Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3P3_LEIMA

TriTrypDb:

LmjF.33.2920 , LMJLV39_330041600 , LMJSD75_330041000

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3P3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3P3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.705
CLV_NRD_NRD_1	175	177	PF00675	0.618
CLV_NRD_NRD_1	200	202	PF00675	0.598
CLV_NRD_NRD_1	205	207	PF00675	0.596
CLV_NRD_NRD_1	222	224	PF00675	0.722
CLV_PCSK_KEX2_1	175	177	PF00082	0.661
CLV_PCSK_KEX2_1	200	202	PF00082	0.598
CLV_PCSK_KEX2_1	205	207	PF00082	0.596
CLV_PCSK_KEX2_1	222	224	PF00082	0.604
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.615
CLV_PCSK_PC7_1	171	177	PF00082	0.671
CLV_PCSK_PC7_1	201	207	PF00082	0.592
CLV_PCSK_SKI1_1	200	204	PF00082	0.776
CLV_PCSK_SKI1_1	211	215	PF00082	0.613
CLV_PCSK_SKI1_1	90	94	PF00082	0.713
DOC_MAPK_gen_1	134	142	PF00069	0.647
DOC_PP4_FxxP_1	273	276	PF00568	0.511
DOC_PP4_FxxP_1	92	95	PF00568	0.592
DOC_USP7_MATH_1	113	117	PF00917	0.794
DOC_USP7_MATH_1	182	186	PF00917	0.672
DOC_USP7_MATH_1	262	266	PF00917	0.672
DOC_USP7_MATH_1	85	89	PF00917	0.720
DOC_WW_Pin1_4	266	271	PF00397	0.640
LIG_14-3-3_CanoR_1	101	107	PF00244	0.619
LIG_14-3-3_CanoR_1	108	113	PF00244	0.653
LIG_14-3-3_CanoR_1	145	151	PF00244	0.598
LIG_14-3-3_CanoR_1	248	253	PF00244	0.685
LIG_BIR_II_1	1	5	PF00653	0.637
LIG_BRCT_BRCA1_1	127	131	PF00533	0.627
LIG_BRCT_BRCA1_1	294	298	PF00533	0.657
LIG_BRCT_BRCA1_1	88	92	PF00533	0.744
LIG_FHA_1	107	113	PF00498	0.670
LIG_IBAR_NPY_1	44	46	PF08397	0.575
LIG_Integrin_RGD_1	187	189	PF01839	0.617
LIG_LIR_Apic_2	265	270	PF02991	0.663
LIG_LIR_Apic_2	89	95	PF02991	0.604
LIG_LIR_Gen_1	290	298	PF02991	0.634
LIG_LIR_Nem_3	2	6	PF02991	0.636
LIG_LIR_Nem_3	214	219	PF02991	0.619
LIG_LIR_Nem_3	231	236	PF02991	0.640
LIG_LIR_Nem_3	290	294	PF02991	0.625
LIG_MLH1_MIPbox_1	127	131	PF16413	0.627
LIG_REV1ctd_RIR_1	128	138	PF16727	0.634
LIG_SH2_CRK	216	220	PF00017	0.565
LIG_SH2_CRK	267	271	PF00017	0.666
LIG_SH2_CRK	291	295	PF00017	0.623
LIG_SH2_GRB2like	291	294	PF00017	0.633
LIG_SH2_NCK_1	291	295	PF00017	0.608
LIG_SH2_SRC	68	71	PF00017	0.672
LIG_SH2_STAT3	27	30	PF00017	0.655
LIG_SH2_STAT3	52	55	PF00017	0.630
LIG_SH2_STAT5	16	19	PF00017	0.593
LIG_SH3_3	193	199	PF00018	0.590
LIG_SH3_3	254	260	PF00018	0.664
LIG_SH3_3	48	54	PF00018	0.649
LIG_TYR_ITSM	212	219	PF00017	0.615
MOD_CK1_1	104	110	PF00069	0.702
MOD_CK1_1	111	117	PF00069	0.576
MOD_CK1_1	292	298	PF00069	0.638
MOD_CK1_1	58	64	PF00069	0.644
MOD_CK1_1	88	94	PF00069	0.615
MOD_CK2_1	294	300	PF00069	0.690
MOD_GlcNHglycan	211	214	PF01048	0.676
MOD_GlcNHglycan	57	60	PF01048	0.658
MOD_GlcNHglycan	64	67	PF01048	0.605
MOD_GSK3_1	102	109	PF00069	0.667
MOD_GSK3_1	262	269	PF00069	0.637
MOD_GSK3_1	292	299	PF00069	0.592
MOD_GSK3_1	58	65	PF00069	0.576
MOD_GSK3_1	81	88	PF00069	0.670
MOD_N-GLC_1	239	244	PF02516	0.540
MOD_N-GLC_1	292	297	PF02516	0.646
MOD_N-GLC_1	62	67	PF02516	0.520
MOD_NEK2_1	86	91	PF00069	0.692
MOD_NEK2_2	146	151	PF00069	0.653
MOD_PIKK_1	135	141	PF00454	0.664
MOD_PIKK_1	71	77	PF00454	0.647
MOD_PK_1	108	114	PF00069	0.581
MOD_PK_1	125	131	PF00069	0.638
MOD_PKA_1	101	107	PF00069	0.654
MOD_PKA_1	200	206	PF00069	0.655
MOD_PKA_2	135	141	PF00069	0.648
MOD_PKA_2	200	206	PF00069	0.655
MOD_Plk_1	25	31	PF00069	0.645
MOD_Plk_2-3	155	161	PF00069	0.484
MOD_Plk_2-3	296	302	PF00069	0.713
MOD_Plk_4	125	131	PF00069	0.638
MOD_Plk_4	262	268	PF00069	0.778
MOD_ProDKin_1	266	272	PF00069	0.636
MOD_SUMO_rev_2	98	104	PF00179	0.636
TRG_DiLeu_BaEn_4	156	162	PF01217	0.552
TRG_ENDOCYTIC_2	165	168	PF00928	0.523
TRG_ENDOCYTIC_2	216	219	PF00928	0.564
TRG_ENDOCYTIC_2	291	294	PF00928	0.644
TRG_ENDOCYTIC_2	46	49	PF00928	0.663
TRG_ER_diArg_1	175	177	PF00400	0.677
TRG_ER_diArg_1	199	201	PF00400	0.600
TRG_ER_diArg_1	238	241	PF00400	0.572
TRG_NLS_Bipartite_1	205	226	PF00514	0.681
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.645

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYS4	Leptomonas seymouri	56%	100%
A0A1X0NRB6	Trypanosomatidae	30%	100%
A0A3S7X783	Leishmania donovani	93%	100%
A4HM03	Leishmania braziliensis	66%	99%
A4I9D4	Leishmania infantum	93%	100%
E9B4D4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%