Putative dynein intermediate chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynein intermediate chain, putative

Species:

Leishmania major

UniProt:

Q4Q3S3_LEIMA

TriTrypDb:

LmjF.33.2630 , LMJLV39_330037400 , LMJSD75_330036700

Length:

1039

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005858	axonemal dynein complex	4	2
GO:0005875	microtubule associated complex	2	2
GO:0005930	axoneme	2	2
GO:0030286	dynein complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	3
GO:1902494	catalytic complex	2	2
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q3S3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3S3

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	2
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0045503	dynein light chain binding	3	2
GO:0045504	dynein heavy chain binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	375	379	PF00656	0.675
CLV_C14_Caspase3-7	477	481	PF00656	0.521
CLV_C14_Caspase3-7	558	562	PF00656	0.784
CLV_C14_Caspase3-7	833	837	PF00656	0.522
CLV_C14_Caspase3-7	965	969	PF00656	0.459
CLV_MEL_PAP_1	588	594	PF00089	0.469
CLV_NRD_NRD_1	1017	1019	PF00675	0.569
CLV_NRD_NRD_1	1034	1036	PF00675	0.424
CLV_NRD_NRD_1	115	117	PF00675	0.678
CLV_NRD_NRD_1	147	149	PF00675	0.762
CLV_NRD_NRD_1	187	189	PF00675	0.622
CLV_NRD_NRD_1	230	232	PF00675	0.599
CLV_NRD_NRD_1	28	30	PF00675	0.660
CLV_NRD_NRD_1	311	313	PF00675	0.544
CLV_NRD_NRD_1	610	612	PF00675	0.481
CLV_NRD_NRD_1	624	626	PF00675	0.611
CLV_NRD_NRD_1	817	819	PF00675	0.752
CLV_NRD_NRD_1	924	926	PF00675	0.423
CLV_NRD_NRD_1	982	984	PF00675	0.460
CLV_PCSK_KEX2_1	1017	1019	PF00082	0.631
CLV_PCSK_KEX2_1	115	117	PF00082	0.678
CLV_PCSK_KEX2_1	147	149	PF00082	0.720
CLV_PCSK_KEX2_1	186	188	PF00082	0.620
CLV_PCSK_KEX2_1	30	32	PF00082	0.654
CLV_PCSK_KEX2_1	610	612	PF00082	0.508
CLV_PCSK_KEX2_1	623	625	PF00082	0.559
CLV_PCSK_KEX2_1	646	648	PF00082	0.566
CLV_PCSK_KEX2_1	982	984	PF00082	0.487
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.646
CLV_PCSK_PC1ET2_1	646	648	PF00082	0.566
CLV_PCSK_SKI1_1	15	19	PF00082	0.643
CLV_PCSK_SKI1_1	231	235	PF00082	0.601
CLV_PCSK_SKI1_1	502	506	PF00082	0.790
CLV_PCSK_SKI1_1	624	628	PF00082	0.541
CLV_PCSK_SKI1_1	827	831	PF00082	0.786
DEG_COP1_1	415	423	PF00400	0.521
DEG_SPOP_SBC_1	19	23	PF00917	0.587
DEG_SPOP_SBC_1	695	699	PF00917	0.417
DOC_ANK_TNKS_1	35	42	PF00023	0.688
DOC_ANK_TNKS_1	831	838	PF00023	0.523
DOC_CKS1_1	319	324	PF01111	0.472
DOC_CKS1_1	992	997	PF01111	0.459
DOC_CYCLIN_RxL_1	621	631	PF00134	0.486
DOC_CYCLIN_yCln2_LP_2	662	668	PF00134	0.349
DOC_MAPK_gen_1	186	192	PF00069	0.613
DOC_MAPK_gen_1	231	239	PF00069	0.571
DOC_MAPK_gen_1	312	320	PF00069	0.536
DOC_MAPK_gen_1	610	618	PF00069	0.457
DOC_MAPK_gen_1	925	931	PF00069	0.455
DOC_MAPK_gen_1	979	989	PF00069	0.465
DOC_MAPK_MEF2A_6	663	672	PF00069	0.446
DOC_PP1_RVXF_1	186	193	PF00149	0.516
DOC_PP1_RVXF_1	585	591	PF00149	0.382
DOC_PP1_RVXF_1	754	761	PF00149	0.350
DOC_PP1_RVXF_1	895	901	PF00149	0.328
DOC_PP4_FxxP_1	592	595	PF00568	0.482
DOC_PP4_FxxP_1	687	690	PF00568	0.390
DOC_USP7_MATH_1	268	272	PF00917	0.465
DOC_USP7_MATH_1	299	303	PF00917	0.544
DOC_USP7_MATH_1	531	535	PF00917	0.647
DOC_USP7_MATH_1	571	575	PF00917	0.608
DOC_USP7_MATH_1	694	698	PF00917	0.397
DOC_USP7_MATH_1	799	803	PF00917	0.509
DOC_USP7_UBL2_3	810	814	PF12436	0.682
DOC_USP7_UBL2_3	819	823	PF12436	0.692
DOC_WW_Pin1_4	179	184	PF00397	0.704
DOC_WW_Pin1_4	239	244	PF00397	0.506
DOC_WW_Pin1_4	318	323	PF00397	0.452
DOC_WW_Pin1_4	493	498	PF00397	0.771
DOC_WW_Pin1_4	50	55	PF00397	0.618
DOC_WW_Pin1_4	517	522	PF00397	0.648
DOC_WW_Pin1_4	564	569	PF00397	0.671
DOC_WW_Pin1_4	591	596	PF00397	0.491
DOC_WW_Pin1_4	636	641	PF00397	0.452
DOC_WW_Pin1_4	898	903	PF00397	0.362
DOC_WW_Pin1_4	991	996	PF00397	0.410
LIG_14-3-3_CanoR_1	115	120	PF00244	0.729
LIG_14-3-3_CanoR_1	171	177	PF00244	0.713
LIG_14-3-3_CanoR_1	207	211	PF00244	0.711
LIG_14-3-3_CanoR_1	231	239	PF00244	0.571
LIG_14-3-3_CanoR_1	269	276	PF00244	0.642
LIG_14-3-3_CanoR_1	502	511	PF00244	0.671
LIG_14-3-3_CanoR_1	581	589	PF00244	0.545
LIG_14-3-3_CanoR_1	60	64	PF00244	0.735
LIG_14-3-3_CanoR_1	635	643	PF00244	0.475
LIG_14-3-3_CanoR_1	8	12	PF00244	0.640
LIG_14-3-3_CanoR_1	930	935	PF00244	0.444
LIG_14-3-3_CanoR_1	982	989	PF00244	0.362
LIG_14-3-3_CterR_2	1035	1039	PF00244	0.412
LIG_BIR_III_2	576	580	PF00653	0.512
LIG_BIR_III_4	357	361	PF00653	0.668
LIG_BRCT_BRCA1_1	108	112	PF00533	0.563
LIG_BRCT_BRCA1_1	162	166	PF00533	0.656
LIG_BRCT_BRCA1_1	188	192	PF00533	0.519
LIG_FHA_1	232	238	PF00498	0.548
LIG_FHA_1	240	246	PF00498	0.486
LIG_FHA_1	262	268	PF00498	0.547
LIG_FHA_1	289	295	PF00498	0.540
LIG_FHA_1	354	360	PF00498	0.491
LIG_FHA_1	425	431	PF00498	0.719
LIG_FHA_1	443	449	PF00498	0.377
LIG_FHA_1	697	703	PF00498	0.368
LIG_FHA_1	727	733	PF00498	0.389
LIG_FHA_1	91	97	PF00498	0.654
LIG_FHA_1	914	920	PF00498	0.363
LIG_FHA_1	945	951	PF00498	0.442
LIG_FHA_1	992	998	PF00498	0.400
LIG_FHA_2	1020	1026	PF00498	0.455
LIG_FHA_2	207	213	PF00498	0.656
LIG_FHA_2	21	27	PF00498	0.580
LIG_FHA_2	221	227	PF00498	0.523
LIG_FHA_2	341	347	PF00498	0.638
LIG_FHA_2	475	481	PF00498	0.518
LIG_FHA_2	556	562	PF00498	0.787
LIG_FHA_2	84	90	PF00498	0.563
LIG_FHA_2	963	969	PF00498	0.465
LIG_GBD_Chelix_1	438	446	PF00786	0.527
LIG_Integrin_RGD_1	1018	1020	PF01839	0.485
LIG_LIR_Apic_2	178	183	PF02991	0.611
LIG_LIR_Apic_2	213	219	PF02991	0.604
LIG_LIR_Apic_2	686	690	PF02991	0.378
LIG_LIR_Gen_1	271	280	PF02991	0.553
LIG_LIR_Gen_1	951	957	PF02991	0.391
LIG_LIR_Gen_1	962	972	PF02991	0.401
LIG_LIR_LC3C_4	994	999	PF02991	0.442
LIG_LIR_Nem_3	174	180	PF02991	0.502
LIG_LIR_Nem_3	271	276	PF02991	0.522
LIG_LIR_Nem_3	951	955	PF02991	0.412
LIG_Pex14_1	641	645	PF04695	0.437
LIG_Rb_LxCxE_1	92	114	PF01857	0.583
LIG_RPA_C_Fungi	605	617	PF08784	0.404
LIG_SH2_CRK	180	184	PF00017	0.571
LIG_SH2_CRK	465	469	PF00017	0.435
LIG_SH2_NCK_1	180	184	PF00017	0.571
LIG_SH2_NCK_1	273	277	PF00017	0.530
LIG_SH2_NCK_1	903	907	PF00017	0.426
LIG_SH2_PTP2	216	219	PF00017	0.524
LIG_SH2_SRC	216	219	PF00017	0.562
LIG_SH2_STAP1	884	888	PF00017	0.414
LIG_SH2_STAP1	903	907	PF00017	0.367
LIG_SH2_STAT3	248	251	PF00017	0.534
LIG_SH2_STAT3	705	708	PF00017	0.459
LIG_SH2_STAT5	216	219	PF00017	0.574
LIG_SH2_STAT5	329	332	PF00017	0.354
LIG_SH2_STAT5	620	623	PF00017	0.484
LIG_SH2_STAT5	673	676	PF00017	0.466
LIG_SH2_STAT5	864	867	PF00017	0.326
LIG_SH2_STAT5	907	910	PF00017	0.309
LIG_SH3_3	215	221	PF00018	0.647
LIG_SH3_3	304	310	PF00018	0.609
LIG_SH3_3	504	510	PF00018	0.675
LIG_SH3_3	520	526	PF00018	0.663
LIG_SH3_3	662	668	PF00018	0.349
LIG_SH3_3	708	714	PF00018	0.498
LIG_SH3_4	819	826	PF00018	0.577
LIG_SUMO_SIM_anti_2	993	1003	PF11976	0.432
LIG_SUMO_SIM_par_1	234	242	PF11976	0.507
LIG_SUMO_SIM_par_1	691	699	PF11976	0.393
LIG_SUMO_SIM_par_1	993	1003	PF11976	0.401
LIG_TRAF2_1	24	27	PF00917	0.662
LIG_TRAF2_1	275	278	PF00917	0.559
LIG_TRAF2_1	343	346	PF00917	0.601
LIG_TRAF2_1	839	842	PF00917	0.618
LIG_TRAF2_1	86	89	PF00917	0.624
LIG_TRAF2_1	990	993	PF00917	0.430
LIG_TYR_ITIM	463	468	PF00017	0.412
MOD_CDK_SPxxK_3	179	186	PF00069	0.572
MOD_CK1_1	114	120	PF00069	0.651
MOD_CK1_1	132	138	PF00069	0.605
MOD_CK1_1	156	162	PF00069	0.591
MOD_CK1_1	21	27	PF00069	0.685
MOD_CK1_1	302	308	PF00069	0.552
MOD_CK1_1	399	405	PF00069	0.782
MOD_CK1_1	4	10	PF00069	0.718
MOD_CK1_1	421	427	PF00069	0.677
MOD_CK1_1	76	82	PF00069	0.639
MOD_CK1_1	802	808	PF00069	0.491
MOD_CK1_1	901	907	PF00069	0.336
MOD_CK2_1	1019	1025	PF00069	0.492
MOD_CK2_1	20	26	PF00069	0.731
MOD_CK2_1	206	212	PF00069	0.731
MOD_CK2_1	220	226	PF00069	0.478
MOD_CK2_1	340	346	PF00069	0.632
MOD_CK2_1	695	701	PF00069	0.442
MOD_CK2_1	728	734	PF00069	0.488
MOD_CK2_1	79	85	PF00069	0.692
MOD_CK2_1	876	882	PF00069	0.408
MOD_CK2_1	887	893	PF00069	0.372
MOD_Cter_Amidation	145	148	PF01082	0.662
MOD_Cter_Amidation	811	814	PF01082	0.649
MOD_GlcNHglycan	142	145	PF01048	0.736
MOD_GlcNHglycan	177	180	PF01048	0.635
MOD_GlcNHglycan	314	317	PF01048	0.534
MOD_GlcNHglycan	415	418	PF01048	0.712
MOD_GlcNHglycan	420	423	PF01048	0.683
MOD_GlcNHglycan	489	492	PF01048	0.690
MOD_GlcNHglycan	547	550	PF01048	0.633
MOD_GlcNHglycan	568	571	PF01048	0.737
MOD_GlcNHglycan	75	78	PF01048	0.688
MOD_GlcNHglycan	751	754	PF01048	0.368
MOD_GlcNHglycan	801	804	PF01048	0.742
MOD_GlcNHglycan	823	826	PF01048	0.644
MOD_GlcNHglycan	832	835	PF01048	0.772
MOD_GlcNHglycan	903	906	PF01048	0.430
MOD_GlcNHglycan	911	914	PF01048	0.315
MOD_GlcNHglycan	984	987	PF01048	0.420
MOD_GSK3_1	101	108	PF00069	0.606
MOD_GSK3_1	110	117	PF00069	0.642
MOD_GSK3_1	120	127	PF00069	0.754
MOD_GSK3_1	129	136	PF00069	0.645
MOD_GSK3_1	153	160	PF00069	0.593
MOD_GSK3_1	17	24	PF00069	0.509
MOD_GSK3_1	175	182	PF00069	0.644
MOD_GSK3_1	2	9	PF00069	0.610
MOD_GSK3_1	233	240	PF00069	0.545
MOD_GSK3_1	279	286	PF00069	0.631
MOD_GSK3_1	288	295	PF00069	0.619
MOD_GSK3_1	392	399	PF00069	0.684
MOD_GSK3_1	401	408	PF00069	0.718
MOD_GSK3_1	438	445	PF00069	0.457
MOD_GSK3_1	513	520	PF00069	0.692
MOD_GSK3_1	591	598	PF00069	0.497
MOD_GSK3_1	72	79	PF00069	0.704
MOD_GSK3_1	821	828	PF00069	0.675
MOD_GSK3_1	865	872	PF00069	0.352
MOD_GSK3_1	874	881	PF00069	0.388
MOD_GSK3_1	909	916	PF00069	0.330
MOD_GSK3_1	944	951	PF00069	0.344
MOD_N-GLC_1	386	391	PF02516	0.614
MOD_N-GLC_1	492	497	PF02516	0.537
MOD_N-GLC_1	50	55	PF02516	0.673
MOD_NEK2_1	1	6	PF00069	0.719
MOD_NEK2_1	101	106	PF00069	0.563
MOD_NEK2_1	1011	1016	PF00069	0.609
MOD_NEK2_1	110	115	PF00069	0.569
MOD_NEK2_1	124	129	PF00069	0.747
MOD_NEK2_1	157	162	PF00069	0.578
MOD_NEK2_1	288	293	PF00069	0.602
MOD_NEK2_1	413	418	PF00069	0.620
MOD_NEK2_1	438	443	PF00069	0.474
MOD_NEK2_1	73	78	PF00069	0.646
MOD_NEK2_1	747	752	PF00069	0.369
MOD_NEK2_1	874	879	PF00069	0.472
MOD_NEK2_2	1004	1009	PF00069	0.371
MOD_NEK2_2	292	297	PF00069	0.565
MOD_NEK2_2	513	518	PF00069	0.598
MOD_NEK2_2	658	663	PF00069	0.342
MOD_PIKK_1	125	131	PF00454	0.740
MOD_PIKK_1	283	289	PF00454	0.576
MOD_PIKK_1	340	346	PF00454	0.602
MOD_PIKK_1	555	561	PF00454	0.571
MOD_PIKK_1	818	824	PF00454	0.672
MOD_PIKK_1	84	90	PF00454	0.665
MOD_PIKK_1	876	882	PF00454	0.408
MOD_PK_1	186	192	PF00069	0.581
MOD_PK_1	930	936	PF00069	0.480
MOD_PKA_1	115	121	PF00069	0.676
MOD_PKA_1	186	192	PF00069	0.622
MOD_PKA_1	231	237	PF00069	0.568
MOD_PKA_1	312	318	PF00069	0.547
MOD_PKA_1	610	616	PF00069	0.421
MOD_PKA_1	818	824	PF00069	0.626
MOD_PKA_1	982	988	PF00069	0.443
MOD_PKA_2	114	120	PF00069	0.675
MOD_PKA_2	146	152	PF00069	0.768
MOD_PKA_2	170	176	PF00069	0.617
MOD_PKA_2	186	192	PF00069	0.573
MOD_PKA_2	206	212	PF00069	0.713
MOD_PKA_2	268	274	PF00069	0.566
MOD_PKA_2	580	586	PF00069	0.475
MOD_PKA_2	59	65	PF00069	0.731
MOD_PKA_2	610	616	PF00069	0.429
MOD_PKA_2	634	640	PF00069	0.668
MOD_PKA_2	7	13	PF00069	0.783
MOD_PKA_2	982	988	PF00069	0.384
MOD_Plk_1	1004	1010	PF00069	0.332
MOD_Plk_1	157	163	PF00069	0.613
MOD_Plk_1	212	218	PF00069	0.595
MOD_Plk_1	276	282	PF00069	0.549
MOD_Plk_1	678	684	PF00069	0.423
MOD_Plk_1	840	846	PF00069	0.449
MOD_Plk_2-3	153	159	PF00069	0.644
MOD_Plk_2-3	962	968	PF00069	0.401
MOD_Plk_4	1004	1010	PF00069	0.366
MOD_Plk_4	101	107	PF00069	0.628
MOD_Plk_4	1011	1017	PF00069	0.432
MOD_Plk_4	206	212	PF00069	0.649
MOD_Plk_4	233	239	PF00069	0.532
MOD_Plk_4	241	247	PF00069	0.541
MOD_Plk_4	393	399	PF00069	0.716
MOD_Plk_4	438	444	PF00069	0.438
MOD_Plk_4	59	65	PF00069	0.750
MOD_Plk_4	688	694	PF00069	0.358
MOD_Plk_4	728	734	PF00069	0.462
MOD_Plk_4	840	846	PF00069	0.710
MOD_Plk_4	869	875	PF00069	0.438
MOD_ProDKin_1	179	185	PF00069	0.703
MOD_ProDKin_1	239	245	PF00069	0.504
MOD_ProDKin_1	318	324	PF00069	0.445
MOD_ProDKin_1	493	499	PF00069	0.772
MOD_ProDKin_1	50	56	PF00069	0.620
MOD_ProDKin_1	517	523	PF00069	0.647
MOD_ProDKin_1	564	570	PF00069	0.667
MOD_ProDKin_1	591	597	PF00069	0.486
MOD_ProDKin_1	636	642	PF00069	0.450
MOD_ProDKin_1	898	904	PF00069	0.359
MOD_ProDKin_1	991	997	PF00069	0.403
MOD_SUMO_rev_2	539	549	PF00179	0.601
TRG_DiLeu_BaEn_1	584	589	PF01217	0.495
TRG_DiLeu_BaEn_1	688	693	PF01217	0.398
TRG_DiLeu_BaEn_1	993	998	PF01217	0.461
TRG_DiLeu_BaEn_2	742	748	PF01217	0.466
TRG_DiLeu_BaLyEn_6	622	627	PF01217	0.422
TRG_DiLeu_LyEn_5	584	589	PF01217	0.458
TRG_ENDOCYTIC_2	273	276	PF00928	0.469
TRG_ENDOCYTIC_2	465	468	PF00928	0.422
TRG_ER_diArg_1	1016	1018	PF00400	0.580
TRG_ER_diArg_1	185	188	PF00400	0.618
TRG_ER_diArg_1	28	31	PF00400	0.664
TRG_ER_diArg_1	623	625	PF00400	0.522
TRG_ER_diArg_1	896	899	PF00400	0.358
TRG_ER_diArg_1	982	984	PF00400	0.464
TRG_NLS_MonoExtC_3	28	34	PF00514	0.645
TRG_Pf-PMV_PEXEL_1	624	629	PF00026	0.629

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P550	Leptomonas seymouri	56%	100%
A0A0S4IZG4	Bodo saltans	36%	100%
A0A3S7X748	Leishmania donovani	90%	96%
A4HLX4	Leishmania braziliensis	74%	81%
A4I9A3	Leishmania infantum	90%	96%
C9ZJC3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B4A3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%