Signal recognition particle receptor subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

signal recognition particle receptor beta subunit, putative

Species:

Leishmania major

UniProt:

Q4Q3S4_LEIMA

TriTrypDb:

LmjF.33.2620 , LMJLV39_330037300 , LMJSD75_330036600

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005785	signal recognition particle receptor complex	3	2
GO:0016020	membrane	2	7
GO:0032991	protein-containing complex	1	2
GO:0098796	membrane protein complex	2	2
GO:0110165	cellular anatomical entity	1	7
GO:0140534	endoplasmic reticulum protein-containing complex	2	2
GO:0005789	endoplasmic reticulum membrane	4	5
GO:0031090	organelle membrane	3	5

Expansion

Sequence features

Q4Q3S4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3S4

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0033365	protein localization to organelle	5	2
GO:0045047	protein targeting to ER	6	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0070972	protein localization to endoplasmic reticulum	6	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0072594	establishment of protein localization to organelle	4	2
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0005488	binding	1	7
GO:0005525	GTP binding	5	7
GO:0017076	purine nucleotide binding	4	7
GO:0019001	guanyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032561	guanyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003676	nucleic acid binding	3	1
GO:0003746	translation elongation factor activity	4	1
GO:0008135	translation factor activity, RNA binding	3	1
GO:0045182	translation regulator activity	1	1
GO:0090079	translation regulator activity, nucleic acid binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	321	325	PF00656	0.492
CLV_C14_Caspase3-7	34	38	PF00656	0.445
CLV_C14_Caspase3-7	425	429	PF00656	0.675
CLV_NRD_NRD_1	133	135	PF00675	0.745
CLV_NRD_NRD_1	230	232	PF00675	0.441
CLV_NRD_NRD_1	350	352	PF00675	0.376
CLV_NRD_NRD_1	370	372	PF00675	0.291
CLV_NRD_NRD_1	418	420	PF00675	0.547
CLV_NRD_NRD_1	439	441	PF00675	0.471
CLV_PCSK_KEX2_1	228	230	PF00082	0.453
CLV_PCSK_KEX2_1	350	352	PF00082	0.323
CLV_PCSK_KEX2_1	358	360	PF00082	0.262
CLV_PCSK_KEX2_1	418	420	PF00082	0.590
CLV_PCSK_KEX2_1	439	441	PF00082	0.471
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.395
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.292
CLV_PCSK_SKI1_1	108	112	PF00082	0.689
CLV_PCSK_SKI1_1	18	22	PF00082	0.644
CLV_PCSK_SKI1_1	246	250	PF00082	0.353
CLV_PCSK_SKI1_1	350	354	PF00082	0.295
CLV_PCSK_SKI1_1	371	375	PF00082	0.292
CLV_PCSK_SKI1_1	419	423	PF00082	0.547
CLV_PCSK_SKI1_1	86	90	PF00082	0.718
CLV_Separin_Metazoa	393	397	PF03568	0.417
DEG_APCC_KENBOX_2	134	138	PF00400	0.433
DEG_SPOP_SBC_1	232	236	PF00917	0.576
DOC_CKS1_1	93	98	PF01111	0.557
DOC_CYCLIN_RxL_1	348	357	PF00134	0.492
DOC_CYCLIN_RxL_1	368	375	PF00134	0.492
DOC_CYCLIN_yCln2_LP_2	459	465	PF00134	0.564
DOC_MAPK_gen_1	228	239	PF00069	0.600
DOC_MAPK_gen_1	418	424	PF00069	0.746
DOC_MAPK_MEF2A_6	233	241	PF00069	0.498
DOC_MAPK_MEF2A_6	246	253	PF00069	0.513
DOC_PP1_RVXF_1	217	224	PF00149	0.511
DOC_PP1_RVXF_1	348	355	PF00149	0.501
DOC_PP2B_LxvP_1	459	462	PF13499	0.572
DOC_USP7_MATH_1	120	124	PF00917	0.478
DOC_USP7_MATH_1	447	451	PF00917	0.743
DOC_USP7_MATH_1	63	67	PF00917	0.482
DOC_USP7_MATH_1	98	102	PF00917	0.504
DOC_USP7_UBL2_3	368	372	PF12436	0.476
DOC_WW_Pin1_4	148	153	PF00397	0.535
DOC_WW_Pin1_4	340	345	PF00397	0.492
DOC_WW_Pin1_4	89	94	PF00397	0.611
LIG_14-3-3_CanoR_1	108	117	PF00244	0.441
LIG_14-3-3_CanoR_1	190	195	PF00244	0.443
LIG_14-3-3_CanoR_1	230	239	PF00244	0.498
LIG_14-3-3_CanoR_1	263	267	PF00244	0.576
LIG_14-3-3_CanoR_1	281	291	PF00244	0.402
LIG_14-3-3_CanoR_1	411	416	PF00244	0.687
LIG_14-3-3_CanoR_1	419	425	PF00244	0.673
LIG_14-3-3_CanoR_1	69	74	PF00244	0.478
LIG_14-3-3_CanoR_1	86	93	PF00244	0.401
LIG_Actin_WH2_2	114	131	PF00022	0.432
LIG_BIR_II_1	1	5	PF00653	0.463
LIG_BRCT_BRCA1_1	342	346	PF00533	0.492
LIG_BRCT_BRCA1_1	452	456	PF00533	0.663
LIG_deltaCOP1_diTrp_1	198	201	PF00928	0.376
LIG_EH1_1	346	354	PF00400	0.492
LIG_eIF4E_1	210	216	PF01652	0.248
LIG_eIF4E_1	347	353	PF01652	0.492
LIG_FHA_1	149	155	PF00498	0.474
LIG_FHA_1	203	209	PF00498	0.453
LIG_FHA_1	232	238	PF00498	0.495
LIG_FHA_1	283	289	PF00498	0.549
LIG_FHA_2	10	16	PF00498	0.442
LIG_FHA_2	319	325	PF00498	0.576
LIG_FHA_2	355	361	PF00498	0.492
LIG_FHA_2	480	486	PF00498	0.547
LIG_GBD_Chelix_1	333	341	PF00786	0.292
LIG_HCF-1_HBM_1	476	479	PF13415	0.606
LIG_LIR_Gen_1	198	207	PF02991	0.311
LIG_LIR_Gen_1	247	254	PF02991	0.576
LIG_LIR_Gen_1	335	346	PF02991	0.508
LIG_LIR_Gen_1	453	464	PF02991	0.578
LIG_LIR_Nem_3	198	202	PF02991	0.311
LIG_LIR_Nem_3	247	253	PF02991	0.492
LIG_LIR_Nem_3	335	341	PF02991	0.514
LIG_LIR_Nem_3	343	349	PF02991	0.474
LIG_LIR_Nem_3	453	459	PF02991	0.579
LIG_MAD2	289	297	PF02301	0.576
LIG_NRBOX	332	338	PF00104	0.466
LIG_SH2_STAP1	365	369	PF00017	0.476
LIG_SH2_STAP1	479	483	PF00017	0.701
LIG_SH2_STAT5	127	130	PF00017	0.416
LIG_SH2_STAT5	210	213	PF00017	0.313
LIG_SH2_STAT5	24	27	PF00017	0.576
LIG_SH3_3	288	294	PF00018	0.503
LIG_SH3_3	90	96	PF00018	0.521
LIG_SUMO_SIM_anti_2	480	486	PF11976	0.657
LIG_SUMO_SIM_par_1	312	319	PF11976	0.499
LIG_SUMO_SIM_par_1	420	425	PF11976	0.643
LIG_TRAF2_1	41	44	PF00917	0.462
LIG_TYR_ITIM	208	213	PF00017	0.335
LIG_UBA3_1	238	246	PF00899	0.492
LIG_WRC_WIRS_1	191	196	PF05994	0.500
LIG_WW_3	436	440	PF00397	0.727
MOD_CK1_1	122	128	PF00069	0.455
MOD_CK1_1	192	198	PF00069	0.532
MOD_CK1_1	244	250	PF00069	0.492
MOD_CK1_1	262	268	PF00069	0.569
MOD_CK1_1	282	288	PF00069	0.390
MOD_CK1_1	32	38	PF00069	0.513
MOD_CK1_1	364	370	PF00069	0.476
MOD_CK1_1	381	387	PF00069	0.492
MOD_CK1_1	450	456	PF00069	0.666
MOD_CK2_1	192	198	PF00069	0.491
MOD_CK2_1	262	268	PF00069	0.476
MOD_CK2_1	38	44	PF00069	0.503
MOD_CK2_1	479	485	PF00069	0.545
MOD_CK2_1	9	15	PF00069	0.432
MOD_Cter_Amidation	132	135	PF01082	0.632
MOD_Cter_Amidation	416	419	PF01082	0.530
MOD_GlcNHglycan	1	4	PF01048	0.692
MOD_GlcNHglycan	100	103	PF01048	0.722
MOD_GlcNHglycan	124	127	PF01048	0.735
MOD_GlcNHglycan	194	197	PF01048	0.607
MOD_GlcNHglycan	202	205	PF01048	0.346
MOD_GlcNHglycan	243	246	PF01048	0.292
MOD_GlcNHglycan	268	272	PF01048	0.368
MOD_GlcNHglycan	31	34	PF01048	0.772
MOD_GlcNHglycan	408	411	PF01048	0.485
MOD_GlcNHglycan	449	452	PF01048	0.479
MOD_GlcNHglycan	49	52	PF01048	0.662
MOD_GSK3_1	148	155	PF00069	0.535
MOD_GSK3_1	65	72	PF00069	0.539
MOD_LATS_1	279	285	PF00433	0.508
MOD_LATS_1	84	90	PF00433	0.520
MOD_N-GLC_1	108	113	PF02516	0.653
MOD_N-GLC_1	282	287	PF02516	0.308
MOD_N-GLC_1	9	14	PF02516	0.642
MOD_NEK2_1	142	147	PF00069	0.416
MOD_NEK2_1	202	207	PF00069	0.453
MOD_NEK2_1	259	264	PF00069	0.492
MOD_NEK2_1	31	36	PF00069	0.460
MOD_NEK2_1	354	359	PF00069	0.510
MOD_NEK2_1	47	52	PF00069	0.482
MOD_PK_1	411	417	PF00069	0.617
MOD_PKA_1	439	445	PF00069	0.664
MOD_PKA_2	189	195	PF00069	0.507
MOD_PKA_2	232	238	PF00069	0.504
MOD_PKA_2	262	268	PF00069	0.502
MOD_PKA_2	439	445	PF00069	0.664
MOD_PKB_1	229	237	PF00069	0.601
MOD_Plk_1	108	114	PF00069	0.436
MOD_Plk_1	170	176	PF00069	0.428
MOD_Plk_1	9	15	PF00069	0.442
MOD_Plk_2-3	318	324	PF00069	0.492
MOD_Plk_4	202	208	PF00069	0.453
MOD_Plk_4	233	239	PF00069	0.492
MOD_Plk_4	9	15	PF00069	0.427
MOD_ProDKin_1	148	154	PF00069	0.536
MOD_ProDKin_1	340	346	PF00069	0.492
MOD_ProDKin_1	89	95	PF00069	0.607
MOD_SUMO_rev_2	470	480	PF00179	0.692
TRG_DiLeu_BaEn_1	43	48	PF01217	0.473
TRG_DiLeu_BaLyEn_6	348	353	PF01217	0.492
TRG_ENDOCYTIC_2	210	213	PF00928	0.335
TRG_ER_diArg_1	229	231	PF00400	0.640
TRG_ER_diArg_1	349	351	PF00400	0.576
TRG_ER_diArg_1	418	420	PF00400	0.759
TRG_ER_diArg_1	438	440	PF00400	0.662
TRG_NLS_MonoCore_2	227	232	PF00514	0.590
TRG_NLS_MonoExtC_3	227	232	PF00514	0.590
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.330
TRG_Pf-PMV_PEXEL_1	371	375	PF00026	0.292

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2X6	Leptomonas seymouri	54%	100%
A0A3S7X750	Leishmania donovani	92%	100%
A4HLX3	Leishmania braziliensis	69%	99%
A4I9A2	Leishmania infantum	92%	100%
E9B4A2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%