LIM zinc-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3S2_LEIMA

TriTrypDb:

LmjF.33.2640 , LMJLV39_330037500 , LMJSD75_330036800

Length:

386

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3S2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3S2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.608
CLV_C14_Caspase3-7	345	349	PF00656	0.635
CLV_C14_Caspase3-7	49	53	PF00656	0.763
CLV_NRD_NRD_1	204	206	PF00675	0.616
CLV_NRD_NRD_1	225	227	PF00675	0.534
CLV_NRD_NRD_1	290	292	PF00675	0.696
CLV_NRD_NRD_1	339	341	PF00675	0.608
CLV_NRD_NRD_1	368	370	PF00675	0.819
CLV_PCSK_FUR_1	288	292	PF00082	0.673
CLV_PCSK_KEX2_1	131	133	PF00082	0.632
CLV_PCSK_KEX2_1	204	206	PF00082	0.616
CLV_PCSK_KEX2_1	225	227	PF00082	0.533
CLV_PCSK_KEX2_1	290	292	PF00082	0.696
CLV_PCSK_KEX2_1	339	341	PF00082	0.640
CLV_PCSK_KEX2_1	368	370	PF00082	0.620
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.731
CLV_PCSK_SKI1_1	40	44	PF00082	0.730
DEG_APCC_DBOX_1	179	187	PF00400	0.591
DEG_Nend_UBRbox_1	1	4	PF02207	0.500
DEG_SPOP_SBC_1	60	64	PF00917	0.778
DOC_CYCLIN_yCln2_LP_2	81	87	PF00134	0.574
DOC_MAPK_gen_1	170	177	PF00069	0.553
DOC_MAPK_gen_1	288	297	PF00069	0.736
DOC_PP2B_LxvP_1	58	61	PF13499	0.535
DOC_PP2B_LxvP_1	81	84	PF13499	0.637
DOC_USP7_MATH_1	207	211	PF00917	0.508
DOC_USP7_MATH_1	240	244	PF00917	0.483
DOC_USP7_MATH_1	59	63	PF00917	0.679
DOC_USP7_MATH_1	98	102	PF00917	0.694
DOC_WW_Pin1_4	112	117	PF00397	0.809
DOC_WW_Pin1_4	359	364	PF00397	0.702
LIG_14-3-3_CanoR_1	111	116	PF00244	0.780
LIG_14-3-3_CanoR_1	117	125	PF00244	0.606
LIG_14-3-3_CanoR_1	282	292	PF00244	0.709
LIG_14-3-3_CanoR_1	327	337	PF00244	0.647
LIG_14-3-3_CanoR_1	369	375	PF00244	0.704
LIG_BRCT_BRCA1_1	132	136	PF00533	0.696
LIG_BRCT_BRCA1_1	209	213	PF00533	0.451
LIG_BRCT_BRCA1_1	63	67	PF00533	0.734
LIG_CtBP_PxDLS_1	316	320	PF00389	0.657
LIG_FHA_1	371	377	PF00498	0.753
LIG_FHA_1	55	61	PF00498	0.729
LIG_FHA_1	80	86	PF00498	0.756
LIG_FHA_2	159	165	PF00498	0.572
LIG_FHA_2	267	273	PF00498	0.662
LIG_FHA_2	343	349	PF00498	0.634
LIG_Integrin_RGD_1	270	272	PF01839	0.740
LIG_LIR_Gen_1	141	150	PF02991	0.642
LIG_LIR_Gen_1	272	279	PF02991	0.627
LIG_LIR_Gen_1	334	343	PF02991	0.616
LIG_LIR_Nem_3	141	147	PF02991	0.644
LIG_LIR_Nem_3	272	277	PF02991	0.613
LIG_MLH1_MIPbox_1	209	213	PF16413	0.490
LIG_SH2_CRK	144	148	PF00017	0.687
LIG_SH2_CRK	159	163	PF00017	0.489
LIG_SH2_CRK	179	183	PF00017	0.324
LIG_SH2_NCK_1	144	148	PF00017	0.630
LIG_SH2_NCK_1	274	278	PF00017	0.591
LIG_SH2_STAP1	144	148	PF00017	0.630
LIG_SH2_STAP1	250	254	PF00017	0.567
LIG_SH2_STAP1	93	97	PF00017	0.789
LIG_SH2_STAT3	343	346	PF00017	0.629
LIG_SH2_STAT5	184	187	PF00017	0.689
LIG_SH2_STAT5	190	193	PF00017	0.295
LIG_SH2_STAT5	221	224	PF00017	0.439
LIG_SH2_STAT5	233	236	PF00017	0.463
LIG_SH2_STAT5	344	347	PF00017	0.625
LIG_SH3_2	199	204	PF14604	0.629
LIG_SH3_3	104	110	PF00018	0.765
LIG_SH3_3	186	192	PF00018	0.620
LIG_SH3_3	196	202	PF00018	0.515
LIG_SH3_3	8	14	PF00018	0.740
LIG_SUMO_SIM_par_1	56	64	PF11976	0.556
LIG_TRAF2_1	255	258	PF00917	0.572
MOD_CDK_SPK_2	112	117	PF00069	0.735
MOD_CK1_1	101	107	PF00069	0.702
MOD_CK1_1	151	157	PF00069	0.692
MOD_CK1_1	30	36	PF00069	0.590
MOD_CK1_1	331	337	PF00069	0.724
MOD_CK1_1	362	368	PF00069	0.776
MOD_CK1_1	68	74	PF00069	0.732
MOD_CK2_1	158	164	PF00069	0.575
MOD_Cter_Amidation	223	226	PF01082	0.492
MOD_Cter_Amidation	366	369	PF01082	0.753
MOD_GlcNHglycan	120	123	PF01048	0.615
MOD_GlcNHglycan	150	153	PF01048	0.685
MOD_GlcNHglycan	29	32	PF01048	0.702
MOD_GlcNHglycan	330	333	PF01048	0.702
MOD_GlcNHglycan	357	360	PF01048	0.731
MOD_GlcNHglycan	48	51	PF01048	0.580
MOD_GlcNHglycan	94	97	PF01048	0.747
MOD_GSK3_1	112	119	PF00069	0.798
MOD_GSK3_1	291	298	PF00069	0.718
MOD_GSK3_1	327	334	PF00069	0.614
MOD_GSK3_1	355	362	PF00069	0.785
MOD_GSK3_1	61	68	PF00069	0.781
MOD_LATS_1	325	331	PF00433	0.657
MOD_N-GLC_1	142	147	PF02516	0.640
MOD_N-GLC_1	328	333	PF02516	0.704
MOD_N-GLC_1	71	76	PF02516	0.688
MOD_N-GLC_2	194	196	PF02516	0.598
MOD_NEK2_1	1	6	PF00069	0.555
MOD_NEK2_1	65	70	PF00069	0.714
MOD_NEK2_2	207	212	PF00069	0.502
MOD_PIKK_1	18	24	PF00454	0.594
MOD_PIKK_1	342	348	PF00454	0.627
MOD_PIKK_1	65	71	PF00454	0.720
MOD_PKA_1	369	375	PF00069	0.706
MOD_PKA_2	110	116	PF00069	0.739
MOD_PKA_2	224	230	PF00069	0.642
MOD_PKA_2	378	384	PF00069	0.697
MOD_Plk_1	142	148	PF00069	0.714
MOD_Plk_4	143	149	PF00069	0.580
MOD_Plk_4	207	213	PF00069	0.493
MOD_Plk_4	3	9	PF00069	0.766
MOD_Plk_4	61	67	PF00069	0.765
MOD_ProDKin_1	112	118	PF00069	0.804
MOD_ProDKin_1	359	365	PF00069	0.704
MOD_SUMO_for_1	42	45	PF00179	0.686
TRG_ENDOCYTIC_2	144	147	PF00928	0.693
TRG_ENDOCYTIC_2	159	162	PF00928	0.483
TRG_ENDOCYTIC_2	233	236	PF00928	0.499
TRG_ENDOCYTIC_2	274	277	PF00928	0.620
TRG_ER_diArg_1	169	172	PF00400	0.591
TRG_ER_diArg_1	203	205	PF00400	0.645
TRG_ER_diArg_1	288	291	PF00400	0.739
TRG_ER_diArg_1	338	340	PF00400	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCS1	Leptomonas seymouri	54%	99%
A0A3S7X718	Leishmania donovani	88%	90%
A4HLX5	Leishmania braziliensis	65%	100%
A4I9A4	Leishmania infantum	88%	90%
E9B4A4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	90%