0.500
LIG_FHA_2	83	89	PF00498	0.548
LIG_LIR_Gen_1	176	186	PF02991	0.625
LIG_LIR_Gen_1	221	232	PF02991	0.394
LIG_LIR_Gen_1	31	42	PF02991	0.611
LIG_LIR_Gen_1	494	505	PF02991	0.449
LIG_LIR_Nem_3	176	182	PF02991	0.604
LIG_LIR_Nem_3	221	227	PF02991	0.389
LIG_LIR_Nem_3	254	260	PF02991	0.390
LIG_LIR_Nem_3	3	7	PF02991	0.673
LIG_LIR_Nem_3	31	37	PF02991	0.533
LIG_LIR_Nem_3	443	449	PF02991	0.385
LIG_LIR_Nem_3	494	500	PF02991	0.412
LIG_PDZ_Class_3	523	528	PF00595	0.570
LIG_PTB_Apo_2	453	460	PF02174	0.493
LIG_RPA_C_Fungi	428	440	PF08784	0.420
LIG_SH2_CRK	257	261	PF00017	0.394
LIG_SH2_CRK	4	8	PF00017	0.651
LIG_SH2_GRB2like	424	427	PF00017	0.443
LIG_SH2_NCK_1	13	17	PF00017	0.557
LIG_SH2_NCK_1	75	79	PF00017	0.526
LIG_SH2_SRC	13	16	PF00017	0.590
LIG_SH2_SRC	424	427	PF00017	0.303
LIG_SH2_STAP1	28	32	PF00017	0.506
LIG_SH2_STAP1	75	79	PF00017	0.478
LIG_SH2_STAT5	147	150	PF00017	0.455
LIG_SH2_STAT5	179	182	PF00017	0.544
LIG_SH2_STAT5	397	400	PF00017	0.443
LIG_SH2_STAT5	450	453	PF00017	0.421
LIG_SH3_3	179	185	PF00018	0.532
LIG_SH3_3	209	215	PF00018	0.385
LIG_SH3_3	446	452	PF00018	0.478
LIG_SUMO_SIM_anti_2	288	294	PF11976	0.517
LIG_SUMO_SIM_anti_2	52	59	PF11976	0.446
LIG_SUMO_SIM_par_1	272	277	PF11976	0.415
LIG_SUMO_SIM_par_1	337	343	PF11976	0.435
LIG_SUMO_SIM_par_1	52	59	PF11976	0.476
LIG_TRAF2_1	12	15	PF00917	0.609
LIG_TRAF2_1	248	251	PF00917	0.479
LIG_UBA3_1	362	366	PF00899	0.428
MOD_CK1_1	109	115	PF00069	0.454
MOD_CK1_1	178	184	PF00069	0.569
MOD_CK1_1	192	198	PF00069	0.560
MOD_CK1_1	30	36	PF00069	0.544
MOD_CK1_1	367	373	PF00069	0.385
MOD_CK1_1	427	433	PF00069	0.521
MOD_CK1_1	469	475	PF00069	0.456
MOD_CK2_1	147	153	PF00069	0.458
MOD_CK2_1	21	27	PF00069	0.428
MOD_CK2_1	220	226	PF00069	0.385
MOD_CK2_1	373	379	PF00069	0.385
MOD_CK2_1	504	510	PF00069	0.454
MOD_CK2_1	8	14	PF00069	0.552
MOD_CK2_1	82	88	PF00069	0.519
MOD_GlcNHglycan	10	13	PF01048	0.592
MOD_GlcNHglycan	18	21	PF01048	0.464
MOD_GlcNHglycan	191	194	PF01048	0.620
MOD_GlcNHglycan	241	245	PF01048	0.503
MOD_GlcNHglycan	366	369	PF01048	0.385
MOD_GlcNHglycan	460	463	PF01048	0.541
MOD_GSK3_1	160	167	PF00069	0.497
MOD_GSK3_1	218	225	PF00069	0.404
MOD_GSK3_1	37	44	PF00069	0.515
MOD_GSK3_1	393	400	PF00069	0.456
MOD_GSK3_1	82	89	PF00069	0.539
MOD_N-GLC_1	16	21	PF02516	0.489
MOD_N-GLC_1	373	378	PF02516	0.394
MOD_N-GLC_1	487	492	PF02516	0.496
MOD_NEK2_1	21	26	PF00069	0.427
MOD_NEK2_1	218	223	PF00069	0.380
MOD_NEK2_1	260	265	PF00069	0.498
MOD_NEK2_2	311	316	PF00069	0.474
MOD_NEK2_2	466	471	PF00069	0.511
MOD_PIKK_1	353	359	PF00454	0.475
MOD_PIKK_1	6	12	PF00454	0.532
MOD_PK_1	106	112	PF00069	0.545
MOD_PKA_2	164	170	PF00069	0.528
MOD_PKA_2	466	472	PF00069	0.413
MOD_PKB_1	6	14	PF00069	0.557
MOD_Plk_1	152	158	PF00069	0.521
MOD_Plk_1	16	22	PF00069	0.484
MOD_Plk_1	175	181	PF00069	0.555
MOD_Plk_1	339	345	PF00069	0.526
MOD_Plk_1	393	399	PF00069	0.478
MOD_Plk_2-3	220	226	PF00069	0.428
MOD_Plk_4	175	181	PF00069	0.546
MOD_Plk_4	340	346	PF00069	0.475
MOD_Plk_4	397	403	PF00069	0.537
MOD_Plk_4	49	55	PF00069	0.475
MOD_ProDKin_1	395	401	PF00069	0.415
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.526
TRG_ENDOCYTIC_2	179	182	PF00928	0.618
TRG_ENDOCYTIC_2	257	260	PF00928	0.381
TRG_ENDOCYTIC_2	4	7	PF00928	0.661
TRG_NES_CRM1_1	360	372	PF08389	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E6	Leptomonas seymouri	76%	100%
A0A0N1PAS4	Leptomonas seymouri	43%	98%
A0A0S4IQ79	Bodo saltans	54%	100%
A0A1X0NWR5	Trypanosomatidae	50%	100%
A0A1X0P4M9	Trypanosomatidae	48%	100%
A0A3R7JY84	Trypanosoma rangeli	50%	100%
A0A3R7N130	Trypanosoma rangeli	57%	94%
A0A3S7WRP1	Leishmania donovani	44%	99%
A0A3S7X742	Leishmania donovani	97%	100%
A0K9N9	Burkholderia cenocepacia (strain HI2424)	30%	100%
A1V5Z5	Burkholderia mallei (strain SAVP1)	28%	100%
A2SAC2	Burkholderia mallei (strain NCTC 10229)	28%	100%
A3MLR1	Burkholderia mallei (strain NCTC 10247)	28%	100%
A3N6U4	Burkholderia pseudomallei (strain 668)	28%	100%
A3NSI1	Burkholderia pseudomallei (strain 1106a)	28%	100%
A3QBG2	Shewanella loihica (strain ATCC BAA-1088 / PV-4)	29%	100%
A4H6I8	Leishmania braziliensis	43%	98%
A4HCW4	Leishmania braziliensis	34%	100%
A4HLW7	Leishmania braziliensis	85%	100%
A4HUX3	Leishmania infantum	44%	99%
A4I996	Leishmania infantum	97%	100%
A4JGZ2	Burkholderia vietnamiensis (strain G4 / LMG 22486)	29%	100%
A5GV03	Synechococcus sp. (strain RCC307)	29%	100%
A7IFB7	Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)	31%	100%
A8LI79	Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)	34%	100%
A9AHG9	Burkholderia multivorans (strain ATCC 17616 / 249)	30%	100%
B0U1L5	Xylella fastidiosa (strain M12)	29%	100%
B1JWV2	Burkholderia cenocepacia (strain MC0-3)	30%	100%
B1V932	Phytoplasma australiense	31%	100%
B1XAZ8	Escherichia coli (strain K12 / DH10B)	34%	100%
B1YUW5	Burkholderia ambifaria (strain MC40-6)	30%	100%
B2I6L3	Xylella fastidiosa (strain M23)	28%	100%
B2JET5	Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815)	29%	100%
B2T146	Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN)	28%	100%
B4E8G9	Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)	30%	100%
B4F2N1	Proteus mirabilis (strain HI4320)	32%	100%
B5ZWY7	Rhizobium leguminosarum bv. trifolii (strain WSM2304)	34%	100%
B8CU18	Shewanella piezotolerans (strain WP3 / JCM 13877)	29%	100%
B8GTX6	Thioalkalivibrio sulfidiphilus (strain HL-EbGR7)	29%	100%
C0QC86	Desulforapulum autotrophicum (strain ATCC 43914 / DSM 3382 / VKM B-1955 / HRM2)	30%	100%
C0QSL9	Persephonella marina (strain DSM 14350 / EX-H1)	32%	100%
C4ZX98	Escherichia coli (strain K12 / MC4100 / BW2952)	34%	100%
C5CCM4	Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230)	34%	100%
C9ZV91	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	79%
D0A654	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	93%
D0A7H3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ANK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	99%
E9B496	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O06865	Synechococcus elongatus (strain PCC 7942 / FACHB-805)	32%	100%
P37095	Escherichia coli (strain K12)	34%	100%
Q0BCQ2	Burkholderia ambifaria (strain ATCC BAA-244 / AMMD)	30%	100%
Q12QW7	Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)	29%	100%
Q143Y9	Paraburkholderia xenovorans (strain LB400)	28%	100%
Q1BUE7	Burkholderia cenocepacia (strain AU 1054)	30%	100%
Q215R8	Rhodopseudomonas palustris (strain BisB18)	32%	100%
Q21KZ5	Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)	29%	100%
Q2JKL5	Synechococcus sp. (strain JA-2-3B'a(2-13))	31%	100%
Q2T0C0	Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)	28%	100%
Q39DS5	Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)	30%	100%
Q3AZE8	Synechococcus sp. (strain CC9902)	31%	100%
Q3JV16	Burkholderia pseudomallei (strain 1710b)	28%	100%
Q488M4	Colwellia psychrerythraea (strain 34H / ATCC BAA-681)	30%	100%
Q4QH17	Leishmania major	43%	98%
Q5N569	Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1)	32%	100%
Q5QY05	Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)	31%	100%
Q606B9	Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)	27%	100%
Q62LH2	Burkholderia mallei (strain ATCC 23344)	28%	100%
Q63WC3	Burkholderia pseudomallei (strain K96243)	28%	100%
Q6A9W5	Cutibacterium acnes (strain DSM 16379 / KPA171202)	33%	100%
Q6LUW0	Photobacterium profundum (strain SS9)	29%	100%
Q6NSR8	Mus musculus	44%	100%
Q7NTY9	Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)	29%	100%
Q7V0D4	Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / NIES-2087 / MED4)	26%	100%
Q87F32	Xylella fastidiosa (strain Temecula1 / ATCC 700964)	28%	100%
Q8EH62	Shewanella oneidensis (strain MR-1)	28%	100%
Q92QY7	Rhizobium meliloti (strain 1021)	36%	100%
Q984S1	Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)	35%	100%
Q9CM16	Pasteurella multocida (strain Pm70)	34%	100%
Q9PH08	Xylella fastidiosa (strain 9a5c)	29%	100%
V5BTR1	Trypanosoma cruzi	57%	95%
V5BWE3	Trypanosoma cruzi	50%	100%