RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3P0_LEIMA

TriTrypDb:

LmjF.33.2960 , LMJLV39_330042000 , LMJSD75_330041400

Length:

670

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3P0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3P0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	194	198	PF00656	0.470
CLV_C14_Caspase3-7	237	241	PF00656	0.587
CLV_C14_Caspase3-7	272	276	PF00656	0.515
CLV_C14_Caspase3-7	322	326	PF00656	0.734
CLV_NRD_NRD_1	201	203	PF00675	0.587
CLV_NRD_NRD_1	417	419	PF00675	0.602
CLV_NRD_NRD_1	523	525	PF00675	0.370
CLV_PCSK_KEX2_1	201	203	PF00082	0.565
CLV_PCSK_KEX2_1	417	419	PF00082	0.592
CLV_PCSK_KEX2_1	555	557	PF00082	0.323
CLV_PCSK_KEX2_1	611	613	PF00082	0.554
CLV_PCSK_KEX2_1	645	647	PF00082	0.407
CLV_PCSK_PC1ET2_1	555	557	PF00082	0.323
CLV_PCSK_PC1ET2_1	611	613	PF00082	0.525
CLV_PCSK_PC1ET2_1	645	647	PF00082	0.407
CLV_PCSK_SKI1_1	230	234	PF00082	0.640
CLV_PCSK_SKI1_1	268	272	PF00082	0.739
CLV_PCSK_SKI1_1	355	359	PF00082	0.466
CLV_PCSK_SKI1_1	459	463	PF00082	0.335
CLV_PCSK_SKI1_1	470	474	PF00082	0.544
DEG_Nend_UBRbox_1	1	4	PF02207	0.500
DEG_SPOP_SBC_1	628	632	PF00917	0.467
DOC_ANK_TNKS_1	23	30	PF00023	0.495
DOC_CYCLIN_RxL_1	342	353	PF00134	0.373
DOC_MAPK_gen_1	352	361	PF00069	0.393
DOC_MAPK_gen_1	372	382	PF00069	0.406
DOC_MAPK_gen_1	417	424	PF00069	0.399
DOC_MAPK_gen_1	524	532	PF00069	0.363
DOC_MAPK_gen_1	645	651	PF00069	0.421
DOC_MAPK_MEF2A_6	525	534	PF00069	0.357
DOC_PP4_FxxP_1	32	35	PF00568	0.529
DOC_PP4_FxxP_1	541	544	PF00568	0.319
DOC_USP7_MATH_1	107	111	PF00917	0.556
DOC_USP7_MATH_1	117	121	PF00917	0.501
DOC_USP7_MATH_1	128	132	PF00917	0.503
DOC_USP7_MATH_1	138	142	PF00917	0.624
DOC_USP7_MATH_1	148	152	PF00917	0.623
DOC_USP7_MATH_1	437	441	PF00917	0.337
DOC_USP7_MATH_1	86	90	PF00917	0.563
DOC_USP7_MATH_1	96	100	PF00917	0.484
DOC_USP7_UBL2_3	239	243	PF12436	0.616
DOC_USP7_UBL2_3	257	261	PF12436	0.511
DOC_USP7_UBL2_3	264	268	PF12436	0.578
DOC_USP7_UBL2_3	269	273	PF12436	0.564
DOC_USP7_UBL2_3	286	290	PF12436	0.703
DOC_USP7_UBL2_3	309	313	PF12436	0.594
DOC_USP7_UBL2_3	319	323	PF12436	0.713
DOC_USP7_UBL2_3	358	362	PF12436	0.452
DOC_USP7_UBL2_3	521	525	PF12436	0.366
DOC_USP7_UBL2_3	619	623	PF12436	0.377
DOC_WW_Pin1_4	473	478	PF00397	0.457
LIG_14-3-3_CanoR_1	201	206	PF00244	0.548
LIG_14-3-3_CanoR_1	208	212	PF00244	0.501
LIG_14-3-3_CanoR_1	417	425	PF00244	0.468
LIG_14-3-3_CanoR_1	524	533	PF00244	0.418
LIG_14-3-3_CanoR_1	565	569	PF00244	0.443
LIG_BRCT_BRCA1_1	439	443	PF00533	0.270
LIG_FHA_1	406	412	PF00498	0.476
LIG_FHA_1	417	423	PF00498	0.459
LIG_FHA_1	431	437	PF00498	0.346
LIG_FHA_1	486	492	PF00498	0.436
LIG_FHA_2	372	378	PF00498	0.422
LIG_FHA_2	391	397	PF00498	0.457
LIG_FHA_2	448	454	PF00498	0.355
LIG_FHA_2	485	491	PF00498	0.563
LIG_FHA_2	615	621	PF00498	0.461
LIG_FHA_2	629	635	PF00498	0.536
LIG_LIR_Apic_2	540	544	PF02991	0.313
LIG_LIR_Gen_1	191	199	PF02991	0.508
LIG_LIR_Gen_1	444	452	PF02991	0.307
LIG_LIR_Gen_1	639	647	PF02991	0.383
LIG_LIR_Nem_3	15	20	PF02991	0.564
LIG_LIR_Nem_3	191	195	PF02991	0.590
LIG_LIR_Nem_3	439	445	PF02991	0.360
LIG_LIR_Nem_3	516	520	PF02991	0.409
LIG_MLH1_MIPbox_1	439	443	PF16413	0.270
LIG_SH2_CRK	17	21	PF00017	0.585
LIG_SH2_CRK	192	196	PF00017	0.580
LIG_SH2_STAP1	640	644	PF00017	0.435
LIG_SH2_STAT5	428	431	PF00017	0.360
LIG_SH2_STAT5	442	445	PF00017	0.219
LIG_SH2_STAT5	446	449	PF00017	0.306
LIG_SH2_STAT5	517	520	PF00017	0.327
LIG_SH2_STAT5	533	536	PF00017	0.328
LIG_SH2_STAT5	616	619	PF00017	0.561
LIG_SH3_2	557	562	PF14604	0.485
LIG_SH3_3	475	481	PF00018	0.436
LIG_SH3_3	554	560	PF00018	0.452
LIG_SUMO_SIM_anti_2	346	351	PF11976	0.431
LIG_SUMO_SIM_par_1	407	414	PF11976	0.360
LIG_TRAF2_1	631	634	PF00917	0.512
LIG_UBA3_1	549	555	PF00899	0.359
LIG_UBA3_1	643	652	PF00899	0.406
MOD_CK1_1	191	197	PF00069	0.567
MOD_CK1_1	246	252	PF00069	0.555
MOD_CK1_1	413	419	PF00069	0.465
MOD_CK1_1	629	635	PF00069	0.458
MOD_CK1_1	67	73	PF00069	0.522
MOD_CK2_1	350	356	PF00069	0.461
MOD_CK2_1	390	396	PF00069	0.296
MOD_CK2_1	447	453	PF00069	0.408
MOD_CK2_1	484	490	PF00069	0.473
MOD_CK2_1	578	584	PF00069	0.358
MOD_CK2_1	614	620	PF00069	0.445
MOD_CK2_1	627	633	PF00069	0.422
MOD_GlcNHglycan	14	17	PF01048	0.654
MOD_GlcNHglycan	226	229	PF01048	0.614
MOD_GlcNHglycan	275	278	PF01048	0.774
MOD_GlcNHglycan	286	289	PF01048	0.772
MOD_GlcNHglycan	339	342	PF01048	0.637
MOD_GlcNHglycan	352	355	PF01048	0.408
MOD_GlcNHglycan	52	55	PF01048	0.612
MOD_GlcNHglycan	526	529	PF01048	0.401
MOD_GlcNHglycan	582	588	PF01048	0.391
MOD_GlcNHglycan	606	609	PF01048	0.411
MOD_GSK3_1	197	204	PF00069	0.611
MOD_GSK3_1	220	227	PF00069	0.587
MOD_GSK3_1	339	346	PF00069	0.435
MOD_GSK3_1	36	43	PF00069	0.594
MOD_GSK3_1	437	444	PF00069	0.344
MOD_GSK3_1	533	540	PF00069	0.405
MOD_GSK3_1	600	607	PF00069	0.393
MOD_GSK3_1	628	635	PF00069	0.521
MOD_N-GLC_1	220	225	PF02516	0.530
MOD_N-GLC_1	405	410	PF02516	0.381
MOD_N-GLC_1	484	489	PF02516	0.413
MOD_N-GLC_1	537	542	PF02516	0.330
MOD_N-GLC_2	224	226	PF02516	0.560
MOD_NEK2_1	337	342	PF00069	0.612
MOD_NEK2_1	537	542	PF00069	0.395
MOD_NEK2_2	107	112	PF00069	0.501
MOD_NEK2_2	117	122	PF00069	0.469
MOD_NEK2_2	128	133	PF00069	0.476
MOD_NEK2_2	138	143	PF00069	0.557
MOD_NEK2_2	148	153	PF00069	0.571
MOD_NEK2_2	157	162	PF00069	0.518
MOD_NEK2_2	166	171	PF00069	0.581
MOD_NEK2_2	175	180	PF00069	0.554
MOD_NEK2_2	183	188	PF00069	0.487
MOD_NEK2_2	357	362	PF00069	0.382
MOD_NEK2_2	86	91	PF00069	0.583
MOD_NEK2_2	96	101	PF00069	0.468
MOD_PIKK_1	416	422	PF00454	0.582
MOD_PK_1	279	285	PF00069	0.580
MOD_PKA_1	201	207	PF00069	0.592
MOD_PKA_1	243	249	PF00069	0.592
MOD_PKA_1	268	274	PF00069	0.581
MOD_PKA_1	279	285	PF00069	0.608
MOD_PKA_1	290	296	PF00069	0.537
MOD_PKA_1	524	530	PF00069	0.380
MOD_PKA_2	201	207	PF00069	0.581
MOD_PKA_2	36	42	PF00069	0.505
MOD_PKA_2	363	369	PF00069	0.412
MOD_PKA_2	416	422	PF00069	0.477
MOD_PKA_2	523	529	PF00069	0.439
MOD_PKA_2	564	570	PF00069	0.377
MOD_Plk_1	405	411	PF00069	0.373
MOD_Plk_1	537	543	PF00069	0.405
MOD_Plk_2-3	390	396	PF00069	0.296
MOD_Plk_4	107	113	PF00069	0.522
MOD_Plk_4	117	123	PF00069	0.545
MOD_Plk_4	128	134	PF00069	0.525
MOD_Plk_4	138	144	PF00069	0.549
MOD_Plk_4	148	154	PF00069	0.534
MOD_Plk_4	157	163	PF00069	0.551
MOD_Plk_4	166	172	PF00069	0.580
MOD_Plk_4	175	181	PF00069	0.499
MOD_Plk_4	183	189	PF00069	0.488
MOD_Plk_4	191	197	PF00069	0.496
MOD_Plk_4	201	207	PF00069	0.477
MOD_Plk_4	363	369	PF00069	0.528
MOD_Plk_4	405	411	PF00069	0.387
MOD_Plk_4	513	519	PF00069	0.365
MOD_Plk_4	537	543	PF00069	0.359
MOD_Plk_4	639	645	PF00069	0.545
MOD_Plk_4	86	92	PF00069	0.626
MOD_Plk_4	96	102	PF00069	0.499
MOD_ProDKin_1	473	479	PF00069	0.456
MOD_SUMO_for_1	251	254	PF00179	0.625
MOD_SUMO_rev_2	210	219	PF00179	0.674
MOD_SUMO_rev_2	227	235	PF00179	0.590
MOD_SUMO_rev_2	236	246	PF00179	0.571
MOD_SUMO_rev_2	248	253	PF00179	0.548
MOD_SUMO_rev_2	254	263	PF00179	0.513
MOD_SUMO_rev_2	267	276	PF00179	0.607
MOD_SUMO_rev_2	278	288	PF00179	0.795
MOD_SUMO_rev_2	289	299	PF00179	0.639
MOD_SUMO_rev_2	301	311	PF00179	0.706
MOD_SUMO_rev_2	353	360	PF00179	0.464
MOD_SUMO_rev_2	365	374	PF00179	0.557
MOD_SUMO_rev_2	629	638	PF00179	0.507
MOD_SUMO_rev_2	655	664	PF00179	0.498
TRG_DiLeu_BaEn_4	558	564	PF01217	0.388
TRG_ENDOCYTIC_2	17	20	PF00928	0.688
TRG_ENDOCYTIC_2	192	195	PF00928	0.592
TRG_ENDOCYTIC_2	442	445	PF00928	0.334
TRG_ENDOCYTIC_2	446	449	PF00928	0.306
TRG_ENDOCYTIC_2	517	520	PF00928	0.327
TRG_ENDOCYTIC_2	640	643	PF00928	0.456
TRG_ENDOCYTIC_2	68	71	PF00928	0.641
TRG_Pf-PMV_PEXEL_1	459	464	PF00026	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NRB5	Trypanosomatidae	33%	79%
A0A1X0NST4	Trypanosomatidae	29%	81%
A0A3Q8II25	Leishmania donovani	90%	100%
A4HM05	Leishmania braziliensis	35%	100%
A4HM06	Leishmania braziliensis	74%	100%
A4I9D8	Leishmania infantum	91%	85%
E9B4D6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B4D7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%