Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3R8_LEIMA

TriTrypDb:

LmjF.33.2680 , LMJLV39_330037900 , LMJSD75_330037300

Length:

835

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3R8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3R8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.576
CLV_C14_Caspase3-7	23	27	PF00656	0.663
CLV_C14_Caspase3-7	510	514	PF00656	0.622
CLV_C14_Caspase3-7	609	613	PF00656	0.684
CLV_NRD_NRD_1	233	235	PF00675	0.697
CLV_NRD_NRD_1	240	242	PF00675	0.731
CLV_NRD_NRD_1	305	307	PF00675	0.768
CLV_NRD_NRD_1	404	406	PF00675	0.546
CLV_NRD_NRD_1	430	432	PF00675	0.539
CLV_NRD_NRD_1	444	446	PF00675	0.618
CLV_NRD_NRD_1	487	489	PF00675	0.731
CLV_NRD_NRD_1	50	52	PF00675	0.802
CLV_NRD_NRD_1	53	55	PF00675	0.763
CLV_NRD_NRD_1	568	570	PF00675	0.524
CLV_NRD_NRD_1	630	632	PF00675	0.805
CLV_NRD_NRD_1	710	712	PF00675	0.805
CLV_NRD_NRD_1	725	727	PF00675	0.614
CLV_NRD_NRD_1	767	769	PF00675	0.723
CLV_NRD_NRD_1	770	772	PF00675	0.718
CLV_NRD_NRD_1	83	85	PF00675	0.778
CLV_NRD_NRD_1	97	99	PF00675	0.691
CLV_PCSK_FUR_1	441	445	PF00082	0.516
CLV_PCSK_FUR_1	51	55	PF00082	0.574
CLV_PCSK_FUR_1	768	772	PF00082	0.815
CLV_PCSK_FUR_1	93	97	PF00082	0.715
CLV_PCSK_KEX2_1	233	235	PF00082	0.697
CLV_PCSK_KEX2_1	240	242	PF00082	0.731
CLV_PCSK_KEX2_1	305	307	PF00082	0.768
CLV_PCSK_KEX2_1	404	406	PF00082	0.546
CLV_PCSK_KEX2_1	430	432	PF00082	0.540
CLV_PCSK_KEX2_1	443	445	PF00082	0.604
CLV_PCSK_KEX2_1	487	489	PF00082	0.744
CLV_PCSK_KEX2_1	50	52	PF00082	0.802
CLV_PCSK_KEX2_1	53	55	PF00082	0.763
CLV_PCSK_KEX2_1	630	632	PF00082	0.805
CLV_PCSK_KEX2_1	710	712	PF00082	0.751
CLV_PCSK_KEX2_1	724	726	PF00082	0.586
CLV_PCSK_KEX2_1	770	772	PF00082	0.728
CLV_PCSK_KEX2_1	83	85	PF00082	0.714
CLV_PCSK_KEX2_1	95	97	PF00082	0.767
CLV_PCSK_PC1ET2_1	770	772	PF00082	0.719
CLV_PCSK_PC7_1	236	242	PF00082	0.703
CLV_PCSK_PC7_1	766	772	PF00082	0.724
CLV_PCSK_PC7_1	93	99	PF00082	0.777
CLV_PCSK_SKI1_1	136	140	PF00082	0.630
CLV_PCSK_SKI1_1	19	23	PF00082	0.592
CLV_PCSK_SKI1_1	391	395	PF00082	0.742
CLV_PCSK_SKI1_1	434	438	PF00082	0.557
DEG_APCC_DBOX_1	390	398	PF00400	0.701
DEG_SCF_FBW7_1	153	160	PF00400	0.594
DEG_SPOP_SBC_1	506	510	PF00917	0.738
DEG_SPOP_SBC_1	614	618	PF00917	0.608
DEG_SPOP_SBC_1	748	752	PF00917	0.685
DEG_SPOP_SBC_1	760	764	PF00917	0.566
DOC_CYCLIN_RxL_1	429	440	PF00134	0.554
DOC_CYCLIN_yCln2_LP_2	598	604	PF00134	0.696
DOC_MAPK_gen_1	131	139	PF00069	0.613
DOC_MAPK_gen_1	401	410	PF00069	0.535
DOC_MAPK_gen_1	430	437	PF00069	0.529
DOC_MAPK_MEF2A_6	401	410	PF00069	0.535
DOC_PIKK_1	732	740	PF02985	0.810
DOC_PP1_RVXF_1	17	23	PF00149	0.587
DOC_PP4_FxxP_1	660	663	PF00568	0.607
DOC_USP7_MATH_1	120	124	PF00917	0.721
DOC_USP7_MATH_1	151	155	PF00917	0.758
DOC_USP7_MATH_1	161	165	PF00917	0.797
DOC_USP7_MATH_1	254	258	PF00917	0.748
DOC_USP7_MATH_1	361	365	PF00917	0.605
DOC_USP7_MATH_1	470	474	PF00917	0.693
DOC_USP7_MATH_1	483	487	PF00917	0.608
DOC_USP7_MATH_1	506	510	PF00917	0.812
DOC_USP7_MATH_1	650	654	PF00917	0.783
DOC_USP7_MATH_1	655	659	PF00917	0.643
DOC_USP7_MATH_1	669	673	PF00917	0.455
DOC_USP7_MATH_1	695	699	PF00917	0.596
DOC_USP7_MATH_1	720	724	PF00917	0.794
DOC_USP7_MATH_1	746	750	PF00917	0.766
DOC_USP7_MATH_1	760	764	PF00917	0.635
DOC_USP7_MATH_1	777	781	PF00917	0.785
DOC_USP7_MATH_1	795	799	PF00917	0.486
DOC_USP7_UBL2_3	434	438	PF12436	0.659
DOC_WW_Pin1_4	153	158	PF00397	0.728
DOC_WW_Pin1_4	277	282	PF00397	0.726
DOC_WW_Pin1_4	294	299	PF00397	0.612
DOC_WW_Pin1_4	59	64	PF00397	0.722
DOC_WW_Pin1_4	593	598	PF00397	0.656
DOC_WW_Pin1_4	615	620	PF00397	0.783
DOC_WW_Pin1_4	659	664	PF00397	0.573
DOC_WW_Pin1_4	713	718	PF00397	0.702
DOC_WW_Pin1_4	9	14	PF00397	0.557
LIG_14-3-3_CanoR_1	146	151	PF00244	0.740
LIG_14-3-3_CanoR_1	197	206	PF00244	0.713
LIG_14-3-3_CanoR_1	240	250	PF00244	0.745
LIG_14-3-3_CanoR_1	341	345	PF00244	0.673
LIG_14-3-3_CanoR_1	346	356	PF00244	0.686
LIG_14-3-3_CanoR_1	37	47	PF00244	0.818
LIG_14-3-3_CanoR_1	405	411	PF00244	0.682
LIG_14-3-3_CanoR_1	719	723	PF00244	0.751
LIG_14-3-3_CanoR_1	776	782	PF00244	0.802
LIG_BIR_II_1	1	5	PF00653	0.645
LIG_BRCT_BRCA1_1	192	196	PF00533	0.749
LIG_BRCT_BRCA1_1	206	210	PF00533	0.648
LIG_BRCT_BRCA1_1	656	660	PF00533	0.663
LIG_CtBP_PxDLS_1	407	411	PF00389	0.637
LIG_CtBP_PxDLS_1	622	626	PF00389	0.723
LIG_FHA_1	15	21	PF00498	0.573
LIG_FHA_1	154	160	PF00498	0.677
LIG_FHA_1	186	192	PF00498	0.604
LIG_FHA_1	320	326	PF00498	0.811
LIG_FHA_1	372	378	PF00498	0.601
LIG_FHA_1	401	407	PF00498	0.619
LIG_FHA_1	524	530	PF00498	0.781
LIG_FHA_1	616	622	PF00498	0.683
LIG_FHA_1	635	641	PF00498	0.457
LIG_FHA_2	274	280	PF00498	0.702
LIG_FHA_2	374	380	PF00498	0.699
LIG_FHA_2	510	516	PF00498	0.808
LIG_FHA_2	677	683	PF00498	0.691
LIG_Integrin_RGD_1	773	775	PF01839	0.706
LIG_LIR_Apic_2	657	663	PF02991	0.631
LIG_LIR_Gen_1	123	130	PF02991	0.523
LIG_LIR_Gen_1	2	8	PF02991	0.614
LIG_LIR_Gen_1	328	339	PF02991	0.626
LIG_LIR_Gen_1	679	689	PF02991	0.781
LIG_LIR_Nem_3	2	7	PF02991	0.619
LIG_LIR_Nem_3	328	334	PF02991	0.682
LIG_LIR_Nem_3	355	359	PF02991	0.660
LIG_LIR_Nem_3	679	684	PF02991	0.772
LIG_LIR_Nem_3	829	835	PF02991	0.606
LIG_MLH1_MIPbox_1	656	660	PF16413	0.663
LIG_MYND_1	619	623	PF01753	0.677
LIG_REV1ctd_RIR_1	66	76	PF16727	0.596
LIG_SH2_CRK	331	335	PF00017	0.632
LIG_SH2_STAP1	4	8	PF00017	0.600
LIG_SH2_STAP1	736	740	PF00017	0.723
LIG_SH2_STAT3	45	48	PF00017	0.816
LIG_SH2_STAT5	125	128	PF00017	0.636
LIG_SH2_STAT5	45	48	PF00017	0.582
LIG_SH3_3	354	360	PF00018	0.653
LIG_SH3_3	616	622	PF00018	0.810
LIG_SH3_3	791	797	PF00018	0.688
LIG_TRAF2_1	309	312	PF00917	0.640
LIG_TRAF2_1	412	415	PF00917	0.689
LIG_TRAF2_1	574	577	PF00917	0.555
LIG_WRC_WIRS_1	656	661	PF05994	0.755
LIG_WRC_WIRS_1	818	823	PF05994	0.627
MOD_CDK_SPxK_1	713	719	PF00069	0.589
MOD_CK1_1	112	118	PF00069	0.698
MOD_CK1_1	123	129	PF00069	0.730
MOD_CK1_1	190	196	PF00069	0.737
MOD_CK1_1	285	291	PF00069	0.693
MOD_CK1_1	41	47	PF00069	0.710
MOD_CK1_1	451	457	PF00069	0.588
MOD_CK1_1	482	488	PF00069	0.724
MOD_CK1_1	508	514	PF00069	0.666
MOD_CK1_1	523	529	PF00069	0.583
MOD_CK1_1	536	542	PF00069	0.621
MOD_CK1_1	560	566	PF00069	0.655
MOD_CK1_1	59	65	PF00069	0.672
MOD_CK1_1	600	606	PF00069	0.761
MOD_CK1_1	624	630	PF00069	0.752
MOD_CK1_1	713	719	PF00069	0.738
MOD_CK1_1	749	755	PF00069	0.728
MOD_CK1_1	82	88	PF00069	0.730
MOD_CK1_1	89	95	PF00069	0.731
MOD_CK2_1	373	379	PF00069	0.709
MOD_CK2_1	527	533	PF00069	0.633
MOD_CK2_1	560	566	PF00069	0.655
MOD_CK2_1	676	682	PF00069	0.687
MOD_GlcNHglycan	111	114	PF01048	0.812
MOD_GlcNHglycan	122	125	PF01048	0.673
MOD_GlcNHglycan	162	166	PF01048	0.735
MOD_GlcNHglycan	169	172	PF01048	0.725
MOD_GlcNHglycan	179	183	PF01048	0.616
MOD_GlcNHglycan	211	214	PF01048	0.772
MOD_GlcNHglycan	227	230	PF01048	0.573
MOD_GlcNHglycan	256	259	PF01048	0.763
MOD_GlcNHglycan	300	303	PF01048	0.581
MOD_GlcNHglycan	394	397	PF01048	0.649
MOD_GlcNHglycan	454	457	PF01048	0.705
MOD_GlcNHglycan	481	484	PF01048	0.716
MOD_GlcNHglycan	58	61	PF01048	0.775
MOD_GlcNHglycan	609	612	PF01048	0.699
MOD_GlcNHglycan	63	66	PF01048	0.765
MOD_GlcNHglycan	646	649	PF01048	0.689
MOD_GlcNHglycan	652	655	PF01048	0.685
MOD_GlcNHglycan	671	674	PF01048	0.514
MOD_GlcNHglycan	712	715	PF01048	0.810
MOD_GSK3_1	109	116	PF00069	0.822
MOD_GSK3_1	120	127	PF00069	0.626
MOD_GSK3_1	151	158	PF00069	0.740
MOD_GSK3_1	163	170	PF00069	0.745
MOD_GSK3_1	183	190	PF00069	0.706
MOD_GSK3_1	205	212	PF00069	0.755
MOD_GSK3_1	221	228	PF00069	0.627
MOD_GSK3_1	273	280	PF00069	0.770
MOD_GSK3_1	285	292	PF00069	0.620
MOD_GSK3_1	294	301	PF00069	0.593
MOD_GSK3_1	340	347	PF00069	0.676
MOD_GSK3_1	371	378	PF00069	0.679
MOD_GSK3_1	406	413	PF00069	0.714
MOD_GSK3_1	448	455	PF00069	0.662
MOD_GSK3_1	458	465	PF00069	0.686
MOD_GSK3_1	479	486	PF00069	0.600
MOD_GSK3_1	505	512	PF00069	0.660
MOD_GSK3_1	520	527	PF00069	0.590
MOD_GSK3_1	593	600	PF00069	0.647
MOD_GSK3_1	650	657	PF00069	0.658
MOD_GSK3_1	669	676	PF00069	0.458
MOD_GSK3_1	691	698	PF00069	0.786
MOD_GSK3_1	74	81	PF00069	0.726
MOD_GSK3_1	746	753	PF00069	0.719
MOD_GSK3_1	82	89	PF00069	0.796
MOD_N-GLC_1	242	247	PF02516	0.629
MOD_N-GLC_1	38	43	PF02516	0.774
MOD_N-GLC_1	456	461	PF02516	0.678
MOD_N-GLC_1	691	696	PF02516	0.782
MOD_N-GLC_1	89	94	PF02516	0.694
MOD_N-GLC_2	235	237	PF02516	0.659
MOD_NEK2_1	172	177	PF00069	0.722
MOD_NEK2_1	191	196	PF00069	0.812
MOD_NEK2_1	209	214	PF00069	0.575
MOD_NEK2_1	319	324	PF00069	0.587
MOD_NEK2_1	462	467	PF00069	0.671
MOD_NEK2_1	535	540	PF00069	0.728
MOD_NEK2_1	554	559	PF00069	0.622
MOD_NEK2_1	817	822	PF00069	0.581
MOD_NEK2_2	655	660	PF00069	0.582
MOD_PIKK_1	221	227	PF00454	0.552
MOD_PIKK_1	590	596	PF00454	0.607
MOD_PK_1	549	555	PF00069	0.544
MOD_PKA_1	710	716	PF00069	0.823
MOD_PKA_1	83	89	PF00069	0.692
MOD_PKA_2	101	107	PF00069	0.699
MOD_PKA_2	109	115	PF00069	0.725
MOD_PKA_2	145	151	PF00069	0.690
MOD_PKA_2	196	202	PF00069	0.713
MOD_PKA_2	235	241	PF00069	0.780
MOD_PKA_2	254	260	PF00069	0.540
MOD_PKA_2	340	346	PF00069	0.657
MOD_PKA_2	506	512	PF00069	0.719
MOD_PKA_2	710	716	PF00069	0.824
MOD_PKA_2	718	724	PF00069	0.696
MOD_PKA_2	777	783	PF00069	0.721
MOD_PKA_2	82	88	PF00069	0.733
MOD_PKB_1	234	242	PF00069	0.711
MOD_PKB_1	54	62	PF00069	0.818
MOD_PKB_1	724	732	PF00069	0.674
MOD_Plk_1	456	462	PF00069	0.537
MOD_Plk_1	524	530	PF00069	0.691
MOD_Plk_4	163	169	PF00069	0.713
MOD_Plk_4	191	197	PF00069	0.756
MOD_Plk_4	205	211	PF00069	0.627
MOD_Plk_4	329	335	PF00069	0.735
MOD_Plk_4	41	47	PF00069	0.583
MOD_Plk_4	549	555	PF00069	0.544
MOD_Plk_4	655	661	PF00069	0.654
MOD_Plk_4	695	701	PF00069	0.708
MOD_Plk_4	777	783	PF00069	0.799
MOD_Plk_4	817	823	PF00069	0.581
MOD_ProDKin_1	153	159	PF00069	0.728
MOD_ProDKin_1	277	283	PF00069	0.725
MOD_ProDKin_1	294	300	PF00069	0.616
MOD_ProDKin_1	59	65	PF00069	0.719
MOD_ProDKin_1	593	599	PF00069	0.659
MOD_ProDKin_1	615	621	PF00069	0.787
MOD_ProDKin_1	659	665	PF00069	0.567
MOD_ProDKin_1	713	719	PF00069	0.706
MOD_ProDKin_1	9	15	PF00069	0.555
MOD_SUMO_for_1	437	440	PF00179	0.659
MOD_SUMO_rev_2	395	403	PF00179	0.658
MOD_SUMO_rev_2	563	572	PF00179	0.667
MOD_SUMO_rev_2	733	743	PF00179	0.727
TRG_DiLeu_BaEn_4	414	420	PF01217	0.434
TRG_ENDOCYTIC_2	125	128	PF00928	0.674
TRG_ENDOCYTIC_2	134	137	PF00928	0.599
TRG_ENDOCYTIC_2	331	334	PF00928	0.749
TRG_ENDOCYTIC_2	4	7	PF00928	0.605
TRG_ENDOCYTIC_2	432	435	PF00928	0.549
TRG_ER_diArg_1	130	133	PF00400	0.607
TRG_ER_diArg_1	233	236	PF00400	0.703
TRG_ER_diArg_1	305	307	PF00400	0.756
TRG_ER_diArg_1	404	406	PF00400	0.546
TRG_ER_diArg_1	430	432	PF00400	0.542
TRG_ER_diArg_1	441	444	PF00400	0.585
TRG_ER_diArg_1	498	501	PF00400	0.660
TRG_ER_diArg_1	53	56	PF00400	0.585
TRG_ER_diArg_1	629	631	PF00400	0.797
TRG_ER_diArg_1	724	726	PF00400	0.735
TRG_ER_diArg_1	93	96	PF00400	0.713
TRG_NES_CRM1_1	812	824	PF08389	0.719
TRG_NLS_MonoCore_2	767	772	PF00514	0.815
TRG_NLS_MonoExtC_3	767	772	PF00514	0.713
TRG_NLS_MonoExtN_4	766	773	PF00514	0.719
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.769
TRG_Pf-PMV_PEXEL_1	546	551	PF00026	0.653

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I487	Leptomonas seymouri	37%	95%
A0A3Q8IKF4	Leishmania donovani	86%	100%
A4HLX9	Leishmania braziliensis	63%	99%
A4I9A8	Leishmania infantum	86%	100%
E9B4A8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%