DNAJ family-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNAJ family-like protein

Species:

Leishmania major

UniProt:

Q4Q3R7_LEIMA

TriTrypDb:

LmjF.33.2690 , LMJLV39_330038000 , LMJSD75_330037400

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q3R7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3R7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.567
CLV_NRD_NRD_1	257	259	PF00675	0.658
CLV_NRD_NRD_1	84	86	PF00675	0.358
CLV_NRD_NRD_1	88	90	PF00675	0.329
CLV_PCSK_KEX2_1	259	261	PF00082	0.590
CLV_PCSK_KEX2_1	84	86	PF00082	0.358
CLV_PCSK_KEX2_1	88	90	PF00082	0.329
CLV_PCSK_PC1ET2_1	259	261	PF00082	0.609
CLV_PCSK_PC7_1	84	90	PF00082	0.444
CLV_PCSK_SKI1_1	105	109	PF00082	0.416
CLV_PCSK_SKI1_1	175	179	PF00082	0.639
CLV_Separin_Metazoa	214	218	PF03568	0.599
DEG_APCC_KENBOX_2	37	41	PF00400	0.541
DEG_SCF_FBW7_1	52	58	PF00400	0.654
DEG_SPOP_SBC_1	6	10	PF00917	0.702
DOC_CKS1_1	204	209	PF01111	0.487
DOC_CKS1_1	52	57	PF01111	0.643
DOC_CYCLIN_yCln2_LP_2	204	210	PF00134	0.629
DOC_MAPK_gen_1	229	236	PF00069	0.499
DOC_MAPK_gen_1	84	94	PF00069	0.348
DOC_MAPK_MEF2A_6	85	94	PF00069	0.444
DOC_PP2B_PxIxI_1	75	81	PF00149	0.567
DOC_USP7_MATH_1	138	142	PF00917	0.680
DOC_USP7_MATH_1	246	250	PF00917	0.640
DOC_USP7_MATH_1	55	59	PF00917	0.653
DOC_USP7_MATH_1	6	10	PF00917	0.772
DOC_USP7_UBL2_3	231	235	PF12436	0.576
DOC_WW_Pin1_4	203	208	PF00397	0.484
DOC_WW_Pin1_4	30	35	PF00397	0.751
DOC_WW_Pin1_4	51	56	PF00397	0.635
LIG_14-3-3_CanoR_1	195	204	PF00244	0.547
LIG_14-3-3_CanoR_1	88	93	PF00244	0.441
LIG_BIR_II_1	1	5	PF00653	0.670
LIG_BRCT_BRCA1_1	90	94	PF00533	0.444
LIG_FHA_1	199	205	PF00498	0.468
LIG_FHA_1	228	234	PF00498	0.623
LIG_FHA_2	111	117	PF00498	0.358
LIG_FHA_2	128	134	PF00498	0.440
LIG_LIR_Gen_1	206	216	PF02991	0.586
LIG_LIR_Gen_1	42	52	PF02991	0.466
LIG_LIR_Nem_3	42	47	PF02991	0.443
LIG_SH2_CRK	87	91	PF00017	0.444
LIG_SH2_STAT5	127	130	PF00017	0.570
LIG_SH2_STAT5	46	49	PF00017	0.536
LIG_SUMO_SIM_par_1	222	230	PF11976	0.509
LIG_TRAF2_1	144	147	PF00917	0.713
LIG_TRAF2_1	185	188	PF00917	0.544
LIG_WRC_WIRS_1	41	46	PF05994	0.555
MOD_CK1_1	198	204	PF00069	0.622
MOD_CK2_1	110	116	PF00069	0.487
MOD_CK2_1	127	133	PF00069	0.584
MOD_CK2_1	5	11	PF00069	0.761
MOD_GlcNHglycan	139	143	PF01048	0.702
MOD_GlcNHglycan	2	5	PF01048	0.727
MOD_GlcNHglycan	241	244	PF01048	0.657
MOD_GlcNHglycan	58	61	PF01048	0.683
MOD_GlcNHglycan	66	69	PF01048	0.733
MOD_GSK3_1	110	117	PF00069	0.444
MOD_GSK3_1	195	202	PF00069	0.498
MOD_GSK3_1	30	37	PF00069	0.622
MOD_GSK3_1	51	58	PF00069	0.571
MOD_GSK3_1	64	71	PF00069	0.712
MOD_N-GLC_1	4	9	PF02516	0.695
MOD_NEK2_1	200	205	PF00069	0.622
MOD_PKA_1	88	94	PF00069	0.444
MOD_PKA_2	88	94	PF00069	0.441
MOD_Plk_4	114	120	PF00069	0.444
MOD_ProDKin_1	203	209	PF00069	0.485
MOD_ProDKin_1	30	36	PF00069	0.732
MOD_ProDKin_1	51	57	PF00069	0.644
TRG_DiLeu_BaLyEn_6	192	197	PF01217	0.572
TRG_ENDOCYTIC_2	46	49	PF00928	0.437
TRG_ENDOCYTIC_2	87	90	PF00928	0.328
TRG_ER_diArg_1	148	151	PF00400	0.495
TRG_ER_diArg_1	258	261	PF00400	0.585
TRG_ER_diArg_1	83	85	PF00400	0.358
TRG_ER_diArg_1	87	89	PF00400	0.329
TRG_NLS_MonoExtC_3	257	262	PF00514	0.699
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	195	199	PF00026	0.572

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5Q0	Leptomonas seymouri	62%	100%
A0A1X0NSQ5	Trypanosomatidae	35%	100%
A0A3Q8IH27	Leishmania donovani	89%	100%
A4HLY0	Leishmania braziliensis	78%	100%
A4I9A9	Leishmania infantum	89%	100%
C9ZJB7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B4A9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BF66	Trypanosoma cruzi	37%	100%