Metallo-peptidase, Clan ME, Family M16

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial-processing peptidase subunit alpha

Species:

Leishmania major

UniProt:

Q4Q3S5_LEIMA

TriTrypDb:

LmjF.33.2610 , LMJLV39_330037100 , LMJSD75_330036400

Length:

483

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0017087	mitochondrial processing peptidase complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0098798	mitochondrial protein-containing complex	2	2
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	2

Expansion

Sequence features

Q4Q3S5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3S5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006839	mitochondrial transport	4	2
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0030150	protein import into mitochondrial matrix	4	2
GO:0033036	macromolecule localization	2	2
GO:0033365	protein localization to organelle	5	2
GO:0044743	protein transmembrane import into intracellular organelle	4	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0055085	transmembrane transport	2	2
GO:0065002	intracellular protein transmembrane transport	4	2
GO:0070585	protein localization to mitochondrion	6	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071806	protein transmembrane transport	3	2
GO:0072594	establishment of protein localization to organelle	4	2
GO:0072655	establishment of protein localization to mitochondrion	5	2
GO:1990542	mitochondrial transmembrane transport	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004175	endopeptidase activity	4	3
GO:0004222	metalloendopeptidase activity	5	3
GO:0005488	binding	1	11
GO:0008233	peptidase activity	3	3
GO:0008237	metallopeptidase activity	4	3
GO:0016787	hydrolase activity	2	3
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.265
CLV_NRD_NRD_1	193	195	PF00675	0.335
CLV_PCSK_KEX2_1	193	195	PF00082	0.335
CLV_PCSK_SKI1_1	149	153	PF00082	0.401
CLV_PCSK_SKI1_1	200	204	PF00082	0.259
CLV_PCSK_SKI1_1	30	34	PF00082	0.308
CLV_PCSK_SKI1_1	325	329	PF00082	0.259
DEG_Nend_Nbox_1	1	3	PF02207	0.524
DEG_SCF_FBW7_1	420	425	PF00400	0.487
DOC_CKS1_1	195	200	PF01111	0.286
DOC_CYCLIN_yCln2_LP_2	169	175	PF00134	0.388
DOC_MAPK_gen_1	109	118	PF00069	0.267
DOC_MAPK_MEF2A_6	275	284	PF00069	0.337
DOC_MAPK_MEF2A_6	378	386	PF00069	0.306
DOC_MAPK_MEF2A_6	98	107	PF00069	0.335
DOC_PP1_RVXF_1	219	225	PF00149	0.281
DOC_PP1_RVXF_1	364	371	PF00149	0.190
DOC_PP2B_LxvP_1	105	108	PF13499	0.330
DOC_USP7_MATH_1	69	73	PF00917	0.396
DOC_USP7_UBL2_3	271	275	PF12436	0.259
DOC_WW_Pin1_4	171	176	PF00397	0.454
DOC_WW_Pin1_4	194	199	PF00397	0.286
DOC_WW_Pin1_4	377	382	PF00397	0.255
DOC_WW_Pin1_4	418	423	PF00397	0.486
DOC_WW_Pin1_4	478	483	PF00397	0.551
LIG_14-3-3_CanoR_1	143	147	PF00244	0.442
LIG_14-3-3_CanoR_1	193	198	PF00244	0.421
LIG_14-3-3_CanoR_1	75	81	PF00244	0.440
LIG_APCC_ABBA_1	451	456	PF00400	0.300
LIG_BRCT_BRCA1_1	152	156	PF00533	0.414
LIG_eIF4E_1	344	350	PF01652	0.259
LIG_FHA_1	150	156	PF00498	0.485
LIG_FHA_1	24	30	PF00498	0.418
LIG_FHA_1	245	251	PF00498	0.286
LIG_FHA_1	294	300	PF00498	0.337
LIG_FHA_1	448	454	PF00498	0.315
LIG_FHA_1	76	82	PF00498	0.577
LIG_FHA_2	125	131	PF00498	0.381
LIG_FHA_2	194	200	PF00498	0.277
LIG_FHA_2	31	37	PF00498	0.335
LIG_FHA_2	419	425	PF00498	0.348
LIG_LIR_Gen_1	153	162	PF02991	0.367
LIG_LIR_Gen_1	186	195	PF02991	0.259
LIG_LIR_Gen_1	296	304	PF02991	0.391
LIG_LIR_Gen_1	408	418	PF02991	0.356
LIG_LIR_Gen_1	473	482	PF02991	0.581
LIG_LIR_Nem_3	153	159	PF02991	0.366
LIG_LIR_Nem_3	186	191	PF02991	0.259
LIG_LIR_Nem_3	293	297	PF02991	0.261
LIG_LIR_Nem_3	321	327	PF02991	0.259
LIG_LIR_Nem_3	408	414	PF02991	0.326
LIG_LIR_Nem_3	450	454	PF02991	0.290
LIG_LIR_Nem_3	462	466	PF02991	0.356
LIG_LIR_Nem_3	473	477	PF02991	0.361
LIG_PDZ_Class_1	478	483	PF00595	0.503
LIG_SH2_CRK	474	478	PF00017	0.518
LIG_SH2_NCK_1	195	199	PF00017	0.302
LIG_SH2_STAT5	195	198	PF00017	0.302
LIG_SH2_STAT5	253	256	PF00017	0.268
LIG_SH2_STAT5	259	262	PF00017	0.273
LIG_SH2_STAT5	294	297	PF00017	0.353
LIG_SH2_STAT5	418	421	PF00017	0.415
LIG_SH3_3	169	175	PF00018	0.383
LIG_SUMO_SIM_anti_2	102	107	PF11976	0.344
LIG_SUMO_SIM_anti_2	114	120	PF11976	0.221
LIG_SUMO_SIM_anti_2	392	400	PF11976	0.380
LIG_SUMO_SIM_par_1	392	400	PF11976	0.380
LIG_TRAF2_1	421	424	PF00917	0.491
LIG_UBA3_1	154	161	PF00899	0.455
LIG_UBA3_1	45	52	PF00899	0.315
LIG_WRC_WIRS_1	294	299	PF05994	0.382
MOD_CDK_SPxK_1	194	200	PF00069	0.286
MOD_CK1_1	145	151	PF00069	0.506
MOD_CK1_1	23	29	PF00069	0.340
MOD_CK1_1	231	237	PF00069	0.432
MOD_CK1_1	309	315	PF00069	0.259
MOD_CK1_1	473	479	PF00069	0.514
MOD_CK2_1	171	177	PF00069	0.521
MOD_CK2_1	193	199	PF00069	0.277
MOD_CK2_1	232	238	PF00069	0.472
MOD_CK2_1	418	424	PF00069	0.353
MOD_GlcNHglycan	164	167	PF01048	0.502
MOD_GlcNHglycan	235	238	PF01048	0.416
MOD_GlcNHglycan	311	314	PF01048	0.259
MOD_GlcNHglycan	354	357	PF01048	0.277
MOD_GlcNHglycan	428	431	PF01048	0.454
MOD_GSK3_1	137	144	PF00069	0.460
MOD_GSK3_1	145	152	PF00069	0.409
MOD_GSK3_1	194	201	PF00069	0.405
MOD_GSK3_1	228	235	PF00069	0.415
MOD_GSK3_1	295	302	PF00069	0.260
MOD_GSK3_1	305	312	PF00069	0.259
MOD_GSK3_1	338	345	PF00069	0.259
MOD_GSK3_1	373	380	PF00069	0.389
MOD_GSK3_1	418	425	PF00069	0.374
MOD_GSK3_1	426	433	PF00069	0.423
MOD_GSK3_1	473	480	PF00069	0.570
MOD_GSK3_1	71	78	PF00069	0.506
MOD_N-GLC_1	18	23	PF02516	0.356
MOD_N-GLC_1	275	280	PF02516	0.254
MOD_N-GLC_1	416	421	PF02516	0.444
MOD_NEK2_1	141	146	PF00069	0.459
MOD_NEK2_1	2	7	PF00069	0.652
MOD_NEK2_1	20	25	PF00069	0.459
MOD_NEK2_1	203	208	PF00069	0.269
MOD_NEK2_1	232	237	PF00069	0.380
MOD_NEK2_1	295	300	PF00069	0.335
MOD_NEK2_1	352	357	PF00069	0.259
MOD_NEK2_1	470	475	PF00069	0.398
MOD_NEK2_1	477	482	PF00069	0.503
MOD_PIKK_1	373	379	PF00454	0.356
MOD_PIKK_1	390	396	PF00454	0.256
MOD_PIKK_1	79	85	PF00454	0.406
MOD_PKA_1	193	199	PF00069	0.335
MOD_PKA_2	142	148	PF00069	0.449
MOD_PKA_2	193	199	PF00069	0.437
MOD_PKA_2	23	29	PF00069	0.346
MOD_PKA_2	74	80	PF00069	0.507
MOD_Plk_1	149	155	PF00069	0.369
MOD_Plk_1	18	24	PF00069	0.356
MOD_Plk_1	198	204	PF00069	0.306
MOD_Plk_1	275	281	PF00069	0.269
MOD_Plk_1	416	422	PF00069	0.450
MOD_Plk_2-3	181	187	PF00069	0.302
MOD_Plk_4	142	148	PF00069	0.545
MOD_Plk_4	150	156	PF00069	0.476
MOD_Plk_4	210	216	PF00069	0.202
MOD_Plk_4	299	305	PF00069	0.257
MOD_Plk_4	99	105	PF00069	0.369
MOD_ProDKin_1	171	177	PF00069	0.458
MOD_ProDKin_1	194	200	PF00069	0.286
MOD_ProDKin_1	377	383	PF00069	0.255
MOD_ProDKin_1	418	424	PF00069	0.485
MOD_SUMO_for_1	51	54	PF00179	0.392
TRG_DiLeu_BaEn_1	462	467	PF01217	0.355
TRG_ENDOCYTIC_2	294	297	PF00928	0.288
TRG_ENDOCYTIC_2	463	466	PF00928	0.399
TRG_ENDOCYTIC_2	474	477	PF00928	0.299
TRG_ER_diArg_1	193	195	PF00400	0.335
TRG_NES_CRM1_1	114	128	PF08389	0.370
TRG_Pf-PMV_PEXEL_1	464	468	PF00026	0.332

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDS4	Leptomonas seymouri	76%	100%
A0A1X0NSX1	Trypanosomatidae	65%	100%
A0A3Q8IMP0	Leishmania donovani	96%	100%
A0A422N4E4	Trypanosoma rangeli	63%	100%
A4HLX2	Leishmania braziliensis	89%	100%
A4I9A1	Leishmania infantum	96%	100%
C9ZJC5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9B4A1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O04308	Arabidopsis thaliana	24%	97%
O05945	Rickettsia prowazekii (strain Madrid E)	20%	100%
O32965	Mycobacterium leprae (strain TN)	21%	100%
O75439	Homo sapiens	23%	99%
O86835	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	21%	100%
O94745	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	96%
P11914	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P20069	Rattus norvegicus	27%	92%
P22695	Homo sapiens	23%	100%
P23004	Bos taurus	22%	100%
P29677	Solanum tuberosum	27%	96%
P31800	Bos taurus	21%	100%
P32551	Rattus norvegicus	21%	100%
P43264	Euglena gracilis	23%	98%
P97997	Blastocladiella emersonii	27%	100%
Q03346	Rattus norvegicus	23%	99%
Q04805	Bacillus subtilis (strain 168)	21%	100%
Q0P5M8	Bos taurus	28%	92%
Q10713	Homo sapiens	27%	92%
Q23295	Caenorhabditis elegans	23%	100%
Q3SZ71	Bos taurus	23%	99%
Q42290	Arabidopsis thaliana	22%	91%
Q4UML9	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	20%	100%
Q4W6B5	Dictyostelium discoideum	21%	100%
Q54F93	Dictyostelium discoideum	24%	100%
Q5R513	Pongo abelii	27%	92%
Q5REK3	Pongo abelii	23%	99%
Q95XN2	Caenorhabditis elegans	25%	94%
Q9CXT8	Mus musculus	23%	99%
Q9CZ13	Mus musculus	20%	100%
Q9DB77	Mus musculus	21%	100%
Q9DC61	Mus musculus	26%	92%
Q9Y8B5	Lentinula edodes	20%	100%
Q9ZU25	Arabidopsis thaliana	25%	96%
V5BIM6	Trypanosoma cruzi	63%	100%