Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3P7_LEIMA

TriTrypDb:

LmjF.33.2880 , LMJLV39_330040100 , LMJSD75_330039700

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3P7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3P7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	274	278	PF00656	0.644
CLV_C14_Caspase3-7	401	405	PF00656	0.602
CLV_NRD_NRD_1	110	112	PF00675	0.581
CLV_NRD_NRD_1	136	138	PF00675	0.533
CLV_NRD_NRD_1	227	229	PF00675	0.642
CLV_NRD_NRD_1	25	27	PF00675	0.517
CLV_NRD_NRD_1	317	319	PF00675	0.645
CLV_NRD_NRD_1	35	37	PF00675	0.539
CLV_NRD_NRD_1	383	385	PF00675	0.606
CLV_NRD_NRD_1	386	388	PF00675	0.647
CLV_NRD_NRD_1	389	391	PF00675	0.671
CLV_PCSK_FUR_1	227	231	PF00082	0.587
CLV_PCSK_FUR_1	384	388	PF00082	0.590
CLV_PCSK_KEX2_1	136	138	PF00082	0.533
CLV_PCSK_KEX2_1	187	189	PF00082	0.594
CLV_PCSK_KEX2_1	227	229	PF00082	0.640
CLV_PCSK_KEX2_1	317	319	PF00082	0.714
CLV_PCSK_KEX2_1	334	336	PF00082	0.432
CLV_PCSK_KEX2_1	35	37	PF00082	0.540
CLV_PCSK_KEX2_1	382	384	PF00082	0.598
CLV_PCSK_KEX2_1	386	388	PF00082	0.649
CLV_PCSK_KEX2_1	389	391	PF00082	0.673
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.594
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.581
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.496
CLV_PCSK_PC7_1	382	388	PF00082	0.586
CLV_PCSK_SKI1_1	261	265	PF00082	0.539
CLV_Separin_Metazoa	179	183	PF03568	0.563
CLV_Separin_Metazoa	262	266	PF03568	0.556
DOC_PP1_RVXF_1	332	339	PF00149	0.566
DOC_PP4_FxxP_1	385	388	PF00568	0.680
DOC_USP7_MATH_1	105	109	PF00917	0.628
DOC_USP7_MATH_1	120	124	PF00917	0.608
DOC_USP7_MATH_1	2	6	PF00917	0.741
DOC_USP7_MATH_1	220	224	PF00917	0.564
DOC_USP7_MATH_1	316	320	PF00917	0.630
DOC_USP7_MATH_1	355	359	PF00917	0.614
DOC_USP7_MATH_1	64	68	PF00917	0.640
DOC_USP7_UBL2_3	190	194	PF12436	0.622
DOC_WW_Pin1_4	11	16	PF00397	0.665
DOC_WW_Pin1_4	122	127	PF00397	0.624
DOC_WW_Pin1_4	285	290	PF00397	0.557
DOC_WW_Pin1_4	91	96	PF00397	0.626
LIG_14-3-3_CanoR_1	111	116	PF00244	0.558
LIG_14-3-3_CanoR_1	298	303	PF00244	0.498
LIG_14-3-3_CanoR_1	317	323	PF00244	0.714
LIG_APCC_ABBAyCdc20_2	228	234	PF00400	0.488
LIG_BIR_II_1	1	5	PF00653	0.586
LIG_BIR_III_3	1	5	PF00653	0.663
LIG_BIR_III_4	146	150	PF00653	0.504
LIG_FHA_1	302	308	PF00498	0.658
LIG_FHA_1	79	85	PF00498	0.631
LIG_FHA_1	86	92	PF00498	0.543
LIG_FHA_2	242	248	PF00498	0.533
LIG_FHA_2	255	261	PF00498	0.517
LIG_LIR_Gen_1	67	77	PF02991	0.538
LIG_LIR_Nem_3	158	164	PF02991	0.504
LIG_LIR_Nem_3	57	62	PF02991	0.519
LIG_LIR_Nem_3	67	72	PF02991	0.531
LIG_LIR_Nem_3	94	99	PF02991	0.520
LIG_LYPXL_yS_3	59	62	PF13949	0.481
LIG_PCNA_PIPBox_1	326	335	PF02747	0.495
LIG_PCNA_yPIPBox_3	167	181	PF02747	0.548
LIG_PCNA_yPIPBox_3	326	337	PF02747	0.513
LIG_RPA_C_Fungi	132	144	PF08784	0.554
LIG_SH2_CRK	69	73	PF00017	0.514
LIG_SH2_NCK_1	104	108	PF00017	0.569
LIG_SH2_NCK_1	253	257	PF00017	0.562
LIG_SH2_NCK_1	37	41	PF00017	0.644
LIG_SH2_SRC	104	107	PF00017	0.565
LIG_SH2_STAT5	243	246	PF00017	0.539
LIG_SH2_STAT5	332	335	PF00017	0.488
LIG_SH3_3	112	118	PF00018	0.630
LIG_SH3_3	153	159	PF00018	0.506
LIG_SH3_3	39	45	PF00018	0.558
LIG_Sin3_3	140	147	PF02671	0.499
LIG_SUMO_SIM_par_1	297	304	PF11976	0.521
LIG_TRAF2_1	256	259	PF00917	0.527
LIG_TRAF2_1	290	293	PF00917	0.677
LIG_TRAF2_1	319	322	PF00917	0.639
LIG_ULM_U2AF65_1	334	339	PF00076	0.490
LIG_WRC_WIRS_1	302	307	PF05994	0.446
LIG_WW_3	14	18	PF00397	0.649
MOD_CDC14_SPxK_1	14	17	PF00782	0.657
MOD_CDK_SPxK_1	11	17	PF00069	0.665
MOD_CK1_1	10	16	PF00069	0.708
MOD_CK1_1	125	131	PF00069	0.632
MOD_CK1_1	254	260	PF00069	0.549
MOD_CK1_1	285	291	PF00069	0.694
MOD_CK1_1	301	307	PF00069	0.550
MOD_CK1_1	344	350	PF00069	0.534
MOD_CK1_1	358	364	PF00069	0.710
MOD_CK2_1	241	247	PF00069	0.538
MOD_CK2_1	254	260	PF00069	0.517
MOD_CK2_1	316	322	PF00069	0.650
MOD_GlcNHglycan	107	110	PF01048	0.681
MOD_GlcNHglycan	122	125	PF01048	0.590
MOD_GlcNHglycan	191	194	PF01048	0.661
MOD_GlcNHglycan	197	200	PF01048	0.629
MOD_GlcNHglycan	2	5	PF01048	0.756
MOD_GlcNHglycan	213	216	PF01048	0.553
MOD_GlcNHglycan	253	256	PF01048	0.530
MOD_GlcNHglycan	265	268	PF01048	0.721
MOD_GlcNHglycan	273	277	PF01048	0.543
MOD_GlcNHglycan	312	315	PF01048	0.606
MOD_GlcNHglycan	357	360	PF01048	0.689
MOD_GSK3_1	125	132	PF00069	0.644
MOD_GSK3_1	189	196	PF00069	0.533
MOD_GSK3_1	241	248	PF00069	0.562
MOD_GSK3_1	278	285	PF00069	0.685
MOD_GSK3_1	294	301	PF00069	0.503
MOD_GSK3_1	338	345	PF00069	0.503
MOD_GSK3_1	44	51	PF00069	0.581
MOD_GSK3_1	7	14	PF00069	0.691
MOD_GSK3_1	80	87	PF00069	0.608
MOD_N-GLC_1	211	216	PF02516	0.676
MOD_N-GLC_1	271	276	PF02516	0.549
MOD_NEK2_1	251	256	PF00069	0.531
MOD_NEK2_1	365	370	PF00069	0.544
MOD_NEK2_1	7	12	PF00069	0.642
MOD_NEK2_1	84	89	PF00069	0.653
MOD_NEK2_2	64	69	PF00069	0.616
MOD_PIKK_1	254	260	PF00454	0.548
MOD_PIKK_1	288	294	PF00454	0.679
MOD_PIKK_1	338	344	PF00454	0.495
MOD_PIKK_1	365	371	PF00454	0.516
MOD_PK_1	111	117	PF00069	0.525
MOD_PK_1	245	251	PF00069	0.494
MOD_PKA_1	111	117	PF00069	0.550
MOD_PKA_2	316	322	PF00069	0.660
MOD_Plk_1	220	226	PF00069	0.596
MOD_Plk_4	245	251	PF00069	0.517
MOD_Plk_4	298	304	PF00069	0.557
MOD_ProDKin_1	11	17	PF00069	0.665
MOD_ProDKin_1	122	128	PF00069	0.620
MOD_ProDKin_1	285	291	PF00069	0.551
MOD_ProDKin_1	91	97	PF00069	0.628
MOD_SUMO_for_1	371	374	PF00179	0.520
MOD_SUMO_rev_2	254	263	PF00179	0.522
TRG_DiLeu_BaEn_4	259	265	PF01217	0.536
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.488
TRG_ENDOCYTIC_2	104	107	PF00928	0.565
TRG_ENDOCYTIC_2	243	246	PF00928	0.576
TRG_ENDOCYTIC_2	37	40	PF00928	0.561
TRG_ENDOCYTIC_2	59	62	PF00928	0.481
TRG_ENDOCYTIC_2	69	72	PF00928	0.522
TRG_ER_diArg_1	226	228	PF00400	0.629
TRG_ER_diArg_1	335	338	PF00400	0.501
TRG_ER_diArg_1	35	37	PF00400	0.470
TRG_ER_diArg_1	382	384	PF00400	0.598
TRG_ER_diArg_1	385	387	PF00400	0.638
TRG_ER_diArg_1	388	390	PF00400	0.664
TRG_NLS_Bipartite_1	317	338	PF00514	0.597
TRG_NLS_MonoExtC_3	227	233	PF00514	0.561
TRG_NLS_MonoExtN_4	227	232	PF00514	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L6	Leptomonas seymouri	54%	100%
A0A3S7X784	Leishmania donovani	90%	100%
A4HLZ9	Leishmania braziliensis	76%	100%
A4I9C9	Leishmania infantum	89%	100%
E9B4C9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%