D-alanyl-glycyl endopeptidase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cysteine peptidase, Clan CA, family C51, putative

Species:

Leishmania major

UniProt:

Q4Q3Q2_LEIMA

TriTrypDb:

LmjF.33.2830 , LMJLV39_330039500 , LMJSD75_330039000

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 27
NetGPI	no	yes: 0, no: 28

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0110165	cellular anatomical entity	1	22
GO:0016020	membrane	2	20

Expansion

Sequence features

Q4Q3Q2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3Q2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016874	ligase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.371
CLV_NRD_NRD_1	203	205	PF00675	0.405
CLV_NRD_NRD_1	91	93	PF00675	0.401
CLV_PCSK_KEX2_1	133	135	PF00082	0.380
CLV_PCSK_KEX2_1	203	205	PF00082	0.450
CLV_PCSK_KEX2_1	91	93	PF00082	0.437
DEG_Nend_Nbox_1	1	3	PF02207	0.438
DEG_SCF_FBW7_1	24	31	PF00400	0.491
DOC_PP2B_LxvP_1	59	62	PF13499	0.377
DOC_WW_Pin1_4	193	198	PF00397	0.444
DOC_WW_Pin1_4	24	29	PF00397	0.422
DOC_WW_Pin1_4	96	101	PF00397	0.199
LIG_14-3-3_CanoR_1	140	148	PF00244	0.349
LIG_APCC_ABBA_1	205	210	PF00400	0.230
LIG_APCC_ABBAyCdc20_2	204	210	PF00400	0.233
LIG_BRCT_BRCA1_1	74	78	PF00533	0.294
LIG_deltaCOP1_diTrp_1	113	119	PF00928	0.247
LIG_deltaCOP1_diTrp_1	186	194	PF00928	0.292
LIG_FHA_1	127	133	PF00498	0.248
LIG_FHA_1	200	206	PF00498	0.393
LIG_FHA_1	211	217	PF00498	0.370
LIG_FHA_1	66	72	PF00498	0.582
LIG_FHA_2	215	221	PF00498	0.346
LIG_FHA_2	58	64	PF00498	0.335
LIG_LIR_Gen_1	118	126	PF02991	0.251
LIG_LIR_Gen_1	53	64	PF02991	0.306
LIG_LIR_Nem_3	118	122	PF02991	0.244
LIG_LIR_Nem_3	53	59	PF02991	0.375
LIG_Pex14_1	115	119	PF04695	0.289
LIG_Pex14_2	36	40	PF04695	0.288
LIG_PTB_Apo_2	113	120	PF02174	0.199
LIG_PTB_Apo_2	34	41	PF02174	0.308
LIG_SH2_CRK	209	213	PF00017	0.431
LIG_SH2_CRK	3	7	PF00017	0.490
LIG_SH2_CRK	79	83	PF00017	0.291
LIG_SH2_GRB2like	135	138	PF00017	0.192
LIG_SH2_GRB2like	42	45	PF00017	0.344
LIG_SH2_GRB2like	56	59	PF00017	0.333
LIG_SH2_PTP2	56	59	PF00017	0.532
LIG_SH2_STAP1	201	205	PF00017	0.340
LIG_SH2_STAP1	89	93	PF00017	0.193
LIG_SH2_STAT3	156	159	PF00017	0.216
LIG_SH2_STAT3	93	96	PF00017	0.332
LIG_SH2_STAT5	104	107	PF00017	0.288
LIG_SH2_STAT5	183	186	PF00017	0.302
LIG_SH2_STAT5	201	204	PF00017	0.509
LIG_SH2_STAT5	49	52	PF00017	0.424
LIG_SH2_STAT5	56	59	PF00017	0.454
LIG_SH2_STAT5	73	76	PF00017	0.468
LIG_SH2_STAT5	79	82	PF00017	0.280
LIG_SH3_3	18	24	PF00018	0.597
LIG_SUMO_SIM_par_1	213	222	PF11976	0.525
LIG_TYR_ITIM	54	59	PF00017	0.509
MOD_CK1_1	124	130	PF00069	0.346
MOD_CK1_1	214	220	PF00069	0.275
MOD_CK1_1	48	54	PF00069	0.365
MOD_CK2_1	57	63	PF00069	0.528
MOD_GSK3_1	210	217	PF00069	0.380
MOD_GSK3_1	24	31	PF00069	0.409
MOD_GSK3_1	45	52	PF00069	0.381
MOD_GSK3_1	65	72	PF00069	0.552
MOD_N-GLC_1	10	15	PF02516	0.577
MOD_N-GLC_1	115	120	PF02516	0.537
MOD_N-GLC_1	124	129	PF02516	0.410
MOD_N-GLC_1	199	204	PF02516	0.336
MOD_N-GLC_1	45	50	PF02516	0.360
MOD_N-GLC_1	57	62	PF02516	0.324
MOD_N-GLC_1	65	70	PF02516	0.328
MOD_NEK2_1	1	6	PF00069	0.566
MOD_NEK2_1	211	216	PF00069	0.397
MOD_NEK2_1	40	45	PF00069	0.349
MOD_PKA_2	139	145	PF00069	0.360
MOD_Plk_1	115	121	PF00069	0.349
MOD_Plk_1	124	130	PF00069	0.331
MOD_Plk_1	15	21	PF00069	0.472
MOD_Plk_1	45	51	PF00069	0.457
MOD_Plk_1	57	63	PF00069	0.322
MOD_Plk_4	104	110	PF00069	0.278
MOD_Plk_4	115	121	PF00069	0.309
MOD_Plk_4	28	34	PF00069	0.319
MOD_Plk_4	45	51	PF00069	0.512
MOD_Plk_4	69	75	PF00069	0.564
MOD_ProDKin_1	193	199	PF00069	0.440
MOD_ProDKin_1	24	30	PF00069	0.418
MOD_ProDKin_1	96	102	PF00069	0.199
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.292
TRG_ENDOCYTIC_2	165	168	PF00928	0.266
TRG_ENDOCYTIC_2	209	212	PF00928	0.407
TRG_ENDOCYTIC_2	3	6	PF00928	0.528
TRG_ENDOCYTIC_2	56	59	PF00928	0.424
TRG_ENDOCYTIC_2	79	82	PF00928	0.274
TRG_ER_diArg_1	132	134	PF00400	0.225
TRG_ER_diArg_1	203	205	PF00400	0.448
TRG_ER_diArg_1	91	93	PF00400	0.202

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I309	Leptomonas seymouri	26%	77%
A0A0S4IP47	Bodo saltans	27%	68%
A0A0S4ITA7	Bodo saltans	34%	75%
A0A0S4IVA9	Bodo saltans	29%	76%
A0A1X0NR96	Trypanosomatidae	50%	81%
A0A1X0NR98	Trypanosomatidae	48%	79%
A0A1X0NRB4	Trypanosomatidae	30%	68%
A0A1X0NYK9	Trypanosomatidae	24%	79%
A0A3R7KMG1	Trypanosoma rangeli	25%	71%
A0A3R7LYQ4	Trypanosoma rangeli	44%	75%
A0A3S5IRC8	Trypanosoma rangeli	44%	82%
A0A3S7WZA9	Leishmania donovani	27%	77%
A0A3S7X769	Leishmania donovani	83%	98%
A0A422NKH5	Trypanosoma rangeli	29%	71%
A4HEJ1	Leishmania braziliensis	27%	70%
A4HLZ4	Leishmania braziliensis	66%	69%
A4I1M7	Leishmania infantum	27%	77%
C9ZJ94	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	85%
C9ZJ95	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	83%
C9ZK72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	80%
D0A867	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	85%
E9AXR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	77%
E9B4C3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	98%
Q4Q9R0	Leishmania major	28%	77%
V5BF57	Trypanosoma cruzi	28%	70%
V5DB66	Trypanosoma cruzi	42%	75%
V5DIU8	Trypanosoma cruzi	26%	79%