PPM-type phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3P1_LEIMA

TriTrypDb:

LmjF.33.2940 , LMJLV39_330041800 , LMJSD75_330041200

Length:

658

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q3P1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3P1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	368	372	PF00656	0.517
CLV_NRD_NRD_1	263	265	PF00675	0.645
CLV_NRD_NRD_1	410	412	PF00675	0.461
CLV_NRD_NRD_1	580	582	PF00675	0.437
CLV_NRD_NRD_1	8	10	PF00675	0.560
CLV_PCSK_KEX2_1	193	195	PF00082	0.614
CLV_PCSK_KEX2_1	234	236	PF00082	0.672
CLV_PCSK_KEX2_1	263	265	PF00082	0.737
CLV_PCSK_KEX2_1	597	599	PF00082	0.487
CLV_PCSK_KEX2_1	8	10	PF00082	0.710
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.614
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.672
CLV_PCSK_PC1ET2_1	597	599	PF00082	0.562
CLV_PCSK_SKI1_1	407	411	PF00082	0.374
CLV_PCSK_SKI1_1	491	495	PF00082	0.511
CLV_PCSK_SKI1_1	507	511	PF00082	0.261
CLV_PCSK_SKI1_1	584	588	PF00082	0.434
CLV_PCSK_SKI1_1	637	641	PF00082	0.617
CLV_Separin_Metazoa	606	610	PF03568	0.472
DOC_AGCK_PIF_1	599	604	PF00069	0.519
DOC_ANK_TNKS_1	550	557	PF00023	0.484
DOC_MAPK_gen_1	263	270	PF00069	0.657
DOC_MAPK_gen_1	416	426	PF00069	0.498
DOC_MAPK_MEF2A_6	419	428	PF00069	0.491
DOC_USP7_MATH_1	148	152	PF00917	0.681
DOC_USP7_MATH_1	158	162	PF00917	0.566
DOC_USP7_MATH_1	181	185	PF00917	0.647
DOC_USP7_MATH_1	275	279	PF00917	0.706
DOC_USP7_MATH_1	296	300	PF00917	0.778
DOC_USP7_MATH_1	449	453	PF00917	0.506
DOC_USP7_MATH_1	617	621	PF00917	0.498
DOC_USP7_MATH_1	99	103	PF00917	0.713
DOC_USP7_UBL2_3	265	269	PF12436	0.720
DOC_USP7_UBL2_3	310	314	PF12436	0.587
DOC_USP7_UBL2_3	348	352	PF12436	0.573
DOC_USP7_UBL2_3	507	511	PF12436	0.393
DOC_WW_Pin1_4	18	23	PF00397	0.739
DOC_WW_Pin1_4	458	463	PF00397	0.422
DOC_WW_Pin1_4	542	547	PF00397	0.534
DOC_WW_Pin1_4	642	647	PF00397	0.494
LIG_14-3-3_CanoR_1	194	204	PF00244	0.644
LIG_14-3-3_CanoR_1	263	270	PF00244	0.624
LIG_14-3-3_CanoR_1	36	41	PF00244	0.718
LIG_Actin_WH2_2	423	440	PF00022	0.487
LIG_BIR_II_1	1	5	PF00653	0.560
LIG_CaM_IQ_9	399	414	PF13499	0.516
LIG_Clathr_ClatBox_1	324	328	PF01394	0.348
LIG_Clathr_ClatBox_1	468	472	PF01394	0.508
LIG_CtBP_PxDLS_1	31	35	PF00389	0.529
LIG_DLG_GKlike_1	36	43	PF00625	0.661
LIG_EH1_1	318	326	PF00400	0.380
LIG_eIF4E_1	319	325	PF01652	0.377
LIG_FHA_1	168	174	PF00498	0.617
LIG_FHA_1	211	217	PF00498	0.683
LIG_FHA_1	352	358	PF00498	0.491
LIG_FHA_1	400	406	PF00498	0.472
LIG_FHA_2	207	213	PF00498	0.724
LIG_FHA_2	281	287	PF00498	0.734
LIG_FHA_2	329	335	PF00498	0.532
LIG_FHA_2	476	482	PF00498	0.478
LIG_FHA_2	510	516	PF00498	0.502
LIG_FHA_2	601	607	PF00498	0.473
LIG_FHA_2	616	622	PF00498	0.548
LIG_FHA_2	642	648	PF00498	0.453
LIG_LIR_Gen_1	452	458	PF02991	0.439
LIG_LIR_Nem_3	198	204	PF02991	0.736
LIG_LIR_Nem_3	601	607	PF02991	0.520
LIG_PCNA_yPIPBox_3	312	325	PF02747	0.419
LIG_REV1ctd_RIR_1	501	511	PF16727	0.362
LIG_SH2_STAP1	453	457	PF00017	0.458
LIG_SH2_STAT5	602	605	PF00017	0.591
LIG_SH3_3	11	17	PF00018	0.707
LIG_SH3_3	25	31	PF00018	0.646
LIG_SH3_3	335	341	PF00018	0.412
LIG_SH3_3	460	466	PF00018	0.404
LIG_SUMO_SIM_anti_2	323	328	PF11976	0.386
LIG_SUMO_SIM_par_1	323	328	PF11976	0.346
LIG_SUMO_SIM_par_1	334	340	PF11976	0.388
LIG_TRAF2_1	514	517	PF00917	0.520
LIG_UBA3_1	468	474	PF00899	0.456
LIG_WRC_WIRS_1	220	225	PF05994	0.689
LIG_WRC_WIRS_1	483	488	PF05994	0.429
LIG_WW_3	589	593	PF00397	0.448
MOD_CDC14_SPxK_1	545	548	PF00782	0.507
MOD_CDK_SPxK_1	542	548	PF00069	0.528
MOD_CK1_1	195	201	PF00069	0.700
MOD_CK1_1	206	212	PF00069	0.734
MOD_CK1_1	255	261	PF00069	0.686
MOD_CK1_1	273	279	PF00069	0.676
MOD_CK1_1	362	368	PF00069	0.476
MOD_CK1_1	44	50	PF00069	0.466
MOD_CK1_1	78	84	PF00069	0.439
MOD_CK2_1	475	481	PF00069	0.405
MOD_CK2_1	509	515	PF00069	0.431
MOD_CK2_1	600	606	PF00069	0.470
MOD_CK2_1	615	621	PF00069	0.467
MOD_CK2_1	641	647	PF00069	0.527
MOD_Cter_Amidation	232	235	PF01082	0.680
MOD_Cter_Amidation	349	352	PF01082	0.582
MOD_GlcNHglycan	194	197	PF01048	0.655
MOD_GlcNHglycan	198	201	PF01048	0.796
MOD_GlcNHglycan	231	234	PF01048	0.592
MOD_GlcNHglycan	272	275	PF01048	0.681
MOD_GlcNHglycan	364	367	PF01048	0.543
MOD_GlcNHglycan	387	390	PF01048	0.390
MOD_GlcNHglycan	49	52	PF01048	0.641
MOD_GlcNHglycan	561	564	PF01048	0.401
MOD_GlcNHglycan	592	595	PF01048	0.462
MOD_GlcNHglycan	615	618	PF01048	0.531
MOD_GlcNHglycan	69	72	PF01048	0.616
MOD_GlcNHglycan	97	100	PF01048	0.758
MOD_GSK3_1	106	113	PF00069	0.622
MOD_GSK3_1	18	25	PF00069	0.716
MOD_GSK3_1	192	199	PF00069	0.675
MOD_GSK3_1	206	213	PF00069	0.631
MOD_GSK3_1	249	256	PF00069	0.796
MOD_GSK3_1	275	282	PF00069	0.724
MOD_GSK3_1	287	294	PF00069	0.640
MOD_GSK3_1	296	303	PF00069	0.607
MOD_GSK3_1	369	376	PF00069	0.415
MOD_GSK3_1	47	54	PF00069	0.768
MOD_GSK3_1	477	484	PF00069	0.462
MOD_GSK3_1	505	512	PF00069	0.485
MOD_GSK3_1	613	620	PF00069	0.520
MOD_GSK3_1	642	649	PF00069	0.551
MOD_GSK3_1	67	74	PF00069	0.716
MOD_GSK3_1	95	102	PF00069	0.703
MOD_N-GLC_1	181	186	PF02516	0.669
MOD_N-GLC_1	253	258	PF02516	0.686
MOD_N-GLC_1	278	283	PF02516	0.748
MOD_NEK2_1	110	115	PF00069	0.698
MOD_NEK2_1	141	146	PF00069	0.637
MOD_NEK2_1	270	275	PF00069	0.732
MOD_NEK2_1	428	433	PF00069	0.350
MOD_NEK2_1	457	462	PF00069	0.409
MOD_NEK2_1	67	72	PF00069	0.628
MOD_NEK2_1	75	80	PF00069	0.510
MOD_NEK2_2	148	153	PF00069	0.689
MOD_NEK2_2	158	163	PF00069	0.583
MOD_NEK2_2	51	56	PF00069	0.541
MOD_PIKK_1	187	193	PF00454	0.745
MOD_PIKK_1	399	405	PF00454	0.485
MOD_PKA_1	263	269	PF00069	0.697
MOD_PKA_1	351	357	PF00069	0.487
MOD_PKA_2	263	269	PF00069	0.643
MOD_Plk_1	181	187	PF00069	0.694
MOD_Plk_1	206	212	PF00069	0.765
MOD_Plk_1	253	259	PF00069	0.684
MOD_Plk_1	428	434	PF00069	0.351
MOD_Plk_1	600	606	PF00069	0.522
MOD_Plk_2-3	334	340	PF00069	0.410
MOD_Plk_4	106	112	PF00069	0.593
MOD_Plk_4	127	133	PF00069	0.626
MOD_Plk_4	136	142	PF00069	0.638
MOD_Plk_4	148	154	PF00069	0.680
MOD_Plk_4	158	164	PF00069	0.583
MOD_Plk_4	30	36	PF00069	0.776
MOD_Plk_4	320	326	PF00069	0.346
MOD_Plk_4	340	346	PF00069	0.525
MOD_Plk_4	369	375	PF00069	0.374
MOD_Plk_4	430	436	PF00069	0.452
MOD_ProDKin_1	18	24	PF00069	0.742
MOD_ProDKin_1	458	464	PF00069	0.421
MOD_ProDKin_1	542	548	PF00069	0.537
MOD_ProDKin_1	642	648	PF00069	0.501
MOD_SUMO_rev_2	266	270	PF00179	0.713
MOD_SUMO_rev_2	285	290	PF00179	0.777
MOD_SUMO_rev_2	575	583	PF00179	0.438
MOD_SUMO_rev_2	615	624	PF00179	0.553
MOD_SUMO_rev_2	633	642	PF00179	0.407
TRG_DiLeu_BaEn_4	515	521	PF01217	0.542
TRG_ENDOCYTIC_2	100	103	PF00928	0.727
TRG_ENDOCYTIC_2	111	114	PF00928	0.629
TRG_ENDOCYTIC_2	201	204	PF00928	0.750
TRG_ENDOCYTIC_2	45	48	PF00928	0.715
TRG_ENDOCYTIC_2	453	456	PF00928	0.411
TRG_ENDOCYTIC_2	604	607	PF00928	0.517
TRG_ENDOCYTIC_2	72	75	PF00928	0.729
TRG_ENDOCYTIC_2	79	82	PF00928	0.648
TRG_ENDOCYTIC_2	86	89	PF00928	0.558
TRG_ER_diArg_1	262	264	PF00400	0.662
TRG_ER_diArg_1	7	9	PF00400	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF45	Leptomonas seymouri	63%	76%
A0A1X0NRD1	Trypanosomatidae	42%	80%
A0A1X0NST4	Trypanosomatidae	31%	80%
A0A3Q8II25	Leishmania donovani	33%	93%
A0A3S7X791	Leishmania donovani	95%	100%
A4HM05	Leishmania braziliensis	79%	100%
A4HM06	Leishmania braziliensis	34%	100%
A4I9D6	Leishmania infantum	95%	100%
A4I9D8	Leishmania infantum	33%	100%
C9ZJQ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	86%
E9B4D6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9B4D7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
V5B7N5	Trypanosoma cruzi	26%	100%
V5D844	Trypanosoma cruzi	38%	100%