TYR_PHOSPHATASE_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

lipid-like atypical dual specificity phosphatase, putative

Species:

Leishmania major

UniProt:

Q4Q3Q1_LEIMA

TriTrypDb:

LmjF.33.2840 , LMJLV39_330039700 , LMJSD75_330039300

Length:

258

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3Q1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3Q1

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	13
GO:0006796	phosphate-containing compound metabolic process	4	13
GO:0008152	metabolic process	1	13
GO:0009987	cellular process	1	13
GO:0016311	dephosphorylation	5	13
GO:0044237	cellular metabolic process	2	13

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004721	phosphoprotein phosphatase activity	3	13
GO:0016787	hydrolase activity	2	13
GO:0016788	hydrolase activity, acting on ester bonds	3	13
GO:0016791	phosphatase activity	5	13
GO:0042578	phosphoric ester hydrolase activity	4	13
GO:0140096	catalytic activity, acting on a protein	2	13
GO:0042577	lipid phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.354
CLV_NRD_NRD_1	9	11	PF00675	0.396
CLV_PCSK_FUR_1	7	11	PF00082	0.409
CLV_PCSK_KEX2_1	179	181	PF00082	0.354
CLV_PCSK_KEX2_1	78	80	PF00082	0.329
CLV_PCSK_KEX2_1	9	11	PF00082	0.474
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.354
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.329
CLV_PCSK_SKI1_1	236	240	PF00082	0.495
CLV_PCSK_SKI1_1	99	103	PF00082	0.484
DEG_APCC_DBOX_1	78	86	PF00400	0.329
DOC_ANK_TNKS_1	9	16	PF00023	0.329
DOC_MAPK_gen_1	236	244	PF00069	0.329
DOC_PP4_FxxP_1	46	49	PF00568	0.303
LIG_14-3-3_CanoR_1	79	83	PF00244	0.403
LIG_Actin_WH2_2	87	104	PF00022	0.303
LIG_CtBP_PxDLS_1	91	95	PF00389	0.470
LIG_eIF4E_1	166	172	PF01652	0.354
LIG_eIF4E_1	40	46	PF01652	0.303
LIG_FHA_1	129	135	PF00498	0.461
LIG_FHA_2	168	174	PF00498	0.363
LIG_FHA_2	213	219	PF00498	0.331
LIG_FHA_2	243	249	PF00498	0.354
LIG_LIR_Apic_2	43	49	PF02991	0.303
LIG_LIR_Gen_1	211	221	PF02991	0.283
LIG_LIR_Nem_3	119	124	PF02991	0.347
LIG_LIR_Nem_3	161	166	PF02991	0.326
LIG_LIR_Nem_3	186	192	PF02991	0.443
LIG_LIR_Nem_3	211	217	PF02991	0.324
LIG_LIR_Nem_3	33	39	PF02991	0.348
LIG_NRBOX	167	173	PF00104	0.329
LIG_Pex14_1	36	40	PF04695	0.301
LIG_SH2_CRK	80	84	PF00017	0.319
LIG_SH2_CRK	87	91	PF00017	0.319
LIG_SH2_PTP2	166	169	PF00017	0.410
LIG_SH2_SRC	220	223	PF00017	0.384
LIG_SH2_STAP1	67	71	PF00017	0.331
LIG_SH2_STAT5	166	169	PF00017	0.354
LIG_SH2_STAT5	183	186	PF00017	0.354
LIG_SH2_STAT5	220	223	PF00017	0.356
LIG_SH2_STAT5	87	90	PF00017	0.388
LIG_SH3_3	187	193	PF00018	0.410
LIG_SUMO_SIM_anti_2	170	178	PF11976	0.228
LIG_SUMO_SIM_par_1	167	173	PF11976	0.354
LIG_SUMO_SIM_par_1	54	59	PF11976	0.228
LIG_UBA3_1	135	143	PF00899	0.329
LIG_UBA3_1	171	179	PF00899	0.292
MOD_CK1_1	142	148	PF00069	0.398
MOD_CK1_1	30	36	PF00069	0.470
MOD_GlcNHglycan	74	78	PF01048	0.458
MOD_GSK3_1	124	131	PF00069	0.397
MOD_GSK3_1	208	215	PF00069	0.254
MOD_GSK3_1	24	31	PF00069	0.488
MOD_N-GLC_1	27	32	PF02516	0.488
MOD_NEK2_1	124	129	PF00069	0.424
MOD_NEK2_1	185	190	PF00069	0.367
MOD_NEK2_1	85	90	PF00069	0.414
MOD_NEK2_2	212	217	PF00069	0.360
MOD_PKA_1	78	84	PF00069	0.329
MOD_PKA_2	78	84	PF00069	0.449
MOD_Plk_4	167	173	PF00069	0.345
MOD_Plk_4	185	191	PF00069	0.298
MOD_SUMO_rev_2	173	181	PF00179	0.301
TRG_DiLeu_BaEn_1	251	256	PF01217	0.303
TRG_ENDOCYTIC_2	121	124	PF00928	0.329
TRG_ENDOCYTIC_2	166	169	PF00928	0.354
TRG_ENDOCYTIC_2	87	90	PF00928	0.448
TRG_ER_diArg_1	7	10	PF00400	0.429
TRG_NES_CRM1_1	247	258	PF08389	0.356
TRG_Pf-PMV_PEXEL_1	253	258	PF00026	0.361
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4V5	Leptomonas seymouri	27%	100%
A0A0N1HYX0	Leptomonas seymouri	47%	100%
A0A0N1PC37	Leptomonas seymouri	55%	100%
A0A0N1PFC3	Leptomonas seymouri	36%	100%
A0A3S7WWX6	Leishmania donovani	29%	100%
A0A3S7X743	Leishmania donovani	88%	100%
A4HZQ2	Leishmania infantum	29%	100%
A4I9C5	Leishmania infantum	88%	100%
E9AVK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B4C5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QBX1	Leishmania major	28%	100%