GRIP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3R9_LEIMA

TriTrypDb:

LmjF.33.2670 , LMJLV39_330037800 , LMJSD75_330037200

Length:

1232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q3R9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3R9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	2
GO:0006996	organelle organization	4	2
GO:0007030	Golgi organization	5	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0016192	vesicle-mediated transport	4	2
GO:0046907	intracellular transport	3	2
GO:0048193	Golgi vesicle transport	5	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0019899	enzyme binding	3	2
GO:0031267	small GTPase binding	5	2
GO:0051020	GTPase binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1174	1178	PF00656	0.606
CLV_C14_Caspase3-7	35	39	PF00656	0.613
CLV_C14_Caspase3-7	897	901	PF00656	0.472
CLV_MEL_PAP_1	367	373	PF00089	0.496
CLV_NRD_NRD_1	1016	1018	PF00675	0.446
CLV_NRD_NRD_1	1048	1050	PF00675	0.496
CLV_NRD_NRD_1	1054	1056	PF00675	0.541
CLV_NRD_NRD_1	1063	1065	PF00675	0.634
CLV_NRD_NRD_1	1092	1094	PF00675	0.486
CLV_NRD_NRD_1	1140	1142	PF00675	0.612
CLV_NRD_NRD_1	206	208	PF00675	0.599
CLV_NRD_NRD_1	456	458	PF00675	0.519
CLV_NRD_NRD_1	511	513	PF00675	0.422
CLV_NRD_NRD_1	524	526	PF00675	0.446
CLV_NRD_NRD_1	551	553	PF00675	0.558
CLV_NRD_NRD_1	655	657	PF00675	0.406
CLV_NRD_NRD_1	789	791	PF00675	0.632
CLV_NRD_NRD_1	861	863	PF00675	0.455
CLV_NRD_NRD_1	92	94	PF00675	0.626
CLV_PCSK_KEX2_1	1016	1018	PF00082	0.482
CLV_PCSK_KEX2_1	1063	1065	PF00082	0.549
CLV_PCSK_KEX2_1	1075	1077	PF00082	0.507
CLV_PCSK_KEX2_1	1140	1142	PF00082	0.605
CLV_PCSK_KEX2_1	206	208	PF00082	0.598
CLV_PCSK_KEX2_1	456	458	PF00082	0.519
CLV_PCSK_KEX2_1	480	482	PF00082	0.527
CLV_PCSK_KEX2_1	510	512	PF00082	0.434
CLV_PCSK_KEX2_1	635	637	PF00082	0.449
CLV_PCSK_KEX2_1	655	657	PF00082	0.361
CLV_PCSK_KEX2_1	666	668	PF00082	0.496
CLV_PCSK_KEX2_1	711	713	PF00082	0.550
CLV_PCSK_KEX2_1	789	791	PF00082	0.632
CLV_PCSK_KEX2_1	861	863	PF00082	0.455
CLV_PCSK_KEX2_1	92	94	PF00082	0.626
CLV_PCSK_KEX2_1	990	992	PF00082	0.407
CLV_PCSK_PC1ET2_1	1075	1077	PF00082	0.507
CLV_PCSK_PC1ET2_1	480	482	PF00082	0.516
CLV_PCSK_PC1ET2_1	635	637	PF00082	0.449
CLV_PCSK_PC1ET2_1	666	668	PF00082	0.482
CLV_PCSK_PC1ET2_1	711	713	PF00082	0.491
CLV_PCSK_PC1ET2_1	990	992	PF00082	0.407
CLV_PCSK_PC7_1	1136	1142	PF00082	0.652
CLV_PCSK_SKI1_1	1055	1059	PF00082	0.493
CLV_PCSK_SKI1_1	1141	1145	PF00082	0.631
CLV_PCSK_SKI1_1	284	288	PF00082	0.392
CLV_PCSK_SKI1_1	347	351	PF00082	0.482
CLV_PCSK_SKI1_1	361	365	PF00082	0.462
CLV_PCSK_SKI1_1	512	516	PF00082	0.417
CLV_PCSK_SKI1_1	590	594	PF00082	0.511
CLV_PCSK_SKI1_1	598	602	PF00082	0.438
CLV_PCSK_SKI1_1	630	634	PF00082	0.529
CLV_PCSK_SKI1_1	636	640	PF00082	0.528
CLV_PCSK_SKI1_1	711	715	PF00082	0.531
CLV_PCSK_SKI1_1	893	897	PF00082	0.465
CLV_PCSK_SKI1_1	93	97	PF00082	0.560
DEG_Nend_Nbox_1	1	3	PF02207	0.559
DEG_SCF_FBW7_1	405	412	PF00400	0.634
DEG_SPOP_SBC_1	1192	1196	PF00917	0.621
DEG_SPOP_SBC_1	392	396	PF00917	0.429
DOC_CKS1_1	264	269	PF01111	0.629
DOC_CYCLIN_RxL_1	627	637	PF00134	0.462
DOC_CYCLIN_RxL_1	89	100	PF00134	0.549
DOC_MAPK_gen_1	56	63	PF00069	0.622
DOC_MAPK_gen_1	880	887	PF00069	0.434
DOC_MAPK_gen_1	924	934	PF00069	0.428
DOC_MAPK_MEF2A_6	755	763	PF00069	0.496
DOC_PP1_RVXF_1	1160	1167	PF00149	0.506
DOC_PP2B_LxvP_1	230	233	PF13499	0.613
DOC_PP2B_LxvP_1	255	258	PF13499	0.613
DOC_PP4_FxxP_1	1211	1214	PF00568	0.686
DOC_USP7_MATH_1	109	113	PF00917	0.612
DOC_USP7_MATH_1	1129	1133	PF00917	0.597
DOC_USP7_MATH_1	1180	1184	PF00917	0.693
DOC_USP7_MATH_1	1187	1191	PF00917	0.615
DOC_USP7_MATH_1	119	123	PF00917	0.597
DOC_USP7_MATH_1	1192	1196	PF00917	0.580
DOC_USP7_MATH_1	1205	1209	PF00917	0.564
DOC_USP7_MATH_1	128	132	PF00917	0.521
DOC_USP7_MATH_1	185	189	PF00917	0.595
DOC_USP7_MATH_1	199	203	PF00917	0.653
DOC_USP7_MATH_1	220	224	PF00917	0.628
DOC_USP7_MATH_1	247	251	PF00917	0.644
DOC_USP7_MATH_1	555	559	PF00917	0.614
DOC_USP7_MATH_1	566	570	PF00917	0.469
DOC_USP7_MATH_1	733	737	PF00917	0.628
DOC_USP7_UBL2_3	1056	1060	PF12436	0.499
DOC_WW_Pin1_4	1195	1200	PF00397	0.682
DOC_WW_Pin1_4	1210	1215	PF00397	0.599
DOC_WW_Pin1_4	1219	1224	PF00397	0.610
DOC_WW_Pin1_4	133	138	PF00397	0.760
DOC_WW_Pin1_4	15	20	PF00397	0.565
DOC_WW_Pin1_4	156	161	PF00397	0.599
DOC_WW_Pin1_4	171	176	PF00397	0.710
DOC_WW_Pin1_4	189	194	PF00397	0.576
DOC_WW_Pin1_4	214	219	PF00397	0.721
DOC_WW_Pin1_4	233	238	PF00397	0.564
DOC_WW_Pin1_4	243	248	PF00397	0.466
DOC_WW_Pin1_4	263	268	PF00397	0.630
DOC_WW_Pin1_4	405	410	PF00397	0.680
LIG_14-3-3_CanoR_1	1076	1085	PF00244	0.444
LIG_14-3-3_CanoR_1	120	125	PF00244	0.579
LIG_14-3-3_CanoR_1	213	218	PF00244	0.676
LIG_14-3-3_CanoR_1	382	386	PF00244	0.497
LIG_14-3-3_CanoR_1	456	460	PF00244	0.442
LIG_14-3-3_CanoR_1	510	519	PF00244	0.464
LIG_14-3-3_CanoR_1	598	607	PF00244	0.439
LIG_14-3-3_CanoR_1	768	772	PF00244	0.613
LIG_14-3-3_CterR_2	1229	1232	PF00244	0.660
LIG_Actin_WH2_2	367	384	PF00022	0.490
LIG_Actin_WH2_2	699	716	PF00022	0.394
LIG_BIR_III_4	873	877	PF00653	0.380
LIG_BRCT_BRCA1_1	1207	1211	PF00533	0.693
LIG_deltaCOP1_diTrp_1	4	12	PF00928	0.464
LIG_FAT_LD_1	759	767	PF03623	0.501
LIG_FHA_1	1186	1192	PF00498	0.607
LIG_FHA_1	4	10	PF00498	0.459
LIG_FHA_1	437	443	PF00498	0.488
LIG_FHA_1	514	520	PF00498	0.525
LIG_FHA_1	832	838	PF00498	0.505
LIG_FHA_1	89	95	PF00498	0.523
LIG_FHA_2	1069	1075	PF00498	0.513
LIG_FHA_2	172	178	PF00498	0.772
LIG_FHA_2	325	331	PF00498	0.450
LIG_FHA_2	363	369	PF00498	0.669
LIG_FHA_2	681	687	PF00498	0.471
LIG_FHA_2	727	733	PF00498	0.568
LIG_FHA_2	920	926	PF00498	0.404
LIG_FHA_2	937	943	PF00498	0.473
LIG_FHA_2	955	961	PF00498	0.342
LIG_HCF-1_HBM_1	615	618	PF13415	0.524
LIG_LIR_Apic_2	1208	1214	PF02991	0.693
LIG_LIR_Gen_1	1161	1168	PF02991	0.486
LIG_LIR_Gen_1	131	140	PF02991	0.596
LIG_LIR_Nem_3	1113	1119	PF02991	0.549
LIG_LIR_Nem_3	1161	1166	PF02991	0.480
LIG_LIR_Nem_3	131	135	PF02991	0.600
LIG_LIR_Nem_3	873	878	PF02991	0.423
LIG_NRBOX	1102	1108	PF00104	0.427
LIG_NRBOX	827	833	PF00104	0.469
LIG_PCNA_yPIPBox_3	905	917	PF02747	0.458
LIG_Pex14_1	853	857	PF04695	0.448
LIG_RPA_C_Fungi	115	127	PF08784	0.578
LIG_SH2_NCK_1	118	122	PF00017	0.647
LIG_SH2_NCK_1	618	622	PF00017	0.471
LIG_SH2_PTP2	1116	1119	PF00017	0.527
LIG_SH2_STAP1	317	321	PF00017	0.436
LIG_SH2_STAT5	1116	1119	PF00017	0.527
LIG_SH3_3	1120	1126	PF00018	0.562
LIG_SH3_3	124	130	PF00018	0.659
LIG_SH3_3	134	140	PF00018	0.637
LIG_SH3_3	261	267	PF00018	0.597
LIG_SH3_3	269	275	PF00018	0.577
LIG_SUMO_SIM_par_1	905	911	PF11976	0.432
LIG_TRAF2_1	1112	1115	PF00917	0.459
LIG_TRAF2_1	415	418	PF00917	0.541
LIG_TRAF2_1	649	652	PF00917	0.492
LIG_TRAF2_1	950	953	PF00917	0.522
LIG_TRAF2_1	964	967	PF00917	0.427
LIG_TYR_ITIM	314	319	PF00017	0.378
LIG_TYR_ITIM	96	101	PF00017	0.534
LIG_WRC_WIRS_1	9	14	PF05994	0.458
MOD_CDC14_SPxK_1	246	249	PF00782	0.537
MOD_CDK_SPxK_1	243	249	PF00069	0.541
MOD_CK1_1	1069	1075	PF00069	0.686
MOD_CK1_1	1171	1177	PF00069	0.649
MOD_CK1_1	1194	1200	PF00069	0.677
MOD_CK1_1	1210	1216	PF00069	0.546
MOD_CK1_1	122	128	PF00069	0.646
MOD_CK1_1	131	137	PF00069	0.622
MOD_CK1_1	138	144	PF00069	0.536
MOD_CK1_1	188	194	PF00069	0.613
MOD_CK1_1	235	241	PF00069	0.645
MOD_CK1_1	243	249	PF00069	0.528
MOD_CK1_1	403	409	PF00069	0.673
MOD_CK1_1	513	519	PF00069	0.503
MOD_CK1_1	558	564	PF00069	0.606
MOD_CK1_1	736	742	PF00069	0.574
MOD_CK2_1	1146	1152	PF00069	0.501
MOD_CK2_1	171	177	PF00069	0.774
MOD_CK2_1	199	205	PF00069	0.613
MOD_CK2_1	330	336	PF00069	0.476
MOD_CK2_1	362	368	PF00069	0.500
MOD_CK2_1	634	640	PF00069	0.486
MOD_CK2_1	680	686	PF00069	0.484
MOD_CK2_1	726	732	PF00069	0.564
MOD_CK2_1	8	14	PF00069	0.486
MOD_CK2_1	919	925	PF00069	0.416
MOD_CK2_1	936	942	PF00069	0.482
MOD_CK2_1	947	953	PF00069	0.419
MOD_CK2_1	998	1004	PF00069	0.442
MOD_Cter_Amidation	478	481	PF01082	0.508
MOD_GlcNHglycan	1103	1106	PF01048	0.436
MOD_GlcNHglycan	1130	1134	PF01048	0.568
MOD_GlcNHglycan	1148	1151	PF01048	0.661
MOD_GlcNHglycan	1172	1176	PF01048	0.716
MOD_GlcNHglycan	124	127	PF01048	0.670
MOD_GlcNHglycan	199	202	PF01048	0.658
MOD_GlcNHglycan	230	233	PF01048	0.593
MOD_GlcNHglycan	237	240	PF01048	0.567
MOD_GlcNHglycan	249	252	PF01048	0.619
MOD_GlcNHglycan	26	29	PF01048	0.739
MOD_GlcNHglycan	332	335	PF01048	0.667
MOD_GlcNHglycan	402	405	PF01048	0.634
MOD_GlcNHglycan	512	515	PF01048	0.446
MOD_GlcNHglycan	553	556	PF01048	0.681
MOD_GlcNHglycan	557	560	PF01048	0.785
MOD_GlcNHglycan	568	571	PF01048	0.470
MOD_GlcNHglycan	636	639	PF01048	0.403
MOD_GlcNHglycan	690	693	PF01048	0.580
MOD_GlcNHglycan	73	76	PF01048	0.634
MOD_GlcNHglycan	735	738	PF01048	0.527
MOD_GlcNHglycan	740	743	PF01048	0.466
MOD_GlcNHglycan	798	802	PF01048	0.681
MOD_GlcNHglycan	82	85	PF01048	0.567
MOD_GlcNHglycan	900	903	PF01048	0.472
MOD_GSK3_1	1187	1194	PF00069	0.817
MOD_GSK3_1	1225	1232	PF00069	0.595
MOD_GSK3_1	131	138	PF00069	0.616
MOD_GSK3_1	171	178	PF00069	0.715
MOD_GSK3_1	185	192	PF00069	0.602
MOD_GSK3_1	195	202	PF00069	0.651
MOD_GSK3_1	228	235	PF00069	0.648
MOD_GSK3_1	243	250	PF00069	0.683
MOD_GSK3_1	324	331	PF00069	0.643
MOD_GSK3_1	391	398	PF00069	0.512
MOD_GSK3_1	4	11	PF00069	0.588
MOD_GSK3_1	405	412	PF00069	0.773
MOD_GSK3_1	540	547	PF00069	0.496
MOD_GSK3_1	551	558	PF00069	0.642
MOD_GSK3_1	562	569	PF00069	0.501
MOD_GSK3_1	57	64	PF00069	0.568
MOD_GSK3_1	827	834	PF00069	0.463
MOD_GSK3_1	894	901	PF00069	0.441
MOD_GSK3_1	936	943	PF00069	0.424
MOD_N-GLC_1	1180	1185	PF02516	0.646
MOD_N-GLC_1	863	868	PF02516	0.439
MOD_NEK2_1	1058	1063	PF00069	0.526
MOD_NEK2_1	381	386	PF00069	0.456
MOD_NEK2_1	548	553	PF00069	0.530
MOD_NEK2_1	833	838	PF00069	0.375
MOD_NEK2_1	969	974	PF00069	0.445
MOD_PIKK_1	1076	1082	PF00454	0.451
MOD_PIKK_1	1110	1116	PF00454	0.472
MOD_PIKK_1	1200	1206	PF00454	0.684
MOD_PIKK_1	163	169	PF00454	0.609
MOD_PIKK_1	220	226	PF00454	0.626
MOD_PIKK_1	266	272	PF00454	0.707
MOD_PIKK_1	437	443	PF00454	0.492
MOD_PIKK_1	513	519	PF00454	0.484
MOD_PIKK_1	743	749	PF00454	0.498
MOD_PIKK_1	940	946	PF00454	0.383
MOD_PIKK_1	998	1004	PF00454	0.442
MOD_PK_1	120	126	PF00069	0.578
MOD_PKA_1	510	516	PF00069	0.396
MOD_PKA_2	119	125	PF00069	0.577
MOD_PKA_2	212	218	PF00069	0.675
MOD_PKA_2	381	387	PF00069	0.494
MOD_PKA_2	455	461	PF00069	0.444
MOD_PKA_2	510	516	PF00069	0.396
MOD_PKA_2	551	557	PF00069	0.574
MOD_PKA_2	57	63	PF00069	0.702
MOD_PKA_2	64	70	PF00069	0.627
MOD_PKA_2	726	732	PF00069	0.553
MOD_PKA_2	767	773	PF00069	0.485
MOD_PKB_1	510	518	PF00069	0.421
MOD_Plk_1	1042	1048	PF00069	0.449
MOD_Plk_1	1069	1075	PF00069	0.524
MOD_Plk_1	180	186	PF00069	0.670
MOD_Plk_1	409	415	PF00069	0.559
MOD_Plk_1	41	47	PF00069	0.574
MOD_Plk_1	853	859	PF00069	0.449
MOD_Plk_1	863	869	PF00069	0.438
MOD_Plk_1	883	889	PF00069	0.317
MOD_Plk_2-3	883	889	PF00069	0.438
MOD_Plk_2-3	919	925	PF00069	0.381
MOD_Plk_2-3	954	960	PF00069	0.507
MOD_Plk_2-3	995	1001	PF00069	0.445
MOD_Plk_4	128	134	PF00069	0.640
MOD_Plk_4	770	776	PF00069	0.558
MOD_Plk_4	838	844	PF00069	0.438
MOD_ProDKin_1	1195	1201	PF00069	0.680
MOD_ProDKin_1	1210	1216	PF00069	0.598
MOD_ProDKin_1	1219	1225	PF00069	0.611
MOD_ProDKin_1	133	139	PF00069	0.758
MOD_ProDKin_1	15	21	PF00069	0.569
MOD_ProDKin_1	156	162	PF00069	0.597
MOD_ProDKin_1	171	177	PF00069	0.713
MOD_ProDKin_1	189	195	PF00069	0.576
MOD_ProDKin_1	214	220	PF00069	0.717
MOD_ProDKin_1	233	239	PF00069	0.564
MOD_ProDKin_1	243	249	PF00069	0.465
MOD_ProDKin_1	263	269	PF00069	0.631
MOD_ProDKin_1	405	411	PF00069	0.677
MOD_SUMO_for_1	502	505	PF00179	0.485
MOD_SUMO_for_1	748	751	PF00179	0.455
MOD_SUMO_for_1	887	890	PF00179	0.509
MOD_SUMO_for_1	964	967	PF00179	0.515
MOD_SUMO_rev_2	430	440	PF00179	0.403
MOD_SUMO_rev_2	458	463	PF00179	0.500
MOD_SUMO_rev_2	730	736	PF00179	0.624
MOD_SUMO_rev_2	751	756	PF00179	0.482
TRG_DiLeu_BaEn_1	1115	1120	PF01217	0.501
TRG_DiLeu_BaEn_1	977	982	PF01217	0.458
TRG_DiLeu_BaEn_4	426	432	PF01217	0.481
TRG_DiLeu_BaEn_4	574	580	PF01217	0.510
TRG_DiLeu_BaEn_4	652	658	PF01217	0.409
TRG_DiLeu_BaEn_4	701	707	PF01217	0.383
TRG_DiLeu_BaEn_4	953	959	PF01217	0.441
TRG_DiLeu_BaLyEn_6	821	826	PF01217	0.536
TRG_ENDOCYTIC_2	1116	1119	PF00928	0.527
TRG_ENDOCYTIC_2	316	319	PF00928	0.379
TRG_ENDOCYTIC_2	98	101	PF00928	0.603
TRG_ER_diArg_1	1016	1019	PF00400	0.451
TRG_ER_diArg_1	306	309	PF00400	0.366
TRG_ER_diArg_1	455	457	PF00400	0.525
TRG_ER_diArg_1	510	512	PF00400	0.393
TRG_ER_diArg_1	576	579	PF00400	0.558
TRG_ER_diArg_1	654	656	PF00400	0.388
TRG_ER_diArg_1	725	728	PF00400	0.548
TRG_ER_diArg_1	861	863	PF00400	0.455
TRG_ER_diArg_1	92	94	PF00400	0.626
TRG_NES_CRM1_1	426	441	PF08389	0.408
TRG_NES_CRM1_1	751	764	PF08389	0.467
TRG_NLS_Bipartite_1	655	670	PF00514	0.386
TRG_Pf-PMV_PEXEL_1	1010	1014	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	1016	1020	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	1049	1053	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	598	602	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	630	634	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	655	660	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	711	715	PF00026	0.566
TRG_Pf-PMV_PEXEL_1	92	97	PF00026	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXK7	Leptomonas seymouri	40%	91%
A0A3Q8IGT3	Leishmania donovani	85%	100%
A4HLX8	Leishmania braziliensis	55%	100%
A4I9A7	Leishmania infantum	85%	100%
E9B4A7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%