LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q3S9_LEIMA
TriTrypDb:
LmjF.33.2580 , LMJLV39_330036700 , LMJSD75_330036000
Length:
99

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

Q4Q3S9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3S9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 8 10 PF00675 0.367
CLV_PCSK_KEX2_1 8 10 PF00082 0.367
CLV_PCSK_SKI1_1 63 67 PF00082 0.635
DEG_Nend_UBRbox_1 1 4 PF02207 0.531
DEG_SCF_FBW7_1 79 85 PF00400 0.505
DOC_CKS1_1 68 73 PF01111 0.445
DOC_CKS1_1 79 84 PF01111 0.417
DOC_WW_Pin1_4 67 72 PF00397 0.435
DOC_WW_Pin1_4 78 83 PF00397 0.433
LIG_FHA_1 28 34 PF00498 0.461
LIG_LIR_Nem_3 30 34 PF02991 0.370
LIG_LIR_Nem_3 42 47 PF02991 0.390
LIG_Pex14_2 53 57 PF04695 0.408
LIG_SH2_PTP2 46 49 PF00017 0.392
LIG_SH2_STAP1 13 17 PF00017 0.362
LIG_SH2_STAT5 46 49 PF00017 0.392
LIG_SH2_STAT5 78 81 PF00017 0.456
LIG_SH2_STAT5 84 87 PF00017 0.474
LIG_TRAF2_1 48 51 PF00917 0.377
MOD_GlcNHglycan 63 66 PF01048 0.674
MOD_GSK3_1 78 85 PF00069 0.472
MOD_NEK2_1 27 32 PF00069 0.430
MOD_NEK2_1 34 39 PF00069 0.347
MOD_Plk_2-3 87 93 PF00069 0.534
MOD_Plk_4 20 26 PF00069 0.350
MOD_ProDKin_1 67 73 PF00069 0.433
MOD_ProDKin_1 78 84 PF00069 0.436
MOD_SUMO_for_1 53 56 PF00179 0.471
TRG_ENDOCYTIC_2 31 34 PF00928 0.361
TRG_ENDOCYTIC_2 46 49 PF00928 0.367
TRG_ER_diArg_1 7 9 PF00400 0.568

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8S3 Leptomonas seymouri 88% 100%
A0A0S4J1K9 Bodo saltans 60% 100%
A0A1X0P3U8 Trypanosomatidae 68% 93%
A0A3Q8IHP4 Leishmania donovani 98% 100%
A4HLW8 Leishmania braziliensis 93% 100%
A4I997 Leishmania infantum 98% 100%
E9B497 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS