Eukaryotic translation initiation factor 5B

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translation initiation factor IF-2, putative

Species:

Leishmania major

UniProt:

Q4Q3R1_LEIMA

TriTrypDb:

LmjF.33.2740 , LMJLV39_330038600 , LMJSD75_330038000

Length:

816

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	yes	yes: 3
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q3R1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3R1

Function

Biological processes
Term	Name	Level	Count
GO:0006413	translational initiation	3	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0003743	translation initiation factor activity	4	11
GO:0003824	catalytic activity	1	11
GO:0003924	GTPase activity	7	11
GO:0005488	binding	1	11
GO:0005525	GTP binding	5	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0019001	guanyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032561	guanyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.719
CLV_NRD_NRD_1	178	180	PF00675	0.606
CLV_NRD_NRD_1	195	197	PF00675	0.582
CLV_NRD_NRD_1	199	201	PF00675	0.601
CLV_NRD_NRD_1	49	51	PF00675	0.585
CLV_NRD_NRD_1	61	63	PF00675	0.626
CLV_NRD_NRD_1	621	623	PF00675	0.293
CLV_NRD_NRD_1	722	724	PF00675	0.563
CLV_NRD_NRD_1	83	85	PF00675	0.592
CLV_NRD_NRD_1	86	88	PF00675	0.622
CLV_PCSK_FUR_1	340	344	PF00082	0.371
CLV_PCSK_KEX2_1	178	180	PF00082	0.606
CLV_PCSK_KEX2_1	342	344	PF00082	0.371
CLV_PCSK_KEX2_1	49	51	PF00082	0.587
CLV_PCSK_KEX2_1	610	612	PF00082	0.291
CLV_PCSK_KEX2_1	620	622	PF00082	0.291
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.371
CLV_PCSK_PC1ET2_1	610	612	PF00082	0.291
CLV_PCSK_PC1ET2_1	620	622	PF00082	0.291
CLV_PCSK_SKI1_1	178	182	PF00082	0.752
CLV_PCSK_SKI1_1	459	463	PF00082	0.473
CLV_PCSK_SKI1_1	497	501	PF00082	0.291
CLV_PCSK_SKI1_1	518	522	PF00082	0.291
CLV_PCSK_SKI1_1	560	564	PF00082	0.596
CLV_PCSK_SKI1_1	594	598	PF00082	0.305
CLV_PCSK_SKI1_1	790	794	PF00082	0.525
CLV_PCSK_SKI1_1	809	813	PF00082	0.477
DEG_MDM2_SWIB_1	382	389	PF02201	0.571
DEG_SCF_FBW7_2	295	302	PF00400	0.491
DEG_SPOP_SBC_1	578	582	PF00917	0.491
DOC_CKS1_1	296	301	PF01111	0.491
DOC_CKS1_1	499	504	PF01111	0.491
DOC_CKS1_1	715	720	PF01111	0.443
DOC_CKS1_1	747	752	PF01111	0.571
DOC_CYCLIN_RxL_1	494	501	PF00134	0.491
DOC_MAPK_DCC_7	285	295	PF00069	0.532
DOC_MAPK_DCC_7	680	689	PF00069	0.416
DOC_MAPK_gen_1	25	32	PF00069	0.660
DOC_MAPK_gen_1	282	290	PF00069	0.521
DOC_MAPK_gen_1	340	350	PF00069	0.497
DOC_MAPK_gen_1	407	415	PF00069	0.491
DOC_MAPK_gen_1	518	528	PF00069	0.491
DOC_MAPK_gen_1	620	632	PF00069	0.521
DOC_MAPK_gen_1	645	651	PF00069	0.505
DOC_MAPK_gen_1	676	684	PF00069	0.456
DOC_MAPK_gen_1	723	732	PF00069	0.620
DOC_MAPK_gen_1	98	106	PF00069	0.712
DOC_MAPK_MEF2A_6	521	528	PF00069	0.491
DOC_MAPK_MEF2A_6	625	632	PF00069	0.479
DOC_PP2B_LxvP_1	288	291	PF13499	0.491
DOC_PP2B_LxvP_1	811	814	PF13499	0.472
DOC_PP4_FxxP_1	568	571	PF00568	0.561
DOC_PP4_FxxP_1	632	635	PF00568	0.571
DOC_USP7_MATH_1	269	273	PF00917	0.569
DOC_USP7_MATH_1	599	603	PF00917	0.491
DOC_USP7_UBL2_3	128	132	PF12436	0.733
DOC_USP7_UBL2_3	197	201	PF12436	0.594
DOC_USP7_UBL2_3	25	29	PF12436	0.373
DOC_USP7_UBL2_3	444	448	PF12436	0.449
DOC_USP7_UBL2_3	7	11	PF12436	0.675
DOC_USP7_UBL2_3	793	797	PF12436	0.558
DOC_USP7_UBL2_3	812	816	PF12436	0.641
DOC_USP7_UBL2_3	88	92	PF12436	0.635
DOC_WW_Pin1_4	223	228	PF00397	0.421
DOC_WW_Pin1_4	295	300	PF00397	0.482
DOC_WW_Pin1_4	498	503	PF00397	0.491
DOC_WW_Pin1_4	714	719	PF00397	0.445
DOC_WW_Pin1_4	746	751	PF00397	0.583
LIG_14-3-3_CanoR_1	310	315	PF00244	0.491
LIG_14-3-3_CanoR_1	410	416	PF00244	0.571
LIG_14-3-3_CanoR_1	678	683	PF00244	0.531
LIG_14-3-3_CanoR_1	734	739	PF00244	0.492
LIG_14-3-3_CanoR_1	783	787	PF00244	0.576
LIG_Actin_WH2_2	675	692	PF00022	0.575
LIG_Actin_WH2_2	701	716	PF00022	0.502
LIG_Clathr_ClatBox_1	293	297	PF01394	0.491
LIG_Clathr_ClatBox_1	429	433	PF01394	0.491
LIG_CtBP_PxDLS_1	751	757	PF00389	0.591
LIG_EH1_1	465	473	PF00400	0.543
LIG_FAT_LD_1	586	594	PF03623	0.491
LIG_FHA_1	238	244	PF00498	0.491
LIG_FHA_1	258	264	PF00498	0.358
LIG_FHA_1	275	281	PF00498	0.491
LIG_FHA_1	465	471	PF00498	0.556
LIG_FHA_1	538	544	PF00498	0.569
LIG_FHA_1	663	669	PF00498	0.486
LIG_FHA_1	697	703	PF00498	0.518
LIG_FHA_2	156	162	PF00498	0.717
LIG_FHA_2	182	188	PF00498	0.708
LIG_FHA_2	444	450	PF00498	0.444
LIG_FHA_2	452	458	PF00498	0.404
LIG_GBD_Chelix_1	320	328	PF00786	0.291
LIG_LIR_Apic_2	532	538	PF02991	0.491
LIG_LIR_Apic_2	567	571	PF02991	0.571
LIG_LIR_Gen_1	166	173	PF02991	0.623
LIG_LIR_Gen_1	384	393	PF02991	0.561
LIG_LIR_Gen_1	623	634	PF02991	0.571
LIG_LIR_LC3C_4	540	545	PF02991	0.426
LIG_LIR_Nem_3	166	172	PF02991	0.642
LIG_LIR_Nem_3	302	307	PF02991	0.491
LIG_LIR_Nem_3	384	389	PF02991	0.571
LIG_LIR_Nem_3	623	629	PF02991	0.556
LIG_LIR_Nem_3	662	667	PF02991	0.544
LIG_NRBOX	585	591	PF00104	0.491
LIG_Pex14_2	382	386	PF04695	0.571
LIG_Rb_pABgroove_1	351	359	PF01858	0.521
LIG_Rb_pABgroove_1	655	663	PF01858	0.491
LIG_SH2_CRK	626	630	PF00017	0.521
LIG_SH2_GRB2like	403	406	PF00017	0.545
LIG_SH2_GRB2like	667	670	PF00017	0.509
LIG_SH2_PTP2	535	538	PF00017	0.543
LIG_SH2_SRC	514	517	PF00017	0.491
LIG_SH2_SRC	535	538	PF00017	0.571
LIG_SH2_STAP1	626	630	PF00017	0.521
LIG_SH2_STAT5	514	517	PF00017	0.505
LIG_SH2_STAT5	535	538	PF00017	0.543
LIG_SH2_STAT5	667	670	PF00017	0.347
LIG_SH3_3	712	718	PF00018	0.457
LIG_SH3_4	128	135	PF00018	0.721
LIG_Sin3_3	318	325	PF02671	0.491
LIG_SUMO_SIM_anti_2	316	321	PF11976	0.491
LIG_SUMO_SIM_anti_2	428	433	PF11976	0.493
LIG_SUMO_SIM_anti_2	467	472	PF11976	0.571
LIG_SUMO_SIM_anti_2	540	546	PF11976	0.433
LIG_SUMO_SIM_anti_2	726	733	PF11976	0.538
LIG_SUMO_SIM_anti_2	799	806	PF11976	0.570
LIG_SUMO_SIM_par_1	292	298	PF11976	0.491
LIG_SUMO_SIM_par_1	318	323	PF11976	0.491
LIG_SUMO_SIM_par_1	428	433	PF11976	0.493
LIG_SUMO_SIM_par_1	704	709	PF11976	0.567
LIG_SUMO_SIM_par_1	743	749	PF11976	0.587
LIG_SUMO_SIM_par_1	799	806	PF11976	0.570
LIG_TRAF2_1	144	147	PF00917	0.736
LIG_TRAF2_1	160	163	PF00917	0.766
LIG_TRAF2_1	44	47	PF00917	0.552
LIG_UBA3_1	22	29	PF00899	0.564
LIG_UBA3_1	589	597	PF00899	0.491
LIG_UBA3_1	656	663	PF00899	0.539
LIG_UBA3_1	803	812	PF00899	0.450
LIG_WRC_WIRS_1	589	594	PF05994	0.521
MOD_CK1_1	272	278	PF00069	0.539
MOD_CK1_1	309	315	PF00069	0.491
MOD_CK1_1	419	425	PF00069	0.491
MOD_CK1_1	498	504	PF00069	0.561
MOD_CK1_1	577	583	PF00069	0.571
MOD_CK1_1	695	701	PF00069	0.521
MOD_CK1_1	760	766	PF00069	0.480
MOD_CK1_1	779	785	PF00069	0.323
MOD_CK2_1	155	161	PF00069	0.703
MOD_CK2_1	181	187	PF00069	0.709
MOD_CK2_1	451	457	PF00069	0.404
MOD_DYRK1A_RPxSP_1	714	718	PF00069	0.562
MOD_GlcNHglycan	274	277	PF01048	0.394
MOD_GlcNHglycan	392	396	PF01048	0.394
MOD_GlcNHglycan	418	421	PF01048	0.291
MOD_GlcNHglycan	528	531	PF01048	0.394
MOD_GlcNHglycan	719	722	PF01048	0.491
MOD_GlcNHglycan	759	762	PF01048	0.480
MOD_GSK3_1	219	226	PF00069	0.531
MOD_GSK3_1	234	241	PF00069	0.443
MOD_GSK3_1	302	309	PF00069	0.491
MOD_GSK3_1	377	384	PF00069	0.521
MOD_GSK3_1	411	418	PF00069	0.491
MOD_GSK3_1	491	498	PF00069	0.561
MOD_GSK3_1	574	581	PF00069	0.529
MOD_GSK3_1	692	699	PF00069	0.603
MOD_NEK2_1	451	456	PF00069	0.404
MOD_NEK2_1	574	579	PF00069	0.563
MOD_NEK2_1	803	808	PF00069	0.422
MOD_PIKK_1	257	263	PF00454	0.491
MOD_PIKK_1	491	497	PF00454	0.491
MOD_PIKK_1	537	543	PF00454	0.566
MOD_PK_1	678	684	PF00069	0.599
MOD_PK_1	725	731	PF00069	0.579
MOD_PKA_1	178	184	PF00069	0.716
MOD_PKA_1	196	202	PF00069	0.682
MOD_PKA_2	178	184	PF00069	0.672
MOD_PKA_2	246	252	PF00069	0.491
MOD_PKA_2	269	275	PF00069	0.538
MOD_PKA_2	309	315	PF00069	0.491
MOD_PKA_2	332	338	PF00069	0.491
MOD_PKA_2	782	788	PF00069	0.431
MOD_PKB_1	308	316	PF00069	0.491
MOD_Plk_1	725	731	PF00069	0.613
MOD_Plk_4	238	244	PF00069	0.491
MOD_Plk_4	263	269	PF00069	0.491
MOD_Plk_4	411	417	PF00069	0.491
MOD_Plk_4	451	457	PF00069	0.404
MOD_Plk_4	588	594	PF00069	0.521
MOD_Plk_4	725	731	PF00069	0.616
MOD_Plk_4	803	809	PF00069	0.441
MOD_ProDKin_1	223	229	PF00069	0.418
MOD_ProDKin_1	295	301	PF00069	0.482
MOD_ProDKin_1	498	504	PF00069	0.491
MOD_ProDKin_1	714	720	PF00069	0.440
MOD_ProDKin_1	746	752	PF00069	0.579
MOD_SUMO_for_1	28	31	PF00179	0.652
MOD_SUMO_for_1	389	392	PF00179	0.505
MOD_SUMO_for_1	792	795	PF00179	0.493
MOD_SUMO_rev_2	192	199	PF00179	0.718
MOD_SUMO_rev_2	794	798	PF00179	0.572
MOD_SUMO_rev_2	80	90	PF00179	0.679
TRG_DiLeu_BaEn_1	334	339	PF01217	0.491
TRG_DiLeu_BaEn_4	37	43	PF01217	0.554
TRG_DiLeu_LyEn_5	334	339	PF01217	0.491
TRG_ENDOCYTIC_2	626	629	PF00928	0.513
TRG_ENDOCYTIC_2	658	661	PF00928	0.491
TRG_ER_diArg_1	307	310	PF00400	0.491
TRG_ER_diArg_1	39	42	PF00400	0.530
TRG_ER_diArg_1	49	52	PF00400	0.537
TRG_ER_diArg_1	508	511	PF00400	0.491
TRG_NES_CRM1_1	677	688	PF08389	0.544
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.291
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	666	670	PF00026	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P688	Leptomonas seymouri	77%	99%
A0A1X0NR88	Trypanosomatidae	69%	98%
A0A3Q8IHQ5	Leishmania donovani	98%	100%
A0A3R7NFT4	Trypanosoma rangeli	69%	98%
A0B8Q6	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	35%	100%
A1RUX2	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	32%	100%
A1RXH6	Thermofilum pendens (strain DSM 2475 / Hrk 5)	36%	100%
A1TSK3	Acidovorax citrulli (strain AAC00-1)	27%	87%
A1VXL9	Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)	27%	94%
A1W8Z4	Acidovorax sp. (strain JS42)	26%	87%
A2BJZ8	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	36%	100%
A2STM8	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	36%	100%
A3CSP4	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	35%	100%
A3DMS0	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	37%	100%
A3MTU7	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	34%	100%
A4FZQ3	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	35%	100%
A4G7S7	Herminiimonas arsenicoxydans	28%	87%
A4HLY5	Leishmania braziliensis	92%	100%
A4I9B4	Leishmania infantum	98%	100%
A4WIK2	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	33%	100%
A4YCQ5	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	36%	100%
A5UJM9	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	31%	100%
A6MVX8	Rhodomonas salina	27%	100%
A6T0Y8	Janthinobacterium sp. (strain Marseille)	28%	87%
A6URS1	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	34%	100%
A6UVG0	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	36%	100%
A6VIS4	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	36%	100%
A7GZZ3	Campylobacter curvus (strain 525.92)	28%	90%
A7H1L5	Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)	27%	96%
A7IAP7	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	35%	100%
A8A8D3	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	36%	100%
A8FJU1	Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828)	27%	94%
A8MBV9	Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)	36%	100%
A9A813	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	36%	100%
B0R6U5	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	37%	100%
B1MZH4	Leuconostoc citreum (strain KM20)	27%	97%
B1YCQ7	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	33%	100%
B2GUV7	Rattus norvegicus	47%	67%
B4RXT8	Alteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype)	26%	94%
B6YWH3	Thermococcus onnurineus (strain NA1)	36%	100%
B8GP02	Thioalkalivibrio sulfidiphilus (strain HL-EbGR7)	25%	96%
B9KEV0	Campylobacter lari (strain RM2100 / D67 / ATCC BAA-1060)	27%	93%
B9LQL7	Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)	33%	100%
C1DFK9	Azotobacter vinelandii (strain DJ / ATCC BAA-1303)	27%	98%
C4L8X4	Tolumonas auensis (strain DSM 9187 / TA4)	26%	90%
C6A1V3	Thermococcus sibiricus (strain DSM 12597 / MM 739)	35%	100%
C9ZJA9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	98%
E9B4B4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
G0S8G9	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	51%	73%
O26359	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	35%	100%
O29490	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	37%	100%
O58822	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	34%	78%
O60841	Homo sapiens	47%	67%
O67825	Aquifex aeolicus (strain VF5)	27%	100%
P39730	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	45%	81%
P95691	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	34%	100%
Q05D44	Mus musculus	47%	67%
Q0VSS1	Alcanivorax borkumensis (strain ATCC 700651 / DSM 11573 / NCIMB 13689 / SK2)	26%	91%
Q0W8X2	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	37%	100%
Q12Z93	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	34%	100%
Q18FT0	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	34%	100%
Q2FU48	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	36%	100%
Q2NGM6	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	33%	100%
Q30WJ0	Oleidesulfovibrio alaskensis (strain ATCC BAA-1058 / DSM 17464 / G20)	25%	83%
Q38W81	Latilactobacillus sakei subsp. sakei (strain 23K)	27%	87%
Q3IMS5	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	32%	100%
Q466D5	Methanosarcina barkeri (strain Fusaro / DSM 804)	34%	100%
Q54XP6	Dictyostelium discoideum	46%	78%
Q57710	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	35%	71%
Q5HX30	Campylobacter jejuni (strain RM1221)	27%	94%
Q5JGR9	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	35%	71%
Q5QTY8	Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)	26%	91%
Q5RDE1	Pongo abelii	46%	67%
Q5UXU6	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	35%	100%
Q609C0	Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)	26%	94%
Q6FF40	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)	28%	91%
Q6M0I6	Methanococcus maripaludis (strain S2 / LL)	35%	100%
Q8PU78	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	34%	100%
Q8TQL5	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	34%	100%
Q8TV06	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	35%	100%
Q8U1R8	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	34%	83%
Q8ZX20	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	34%	100%
Q976A1	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	35%	100%
Q97BK4	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	31%	100%
Q980Q8	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	35%	100%
Q98R05	Mycoplasmopsis pulmonis (strain UAB CTIP)	25%	100%
Q9HJ60	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	31%	100%
Q9HNQ2	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	37%	100%
Q9PIZ1	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	27%	94%
Q9UZK7	Pyrococcus abyssi (strain GE5 / Orsay)	35%	82%
Q9Y9B3	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	35%	100%
V5AV36	Trypanosoma cruzi	70%	92%