Eukaryotic translation initiation factor 5B

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translation initiation factor IF-2, putative

Species:

Leishmania major

UniProt:

Q4Q3R1_LEIMA

TriTrypDb:

LmjF.33.2740 , LMJLV39_330038600 , LMJSD75_330038000

Length:

816

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	yes	yes: 3
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4Q3R1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3R1

Function

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Biological processes
Term	Name	Level	Count
GO:0006413	translational initiation	3	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0044237	cellular metabolic process	2	2

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0003743	translation initiation factor activity	4	11
GO:0003824	catalytic activity	1	11
GO:0003924	GTPase activity	7	11
GO:0005488	binding	1	11
GO:0005525	GTP binding	5	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.719
CLV_NRD_NRD_1	178	180	PF00675	0.606
CLV_NRD_NRD_1	195	197	PF00675	0.582
CLV_NRD_NRD_1	199	201	PF00675	0.601
CLV_NRD_NRD_1	49	51	PF00675	0.585
CLV_NRD_NRD_1	61	63	PF00675	0.626
CLV_NRD_NRD_1	621	623	PF00675	0.293
CLV_NRD_NRD_1	722	724	PF00675	0.563
CLV_NRD_NRD_1	83	85	PF00675	0.592
CLV_NRD_NRD_1	86	88	PF00675	0.622

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P688	Leptomonas seymouri	77%	99%
A0A1X0NR88	Trypanosomatidae	69%	98%
A0A3Q8IHQ5	Leishmania donovani	98%	100%
A0A3R7NFT4	Trypanosoma rangeli	69%	98%
A0B8Q6	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	35%	100%
A1RUX2	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	32%	100%
A1RXH6	Thermofilum pendens (strain DSM 2475 / Hrk 5)	36%	100%
A1TSK3	Acidovorax citrulli (strain AAC00-1)	27%	87%
A1VXL9	Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)	27%	94%
A1W8Z4	Acidovorax sp. (strain JS42)	26%	87%

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