Transmembrane protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3P9_LEIMA

TriTrypDb:

LmjF.33.2860 , LMJLV39_330039900 , LMJSD75_330039500

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q3P9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3P9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016874	ligase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	184	186	PF00675	0.312
CLV_NRD_NRD_1	216	218	PF00675	0.437
CLV_NRD_NRD_1	363	365	PF00675	0.518
CLV_NRD_NRD_1	431	433	PF00675	0.562
CLV_NRD_NRD_1	441	443	PF00675	0.544
CLV_NRD_NRD_1	74	76	PF00675	0.627
CLV_PCSK_KEX2_1	184	186	PF00082	0.311
CLV_PCSK_KEX2_1	216	218	PF00082	0.437
CLV_PCSK_KEX2_1	363	365	PF00082	0.518
CLV_PCSK_KEX2_1	441	443	PF00082	0.502
CLV_PCSK_KEX2_1	74	76	PF00082	0.627
CLV_PCSK_SKI1_1	130	134	PF00082	0.351
CLV_PCSK_SKI1_1	22	26	PF00082	0.645
CLV_PCSK_SKI1_1	269	273	PF00082	0.392
CLV_PCSK_SKI1_1	354	358	PF00082	0.536
CLV_PCSK_SKI1_1	442	446	PF00082	0.415
CLV_PCSK_SKI1_1	448	452	PF00082	0.363
CLV_Separin_Metazoa	381	385	PF03568	0.623
DOC_CYCLIN_RxL_1	448	460	PF00134	0.535
DOC_CYCLIN_yCln2_LP_2	122	128	PF00134	0.600
DOC_MAPK_DCC_7	25	33	PF00069	0.483
DOC_MAPK_gen_1	216	227	PF00069	0.609
DOC_MAPK_gen_1	25	33	PF00069	0.485
DOC_PP1_RVXF_1	309	316	PF00149	0.580
DOC_PP2B_LxvP_1	122	125	PF13499	0.598
DOC_PP2B_PxIxI_1	89	95	PF00149	0.428
DOC_USP7_MATH_1	134	138	PF00917	0.618
DOC_USP7_MATH_1	282	286	PF00917	0.667
DOC_USP7_MATH_1	302	306	PF00917	0.651
DOC_WW_Pin1_4	130	135	PF00397	0.573
DOC_WW_Pin1_4	26	31	PF00397	0.496
DOC_WW_Pin1_4	86	91	PF00397	0.446
LIG_14-3-3_CanoR_1	20	25	PF00244	0.523
LIG_14-3-3_CanoR_1	220	225	PF00244	0.686
LIG_14-3-3_CanoR_1	441	450	PF00244	0.653
LIG_14-3-3_CanoR_1	74	84	PF00244	0.522
LIG_BIR_II_1	1	5	PF00653	0.606
LIG_BRCT_BRCA1_1	20	24	PF00533	0.454
LIG_deltaCOP1_diTrp_1	397	405	PF00928	0.545
LIG_FHA_1	106	112	PF00498	0.335
LIG_FHA_1	188	194	PF00498	0.495
LIG_FHA_1	449	455	PF00498	0.604
LIG_FHA_2	355	361	PF00498	0.796
LIG_FHA_2	410	416	PF00498	0.736
LIG_GBD_Chelix_1	103	111	PF00786	0.335
LIG_Integrin_isoDGR_2	214	216	PF01839	0.411
LIG_LIR_Apic_2	458	462	PF02991	0.562
LIG_LIR_Gen_1	161	171	PF02991	0.563
LIG_LIR_Gen_1	175	182	PF02991	0.499
LIG_LIR_Gen_1	228	235	PF02991	0.553
LIG_LIR_Gen_1	403	411	PF02991	0.682
LIG_LIR_Nem_3	115	120	PF02991	0.335
LIG_LIR_Nem_3	133	138	PF02991	0.553
LIG_LIR_Nem_3	161	166	PF02991	0.554
LIG_LIR_Nem_3	175	180	PF02991	0.506
LIG_LIR_Nem_3	183	189	PF02991	0.500
LIG_LIR_Nem_3	194	198	PF02991	0.624
LIG_LIR_Nem_3	228	233	PF02991	0.630
LIG_LIR_Nem_3	312	318	PF02991	0.606
LIG_LIR_Nem_3	36	42	PF02991	0.619
LIG_LIR_Nem_3	387	393	PF02991	0.537
LIG_LIR_Nem_3	403	408	PF02991	0.662
LIG_NRBOX	102	108	PF00104	0.355
LIG_NRBOX	188	194	PF00104	0.608
LIG_PCNA_yPIPBox_3	472	480	PF02747	0.534
LIG_PDZ_Class_1	480	485	PF00595	0.565
LIG_Pex14_2	116	120	PF04695	0.453
LIG_SH2_CRK	230	234	PF00017	0.633
LIG_SH2_CRK	39	43	PF00017	0.515
LIG_SH2_CRK	459	463	PF00017	0.605
LIG_SH2_GRB2like	148	151	PF00017	0.627
LIG_SH2_GRB2like	230	233	PF00017	0.542
LIG_SH2_GRB2like	459	462	PF00017	0.654
LIG_SH2_STAP1	182	186	PF00017	0.497
LIG_SH2_STAP1	230	234	PF00017	0.548
LIG_SH2_STAT5	117	120	PF00017	0.335
LIG_SH2_STAT5	172	175	PF00017	0.513
LIG_SH2_STAT5	182	185	PF00017	0.482
LIG_SH2_STAT5	230	233	PF00017	0.526
LIG_SH2_STAT5	410	413	PF00017	0.730
LIG_SH3_3	193	199	PF00018	0.540
LIG_SH3_3	2	8	PF00018	0.577
LIG_SH3_3	296	302	PF00018	0.562
LIG_SH3_3	325	331	PF00018	0.691
LIG_SH3_CIN85_PxpxPR_1	30	35	PF14604	0.550
LIG_SUMO_SIM_anti_2	108	115	PF11976	0.453
LIG_SUMO_SIM_anti_2	451	458	PF11976	0.532
LIG_SUMO_SIM_par_1	108	115	PF11976	0.389
LIG_SUMO_SIM_par_1	451	458	PF11976	0.532
LIG_TYR_ITIM	388	393	PF00017	0.529
LIG_WRC_WIRS_1	113	118	PF05994	0.453
MOD_CK1_1	191	197	PF00069	0.515
MOD_CK1_1	219	225	PF00069	0.556
MOD_CK1_1	409	415	PF00069	0.650
MOD_CK1_1	435	441	PF00069	0.685
MOD_CK1_1	77	83	PF00069	0.458
MOD_CK2_1	371	377	PF00069	0.767
MOD_CK2_1	400	406	PF00069	0.599
MOD_Cter_Amidation	214	217	PF01082	0.407
MOD_GlcNHglycan	122	125	PF01048	0.410
MOD_GlcNHglycan	259	262	PF01048	0.536
MOD_GlcNHglycan	289	292	PF01048	0.477
MOD_GlcNHglycan	347	350	PF01048	0.448
MOD_GlcNHglycan	366	369	PF01048	0.591
MOD_GlcNHglycan	373	376	PF01048	0.572
MOD_GlcNHglycan	434	438	PF01048	0.559
MOD_GlcNHglycan	54	57	PF01048	0.703
MOD_GlcNHglycan	63	66	PF01048	0.778
MOD_GlcNHglycan	69	72	PF01048	0.703
MOD_GSK3_1	130	137	PF00069	0.580
MOD_GSK3_1	187	194	PF00069	0.472
MOD_GSK3_1	216	223	PF00069	0.599
MOD_GSK3_1	354	361	PF00069	0.763
MOD_GSK3_1	400	407	PF00069	0.550
MOD_GSK3_1	417	424	PF00069	0.647
MOD_GSK3_1	57	64	PF00069	0.456
MOD_GSK3_1	82	89	PF00069	0.439
MOD_N-GLC_1	241	246	PF02516	0.517
MOD_N-GLC_1	257	262	PF02516	0.515
MOD_N-GLC_1	319	324	PF02516	0.448
MOD_N-GLC_1	354	359	PF02516	0.541
MOD_N-GLC_1	371	376	PF02516	0.578
MOD_N-GLC_1	417	422	PF02516	0.473
MOD_N-GLC_1	448	453	PF02516	0.435
MOD_NEK2_1	112	117	PF00069	0.345
MOD_NEK2_1	120	125	PF00069	0.497
MOD_NEK2_1	139	144	PF00069	0.570
MOD_NEK2_1	180	185	PF00069	0.491
MOD_NEK2_1	233	238	PF00069	0.573
MOD_NEK2_1	259	264	PF00069	0.686
MOD_NEK2_1	467	472	PF00069	0.548
MOD_NEK2_1	66	71	PF00069	0.503
MOD_PIKK_1	234	240	PF00454	0.600
MOD_PIKK_1	338	344	PF00454	0.731
MOD_PIKK_1	435	441	PF00454	0.641
MOD_PIKK_1	442	448	PF00454	0.566
MOD_PK_1	220	226	PF00069	0.681
MOD_PK_1	319	325	PF00069	0.669
MOD_PK_1	384	390	PF00069	0.554
MOD_PKA_1	216	222	PF00069	0.593
MOD_PKA_1	363	369	PF00069	0.694
MOD_PKA_1	432	438	PF00069	0.666
MOD_PKA_1	74	80	PF00069	0.414
MOD_PKA_2	216	222	PF00069	0.695
MOD_PKA_2	228	234	PF00069	0.514
MOD_PKA_2	363	369	PF00069	0.694
MOD_PKA_2	421	427	PF00069	0.659
MOD_PKA_2	479	485	PF00069	0.576
MOD_PKA_2	61	67	PF00069	0.601
MOD_PKA_2	74	80	PF00069	0.382
MOD_Plk_1	201	207	PF00069	0.474
MOD_Plk_1	319	325	PF00069	0.715
MOD_Plk_1	448	454	PF00069	0.677
MOD_Plk_4	105	111	PF00069	0.348
MOD_Plk_4	112	118	PF00069	0.344
MOD_Plk_4	134	140	PF00069	0.548
MOD_Plk_4	188	194	PF00069	0.508
MOD_Plk_4	201	207	PF00069	0.474
MOD_Plk_4	220	226	PF00069	0.724
MOD_Plk_4	384	390	PF00069	0.583
MOD_Plk_4	406	412	PF00069	0.572
MOD_ProDKin_1	130	136	PF00069	0.570
MOD_ProDKin_1	26	32	PF00069	0.496
MOD_ProDKin_1	86	92	PF00069	0.446
TRG_DiLeu_BaEn_2	311	317	PF01217	0.687
TRG_ENDOCYTIC_2	117	120	PF00928	0.335
TRG_ENDOCYTIC_2	186	189	PF00928	0.592
TRG_ENDOCYTIC_2	230	233	PF00928	0.542
TRG_ENDOCYTIC_2	39	42	PF00928	0.512
TRG_ENDOCYTIC_2	390	393	PF00928	0.524
TRG_ER_diArg_1	184	186	PF00400	0.511
TRG_ER_diArg_1	263	266	PF00400	0.650
TRG_ER_diArg_1	363	365	PF00400	0.718
TRG_ER_diArg_1	74	76	PF00400	0.427
TRG_NES_CRM1_1	158	169	PF08389	0.563
TRG_NES_CRM1_1	446	458	PF08389	0.501
TRG_Pf-PMV_PEXEL_1	74	79	PF00026	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRT1	Leptomonas seymouri	52%	100%
A0A3S7X756	Leishmania donovani	88%	100%
A4HLZ7	Leishmania braziliensis	71%	100%
A4I9C7	Leishmania infantum	88%	100%
E9B4C7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%