Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3Q9_LEIMA

TriTrypDb:

LmjF.33.2760 , LMJLV39_330038800 , LMJSD75_330038300

Length:

688

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3Q9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3Q9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.572
CLV_NRD_NRD_1	206	208	PF00675	0.628
CLV_NRD_NRD_1	228	230	PF00675	0.513
CLV_NRD_NRD_1	256	258	PF00675	0.546
CLV_NRD_NRD_1	396	398	PF00675	0.585
CLV_NRD_NRD_1	470	472	PF00675	0.533
CLV_NRD_NRD_1	473	475	PF00675	0.564
CLV_NRD_NRD_1	504	506	PF00675	0.514
CLV_NRD_NRD_1	614	616	PF00675	0.504
CLV_NRD_NRD_1	656	658	PF00675	0.382
CLV_NRD_NRD_1	678	680	PF00675	0.571
CLV_PCSK_FUR_1	471	475	PF00082	0.439
CLV_PCSK_KEX2_1	124	126	PF00082	0.572
CLV_PCSK_KEX2_1	228	230	PF00082	0.621
CLV_PCSK_KEX2_1	256	258	PF00082	0.546
CLV_PCSK_KEX2_1	470	472	PF00082	0.425
CLV_PCSK_KEX2_1	473	475	PF00082	0.432
CLV_PCSK_KEX2_1	504	506	PF00082	0.514
CLV_PCSK_KEX2_1	678	680	PF00082	0.571
CLV_PCSK_SKI1_1	265	269	PF00082	0.602
CLV_PCSK_SKI1_1	297	301	PF00082	0.602
CLV_PCSK_SKI1_1	398	402	PF00082	0.639
CLV_PCSK_SKI1_1	450	454	PF00082	0.608
CLV_PCSK_SKI1_1	476	480	PF00082	0.585
CLV_PCSK_SKI1_1	492	496	PF00082	0.518
CLV_PCSK_SKI1_1	594	598	PF00082	0.483
DEG_APCC_DBOX_1	520	528	PF00400	0.473
DEG_APCC_DBOX_1	656	664	PF00400	0.384
DEG_MDM2_SWIB_1	462	469	PF02201	0.419
DEG_Nend_UBRbox_2	1	3	PF02207	0.562
DEG_SCF_TRCP1_1	2	8	PF00400	0.666
DEG_SPOP_SBC_1	181	185	PF00917	0.665
DOC_CYCLIN_RxL_1	291	304	PF00134	0.593
DOC_MAPK_gen_1	256	263	PF00069	0.531
DOC_MAPK_gen_1	461	469	PF00069	0.503
DOC_MAPK_gen_1	504	510	PF00069	0.454
DOC_MAPK_gen_1	657	665	PF00069	0.387
DOC_MAPK_MEF2A_6	657	665	PF00069	0.387
DOC_PP2B_LxvP_1	12	15	PF13499	0.532
DOC_PP2B_LxvP_1	358	361	PF13499	0.493
DOC_USP7_MATH_1	107	111	PF00917	0.616
DOC_USP7_MATH_1	141	145	PF00917	0.696
DOC_USP7_MATH_1	182	186	PF00917	0.675
DOC_USP7_MATH_1	380	384	PF00917	0.587
DOC_USP7_MATH_1	555	559	PF00917	0.576
DOC_USP7_MATH_1	67	71	PF00917	0.679
DOC_USP7_MATH_2	161	167	PF00917	0.655
DOC_WW_Pin1_4	113	118	PF00397	0.675
DOC_WW_Pin1_4	132	137	PF00397	0.618
DOC_WW_Pin1_4	139	144	PF00397	0.633
DOC_WW_Pin1_4	15	20	PF00397	0.566
DOC_WW_Pin1_4	154	159	PF00397	0.723
DOC_WW_Pin1_4	241	246	PF00397	0.726
DOC_WW_Pin1_4	399	404	PF00397	0.527
DOC_WW_Pin1_4	50	55	PF00397	0.551
DOC_WW_Pin1_4	670	675	PF00397	0.683
DOC_WW_Pin1_4	71	76	PF00397	0.783
LIG_14-3-3_CanoR_1	118	126	PF00244	0.579
LIG_14-3-3_CanoR_1	207	213	PF00244	0.626
LIG_14-3-3_CanoR_1	450	455	PF00244	0.700
LIG_14-3-3_CanoR_1	461	467	PF00244	0.361
LIG_14-3-3_CanoR_1	504	510	PF00244	0.354
LIG_14-3-3_CanoR_1	521	525	PF00244	0.350
LIG_14-3-3_CanoR_1	604	612	PF00244	0.369
LIG_Actin_WH2_2	460	478	PF00022	0.458
LIG_Actin_WH2_2	629	645	PF00022	0.453
LIG_APCC_ABBA_1	437	442	PF00400	0.387
LIG_BRCT_BRCA1_1	184	188	PF00533	0.576
LIG_BRCT_BRCA1_1	231	235	PF00533	0.593
LIG_eIF4E_1	655	661	PF01652	0.404
LIG_FHA_1	129	135	PF00498	0.723
LIG_FHA_1	212	218	PF00498	0.578
LIG_FHA_1	361	367	PF00498	0.714
LIG_FHA_1	454	460	PF00498	0.522
LIG_FHA_1	533	539	PF00498	0.430
LIG_FHA_1	81	87	PF00498	0.700
LIG_FHA_1	97	103	PF00498	0.629
LIG_FHA_2	151	157	PF00498	0.731
LIG_FHA_2	339	345	PF00498	0.586
LIG_FHA_2	429	435	PF00498	0.509
LIG_FHA_2	597	603	PF00498	0.616
LIG_HCF-1_HBM_1	517	520	PF13415	0.474
LIG_LIR_Apic_2	321	325	PF02991	0.540
LIG_LIR_Gen_1	465	472	PF02991	0.487
LIG_LIR_Gen_1	570	578	PF02991	0.484
LIG_LIR_Nem_3	434	440	PF02991	0.394
LIG_LIR_Nem_3	465	469	PF02991	0.481
LIG_LIR_Nem_3	531	537	PF02991	0.467
LIG_LIR_Nem_3	570	575	PF02991	0.490
LIG_MAD2	25	33	PF02301	0.685
LIG_MAD2	604	612	PF02301	0.423
LIG_MYND_1	237	241	PF01753	0.502
LIG_MYND_1	75	79	PF01753	0.650
LIG_PCNA_yPIPBox_3	504	514	PF02747	0.428
LIG_PCNA_yPIPBox_3	657	669	PF02747	0.476
LIG_PDZ_Class_2	683	688	PF00595	0.588
LIG_Pex14_1	319	323	PF04695	0.746
LIG_Pex14_2	462	466	PF04695	0.494
LIG_Pex14_2	549	553	PF04695	0.556
LIG_SH2_STAP1	447	451	PF00017	0.566
LIG_SH2_STAP1	528	532	PF00017	0.427
LIG_SH2_STAT5	440	443	PF00017	0.487
LIG_SH2_STAT5	528	531	PF00017	0.346
LIG_SH3_1	73	79	PF00018	0.576
LIG_SH3_2	11	16	PF14604	0.620
LIG_SH3_3	111	117	PF00018	0.685
LIG_SH3_3	120	126	PF00018	0.608
LIG_SH3_3	137	143	PF00018	0.699
LIG_SH3_3	155	161	PF00018	0.582
LIG_SH3_3	239	245	PF00018	0.782
LIG_SH3_3	258	264	PF00018	0.514
LIG_SH3_3	400	406	PF00018	0.609
LIG_SH3_3	606	612	PF00018	0.408
LIG_SH3_3	69	75	PF00018	0.708
LIG_SH3_3	8	14	PF00018	0.616
LIG_SH3_3	83	89	PF00018	0.677
LIG_SH3_3	98	104	PF00018	0.608
LIG_SH3_CIN85_PxpxPR_1	11	16	PF14604	0.539
LIG_SUMO_SIM_anti_2	523	529	PF11976	0.401
LIG_SUMO_SIM_anti_2	535	541	PF11976	0.419
LIG_SUMO_SIM_par_1	362	369	PF11976	0.513
LIG_SUMO_SIM_par_1	450	456	PF11976	0.560
LIG_TRAF2_1	290	293	PF00917	0.562
LIG_TRAF2_1	587	590	PF00917	0.476
LIG_WW_2	75	78	PF00397	0.653
LIG_WW_3	13	17	PF00397	0.537
MOD_CDK_SPK_2	113	118	PF00069	0.567
MOD_CDK_SPK_2	132	137	PF00069	0.554
MOD_CDK_SPK_2	154	159	PF00069	0.569
MOD_CDK_SPK_2	670	675	PF00069	0.481
MOD_CK1_1	183	189	PF00069	0.800
MOD_CK1_1	3	9	PF00069	0.561
MOD_CK1_1	346	352	PF00069	0.745
MOD_CK1_1	66	72	PF00069	0.686
MOD_CK2_1	107	113	PF00069	0.554
MOD_CK2_1	150	156	PF00069	0.714
MOD_CK2_1	187	193	PF00069	0.658
MOD_CK2_1	584	590	PF00069	0.520
MOD_CK2_1	596	602	PF00069	0.535
MOD_CK2_1	638	644	PF00069	0.546
MOD_GlcNHglycan	109	112	PF01048	0.561
MOD_GlcNHglycan	143	146	PF01048	0.651
MOD_GlcNHglycan	165	168	PF01048	0.722
MOD_GlcNHglycan	193	198	PF01048	0.649
MOD_GlcNHglycan	2	5	PF01048	0.641
MOD_GlcNHglycan	214	217	PF01048	0.681
MOD_GlcNHglycan	231	234	PF01048	0.575
MOD_GlcNHglycan	258	261	PF01048	0.715
MOD_GlcNHglycan	271	274	PF01048	0.539
MOD_GlcNHglycan	328	331	PF01048	0.616
MOD_GlcNHglycan	348	351	PF01048	0.631
MOD_GlcNHglycan	50	53	PF01048	0.749
MOD_GlcNHglycan	586	589	PF01048	0.604
MOD_GlcNHglycan	65	68	PF01048	0.681
MOD_GlcNHglycan	670	673	PF01048	0.557
MOD_GSK3_1	113	120	PF00069	0.688
MOD_GSK3_1	128	135	PF00069	0.665
MOD_GSK3_1	150	157	PF00069	0.742
MOD_GSK3_1	180	187	PF00069	0.805
MOD_GSK3_1	2	9	PF00069	0.695
MOD_GSK3_1	208	215	PF00069	0.633
MOD_GSK3_1	265	272	PF00069	0.684
MOD_GSK3_1	345	352	PF00069	0.716
MOD_GSK3_1	360	367	PF00069	0.509
MOD_GSK3_1	372	379	PF00069	0.629
MOD_GSK3_1	46	53	PF00069	0.755
MOD_GSK3_1	63	70	PF00069	0.599
MOD_GSK3_1	664	671	PF00069	0.481
MOD_LATS_1	254	260	PF00433	0.546
MOD_N-GLC_1	229	234	PF02516	0.619
MOD_N-GLC_1	36	41	PF02516	0.538
MOD_NEK2_1	212	217	PF00069	0.629
MOD_NEK2_1	420	425	PF00069	0.632
MOD_NEK2_1	441	446	PF00069	0.420
MOD_NEK2_1	462	467	PF00069	0.496
MOD_NEK2_1	495	500	PF00069	0.471
MOD_NEK2_1	80	85	PF00069	0.547
MOD_OFUCOSY	311	316	PF10250	0.505
MOD_PIKK_1	117	123	PF00454	0.678
MOD_PIKK_1	187	193	PF00454	0.653
MOD_PIKK_1	496	502	PF00454	0.436
MOD_PIKK_1	503	509	PF00454	0.405
MOD_PIKK_1	526	532	PF00454	0.459
MOD_PIKK_1	6	12	PF00454	0.555
MOD_PIKK_1	67	73	PF00454	0.610
MOD_PKA_1	256	262	PF00069	0.532
MOD_PKA_2	117	123	PF00069	0.570
MOD_PKA_2	256	262	PF00069	0.555
MOD_PKA_2	323	329	PF00069	0.655
MOD_PKA_2	503	509	PF00069	0.356
MOD_PKA_2	520	526	PF00069	0.351
MOD_Plk_1	343	349	PF00069	0.650
MOD_Plk_1	36	42	PF00069	0.551
MOD_Plk_1	380	386	PF00069	0.541
MOD_Plk_1	441	447	PF00069	0.395
MOD_Plk_1	61	67	PF00069	0.617
MOD_Plk_2-3	428	434	PF00069	0.530
MOD_Plk_4	208	214	PF00069	0.597
MOD_Plk_4	265	271	PF00069	0.550
MOD_Plk_4	318	324	PF00069	0.557
MOD_Plk_4	360	366	PF00069	0.614
MOD_Plk_4	420	426	PF00069	0.661
MOD_Plk_4	567	573	PF00069	0.505
MOD_Plk_4	664	670	PF00069	0.500
MOD_Plk_4	96	102	PF00069	0.614
MOD_ProDKin_1	113	119	PF00069	0.675
MOD_ProDKin_1	132	138	PF00069	0.616
MOD_ProDKin_1	139	145	PF00069	0.632
MOD_ProDKin_1	15	21	PF00069	0.566
MOD_ProDKin_1	154	160	PF00069	0.724
MOD_ProDKin_1	241	247	PF00069	0.731
MOD_ProDKin_1	399	405	PF00069	0.523
MOD_ProDKin_1	50	56	PF00069	0.552
MOD_ProDKin_1	670	676	PF00069	0.685
MOD_ProDKin_1	71	77	PF00069	0.784
MOD_SUMO_for_1	684	687	PF00179	0.477
MOD_SUMO_rev_2	486	491	PF00179	0.387
TRG_DiLeu_BaLyEn_6	447	452	PF01217	0.570
TRG_ER_diArg_1	123	125	PF00400	0.572
TRG_ER_diArg_1	256	258	PF00400	0.546
TRG_ER_diArg_1	386	389	PF00400	0.603
TRG_ER_diArg_1	469	471	PF00400	0.425
TRG_ER_diArg_1	473	476	PF00400	0.431
TRG_ER_diArg_1	559	562	PF00400	0.593
TRG_ER_diArg_1	677	679	PF00400	0.567
TRG_NLS_MonoExtC_3	614	620	PF00514	0.445
TRG_NLS_MonoExtN_4	612	619	PF00514	0.444
TRG_Pf-PMV_PEXEL_1	125	130	PF00026	0.730
TRG_Pf-PMV_PEXEL_1	297	301	PF00026	0.602
TRG_Pf-PMV_PEXEL_1	675	680	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7V3	Leishmania donovani	79%	76%
A4HLY7	Leishmania braziliensis	53%	79%
A4I9B6	Leishmania infantum	79%	84%
E9B4B6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	93%