D-alanyl-glycyl endopeptidase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cysteine peptidase, Clan CA, family C51, putative

Species:

Leishmania major

UniProt:

Q4Q3Q0_LEIMA

TriTrypDb:

LmjF.33.2850 , LMJLV39_330039800 , LMJSD75_330039400

Length:

421

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0110165	cellular anatomical entity	1	12
GO:0016020	membrane	2	10

Expansion

Sequence features

Q4Q3Q0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3Q0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016874	ligase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.441
CLV_C14_Caspase3-7	282	286	PF00656	0.335
CLV_C14_Caspase3-7	346	350	PF00656	0.267
CLV_NRD_NRD_1	251	253	PF00675	0.481
CLV_NRD_NRD_1	43	45	PF00675	0.433
CLV_NRD_NRD_1	86	88	PF00675	0.536
CLV_PCSK_FUR_1	41	45	PF00082	0.429
CLV_PCSK_KEX2_1	251	253	PF00082	0.481
CLV_PCSK_KEX2_1	43	45	PF00082	0.433
CLV_PCSK_SKI1_1	225	229	PF00082	0.648
CLV_PCSK_SKI1_1	236	240	PF00082	0.608
DOC_CKS1_1	162	167	PF01111	0.387
DOC_CYCLIN_RxL_1	381	393	PF00134	0.389
DOC_MAPK_FxFP_2	6	9	PF00069	0.558
DOC_MAPK_gen_1	121	130	PF00069	0.460
DOC_MAPK_gen_1	358	366	PF00069	0.317
DOC_MAPK_MEF2A_6	121	130	PF00069	0.534
DOC_MAPK_MEF2A_6	385	392	PF00069	0.331
DOC_PP2B_LxvP_1	228	231	PF13499	0.449
DOC_PP2B_PxIxI_1	125	131	PF00149	0.329
DOC_PP4_FxxP_1	36	39	PF00568	0.609
DOC_PP4_FxxP_1	6	9	PF00568	0.558
DOC_USP7_MATH_1	158	162	PF00917	0.522
DOC_USP7_MATH_1	343	347	PF00917	0.280
DOC_USP7_MATH_1	39	43	PF00917	0.620
DOC_USP7_MATH_1	73	77	PF00917	0.650
DOC_USP7_MATH_1	90	94	PF00917	0.560
DOC_WW_Pin1_4	122	127	PF00397	0.485
DOC_WW_Pin1_4	161	166	PF00397	0.468
DOC_WW_Pin1_4	256	261	PF00397	0.281
DOC_WW_Pin1_4	351	356	PF00397	0.221
DOC_WW_Pin1_4	42	47	PF00397	0.590
LIG_14-3-3_CanoR_1	236	244	PF00244	0.361
LIG_14-3-3_CanoR_1	358	366	PF00244	0.208
LIG_Actin_WH2_2	137	154	PF00022	0.469
LIG_Clathr_ClatBox_1	389	393	PF01394	0.325
LIG_deltaCOP1_diTrp_1	368	376	PF00928	0.361
LIG_FHA_1	135	141	PF00498	0.471
LIG_FHA_1	157	163	PF00498	0.466
LIG_FHA_1	232	238	PF00498	0.411
LIG_FHA_1	287	293	PF00498	0.286
LIG_FHA_1	318	324	PF00498	0.210
LIG_FHA_2	108	114	PF00498	0.572
LIG_FHA_2	158	164	PF00498	0.484
LIG_FHA_2	224	230	PF00498	0.440
LIG_FHA_2	280	286	PF00498	0.338
LIG_FHA_2	337	343	PF00498	0.279
LIG_FHA_2	401	407	PF00498	0.373
LIG_HP1_1	388	392	PF01393	0.331
LIG_IBAR_NPY_1	378	380	PF08397	0.341
LIG_LIR_Apic_2	373	379	PF02991	0.417
LIG_LIR_Gen_1	273	283	PF02991	0.276
LIG_LIR_Gen_1	368	379	PF02991	0.316
LIG_LIR_LC3C_4	137	142	PF02991	0.329
LIG_LIR_LC3C_4	386	391	PF02991	0.331
LIG_LIR_Nem_3	185	190	PF02991	0.356
LIG_LIR_Nem_3	273	278	PF02991	0.276
LIG_LIR_Nem_3	29	34	PF02991	0.604
LIG_LIR_Nem_3	368	374	PF02991	0.406
LIG_NBox_RRM_1	264	274	PF00076	0.221
LIG_NRBOX	128	134	PF00104	0.490
LIG_Pex14_1	376	380	PF04695	0.371
LIG_Pex14_2	2	6	PF04695	0.553
LIG_SH2_CRK	34	38	PF00017	0.574
LIG_SH2_GRB2like	200	203	PF00017	0.358
LIG_SH2_GRB2like	380	383	PF00017	0.400
LIG_SH2_STAP1	101	105	PF00017	0.628
LIG_SH2_STAP1	249	253	PF00017	0.266
LIG_SH2_STAP1	383	387	PF00017	0.362
LIG_SH2_STAT3	177	180	PF00017	0.288
LIG_SH2_STAT5	177	180	PF00017	0.447
LIG_SH2_STAT5	365	368	PF00017	0.370
LIG_SH2_STAT5	402	405	PF00017	0.391
LIG_SH3_3	159	165	PF00018	0.482
LIG_SH3_3	216	222	PF00018	0.407
LIG_SH3_3	332	338	PF00018	0.296
LIG_SH3_3	371	377	PF00018	0.456
LIG_SUMO_SIM_par_1	386	394	PF11976	0.332
LIG_TRAF2_1	109	112	PF00917	0.551
LIG_TYR_ITIM	141	146	PF00017	0.614
LIG_WRC_WIRS_1	27	32	PF05994	0.573
MOD_CDK_SPK_2	351	356	PF00069	0.221
MOD_CDK_SPxxK_3	351	358	PF00069	0.221
MOD_CK1_1	161	167	PF00069	0.445
MOD_CK1_1	42	48	PF00069	0.694
MOD_CK1_1	64	70	PF00069	0.671
MOD_CK2_1	107	113	PF00069	0.562
MOD_CK2_1	157	163	PF00069	0.481
MOD_CK2_1	336	342	PF00069	0.261
MOD_GlcNHglycan	305	308	PF01048	0.470
MOD_GlcNHglycan	393	396	PF01048	0.550
MOD_GlcNHglycan	69	72	PF01048	0.466
MOD_GSK3_1	157	164	PF00069	0.519
MOD_GSK3_1	198	205	PF00069	0.391
MOD_GSK3_1	22	29	PF00069	0.784
MOD_GSK3_1	232	239	PF00069	0.396
MOD_GSK3_1	400	407	PF00069	0.431
MOD_GSK3_1	57	64	PF00069	0.786
MOD_N-GLC_1	285	290	PF02516	0.500
MOD_N-GLC_1	381	386	PF02516	0.579
MOD_NEK2_1	157	162	PF00069	0.455
MOD_NEK2_1	198	203	PF00069	0.361
MOD_NEK2_1	237	242	PF00069	0.313
MOD_NEK2_1	26	31	PF00069	0.575
MOD_NEK2_1	62	67	PF00069	0.647
MOD_OFUCOSY	203	208	PF10250	0.541
MOD_PIKK_1	164	170	PF00454	0.377
MOD_PKA_2	317	323	PF00069	0.248
MOD_PKA_2	359	365	PF00069	0.208
MOD_Plk_1	10	16	PF00069	0.579
MOD_Plk_1	146	152	PF00069	0.388
MOD_Plk_1	343	349	PF00069	0.285
MOD_Plk_1	404	410	PF00069	0.439
MOD_Plk_4	124	130	PF00069	0.411
MOD_Plk_4	22	28	PF00069	0.616
MOD_Plk_4	279	285	PF00069	0.337
MOD_Plk_4	343	349	PF00069	0.326
MOD_Plk_4	57	63	PF00069	0.651
MOD_Plk_4	73	79	PF00069	0.601
MOD_ProDKin_1	122	128	PF00069	0.485
MOD_ProDKin_1	161	167	PF00069	0.460
MOD_ProDKin_1	256	262	PF00069	0.281
MOD_ProDKin_1	351	357	PF00069	0.221
MOD_ProDKin_1	42	48	PF00069	0.592
MOD_SUMO_for_1	333	336	PF00179	0.353
TRG_DiLeu_BaLyEn_6	101	106	PF01217	0.501
TRG_DiLeu_BaLyEn_6	288	293	PF01217	0.293
TRG_ENDOCYTIC_2	143	146	PF00928	0.496
TRG_ENDOCYTIC_2	253	256	PF00928	0.293
TRG_ENDOCYTIC_2	326	329	PF00928	0.289
TRG_ENDOCYTIC_2	33	36	PF00928	0.615
TRG_ER_diArg_1	120	123	PF00400	0.697
TRG_ER_diArg_1	251	253	PF00400	0.281
TRG_ER_diArg_1	357	360	PF00400	0.357
TRG_ER_diArg_1	40	43	PF00400	0.714
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB04	Leptomonas seymouri	57%	100%
A0A1X0NR96	Trypanosomatidae	44%	100%
A0A3S5IRC8	Trypanosoma rangeli	38%	100%
A0A3S7WZA9	Leishmania donovani	28%	100%
A0A3S7X774	Leishmania donovani	86%	100%
A4HLZ4	Leishmania braziliensis	34%	96%
A4HLZ6	Leishmania braziliensis	69%	100%
A4I1M7	Leishmania infantum	28%	100%
A4I9C6	Leishmania infantum	86%	100%
E9AXR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B4C6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q9R0	Leishmania major	29%	100%