CCHC-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3S0_LEIMA

TriTrypDb:

LmjF.33.2660 , LMJLV39_330037700 , LMJSD75_330037000 , LMJSD75_330037100

Length:

1166

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3S0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3S0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1161	1165	PF00656	0.692
CLV_C14_Caspase3-7	54	58	PF00656	0.523
CLV_C14_Caspase3-7	609	613	PF00656	0.705
CLV_C14_Caspase3-7	892	896	PF00656	0.748
CLV_NRD_NRD_1	1012	1014	PF00675	0.775
CLV_NRD_NRD_1	1107	1109	PF00675	0.640
CLV_NRD_NRD_1	1148	1150	PF00675	0.760
CLV_NRD_NRD_1	1152	1154	PF00675	0.775
CLV_NRD_NRD_1	120	122	PF00675	0.537
CLV_NRD_NRD_1	183	185	PF00675	0.491
CLV_NRD_NRD_1	220	222	PF00675	0.669
CLV_NRD_NRD_1	376	378	PF00675	0.735
CLV_NRD_NRD_1	559	561	PF00675	0.512
CLV_NRD_NRD_1	59	61	PF00675	0.543
CLV_NRD_NRD_1	773	775	PF00675	0.705
CLV_NRD_NRD_1	975	977	PF00675	0.640
CLV_NRD_NRD_1	982	984	PF00675	0.626
CLV_PCSK_FUR_1	1149	1153	PF00082	0.712
CLV_PCSK_FUR_1	374	378	PF00082	0.672
CLV_PCSK_KEX2_1	1012	1014	PF00082	0.775
CLV_PCSK_KEX2_1	1148	1150	PF00082	0.769
CLV_PCSK_KEX2_1	1151	1153	PF00082	0.779
CLV_PCSK_KEX2_1	120	122	PF00082	0.537
CLV_PCSK_KEX2_1	183	185	PF00082	0.465
CLV_PCSK_KEX2_1	219	221	PF00082	0.670
CLV_PCSK_KEX2_1	376	378	PF00082	0.737
CLV_PCSK_KEX2_1	559	561	PF00082	0.450
CLV_PCSK_KEX2_1	59	61	PF00082	0.543
CLV_PCSK_KEX2_1	773	775	PF00082	0.705
CLV_PCSK_KEX2_1	982	984	PF00082	0.657
CLV_PCSK_PC7_1	1148	1154	PF00082	0.697
CLV_PCSK_SKI1_1	1128	1132	PF00082	0.745
CLV_PCSK_SKI1_1	206	210	PF00082	0.636
CLV_PCSK_SKI1_1	30	34	PF00082	0.521
CLV_PCSK_SKI1_1	473	477	PF00082	0.536
CLV_PCSK_SKI1_1	542	546	PF00082	0.543
CLV_PCSK_SKI1_1	631	635	PF00082	0.660
CLV_PCSK_SKI1_1	819	823	PF00082	0.583
DEG_APCC_DBOX_1	222	230	PF00400	0.612
DEG_APCC_DBOX_1	308	316	PF00400	0.680
DEG_APCC_DBOX_1	536	544	PF00400	0.559
DEG_SIAH_1	945	953	PF03145	0.519
DEG_SPOP_SBC_1	1022	1026	PF00917	0.702
DOC_ANK_TNKS_1	453	460	PF00023	0.553
DOC_ANK_TNKS_1	773	780	PF00023	0.717
DOC_CDC14_PxL_1	640	648	PF14671	0.773
DOC_CYCLIN_RxL_1	537	549	PF00134	0.557
DOC_CYCLIN_RxL_1	861	872	PF00134	0.677
DOC_CYCLIN_yCln2_LP_2	634	640	PF00134	0.675
DOC_MAPK_gen_1	1052	1060	PF00069	0.597
DOC_MAPK_gen_1	1148	1158	PF00069	0.726
DOC_MAPK_gen_1	138	145	PF00069	0.545
DOC_MAPK_gen_1	384	392	PF00069	0.623
DOC_MAPK_MEF2A_6	1052	1060	PF00069	0.597
DOC_MAPK_MEF2A_6	346	355	PF00069	0.505
DOC_MAPK_MEF2A_6	4	11	PF00069	0.581
DOC_MAPK_MEF2A_6	815	824	PF00069	0.491
DOC_PP2B_LxvP_1	355	358	PF13499	0.560
DOC_PP2B_LxvP_1	866	869	PF13499	0.805
DOC_PP4_FxxP_1	316	319	PF00568	0.591
DOC_PP4_FxxP_1	581	584	PF00568	0.706
DOC_USP7_MATH_1	1004	1008	PF00917	0.676
DOC_USP7_MATH_1	1031	1035	PF00917	0.700
DOC_USP7_MATH_1	113	117	PF00917	0.465
DOC_USP7_MATH_1	188	192	PF00917	0.635
DOC_USP7_MATH_1	19	23	PF00917	0.655
DOC_USP7_MATH_1	50	54	PF00917	0.399
DOC_USP7_MATH_1	528	532	PF00917	0.726
DOC_USP7_MATH_1	547	551	PF00917	0.560
DOC_USP7_MATH_1	582	586	PF00917	0.684
DOC_USP7_MATH_1	621	625	PF00917	0.714
DOC_USP7_MATH_1	658	662	PF00917	0.707
DOC_USP7_MATH_1	72	76	PF00917	0.787
DOC_USP7_MATH_1	778	782	PF00917	0.781
DOC_USP7_MATH_1	90	94	PF00917	0.465
DOC_USP7_MATH_1	938	942	PF00917	0.783
DOC_USP7_MATH_1	970	974	PF00917	0.703
DOC_WW_Pin1_4	1018	1023	PF00397	0.723
DOC_WW_Pin1_4	1027	1032	PF00397	0.620
DOC_WW_Pin1_4	145	150	PF00397	0.508
DOC_WW_Pin1_4	320	325	PF00397	0.685
DOC_WW_Pin1_4	395	400	PF00397	0.636
DOC_WW_Pin1_4	506	511	PF00397	0.720
DOC_WW_Pin1_4	532	537	PF00397	0.588
DOC_WW_Pin1_4	936	941	PF00397	0.618
LIG_14-3-3_CanoR_1	1128	1137	PF00244	0.746
LIG_14-3-3_CanoR_1	1138	1147	PF00244	0.788
LIG_14-3-3_CanoR_1	1151	1157	PF00244	0.718
LIG_14-3-3_CanoR_1	187	195	PF00244	0.675
LIG_14-3-3_CanoR_1	24	32	PF00244	0.654
LIG_14-3-3_CanoR_1	259	265	PF00244	0.650
LIG_14-3-3_CanoR_1	311	316	PF00244	0.529
LIG_14-3-3_CanoR_1	350	356	PF00244	0.470
LIG_14-3-3_CanoR_1	374	383	PF00244	0.821
LIG_14-3-3_CanoR_1	384	389	PF00244	0.474
LIG_14-3-3_CanoR_1	471	480	PF00244	0.517
LIG_14-3-3_CanoR_1	627	634	PF00244	0.682
LIG_14-3-3_CanoR_1	67	77	PF00244	0.622
LIG_14-3-3_CanoR_1	724	734	PF00244	0.691
LIG_14-3-3_CanoR_1	794	802	PF00244	0.593
LIG_14-3-3_CanoR_1	993	1002	PF00244	0.660
LIG_Actin_WH2_2	417	433	PF00022	0.588
LIG_Actin_WH2_2	457	475	PF00022	0.527
LIG_Actin_WH2_2	536	554	PF00022	0.651
LIG_Actin_WH2_2	817	833	PF00022	0.626
LIG_BIR_III_2	720	724	PF00653	0.536
LIG_BRCT_BRCA1_1	235	239	PF00533	0.558
LIG_BRCT_BRCA1_1	327	331	PF00533	0.746
LIG_BRCT_BRCA1_1	388	392	PF00533	0.485
LIG_BRCT_BRCA1_1	510	514	PF00533	0.647
LIG_BRCT_BRCA1_1	943	947	PF00533	0.795
LIG_FHA_1	1044	1050	PF00498	0.600
LIG_FHA_1	165	171	PF00498	0.563
LIG_FHA_1	228	234	PF00498	0.508
LIG_FHA_1	43	49	PF00498	0.579
LIG_FHA_1	628	634	PF00498	0.773
LIG_FHA_1	94	100	PF00498	0.495
LIG_FHA_2	146	152	PF00498	0.476
LIG_FHA_2	410	416	PF00498	0.520
LIG_FHA_2	474	480	PF00498	0.503
LIG_FHA_2	807	813	PF00498	0.719
LIG_FHA_2	898	904	PF00498	0.629
LIG_HP1_1	108	112	PF01393	0.466
LIG_IBAR_NPY_1	210	212	PF08397	0.625
LIG_LIR_Apic_2	314	319	PF02991	0.651
LIG_LIR_Gen_1	389	399	PF02991	0.370
LIG_LIR_Gen_1	944	955	PF02991	0.515
LIG_LIR_Nem_3	167	171	PF02991	0.438
LIG_LIR_Nem_3	271	277	PF02991	0.481
LIG_LIR_Nem_3	389	395	PF02991	0.476
LIG_LIR_Nem_3	944	950	PF02991	0.538
LIG_PCNA_yPIPBox_3	279	292	PF02747	0.510
LIG_RPA_C_Fungi	959	971	PF08784	0.686
LIG_SH2_CRK	168	172	PF00017	0.462
LIG_SH2_PTP2	109	112	PF00017	0.466
LIG_SH2_STAP1	562	566	PF00017	0.485
LIG_SH2_STAT3	600	603	PF00017	0.553
LIG_SH2_STAT3	922	925	PF00017	0.527
LIG_SH2_STAT5	1050	1053	PF00017	0.624
LIG_SH2_STAT5	109	112	PF00017	0.466
LIG_SH2_STAT5	185	188	PF00017	0.562
LIG_SH2_STAT5	212	215	PF00017	0.582
LIG_SH2_STAT5	291	294	PF00017	0.609
LIG_SH2_STAT5	436	439	PF00017	0.573
LIG_SH2_STAT5	628	631	PF00017	0.673
LIG_SH2_STAT5	734	737	PF00017	0.468
LIG_SH2_STAT5	834	837	PF00017	0.620
LIG_SH2_STAT5	989	992	PF00017	0.609
LIG_SH3_2	802	807	PF14604	0.584
LIG_SH3_3	1016	1022	PF00018	0.549
LIG_SH3_3	107	113	PF00018	0.478
LIG_SH3_3	1084	1090	PF00018	0.587
LIG_SH3_3	369	375	PF00018	0.684
LIG_SH3_3	377	383	PF00018	0.655
LIG_SH3_3	478	484	PF00018	0.493
LIG_SH3_3	507	513	PF00018	0.601
LIG_SH3_3	533	539	PF00018	0.521
LIG_SH3_3	576	582	PF00018	0.644
LIG_SH3_3	727	733	PF00018	0.686
LIG_SH3_3	799	805	PF00018	0.727
LIG_SH3_3	811	817	PF00018	0.507
LIG_SH3_3	84	90	PF00018	0.603
LIG_SH3_3	874	880	PF00018	0.735
LIG_SH3_3	946	952	PF00018	0.766
LIG_SUMO_SIM_anti_2	851	858	PF11976	0.659
LIG_SUMO_SIM_par_1	141	146	PF11976	0.474
LIG_SUMO_SIM_par_1	393	398	PF11976	0.513
LIG_SUMO_SIM_par_1	563	569	PF11976	0.525
LIG_TRAF2_1	445	448	PF00917	0.482
LIG_TRAF2_1	476	479	PF00917	0.495
LIG_TRAF2_1	737	740	PF00917	0.717
LIG_TRAF2_2	195	200	PF00917	0.620
LIG_TYR_ITIM	107	112	PF00017	0.342
LIG_UBA3_1	1038	1042	PF00899	0.483
LIG_UBA3_1	544	552	PF00899	0.466
LIG_WW_3	804	808	PF00397	0.580
MOD_CDK_SPK_2	395	400	PF00069	0.636
MOD_CDK_SPK_2	532	537	PF00069	0.492
MOD_CK1_1	1021	1027	PF00069	0.734
MOD_CK1_1	22	28	PF00069	0.636
MOD_CK1_1	314	320	PF00069	0.691
MOD_CK1_1	46	52	PF00069	0.442
MOD_CK1_1	506	512	PF00069	0.678
MOD_CK1_1	530	536	PF00069	0.667
MOD_CK1_1	688	694	PF00069	0.702
MOD_CK1_1	70	76	PF00069	0.726
MOD_CK1_1	713	719	PF00069	0.733
MOD_CK1_1	749	755	PF00069	0.695
MOD_CK1_1	792	798	PF00069	0.722
MOD_CK1_1	871	877	PF00069	0.640
MOD_CK1_1	93	99	PF00069	0.457
MOD_CK1_1	941	947	PF00069	0.652
MOD_CK2_1	1004	1010	PF00069	0.755
MOD_CK2_1	314	320	PF00069	0.475
MOD_CK2_1	414	420	PF00069	0.501
MOD_CK2_1	473	479	PF00069	0.472
MOD_CK2_1	569	575	PF00069	0.574
MOD_CK2_1	700	706	PF00069	0.723
MOD_CK2_1	806	812	PF00069	0.752
MOD_Cter_Amidation	1149	1152	PF01082	0.655
MOD_Cter_Amidation	57	60	PF01082	0.532
MOD_GlcNHglycan	1033	1036	PF01048	0.756
MOD_GlcNHglycan	1074	1077	PF01048	0.747
MOD_GlcNHglycan	17	20	PF01048	0.688
MOD_GlcNHglycan	21	24	PF01048	0.675
MOD_GlcNHglycan	235	238	PF01048	0.596
MOD_GlcNHglycan	25	28	PF01048	0.637
MOD_GlcNHglycan	301	304	PF01048	0.663
MOD_GlcNHglycan	316	319	PF01048	0.607
MOD_GlcNHglycan	327	330	PF01048	0.611
MOD_GlcNHglycan	37	40	PF01048	0.452
MOD_GlcNHglycan	473	476	PF01048	0.530
MOD_GlcNHglycan	48	51	PF01048	0.440
MOD_GlcNHglycan	53	56	PF01048	0.602
MOD_GlcNHglycan	530	533	PF01048	0.738
MOD_GlcNHglycan	571	574	PF01048	0.370
MOD_GlcNHglycan	662	665	PF01048	0.655
MOD_GlcNHglycan	687	690	PF01048	0.759
MOD_GlcNHglycan	70	73	PF01048	0.738
MOD_GlcNHglycan	702	705	PF01048	0.646
MOD_GlcNHglycan	712	715	PF01048	0.698
MOD_GlcNHglycan	74	77	PF01048	0.706
MOD_GlcNHglycan	935	939	PF01048	0.714
MOD_GlcNHglycan	940	943	PF01048	0.709
MOD_GSK3_1	1018	1025	PF00069	0.741
MOD_GSK3_1	1027	1034	PF00069	0.807
MOD_GSK3_1	11	18	PF00069	0.713
MOD_GSK3_1	1108	1115	PF00069	0.755
MOD_GSK3_1	1133	1140	PF00069	0.670
MOD_GSK3_1	1158	1165	PF00069	0.700
MOD_GSK3_1	143	150	PF00069	0.459
MOD_GSK3_1	19	26	PF00069	0.682
MOD_GSK3_1	196	203	PF00069	0.693
MOD_GSK3_1	240	247	PF00069	0.678
MOD_GSK3_1	249	256	PF00069	0.612
MOD_GSK3_1	307	314	PF00069	0.586
MOD_GSK3_1	409	416	PF00069	0.570
MOD_GSK3_1	42	49	PF00069	0.575
MOD_GSK3_1	504	511	PF00069	0.627
MOD_GSK3_1	524	531	PF00069	0.712
MOD_GSK3_1	547	554	PF00069	0.484
MOD_GSK3_1	622	629	PF00069	0.739
MOD_GSK3_1	63	70	PF00069	0.738
MOD_GSK3_1	789	796	PF00069	0.744
MOD_GSK3_1	868	875	PF00069	0.627
MOD_GSK3_1	889	896	PF00069	0.717
MOD_GSK3_1	934	941	PF00069	0.686
MOD_LATS_1	65	71	PF00433	0.689
MOD_N-GLC_1	337	342	PF02516	0.528
MOD_N-GLC_1	667	672	PF02516	0.650
MOD_NEK2_1	1072	1077	PF00069	0.645
MOD_NEK2_1	298	303	PF00069	0.600
MOD_NEK2_1	337	342	PF00069	0.699
MOD_NEK2_1	566	571	PF00069	0.498
MOD_NEK2_1	622	627	PF00069	0.717
MOD_NEK2_1	690	695	PF00069	0.754
MOD_NEK2_1	889	894	PF00069	0.691
MOD_NEK2_2	547	552	PF00069	0.522
MOD_OFUCOSY	745	750	PF10250	0.499
MOD_PIKK_1	1103	1109	PF00454	0.820
MOD_PIKK_1	1114	1120	PF00454	0.652
MOD_PIKK_1	337	343	PF00454	0.647
MOD_PIKK_1	43	49	PF00454	0.496
MOD_PIKK_1	678	684	PF00454	0.705
MOD_PIKK_1	690	696	PF00454	0.601
MOD_PIKK_1	879	885	PF00454	0.566
MOD_PK_1	1152	1158	PF00069	0.706
MOD_PK_1	376	382	PF00069	0.810
MOD_PKA_1	1108	1114	PF00069	0.601
MOD_PKA_1	1152	1158	PF00069	0.705
MOD_PKA_1	376	382	PF00069	0.816
MOD_PKA_2	1072	1078	PF00069	0.720
MOD_PKA_2	1133	1139	PF00069	0.710
MOD_PKA_2	1152	1158	PF00069	0.667
MOD_PKA_2	23	29	PF00069	0.628
MOD_PKA_2	375	381	PF00069	0.725
MOD_PKA_2	626	632	PF00069	0.761
MOD_PKA_2	66	72	PF00069	0.670
MOD_PKA_2	700	706	PF00069	0.677
MOD_PKA_2	793	799	PF00069	0.714
MOD_PKA_2	806	812	PF00069	0.647
MOD_PKB_1	309	317	PF00069	0.635
MOD_PKB_1	374	382	PF00069	0.653
MOD_PKB_1	471	479	PF00069	0.531
MOD_PKB_1	604	612	PF00069	0.612
MOD_Plk_1	227	233	PF00069	0.574
MOD_Plk_1	676	682	PF00069	0.672
MOD_Plk_4	114	120	PF00069	0.492
MOD_Plk_4	1152	1158	PF00069	0.717
MOD_Plk_4	311	317	PF00069	0.638
MOD_Plk_4	767	773	PF00069	0.713
MOD_Plk_4	806	812	PF00069	0.686
MOD_Plk_4	889	895	PF00069	0.640
MOD_Plk_4	90	96	PF00069	0.535
MOD_ProDKin_1	1018	1024	PF00069	0.727
MOD_ProDKin_1	1027	1033	PF00069	0.619
MOD_ProDKin_1	145	151	PF00069	0.506
MOD_ProDKin_1	320	326	PF00069	0.692
MOD_ProDKin_1	395	401	PF00069	0.643
MOD_ProDKin_1	506	512	PF00069	0.719
MOD_ProDKin_1	532	538	PF00069	0.581
MOD_ProDKin_1	936	942	PF00069	0.618
TRG_DiLeu_BaEn_1	491	496	PF01217	0.572
TRG_DiLeu_BaEn_1	857	862	PF01217	0.567
TRG_DiLeu_BaEn_4	478	484	PF01217	0.493
TRG_DiLeu_BaEn_4	825	831	PF01217	0.578
TRG_DiLeu_BaLyEn_6	539	544	PF01217	0.510
TRG_DiLeu_BaLyEn_6	641	646	PF01217	0.679
TRG_DiLeu_BaLyEn_6	949	954	PF01217	0.744
TRG_ENDOCYTIC_2	109	112	PF00928	0.466
TRG_ENDOCYTIC_2	168	171	PF00928	0.463
TRG_ENDOCYTIC_2	562	565	PF00928	0.455
TRG_ER_diArg_1	1147	1149	PF00400	0.766
TRG_ER_diArg_1	1151	1153	PF00400	0.776
TRG_ER_diArg_1	119	121	PF00400	0.521
TRG_ER_diArg_1	183	185	PF00400	0.473
TRG_ER_diArg_1	219	221	PF00400	0.625
TRG_ER_diArg_1	292	295	PF00400	0.496
TRG_ER_diArg_1	309	312	PF00400	0.639
TRG_ER_diArg_1	374	377	PF00400	0.729
TRG_ER_diArg_1	559	561	PF00400	0.512
TRG_ER_diArg_1	59	61	PF00400	0.543
TRG_ER_diArg_1	772	774	PF00400	0.720
TRG_ER_diArg_1	982	984	PF00400	0.668

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P548	Leptomonas seymouri	47%	100%
A0A3S7X755	Leishmania donovani	89%	100%
A4HLX7	Leishmania braziliensis	73%	100%
A4I9A6	Leishmania infantum	88%	100%
E9B4A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%