Mitochondrial guide RNA binding complex subunit 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

guide RNA associated protein 1, putative

Species:

Leishmania major

UniProt:

Q4Q3R2_LEIMA

TriTrypDb:

LmjF.33.2730 , LMJLV39_330038500 , LMJSD75_330037900

Length:

502

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	4
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q3R2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3R2

Function

Biological processes
Term	Name	Level	Count
GO:0000959	mitochondrial RNA metabolic process	6	3
GO:0000963	mitochondrial RNA processing	6	3
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006396	RNA processing	6	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009451	RNA modification	5	2
GO:0009987	cellular process	1	3
GO:0010467	gene expression	4	3
GO:0016070	RNA metabolic process	5	3
GO:0016071	mRNA metabolic process	6	2
GO:0016556	mRNA modification	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0046483	heterocycle metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:0090304	nucleic acid metabolic process	4	3
GO:0140053	mitochondrial gene expression	5	3
GO:1901360	organic cyclic compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003723	RNA binding	4	3
GO:0003729	mRNA binding	5	3
GO:0005488	binding	1	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	329	333	PF00656	0.508
CLV_C14_Caspase3-7	390	394	PF00656	0.477
CLV_NRD_NRD_1	160	162	PF00675	0.580
CLV_NRD_NRD_1	17	19	PF00675	0.707
CLV_NRD_NRD_1	232	234	PF00675	0.472
CLV_NRD_NRD_1	325	327	PF00675	0.427
CLV_NRD_NRD_1	414	416	PF00675	0.337
CLV_NRD_NRD_1	433	435	PF00675	0.489
CLV_PCSK_KEX2_1	160	162	PF00082	0.564
CLV_PCSK_KEX2_1	17	19	PF00082	0.705
CLV_PCSK_KEX2_1	232	234	PF00082	0.472
CLV_PCSK_KEX2_1	325	327	PF00082	0.450
CLV_PCSK_KEX2_1	376	378	PF00082	0.373
CLV_PCSK_KEX2_1	433	435	PF00082	0.393
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.421
CLV_PCSK_SKI1_1	257	261	PF00082	0.453
CLV_PCSK_SKI1_1	376	380	PF00082	0.451
DOC_MAPK_gen_1	160	168	PF00069	0.538
DOC_MAPK_gen_1	266	274	PF00069	0.461
DOC_MAPK_gen_1	433	439	PF00069	0.405
DOC_MAPK_MEF2A_6	358	366	PF00069	0.447
DOC_MAPK_MEF2A_6	420	429	PF00069	0.418
DOC_PP1_RVXF_1	231	238	PF00149	0.410
DOC_PP1_RVXF_1	255	261	PF00149	0.472
DOC_SPAK_OSR1_1	350	354	PF12202	0.372
DOC_SPAK_OSR1_1	365	369	PF12202	0.486
DOC_USP7_MATH_1	100	104	PF00917	0.402
DOC_USP7_MATH_1	207	211	PF00917	0.517
DOC_USP7_MATH_1	291	295	PF00917	0.371
DOC_USP7_MATH_1	316	320	PF00917	0.398
DOC_USP7_MATH_1	498	502	PF00917	0.672
DOC_USP7_MATH_1	88	92	PF00917	0.590
DOC_WW_Pin1_4	397	402	PF00397	0.420
DOC_WW_Pin1_4	432	437	PF00397	0.395
LIG_14-3-3_CanoR_1	26	30	PF00244	0.663
LIG_14-3-3_CanoR_1	269	273	PF00244	0.444
LIG_14-3-3_CanoR_1	325	331	PF00244	0.593
LIG_14-3-3_CanoR_1	377	383	PF00244	0.407
LIG_14-3-3_CanoR_1	41	48	PF00244	0.650
LIG_Actin_WH2_2	159	174	PF00022	0.516
LIG_BIR_II_1	1	5	PF00653	0.561
LIG_BRCT_BRCA1_1	90	94	PF00533	0.485
LIG_deltaCOP1_diTrp_1	150	157	PF00928	0.577
LIG_deltaCOP1_diTrp_1	236	243	PF00928	0.386
LIG_deltaCOP1_diTrp_1	58	64	PF00928	0.451
LIG_FHA_1	269	275	PF00498	0.587
LIG_FHA_1	31	37	PF00498	0.702
LIG_FHA_1	352	358	PF00498	0.481
LIG_FHA_1	424	430	PF00498	0.379
LIG_FHA_1	433	439	PF00498	0.403
LIG_FHA_1	54	60	PF00498	0.570
LIG_FHA_1	72	78	PF00498	0.385
LIG_FHA_1	91	97	PF00498	0.614
LIG_FHA_2	131	137	PF00498	0.611
LIG_FHA_2	139	145	PF00498	0.617
LIG_FHA_2	197	203	PF00498	0.466
LIG_GBD_Chelix_1	304	312	PF00786	0.431
LIG_LIR_Gen_1	164	173	PF02991	0.522
LIG_LIR_Gen_1	450	461	PF02991	0.349
LIG_LIR_Gen_1	51	60	PF02991	0.426
LIG_LIR_Nem_3	164	168	PF02991	0.533
LIG_LIR_Nem_3	175	180	PF02991	0.496
LIG_LIR_Nem_3	450	456	PF02991	0.350
LIG_LIR_Nem_3	475	479	PF02991	0.467
LIG_LIR_Nem_3	51	55	PF02991	0.440
LIG_SH2_CRK	185	189	PF00017	0.419
LIG_SH2_CRK	261	265	PF00017	0.465
LIG_SH2_CRK	476	480	PF00017	0.467
LIG_SH2_SRC	282	285	PF00017	0.416
LIG_SH2_SRC	382	385	PF00017	0.382
LIG_SH2_STAP1	451	455	PF00017	0.299
LIG_SH2_STAT3	79	82	PF00017	0.434
LIG_SH2_STAT5	216	219	PF00017	0.479
LIG_SH2_STAT5	287	290	PF00017	0.450
LIG_SH2_STAT5	356	359	PF00017	0.377
LIG_SH2_STAT5	382	385	PF00017	0.552
LIG_SH2_STAT5	408	411	PF00017	0.357
LIG_SH2_STAT5	80	83	PF00017	0.435
LIG_SH3_1	176	182	PF00018	0.465
LIG_SH3_3	176	182	PF00018	0.465
LIG_SH3_3	395	401	PF00018	0.440
LIG_SH3_3	452	458	PF00018	0.349
LIG_SH3_3	92	98	PF00018	0.509
LIG_SUMO_SIM_anti_2	452	458	PF11976	0.473
LIG_SUMO_SIM_par_1	435	440	PF11976	0.429
LIG_TYR_ITIM	259	264	PF00017	0.440
LIG_TYR_ITIM	449	454	PF00017	0.361
MOD_CK1_1	190	196	PF00069	0.453
MOD_CK1_1	30	36	PF00069	0.641
MOD_CK1_1	394	400	PF00069	0.431
MOD_CK1_1	53	59	PF00069	0.494
MOD_CK1_1	71	77	PF00069	0.568
MOD_CK2_1	138	144	PF00069	0.700
MOD_CK2_1	293	299	PF00069	0.412
MOD_CK2_1	70	76	PF00069	0.413
MOD_CMANNOS	61	64	PF00535	0.395
MOD_GlcNHglycan	1	4	PF01048	0.753
MOD_GlcNHglycan	113	116	PF01048	0.518
MOD_GlcNHglycan	191	195	PF01048	0.546
MOD_GlcNHglycan	293	296	PF01048	0.488
MOD_GlcNHglycan	44	47	PF01048	0.637
MOD_GlcNHglycan	469	472	PF01048	0.397
MOD_GSK3_1	126	133	PF00069	0.747
MOD_GSK3_1	27	34	PF00069	0.706
MOD_GSK3_1	316	323	PF00069	0.341
MOD_GSK3_1	387	394	PF00069	0.439
MOD_GSK3_1	490	497	PF00069	0.569
MOD_GSK3_1	71	78	PF00069	0.351
MOD_N-GLC_1	30	35	PF02516	0.772
MOD_NEK2_1	242	247	PF00069	0.404
MOD_NEK2_1	260	265	PF00069	0.557
MOD_NEK2_1	339	344	PF00069	0.397
MOD_NEK2_1	351	356	PF00069	0.330
MOD_NEK2_1	36	41	PF00069	0.738
MOD_NEK2_1	429	434	PF00069	0.378
MOD_NEK2_1	437	442	PF00069	0.456
MOD_NEK2_1	492	497	PF00069	0.523
MOD_NEK2_1	70	75	PF00069	0.362
MOD_NEK2_2	320	325	PF00069	0.312
MOD_PIKK_1	356	362	PF00454	0.346
MOD_PIKK_1	418	424	PF00454	0.514
MOD_PKA_1	101	107	PF00069	0.572
MOD_PKA_1	325	331	PF00069	0.533
MOD_PKA_1	376	382	PF00069	0.358
MOD_PKA_2	25	31	PF00069	0.706
MOD_PKA_2	268	274	PF00069	0.588
MOD_PKA_2	324	330	PF00069	0.542
MOD_PKA_2	376	382	PF00069	0.453
MOD_PKA_2	388	394	PF00069	0.469
MOD_Plk_1	138	144	PF00069	0.712
MOD_Plk_1	50	56	PF00069	0.475
MOD_Plk_1	75	81	PF00069	0.530
MOD_Plk_4	101	107	PF00069	0.518
MOD_Plk_4	394	400	PF00069	0.413
MOD_Plk_4	75	81	PF00069	0.519
MOD_Plk_4	90	96	PF00069	0.613
MOD_ProDKin_1	397	403	PF00069	0.414
MOD_ProDKin_1	432	438	PF00069	0.399
TRG_DiLeu_BaLyEn_6	433	438	PF01217	0.400
TRG_ENDOCYTIC_2	165	168	PF00928	0.586
TRG_ENDOCYTIC_2	177	180	PF00928	0.394
TRG_ENDOCYTIC_2	185	188	PF00928	0.213
TRG_ENDOCYTIC_2	261	264	PF00928	0.441
TRG_ENDOCYTIC_2	287	290	PF00928	0.380
TRG_ENDOCYTIC_2	451	454	PF00928	0.331
TRG_ENDOCYTIC_2	476	479	PF00928	0.469
TRG_ER_diArg_1	20	23	PF00400	0.655
TRG_ER_diArg_1	231	233	PF00400	0.380
TRG_ER_diArg_1	324	326	PF00400	0.397
TRG_ER_diArg_1	368	371	PF00400	0.368
TRG_NES_CRM1_1	186	202	PF08389	0.481
TRG_NES_CRM1_1	299	314	PF08389	0.525
TRG_NLS_MonoExtC_3	374	380	PF00514	0.406
TRG_NLS_MonoExtN_4	373	379	PF00514	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK37	Leptomonas seymouri	28%	100%
A0A0N1IKX3	Leptomonas seymouri	81%	92%
A0A0S4IN88	Bodo saltans	28%	94%
A0A0S4JQR1	Bodo saltans	55%	93%
A0A1X0NRA1	Trypanosomatidae	69%	98%
A0A1X0NTQ0	Trypanosomatidae	29%	100%
A0A3Q8II17	Leishmania donovani	95%	100%
A0A3S7WX47	Leishmania donovani	28%	100%
A0A422NDT8	Trypanosoma rangeli	29%	100%
A0A422NKD3	Trypanosoma rangeli	67%	100%
A4HCA9	Leishmania braziliensis	25%	100%
A4HLY4	Leishmania braziliensis	88%	100%
A4HZU2	Leishmania infantum	28%	100%
A4I9B3	Leishmania infantum	95%	100%
C9ZJB1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
C9ZRN1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AVP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B4B3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QBT2	Leishmania major	28%	100%
V5BAI0	Trypanosoma cruzi	68%	100%
V5BVS4	Trypanosoma cruzi	29%	100%