LeishMANIAdb
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PWWP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
PWWP domain-containing protein
Gene product:
PWWP domain/TFIIS helical bundle-like domain containing protein, putative
Species:
Leishmania major
UniProt:
Q4Q3Q3_LEIMA
TriTrypDb:
LmjF.33.2820 , LMJLV39_330039400 * , LMJSD75_330038900
Length:
593

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 9
GO:0043226 organelle 2 9
GO:0043227 membrane-bounded organelle 3 9
GO:0043229 intracellular organelle 3 9
GO:0043231 intracellular membrane-bounded organelle 4 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

Q4Q3Q3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3Q3

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 4
GO:0006351 DNA-templated transcription 7 4
GO:0006725 cellular aromatic compound metabolic process 3 4
GO:0006807 nitrogen compound metabolic process 2 4
GO:0008152 metabolic process 1 4
GO:0009058 biosynthetic process 2 4
GO:0009059 macromolecule biosynthetic process 4 4
GO:0009987 cellular process 1 4
GO:0016070 RNA metabolic process 5 4
GO:0018130 heterocycle biosynthetic process 4 4
GO:0019438 aromatic compound biosynthetic process 4 4
GO:0032774 RNA biosynthetic process 5 4
GO:0034641 cellular nitrogen compound metabolic process 3 4
GO:0034654 nucleobase-containing compound biosynthetic process 4 4
GO:0043170 macromolecule metabolic process 3 4
GO:0044237 cellular metabolic process 2 4
GO:0044238 primary metabolic process 2 4
GO:0044249 cellular biosynthetic process 3 4
GO:0044271 cellular nitrogen compound biosynthetic process 4 4
GO:0046483 heterocycle metabolic process 3 4
GO:0071704 organic substance metabolic process 2 4
GO:0090304 nucleic acid metabolic process 4 4
GO:0097659 nucleic acid-templated transcription 6 4
GO:1901360 organic cyclic compound metabolic process 3 4
GO:1901362 organic cyclic compound biosynthetic process 4 4
GO:1901576 organic substance biosynthetic process 3 4
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 2
GO:0005488 binding 1 2
GO:0008270 zinc ion binding 6 2
GO:0043167 ion binding 2 2
GO:0043169 cation binding 3 2
GO:0046872 metal ion binding 4 2
GO:0046914 transition metal ion binding 5 2
GO:0097159 organic cyclic compound binding 2 2
GO:1901363 heterocyclic compound binding 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 177 181 PF00656 0.616
CLV_C14_Caspase3-7 218 222 PF00656 0.605
CLV_C14_Caspase3-7 395 399 PF00656 0.733
CLV_C14_Caspase3-7 421 425 PF00656 0.491
CLV_C14_Caspase3-7 516 520 PF00656 0.722
CLV_C14_Caspase3-7 61 65 PF00656 0.515
CLV_NRD_NRD_1 170 172 PF00675 0.768
CLV_NRD_NRD_1 188 190 PF00675 0.703
CLV_NRD_NRD_1 191 193 PF00675 0.707
CLV_NRD_NRD_1 201 203 PF00675 0.636
CLV_NRD_NRD_1 234 236 PF00675 0.639
CLV_NRD_NRD_1 279 281 PF00675 0.600
CLV_NRD_NRD_1 286 288 PF00675 0.516
CLV_NRD_NRD_1 444 446 PF00675 0.533
CLV_NRD_NRD_1 469 471 PF00675 0.426
CLV_NRD_NRD_1 498 500 PF00675 0.648
CLV_PCSK_FUR_1 496 500 PF00082 0.619
CLV_PCSK_KEX2_1 170 172 PF00082 0.687
CLV_PCSK_KEX2_1 201 203 PF00082 0.695
CLV_PCSK_KEX2_1 234 236 PF00082 0.688
CLV_PCSK_KEX2_1 286 288 PF00082 0.520
CLV_PCSK_KEX2_1 444 446 PF00082 0.533
CLV_PCSK_KEX2_1 469 471 PF00082 0.426
CLV_PCSK_KEX2_1 498 500 PF00082 0.647
CLV_PCSK_PC1ET2_1 170 172 PF00082 0.672
CLV_PCSK_PC7_1 494 500 PF00082 0.616
CLV_PCSK_SKI1_1 236 240 PF00082 0.667
CLV_PCSK_SKI1_1 246 250 PF00082 0.639
CLV_PCSK_SKI1_1 327 331 PF00082 0.398
CLV_PCSK_SKI1_1 353 357 PF00082 0.360
CLV_PCSK_SKI1_1 469 473 PF00082 0.505
DEG_SCF_FBW7_1 113 120 PF00400 0.821
DEG_SPOP_SBC_1 288 292 PF00917 0.408
DOC_CKS1_1 354 359 PF01111 0.550
DOC_CYCLIN_RxL_1 466 474 PF00134 0.489
DOC_MAPK_DCC_7 353 362 PF00069 0.542
DOC_MAPK_gen_1 327 336 PF00069 0.591
DOC_MAPK_gen_1 496 505 PF00069 0.701
DOC_MAPK_MEF2A_6 327 336 PF00069 0.591
DOC_MAPK_MEF2A_6 353 362 PF00069 0.552
DOC_PP4_FxxP_1 354 357 PF00568 0.561
DOC_PP4_FxxP_1 507 510 PF00568 0.686
DOC_PP4_FxxP_1 541 544 PF00568 0.729
DOC_USP7_MATH_1 10 14 PF00917 0.527
DOC_USP7_MATH_1 100 104 PF00917 0.543
DOC_USP7_MATH_1 106 110 PF00917 0.730
DOC_USP7_MATH_1 117 121 PF00917 0.625
DOC_USP7_MATH_1 214 218 PF00917 0.737
DOC_USP7_MATH_1 238 242 PF00917 0.747
DOC_USP7_MATH_1 288 292 PF00917 0.552
DOC_USP7_MATH_1 3 7 PF00917 0.667
DOC_USP7_MATH_1 347 351 PF00917 0.542
DOC_USP7_MATH_1 51 55 PF00917 0.510
DOC_USP7_MATH_1 563 567 PF00917 0.527
DOC_USP7_MATH_1 83 87 PF00917 0.598
DOC_USP7_UBL2_3 163 167 PF12436 0.677
DOC_WW_Pin1_4 113 118 PF00397 0.773
DOC_WW_Pin1_4 267 272 PF00397 0.691
DOC_WW_Pin1_4 353 358 PF00397 0.550
DOC_WW_Pin1_4 506 511 PF00397 0.718
DOC_WW_Pin1_4 517 522 PF00397 0.669
DOC_WW_Pin1_4 526 531 PF00397 0.627
DOC_WW_Pin1_4 535 540 PF00397 0.534
LIG_14-3-3_CanoR_1 286 294 PF00244 0.494
LIG_14-3-3_CanoR_1 295 304 PF00244 0.463
LIG_14-3-3_CanoR_1 547 556 PF00244 0.642
LIG_Actin_WH2_2 315 332 PF00022 0.548
LIG_BIR_II_1 1 5 PF00653 0.714
LIG_BIR_III_2 105 109 PF00653 0.767
LIG_BRCT_BRCA1_1 537 541 PF00533 0.750
LIG_CSL_BTD_1 23 26 PF09270 0.501
LIG_FHA_1 296 302 PF00498 0.503
LIG_FHA_1 354 360 PF00498 0.536
LIG_FHA_1 41 47 PF00498 0.457
LIG_FHA_1 484 490 PF00498 0.629
LIG_FHA_1 547 553 PF00498 0.605
LIG_FHA_1 586 592 PF00498 0.464
LIG_FHA_2 189 195 PF00498 0.721
LIG_FHA_2 263 269 PF00498 0.717
LIG_FHA_2 3 9 PF00498 0.680
LIG_FHA_2 312 318 PF00498 0.514
LIG_FHA_2 393 399 PF00498 0.671
LIG_FHA_2 416 422 PF00498 0.463
LIG_LIR_Apic_2 506 510 PF02991 0.685
LIG_LIR_Apic_2 538 544 PF02991 0.741
LIG_LIR_Apic_2 550 556 PF02991 0.491
LIG_LIR_Gen_1 13 22 PF02991 0.560
LIG_LIR_Gen_1 136 146 PF02991 0.702
LIG_LIR_Gen_1 523 530 PF02991 0.765
LIG_LIR_Nem_3 13 17 PF02991 0.560
LIG_LIR_Nem_3 136 142 PF02991 0.708
LIG_LIR_Nem_3 523 528 PF02991 0.797
LIG_NRBOX 467 473 PF00104 0.570
LIG_PALB2_WD40_1 366 374 PF16756 0.501
LIG_PTB_Apo_2 365 372 PF02174 0.552
LIG_SH2_CRK 279 283 PF00017 0.631
LIG_SH2_CRK 553 557 PF00017 0.521
LIG_SH2_STAP1 568 572 PF00017 0.579
LIG_SH2_STAT3 250 253 PF00017 0.660
LIG_SH2_STAT3 568 571 PF00017 0.585
LIG_SH2_STAT5 478 481 PF00017 0.592
LIG_SH3_3 20 26 PF00018 0.515
LIG_SH3_3 518 524 PF00018 0.672
LIG_SUMO_SIM_anti_2 428 433 PF11976 0.498
LIG_SUMO_SIM_anti_2 43 49 PF11976 0.561
LIG_SUMO_SIM_par_1 489 495 PF11976 0.548
LIG_TRAF2_1 108 111 PF00917 0.698
LIG_TRAF2_1 418 421 PF00917 0.480
LIG_TRAF2_1 93 96 PF00917 0.525
LIG_TRFH_1 259 263 PF08558 0.752
LIG_UBA3_1 322 330 PF00899 0.492
MOD_CDK_SPK_2 267 272 PF00069 0.676
MOD_CDK_SPxxK_3 540 547 PF00069 0.771
MOD_CK1_1 173 179 PF00069 0.621
MOD_CK1_1 188 194 PF00069 0.469
MOD_CK1_1 2 8 PF00069 0.709
MOD_CK1_1 240 246 PF00069 0.629
MOD_CK1_1 267 273 PF00069 0.685
MOD_CK1_1 392 398 PF00069 0.623
MOD_CK1_1 415 421 PF00069 0.561
MOD_CK1_1 520 526 PF00069 0.711
MOD_CK1_1 535 541 PF00069 0.680
MOD_CK1_1 566 572 PF00069 0.623
MOD_CK1_1 86 92 PF00069 0.598
MOD_CK2_1 207 213 PF00069 0.757
MOD_CK2_1 251 257 PF00069 0.643
MOD_CK2_1 287 293 PF00069 0.638
MOD_CK2_1 415 421 PF00069 0.498
MOD_GlcNHglycan 1 4 PF01048 0.714
MOD_GlcNHglycan 117 120 PF01048 0.757
MOD_GlcNHglycan 131 134 PF01048 0.799
MOD_GlcNHglycan 154 157 PF01048 0.593
MOD_GlcNHglycan 176 179 PF01048 0.750
MOD_GlcNHglycan 19 22 PF01048 0.286
MOD_GlcNHglycan 209 212 PF01048 0.714
MOD_GlcNHglycan 217 220 PF01048 0.675
MOD_GlcNHglycan 242 245 PF01048 0.618
MOD_GlcNHglycan 283 286 PF01048 0.624
MOD_GlcNHglycan 309 312 PF01048 0.591
MOD_GlcNHglycan 382 385 PF01048 0.617
MOD_GlcNHglycan 5 8 PF01048 0.617
MOD_GlcNHglycan 51 54 PF01048 0.353
MOD_GlcNHglycan 61 64 PF01048 0.362
MOD_GSK3_1 113 120 PF00069 0.792
MOD_GSK3_1 170 177 PF00069 0.625
MOD_GSK3_1 289 296 PF00069 0.563
MOD_GSK3_1 303 310 PF00069 0.433
MOD_GSK3_1 49 56 PF00069 0.501
MOD_GSK3_1 513 520 PF00069 0.783
MOD_GSK3_1 533 540 PF00069 0.702
MOD_GSK3_1 542 549 PF00069 0.590
MOD_LATS_1 168 174 PF00433 0.624
MOD_N-GLC_1 173 178 PF02516 0.750
MOD_N-GLC_1 483 488 PF02516 0.613
MOD_NEK2_1 1 6 PF00069 0.731
MOD_NEK2_1 339 344 PF00069 0.521
MOD_NEK2_1 492 497 PF00069 0.524
MOD_OFUCOSY 391 396 PF10250 0.720
MOD_PIKK_1 295 301 PF00454 0.598
MOD_PIKK_1 375 381 PF00454 0.486
MOD_PKA_1 170 176 PF00069 0.754
MOD_PKA_2 17 23 PF00069 0.431
MOD_PKA_2 170 176 PF00069 0.625
MOD_PKA_2 188 194 PF00069 0.762
MOD_PKA_2 251 257 PF00069 0.645
MOD_PKA_2 389 395 PF00069 0.636
MOD_PKA_2 546 552 PF00069 0.668
MOD_Plk_1 332 338 PF00069 0.525
MOD_Plk_2-3 389 395 PF00069 0.664
MOD_Plk_4 10 16 PF00069 0.366
MOD_Plk_4 347 353 PF00069 0.548
MOD_Plk_4 53 59 PF00069 0.598
MOD_ProDKin_1 113 119 PF00069 0.773
MOD_ProDKin_1 267 273 PF00069 0.691
MOD_ProDKin_1 353 359 PF00069 0.550
MOD_ProDKin_1 506 512 PF00069 0.716
MOD_ProDKin_1 517 523 PF00069 0.671
MOD_ProDKin_1 526 532 PF00069 0.680
MOD_ProDKin_1 535 541 PF00069 0.604
MOD_SUMO_for_1 248 251 PF00179 0.654
TRG_DiLeu_BaEn_1 76 81 PF01217 0.515
TRG_DiLeu_BaEn_2 299 305 PF01217 0.596
TRG_DiLeu_BaLyEn_6 467 472 PF01217 0.573
TRG_DiLeu_BaLyEn_6 487 492 PF01217 0.542
TRG_ENDOCYTIC_2 279 282 PF00928 0.632
TRG_ENDOCYTIC_2 525 528 PF00928 0.724
TRG_ER_diArg_1 201 204 PF00400 0.761
TRG_ER_diArg_1 468 470 PF00400 0.423
TRG_ER_diArg_1 493 496 PF00400 0.562
TRG_ER_diArg_1 498 500 PF00400 0.615
TRG_NLS_Bipartite_1 171 193 PF00514 0.740
TRG_NLS_Bipartite_1 234 250 PF00514 0.661
TRG_NLS_MonoExtC_3 188 193 PF00514 0.710
TRG_NLS_MonoExtC_3 245 251 PF00514 0.671
TRG_NLS_MonoExtN_4 167 174 PF00514 0.761
TRG_Pf-PMV_PEXEL_1 469 474 PF00026 0.447

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I5Y6 Leptomonas seymouri 53% 100%
A0A1X0NRB1 Trypanosomatidae 31% 100%
A0A3Q8IKG6 Leishmania donovani 91% 100%
A0A422NKE1 Trypanosoma rangeli 33% 100%
A4HLZ3 Leishmania braziliensis 78% 100%
A4I9C3 Leishmania infantum 91% 100%
E9B4C2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS