Complex1_LYR_dom domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Complex 1 protein (LYR family), putative

Species:

Leishmania major

UniProt:

Q4Q3R5_LEIMA

TriTrypDb:

LmjF.33.2710 , LMJLV39_330038200 , LMJSD75_330037600

Length:

165

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3R5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3R5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.753
CLV_NRD_NRD_1	107	109	PF00675	0.705
CLV_NRD_NRD_1	59	61	PF00675	0.419
CLV_PCSK_KEX2_1	107	109	PF00082	0.598
CLV_PCSK_KEX2_1	163	165	PF00082	0.636
CLV_PCSK_KEX2_1	74	76	PF00082	0.350
CLV_PCSK_KEX2_1	88	90	PF00082	0.306
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.411
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.268
CLV_PCSK_SKI1_1	45	49	PF00082	0.355
CLV_PCSK_SKI1_1	61	65	PF00082	0.355
CLV_PCSK_SKI1_1	98	102	PF00082	0.541
DEG_APCC_DBOX_1	44	52	PF00400	0.355
DEG_Nend_Nbox_1	1	3	PF02207	0.610
DOC_CYCLIN_RxL_1	95	105	PF00134	0.599
DOC_MAPK_gen_1	88	96	PF00069	0.440
DOC_PP1_RVXF_1	59	66	PF00149	0.447
DOC_WW_Pin1_4	6	11	PF00397	0.708
LIG_deltaCOP1_diTrp_1	120	126	PF00928	0.598
LIG_FHA_1	155	161	PF00498	0.582
LIG_FHA_1	38	44	PF00498	0.408
LIG_FHA_2	108	114	PF00498	0.752
LIG_LIR_Gen_1	120	129	PF02991	0.537
LIG_LIR_Nem_3	120	126	PF02991	0.531
LIG_LIR_Nem_3	29	33	PF02991	0.491
LIG_NRP_CendR_1	163	165	PF00754	0.665
LIG_SH2_GRB2like	140	143	PF00017	0.693
LIG_SH2_SRC	140	143	PF00017	0.693
LIG_SH2_STAP1	140	144	PF00017	0.664
LIG_SH2_STAT3	151	154	PF00017	0.612
LIG_SH2_STAT3	35	38	PF00017	0.529
LIG_SH2_STAT5	151	154	PF00017	0.635
LIG_SH2_STAT5	42	45	PF00017	0.438
LIG_WRC_WIRS_1	27	32	PF05994	0.482
MOD_CDK_SPK_2	6	11	PF00069	0.655
MOD_CK1_1	145	151	PF00069	0.692
MOD_CK1_1	29	35	PF00069	0.604
MOD_GlcNHglycan	129	132	PF01048	0.571
MOD_GlcNHglycan	147	150	PF01048	0.606
MOD_GlcNHglycan	83	86	PF01048	0.379
MOD_GSK3_1	140	147	PF00069	0.620
MOD_GSK3_1	150	157	PF00069	0.592
MOD_NEK2_1	144	149	PF00069	0.572
MOD_NEK2_2	37	42	PF00069	0.497
MOD_PIKK_1	150	156	PF00454	0.616
MOD_PKA_1	107	113	PF00069	0.700
MOD_PKA_2	107	113	PF00069	0.700
MOD_Plk_1	140	146	PF00069	0.735
MOD_Plk_4	147	153	PF00069	0.687
MOD_Plk_4	37	43	PF00069	0.394
MOD_ProDKin_1	6	12	PF00069	0.710
MOD_SUMO_rev_2	58	63	PF00179	0.480
TRG_DiLeu_BaEn_1	59	64	PF01217	0.355
TRG_ENDOCYTIC_2	44	47	PF00928	0.319
TRG_ER_diArg_1	106	108	PF00400	0.625
TRG_ER_diArg_1	163	165	PF00400	0.690
TRG_ER_diArg_1	65	68	PF00400	0.350
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZD1	Leptomonas seymouri	80%	99%
A0A0S4JQG9	Bodo saltans	45%	92%
A0A1X0NRJ6	Trypanosomatidae	61%	100%
A0A3Q8IU86	Leishmania donovani	98%	99%
A0A422N9P9	Trypanosoma rangeli	59%	100%
A4HLY2	Leishmania braziliensis	89%	100%
A4I9B1	Leishmania infantum	99%	99%
C9ZJB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9B4B1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%