Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3S8_LEIMA

TriTrypDb:

LmjF.33.2585 , LMJLV39_330036800 , LMJSD75_330036100

Length:

588

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3S8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3S8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	239	243	PF00656	0.551
CLV_C14_Caspase3-7	407	411	PF00656	0.627
CLV_NRD_NRD_1	305	307	PF00675	0.554
CLV_NRD_NRD_1	424	426	PF00675	0.651
CLV_NRD_NRD_1	49	51	PF00675	0.756
CLV_NRD_NRD_1	504	506	PF00675	0.581
CLV_NRD_NRD_1	61	63	PF00675	0.510
CLV_PCSK_KEX2_1	423	425	PF00082	0.663
CLV_PCSK_KEX2_1	49	51	PF00082	0.756
CLV_PCSK_KEX2_1	61	63	PF00082	0.510
CLV_PCSK_PC7_1	57	63	PF00082	0.606
CLV_PCSK_SKI1_1	101	105	PF00082	0.705
CLV_PCSK_SKI1_1	215	219	PF00082	0.601
CLV_PCSK_SKI1_1	354	358	PF00082	0.575
CLV_PCSK_SKI1_1	365	369	PF00082	0.402
CLV_PCSK_SKI1_1	433	437	PF00082	0.535
CLV_PCSK_SKI1_1	506	510	PF00082	0.585
CLV_PCSK_SKI1_1	539	543	PF00082	0.411
CLV_PCSK_SKI1_1	71	75	PF00082	0.418
CLV_PCSK_SKI1_1	80	84	PF00082	0.552
DEG_APCC_DBOX_1	133	141	PF00400	0.510
DEG_APCC_DBOX_1	451	459	PF00400	0.587
DEG_Nend_UBRbox_1	1	4	PF02207	0.597
DEG_SPOP_SBC_1	115	119	PF00917	0.634
DEG_SPOP_SBC_1	371	375	PF00917	0.466
DEG_SPOP_SBC_1	484	488	PF00917	0.644
DOC_CDC14_PxL_1	534	542	PF14671	0.423
DOC_MAPK_DCC_7	66	75	PF00069	0.398
DOC_MAPK_gen_1	423	429	PF00069	0.539
DOC_MAPK_gen_1	66	75	PF00069	0.410
DOC_MAPK_MEF2A_6	535	542	PF00069	0.458
DOC_PP1_RVXF_1	305	312	PF00149	0.614
DOC_PP1_RVXF_1	59	66	PF00149	0.544
DOC_PP2B_LxvP_1	28	31	PF13499	0.682
DOC_USP7_MATH_1	115	119	PF00917	0.620
DOC_USP7_MATH_1	185	189	PF00917	0.586
DOC_USP7_MATH_1	276	280	PF00917	0.658
DOC_USP7_MATH_1	359	363	PF00917	0.477
DOC_USP7_MATH_1	371	375	PF00917	0.591
DOC_USP7_MATH_1	418	422	PF00917	0.786
DOC_USP7_MATH_1	484	488	PF00917	0.703
DOC_USP7_MATH_1	563	567	PF00917	0.524
DOC_USP7_MATH_1	568	572	PF00917	0.519
DOC_WW_Pin1_4	188	193	PF00397	0.576
DOC_WW_Pin1_4	221	226	PF00397	0.630
DOC_WW_Pin1_4	267	272	PF00397	0.568
DOC_WW_Pin1_4	284	289	PF00397	0.696
DOC_WW_Pin1_4	374	379	PF00397	0.462
DOC_WW_Pin1_4	476	481	PF00397	0.641
DOC_WW_Pin1_4	486	491	PF00397	0.662
DOC_WW_Pin1_4	574	579	PF00397	0.477
DOC_WW_Pin1_4	9	14	PF00397	0.587
LIG_14-3-3_CanoR_1	2	8	PF00244	0.603
LIG_14-3-3_CanoR_1	24	29	PF00244	0.574
LIG_14-3-3_CanoR_1	277	285	PF00244	0.623
LIG_14-3-3_CanoR_1	306	312	PF00244	0.585
LIG_14-3-3_CanoR_1	365	370	PF00244	0.555
LIG_14-3-3_CanoR_1	423	428	PF00244	0.640
LIG_14-3-3_CanoR_1	505	514	PF00244	0.753
LIG_14-3-3_CanoR_1	562	568	PF00244	0.528
LIG_14-3-3_CanoR_1	61	66	PF00244	0.676
LIG_14-3-3_CanoR_1	71	76	PF00244	0.400
LIG_BIR_III_4	204	208	PF00653	0.479
LIG_BIR_III_4	246	250	PF00653	0.542
LIG_BIR_III_4	394	398	PF00653	0.688
LIG_BRCT_BRCA1_1	255	259	PF00533	0.707
LIG_BRCT_BRCA1_1	3	7	PF00533	0.709
LIG_BRCT_BRCA1_1	342	346	PF00533	0.495
LIG_FHA_1	107	113	PF00498	0.690
LIG_FHA_1	148	154	PF00498	0.549
LIG_FHA_1	204	210	PF00498	0.396
LIG_FHA_1	33	39	PF00498	0.739
LIG_FHA_1	90	96	PF00498	0.495
LIG_FHA_2	411	417	PF00498	0.628
LIG_FHA_2	42	48	PF00498	0.677
LIG_FHA_2	467	473	PF00498	0.420
LIG_FHA_2	477	483	PF00498	0.531
LIG_Integrin_RGD_1	131	133	PF01839	0.597
LIG_LIR_Apic_2	291	296	PF02991	0.530
LIG_LIR_Gen_1	256	263	PF02991	0.643
LIG_LIR_Gen_1	343	351	PF02991	0.530
LIG_LIR_Gen_1	377	387	PF02991	0.619
LIG_LIR_Nem_3	256	262	PF02991	0.644
LIG_LIR_Nem_3	343	349	PF02991	0.522
LIG_LIR_Nem_3	377	382	PF02991	0.693
LIG_LIR_Nem_3	546	552	PF02991	0.454
LIG_LYPXL_yS_3	537	540	PF13949	0.427
LIG_RPA_C_Fungi	155	167	PF08784	0.506
LIG_SH2_STAP1	197	201	PF00017	0.376
LIG_SH2_STAP1	326	330	PF00017	0.528
LIG_SH2_STAP1	360	364	PF00017	0.544
LIG_SH2_STAT5	337	340	PF00017	0.387
LIG_SH2_STAT5	467	470	PF00017	0.418
LIG_SH3_1	222	228	PF00018	0.606
LIG_SH3_1	425	431	PF00018	0.644
LIG_SH3_2	225	230	PF14604	0.520
LIG_SH3_2	428	433	PF14604	0.619
LIG_SH3_3	222	228	PF00018	0.674
LIG_SH3_3	282	288	PF00018	0.582
LIG_SH3_3	424	430	PF00018	0.647
LIG_SH3_3	434	440	PF00018	0.385
LIG_SH3_3	52	58	PF00018	0.698
LIG_SH3_3	575	581	PF00018	0.485
LIG_SH3_3	92	98	PF00018	0.599
LIG_SH3_CIN85_PxpxPR_1	428	433	PF14604	0.619
LIG_SUMO_SIM_par_1	442	449	PF11976	0.557
LIG_TRAF2_1	103	106	PF00917	0.743
LIG_TRAF2_1	412	415	PF00917	0.623
LIG_TRFH_1	436	440	PF08558	0.429
LIG_TYR_ITIM	195	200	PF00017	0.450
LIG_UBA3_1	531	535	PF00899	0.389
LIG_WW_3	430	434	PF00397	0.600
MOD_CDC14_SPxK_1	227	230	PF00782	0.524
MOD_CDK_SPxK_1	224	230	PF00069	0.517
MOD_CK1_1	113	119	PF00069	0.794
MOD_CK1_1	16	22	PF00069	0.627
MOD_CK1_1	175	181	PF00069	0.619
MOD_CK1_1	188	194	PF00069	0.455
MOD_CK1_1	203	209	PF00069	0.350
MOD_CK1_1	224	230	PF00069	0.574
MOD_CK1_1	236	242	PF00069	0.527
MOD_CK1_1	270	276	PF00069	0.638
MOD_CK1_1	310	316	PF00069	0.595
MOD_CK1_1	374	380	PF00069	0.712
MOD_CK1_1	486	492	PF00069	0.744
MOD_CK1_1	566	572	PF00069	0.455
MOD_CK1_1	577	583	PF00069	0.393
MOD_CK1_1	64	70	PF00069	0.707
MOD_CK2_1	410	416	PF00069	0.600
MOD_CK2_1	466	472	PF00069	0.431
MOD_CK2_1	491	497	PF00069	0.639
MOD_Cter_Amidation	503	506	PF01082	0.660
MOD_GlcNHglycan	113	116	PF01048	0.633
MOD_GlcNHglycan	118	121	PF01048	0.595
MOD_GlcNHglycan	15	18	PF01048	0.627
MOD_GlcNHglycan	236	239	PF01048	0.670
MOD_GlcNHglycan	255	258	PF01048	0.564
MOD_GlcNHglycan	272	275	PF01048	0.587
MOD_GlcNHglycan	3	6	PF01048	0.606
MOD_GlcNHglycan	379	382	PF01048	0.638
MOD_GlcNHglycan	394	398	PF01048	0.624
MOD_GlcNHglycan	463	466	PF01048	0.516
MOD_GlcNHglycan	493	496	PF01048	0.628
MOD_GlcNHglycan	509	512	PF01048	0.690
MOD_GlcNHglycan	565	568	PF01048	0.563
MOD_GSK3_1	106	113	PF00069	0.617
MOD_GSK3_1	114	121	PF00069	0.688
MOD_GSK3_1	186	193	PF00069	0.584
MOD_GSK3_1	220	227	PF00069	0.653
MOD_GSK3_1	3	10	PF00069	0.666
MOD_GSK3_1	370	377	PF00069	0.547
MOD_GSK3_1	385	392	PF00069	0.647
MOD_GSK3_1	457	464	PF00069	0.499
MOD_GSK3_1	57	64	PF00069	0.714
MOD_GSK3_1	97	104	PF00069	0.765
MOD_N-GLC_1	175	180	PF02516	0.594
MOD_N-GLC_2	545	547	PF02516	0.541
MOD_NEK2_1	1	6	PF00069	0.597
MOD_NEK2_1	146	151	PF00069	0.417
MOD_NEK2_1	457	462	PF00069	0.560
MOD_NEK2_1	507	512	PF00069	0.627
MOD_NEK2_2	418	423	PF00069	0.653
MOD_PIKK_1	101	107	PF00454	0.644
MOD_PK_1	423	429	PF00069	0.571
MOD_PKA_1	423	429	PF00069	0.635
MOD_PKA_1	61	67	PF00069	0.604
MOD_PKA_2	1	7	PF00069	0.598
MOD_PKA_2	276	282	PF00069	0.630
MOD_PKA_2	423	429	PF00069	0.635
MOD_PKA_2	56	62	PF00069	0.639
MOD_PKA_2	563	569	PF00069	0.468
MOD_Plk_1	147	153	PF00069	0.401
MOD_Plk_2-3	410	416	PF00069	0.623
MOD_Plk_4	190	196	PF00069	0.566
MOD_Plk_4	3	9	PF00069	0.665
MOD_Plk_4	385	391	PF00069	0.565
MOD_ProDKin_1	188	194	PF00069	0.567
MOD_ProDKin_1	221	227	PF00069	0.631
MOD_ProDKin_1	267	273	PF00069	0.571
MOD_ProDKin_1	284	290	PF00069	0.693
MOD_ProDKin_1	374	380	PF00069	0.470
MOD_ProDKin_1	476	482	PF00069	0.656
MOD_ProDKin_1	486	492	PF00069	0.661
MOD_ProDKin_1	574	580	PF00069	0.475
MOD_ProDKin_1	9	15	PF00069	0.587
MOD_SUMO_rev_2	121	130	PF00179	0.529
TRG_ENDOCYTIC_2	197	200	PF00928	0.379
TRG_ENDOCYTIC_2	537	540	PF00928	0.475
TRG_ER_diArg_1	212	215	PF00400	0.382
TRG_ER_diArg_1	422	425	PF00400	0.657
TRG_ER_diArg_1	48	50	PF00400	0.751
TRG_ER_diArg_1	559	562	PF00400	0.594
TRG_ER_diArg_1	61	63	PF00400	0.497
TRG_ER_diArg_1	65	68	PF00400	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBA9	Leptomonas seymouri	30%	99%
A0A3Q8IF25	Leishmania donovani	86%	100%
A4HLW9	Leishmania braziliensis	63%	100%
A4I998	Leishmania infantum	86%	100%
E9B498	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%