Putative GTP-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GTP-binding elongation factor tu family protein, putative

Species:

Leishmania major

UniProt:

Q4Q3Q6_LEIMA

TriTrypDb:

LmjF.33.2790 , LMJLV39_330039100 , LMJSD75_330038600

Length:

839

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3Q6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3Q6

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	9
GO:0003746	translation elongation factor activity	4	9
GO:0003824	catalytic activity	1	12
GO:0003924	GTPase activity	7	12
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0008135	translation factor activity, RNA binding	3	9
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0045182	translation regulator activity	1	9
GO:0090079	translation regulator activity, nucleic acid binding	2	9
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	52	56	PF00656	0.548
CLV_C14_Caspase3-7	543	547	PF00656	0.431
CLV_NRD_NRD_1	170	172	PF00675	0.423
CLV_NRD_NRD_1	243	245	PF00675	0.492
CLV_NRD_NRD_1	344	346	PF00675	0.521
CLV_NRD_NRD_1	432	434	PF00675	0.302
CLV_NRD_NRD_1	569	571	PF00675	0.235
CLV_NRD_NRD_1	577	579	PF00675	0.226
CLV_NRD_NRD_1	620	622	PF00675	0.362
CLV_NRD_NRD_1	710	712	PF00675	0.370
CLV_NRD_NRD_1	824	826	PF00675	0.546
CLV_NRD_NRD_1	87	89	PF00675	0.560
CLV_PCSK_KEX2_1	153	155	PF00082	0.613
CLV_PCSK_KEX2_1	243	245	PF00082	0.492
CLV_PCSK_KEX2_1	343	345	PF00082	0.485
CLV_PCSK_KEX2_1	432	434	PF00082	0.245
CLV_PCSK_KEX2_1	577	579	PF00082	0.246
CLV_PCSK_KEX2_1	706	708	PF00082	0.398
CLV_PCSK_KEX2_1	87	89	PF00082	0.561
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.613
CLV_PCSK_PC1ET2_1	706	708	PF00082	0.411
CLV_PCSK_SKI1_1	163	167	PF00082	0.521
CLV_PCSK_SKI1_1	315	319	PF00082	0.767
CLV_PCSK_SKI1_1	481	485	PF00082	0.243
CLV_PCSK_SKI1_1	493	497	PF00082	0.235
CLV_PCSK_SKI1_1	562	566	PF00082	0.242
CLV_PCSK_SKI1_1	793	797	PF00082	0.298
CLV_Separin_Metazoa	767	771	PF03568	0.431
DEG_SCF_TRCP1_1	363	368	PF00400	0.431
DEG_SPOP_SBC_1	326	330	PF00917	0.636
DOC_ANK_TNKS_1	799	806	PF00023	0.442
DOC_CKS1_1	469	474	PF01111	0.529
DOC_CYCLIN_yCln2_LP_2	534	540	PF00134	0.431
DOC_CYCLIN_yCln2_LP_2	832	838	PF00134	0.522
DOC_MAPK_gen_1	522	532	PF00069	0.431
DOC_MAPK_gen_1	577	584	PF00069	0.442
DOC_MAPK_gen_1	711	717	PF00069	0.434
DOC_MAPK_gen_1	797	806	PF00069	0.498
DOC_MAPK_MEF2A_6	525	534	PF00069	0.431
DOC_MAPK_MEF2A_6	94	103	PF00069	0.400
DOC_MAPK_NFAT4_5	525	533	PF00069	0.442
DOC_MAPK_RevD_3	138	154	PF00069	0.370
DOC_MAPK_RevD_3	606	622	PF00069	0.501
DOC_PP1_RVXF_1	791	797	PF00149	0.535
DOC_PP2B_LxvP_1	534	537	PF13499	0.431
DOC_PP2B_LxvP_1	564	567	PF13499	0.431
DOC_PP2B_LxvP_1	832	835	PF13499	0.518
DOC_USP7_MATH_1	113	117	PF00917	0.633
DOC_USP7_MATH_1	199	203	PF00917	0.527
DOC_USP7_MATH_1	208	212	PF00917	0.637
DOC_USP7_MATH_1	311	315	PF00917	0.668
DOC_USP7_MATH_1	325	329	PF00917	0.789
DOC_USP7_MATH_1	449	453	PF00917	0.514
DOC_USP7_MATH_1	454	458	PF00917	0.509
DOC_USP7_MATH_1	476	480	PF00917	0.462
DOC_USP7_UBL2_3	823	827	PF12436	0.580
DOC_WW_Pin1_4	204	209	PF00397	0.785
DOC_WW_Pin1_4	217	222	PF00397	0.775
DOC_WW_Pin1_4	319	324	PF00397	0.792
DOC_WW_Pin1_4	327	332	PF00397	0.668
DOC_WW_Pin1_4	468	473	PF00397	0.529
DOC_WW_Pin1_4	545	550	PF00397	0.431
DOC_WW_Pin1_4	61	66	PF00397	0.694
DOC_WW_Pin1_4	719	724	PF00397	0.496
LIG_14-3-3_CanoR_1	400	405	PF00244	0.455
LIG_14-3-3_CanoR_1	493	502	PF00244	0.442
LIG_14-3-3_CanoR_1	570	575	PF00244	0.492
LIG_14-3-3_CanoR_1	756	764	PF00244	0.431
LIG_Actin_WH2_2	481	498	PF00022	0.431
LIG_Actin_WH2_2	757	772	PF00022	0.431
LIG_APCC_ABBA_1	105	110	PF00400	0.388
LIG_BIR_II_1	1	5	PF00653	0.566
LIG_BRCT_BRCA1_1	637	641	PF00533	0.375
LIG_FHA_1	251	257	PF00498	0.434
LIG_FHA_1	330	336	PF00498	0.598
LIG_FHA_1	368	374	PF00498	0.431
LIG_FHA_1	399	405	PF00498	0.431
LIG_FHA_1	42	48	PF00498	0.601
LIG_FHA_1	495	501	PF00498	0.431
LIG_FHA_1	52	58	PF00498	0.760
LIG_FHA_1	637	643	PF00498	0.362
LIG_FHA_1	64	70	PF00498	0.597
LIG_FHA_1	652	658	PF00498	0.274
LIG_FHA_1	661	667	PF00498	0.313
LIG_FHA_1	799	805	PF00498	0.431
LIG_FHA_1	806	812	PF00498	0.431
LIG_FHA_2	426	432	PF00498	0.552
LIG_FHA_2	469	475	PF00498	0.479
LIG_FHA_2	482	488	PF00498	0.388
LIG_FHA_2	541	547	PF00498	0.431
LIG_FHA_2	618	624	PF00498	0.416
LIG_FHA_2	81	87	PF00498	0.563
LIG_GBD_Chelix_1	166	174	PF00786	0.445
LIG_GBD_Chelix_1	528	536	PF00786	0.335
LIG_LIR_Gen_1	508	516	PF02991	0.431
LIG_LIR_Nem_3	252	257	PF02991	0.368
LIG_LIR_Nem_3	508	512	PF02991	0.431
LIG_LIR_Nem_3	669	674	PF02991	0.382
LIG_LIR_Nem_3	725	729	PF02991	0.445
LIG_LIR_Nem_3	743	749	PF02991	0.474
LIG_MLH1_MIPbox_1	637	641	PF16413	0.375
LIG_Rb_pABgroove_1	480	488	PF01858	0.431
LIG_SH2_CRK	420	424	PF00017	0.498
LIG_SH2_CRK	509	513	PF00017	0.431
LIG_SH2_NCK_1	196	200	PF00017	0.576
LIG_SH2_NCK_1	486	490	PF00017	0.431
LIG_SH2_SRC	196	199	PF00017	0.625
LIG_SH2_SRC	746	749	PF00017	0.431
LIG_SH2_STAP1	509	513	PF00017	0.431
LIG_SH2_STAT3	763	766	PF00017	0.456
LIG_SH2_STAT5	494	497	PF00017	0.431
LIG_SH2_STAT5	763	766	PF00017	0.456
LIG_SH3_3	318	324	PF00018	0.634
LIG_SH3_3	431	437	PF00018	0.535
LIG_SUMO_SIM_anti_2	141	147	PF11976	0.540
LIG_SUMO_SIM_anti_2	732	737	PF11976	0.431
LIG_SUMO_SIM_par_1	479	487	PF11976	0.443
LIG_SUMO_SIM_par_1	675	681	PF11976	0.472
LIG_TRAF2_1	2	5	PF00917	0.424
LIG_TRAF2_2	48	53	PF00917	0.539
LIG_TYR_ITIM	12	17	PF00017	0.345
LIG_TYR_ITIM	418	423	PF00017	0.411
LIG_UBA3_1	563	571	PF00899	0.303
MOD_CDK_SPK_2	468	473	PF00069	0.309
MOD_CDK_SPK_2	719	724	PF00069	0.377
MOD_CK1_1	116	122	PF00069	0.355
MOD_CK1_1	202	208	PF00069	0.657
MOD_CK1_1	216	222	PF00069	0.703
MOD_CK1_1	329	335	PF00069	0.673
MOD_CK1_1	364	370	PF00069	0.280
MOD_CK1_1	371	377	PF00069	0.266
MOD_CK1_1	402	408	PF00069	0.297
MOD_CK1_1	452	458	PF00069	0.489
MOD_CK1_1	59	65	PF00069	0.687
MOD_CK1_1	601	607	PF00069	0.266
MOD_CK1_1	722	728	PF00069	0.432
MOD_CK2_1	264	270	PF00069	0.370
MOD_CK2_1	400	406	PF00069	0.266
MOD_CK2_1	425	431	PF00069	0.359
MOD_CK2_1	468	474	PF00069	0.479
MOD_GlcNHglycan	176	179	PF01048	0.553
MOD_GlcNHglycan	201	204	PF01048	0.741
MOD_GlcNHglycan	302	305	PF01048	0.604
MOD_GlcNHglycan	307	310	PF01048	0.603
MOD_GlcNHglycan	363	366	PF01048	0.326
MOD_GlcNHglycan	411	414	PF01048	0.405
MOD_GlcNHglycan	446	449	PF01048	0.365
MOD_GlcNHglycan	451	454	PF01048	0.351
MOD_GlcNHglycan	456	459	PF01048	0.293
MOD_GlcNHglycan	461	464	PF01048	0.221
MOD_GlcNHglycan	514	517	PF01048	0.266
MOD_GlcNHglycan	58	61	PF01048	0.647
MOD_GlcNHglycan	707	710	PF01048	0.355
MOD_GlcNHglycan	757	760	PF01048	0.270
MOD_GSK3_1	204	211	PF00069	0.646
MOD_GSK3_1	213	220	PF00069	0.662
MOD_GSK3_1	264	271	PF00069	0.495
MOD_GSK3_1	311	318	PF00069	0.695
MOD_GSK3_1	325	332	PF00069	0.741
MOD_GSK3_1	361	368	PF00069	0.298
MOD_GSK3_1	395	402	PF00069	0.267
MOD_GSK3_1	452	459	PF00069	0.380
MOD_GSK3_1	477	484	PF00069	0.254
MOD_GSK3_1	540	547	PF00069	0.200
MOD_GSK3_1	59	66	PF00069	0.626
MOD_GSK3_1	636	643	PF00069	0.404
MOD_GSK3_1	736	743	PF00069	0.325
MOD_GSK3_1	751	758	PF00069	0.197
MOD_GSK3_1	768	775	PF00069	0.266
MOD_N-GLC_1	199	204	PF02516	0.729
MOD_N-GLC_1	601	606	PF02516	0.281
MOD_N-GLC_1	660	665	PF02516	0.425
MOD_NEK2_1	166	171	PF00069	0.405
MOD_NEK2_1	174	179	PF00069	0.421
MOD_NEK2_1	444	449	PF00069	0.265
MOD_NEK2_1	495	500	PF00069	0.280
MOD_NEK2_1	598	603	PF00069	0.281
MOD_NEK2_1	640	645	PF00069	0.433
MOD_NEK2_1	736	741	PF00069	0.281
MOD_NEK2_2	463	468	PF00069	0.287
MOD_PIKK_1	63	69	PF00454	0.550
MOD_PIKK_1	651	657	PF00454	0.305
MOD_PK_1	400	406	PF00069	0.266
MOD_PKA_1	570	576	PF00069	0.200
MOD_PKA_1	87	93	PF00069	0.560
MOD_PKA_2	399	405	PF00069	0.365
MOD_PKA_2	477	483	PF00069	0.360
MOD_PKA_2	521	527	PF00069	0.266
MOD_PKA_2	755	761	PF00069	0.266
MOD_PKA_2	87	93	PF00069	0.564
MOD_Plk_1	235	241	PF00069	0.516
MOD_Plk_1	553	559	PF00069	0.360
MOD_Plk_1	580	586	PF00069	0.331
MOD_Plk_1	636	642	PF00069	0.353
MOD_Plk_1	660	666	PF00069	0.420
MOD_Plk_1	772	778	PF00069	0.266
MOD_Plk_4	155	161	PF00069	0.536
MOD_Plk_4	250	256	PF00069	0.439
MOD_Plk_4	331	337	PF00069	0.602
MOD_Plk_4	368	374	PF00069	0.281
MOD_Plk_4	481	487	PF00069	0.276
MOD_Plk_4	495	501	PF00069	0.242
MOD_Plk_4	636	642	PF00069	0.365
MOD_Plk_4	644	650	PF00069	0.337
MOD_Plk_4	660	666	PF00069	0.341
MOD_Plk_4	722	728	PF00069	0.315
MOD_ProDKin_1	204	210	PF00069	0.786
MOD_ProDKin_1	217	223	PF00069	0.774
MOD_ProDKin_1	319	325	PF00069	0.794
MOD_ProDKin_1	327	333	PF00069	0.650
MOD_ProDKin_1	468	474	PF00069	0.403
MOD_ProDKin_1	545	551	PF00069	0.266
MOD_ProDKin_1	61	67	PF00069	0.685
MOD_ProDKin_1	719	725	PF00069	0.489
MOD_SUMO_for_1	35	38	PF00179	0.467
MOD_SUMO_for_1	702	705	PF00179	0.386
TRG_DiLeu_BaEn_1	252	257	PF01217	0.427
TRG_DiLeu_BaEn_1	790	795	PF01217	0.331
TRG_DiLeu_BaEn_1	813	818	PF01217	0.492
TRG_DiLeu_BaEn_4	4	10	PF01217	0.363
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.592
TRG_DiLeu_LyEn_5	790	795	PF01217	0.331
TRG_ENDOCYTIC_2	14	17	PF00928	0.360
TRG_ENDOCYTIC_2	420	423	PF00928	0.360
TRG_ENDOCYTIC_2	509	512	PF00928	0.266
TRG_ENDOCYTIC_2	746	749	PF00928	0.411
TRG_ER_diArg_1	242	244	PF00400	0.486
TRG_ER_diArg_1	342	345	PF00400	0.525
TRG_ER_diArg_1	432	434	PF00400	0.200
TRG_ER_diArg_1	576	578	PF00400	0.287
TRG_NLS_Bipartite_1	153	175	PF00514	0.431
TRG_NLS_MonoExtC_3	824	830	PF00514	0.501
TRG_NLS_MonoExtN_4	823	829	PF00514	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4K5	Leptomonas seymouri	69%	100%
A0A0S4JM58	Bodo saltans	53%	100%
A0A1X0NRK6	Trypanosomatidae	46%	97%
A0A3R7MHD3	Trypanosoma rangeli	51%	100%
A0A3S7X775	Leishmania donovani	93%	100%
A4HLZ0	Leishmania braziliensis	84%	99%
A4I9C0	Leishmania infantum	93%	100%
C9ZJA2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9B4B9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BF52	Trypanosoma cruzi	50%	99%