Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q3N6_LEIMA

TriTrypDb:

LmjF.33.3000 , LMJLV39_330042500 , LMJSD75_330041800 , LMJSD75_330041900

Length:

990

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3N6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3N6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	515	519	PF00656	0.682
CLV_C14_Caspase3-7	967	971	PF00656	0.492
CLV_MEL_PAP_1	325	331	PF00089	0.680
CLV_NRD_NRD_1	16	18	PF00675	0.689
CLV_NRD_NRD_1	358	360	PF00675	0.561
CLV_NRD_NRD_1	56	58	PF00675	0.622
CLV_NRD_NRD_1	594	596	PF00675	0.518
CLV_NRD_NRD_1	792	794	PF00675	0.501
CLV_NRD_NRD_1	919	921	PF00675	0.671
CLV_NRD_NRD_1	927	929	PF00675	0.471
CLV_NRD_NRD_1	982	984	PF00675	0.547
CLV_PCSK_KEX2_1	56	58	PF00082	0.650
CLV_PCSK_KEX2_1	594	596	PF00082	0.518
CLV_PCSK_KEX2_1	813	815	PF00082	0.619
CLV_PCSK_KEX2_1	919	921	PF00082	0.712
CLV_PCSK_KEX2_1	927	929	PF00082	0.538
CLV_PCSK_KEX2_1	982	984	PF00082	0.583
CLV_PCSK_PC1ET2_1	813	815	PF00082	0.619
CLV_PCSK_SKI1_1	126	130	PF00082	0.695
CLV_PCSK_SKI1_1	386	390	PF00082	0.560
CLV_PCSK_SKI1_1	428	432	PF00082	0.670
CLV_PCSK_SKI1_1	545	549	PF00082	0.646
CLV_PCSK_SKI1_1	668	672	PF00082	0.498
CLV_PCSK_SKI1_1	934	938	PF00082	0.582
CLV_PCSK_SKI1_1	956	960	PF00082	0.474
DEG_Nend_UBRbox_1	1	4	PF02207	0.577
DEG_SCF_FBW7_1	448	454	PF00400	0.693
DOC_CKS1_1	193	198	PF01111	0.709
DOC_CKS1_1	448	453	PF01111	0.691
DOC_CYCLIN_yCln2_LP_2	628	634	PF00134	0.541
DOC_MAPK_gen_1	359	366	PF00069	0.432
DOC_MAPK_gen_1	793	800	PF00069	0.543
DOC_MAPK_RevD_3	780	794	PF00069	0.423
DOC_PP1_RVXF_1	124	130	PF00149	0.692
DOC_PP2B_LxvP_1	166	169	PF13499	0.576
DOC_PP4_FxxP_1	26	29	PF00568	0.736
DOC_PP4_FxxP_1	884	887	PF00568	0.590
DOC_PP4_MxPP_1	200	203	PF00568	0.717
DOC_USP7_MATH_1	144	148	PF00917	0.773
DOC_USP7_MATH_1	233	237	PF00917	0.769
DOC_USP7_MATH_1	239	243	PF00917	0.727
DOC_USP7_MATH_1	398	402	PF00917	0.710
DOC_USP7_MATH_1	424	428	PF00917	0.732
DOC_USP7_MATH_1	478	482	PF00917	0.750
DOC_USP7_MATH_1	492	496	PF00917	0.692
DOC_USP7_MATH_1	634	638	PF00917	0.536
DOC_USP7_MATH_1	696	700	PF00917	0.474
DOC_USP7_MATH_1	747	751	PF00917	0.439
DOC_USP7_MATH_1	834	838	PF00917	0.636
DOC_USP7_MATH_1	86	90	PF00917	0.644
DOC_USP7_MATH_1	968	972	PF00917	0.444
DOC_USP7_UBL2_3	626	630	PF12436	0.531
DOC_WW_Pin1_4	145	150	PF00397	0.793
DOC_WW_Pin1_4	192	197	PF00397	0.723
DOC_WW_Pin1_4	252	257	PF00397	0.731
DOC_WW_Pin1_4	272	277	PF00397	0.710
DOC_WW_Pin1_4	403	408	PF00397	0.671
DOC_WW_Pin1_4	410	415	PF00397	0.647
DOC_WW_Pin1_4	440	445	PF00397	0.694
DOC_WW_Pin1_4	447	452	PF00397	0.629
DOC_WW_Pin1_4	474	479	PF00397	0.818
DOC_WW_Pin1_4	531	536	PF00397	0.519
LIG_14-3-3_CanoR_1	21	27	PF00244	0.708
LIG_14-3-3_CanoR_1	328	333	PF00244	0.692
LIG_14-3-3_CanoR_1	545	551	PF00244	0.536
LIG_14-3-3_CanoR_1	594	600	PF00244	0.560
LIG_14-3-3_CanoR_1	648	657	PF00244	0.509
LIG_14-3-3_CanoR_1	736	744	PF00244	0.569
LIG_14-3-3_CanoR_1	928	936	PF00244	0.482
LIG_14-3-3_CanoR_1	982	987	PF00244	0.628
LIG_BRCT_BRCA1_1	393	397	PF00533	0.670
LIG_BRCT_BRCA1_1	666	670	PF00533	0.490
LIG_EH1_1	584	592	PF00400	0.436
LIG_EH1_1	702	710	PF00400	0.540
LIG_eIF4E_1	703	709	PF01652	0.528
LIG_EVH1_1	187	191	PF00568	0.722
LIG_FHA_1	296	302	PF00498	0.754
LIG_FHA_1	320	326	PF00498	0.674
LIG_FHA_1	404	410	PF00498	0.592
LIG_FHA_1	451	457	PF00498	0.695
LIG_FHA_1	496	502	PF00498	0.621
LIG_FHA_1	525	531	PF00498	0.633
LIG_FHA_1	560	566	PF00498	0.649
LIG_FHA_1	743	749	PF00498	0.538
LIG_FHA_1	785	791	PF00498	0.507
LIG_FHA_1	863	869	PF00498	0.531
LIG_FHA_1	888	894	PF00498	0.560
LIG_FHA_1	935	941	PF00498	0.539
LIG_FHA_2	513	519	PF00498	0.689
LIG_FHA_2	579	585	PF00498	0.667
LIG_FHA_2	596	602	PF00498	0.427
LIG_FHA_2	773	779	PF00498	0.508
LIG_HP1_1	407	411	PF01393	0.628
LIG_LIR_Apic_2	24	29	PF02991	0.802
LIG_LIR_Apic_2	882	887	PF02991	0.573
LIG_LIR_Gen_1	676	685	PF02991	0.517
LIG_LIR_Nem_3	282	286	PF02991	0.562
LIG_LIR_Nem_3	330	335	PF02991	0.564
LIG_LIR_Nem_3	676	680	PF02991	0.485
LIG_LIR_Nem_3	734	738	PF02991	0.624
LIG_MYND_1	444	448	PF01753	0.594
LIG_NRBOX	384	390	PF00104	0.592
LIG_PCNA_yPIPBox_3	777	786	PF02747	0.542
LIG_Pex14_2	671	675	PF04695	0.509
LIG_Pex14_2	880	884	PF04695	0.578
LIG_SH2_CRK	735	739	PF00017	0.567
LIG_SH2_CRK	889	893	PF00017	0.577
LIG_SH2_NCK_1	703	707	PF00017	0.466
LIG_SH2_SRC	540	543	PF00017	0.566
LIG_SH2_SRC	965	968	PF00017	0.456
LIG_SH2_STAP1	616	620	PF00017	0.518
LIG_SH2_STAP1	661	665	PF00017	0.619
LIG_SH2_STAP1	889	893	PF00017	0.577
LIG_SH2_STAP1	965	969	PF00017	0.483
LIG_SH2_STAT3	661	664	PF00017	0.519
LIG_SH2_STAT5	192	195	PF00017	0.676
LIG_SH2_STAT5	206	209	PF00017	0.596
LIG_SH2_STAT5	889	892	PF00017	0.555
LIG_SH3_1	171	177	PF00018	0.600
LIG_SH3_1	185	191	PF00018	0.666
LIG_SH3_3	143	149	PF00018	0.689
LIG_SH3_3	171	177	PF00018	0.693
LIG_SH3_3	185	191	PF00018	0.610
LIG_SH3_3	211	217	PF00018	0.709
LIG_SH3_3	250	256	PF00018	0.743
LIG_SH3_3	278	284	PF00018	0.680
LIG_SH3_3	332	338	PF00018	0.566
LIG_SH3_3	426	432	PF00018	0.729
LIG_SH3_3	44	50	PF00018	0.761
LIG_SH3_3	445	451	PF00018	0.655
LIG_SH3_3	453	459	PF00018	0.735
LIG_SH3_3	514	520	PF00018	0.767
LIG_SH3_3	75	81	PF00018	0.596
LIG_SH3_3	947	953	PF00018	0.564
LIG_SUMO_SIM_anti_2	704	712	PF11976	0.487
LIG_SUMO_SIM_par_1	619	625	PF11976	0.593
LIG_SUMO_SIM_par_1	889	895	PF11976	0.556
LIG_TRAF2_1	134	137	PF00917	0.708
LIG_TRAF2_1	459	462	PF00917	0.711
LIG_TRAF2_1	799	802	PF00917	0.590
LIG_TYR_ITIM	733	738	PF00017	0.621
LIG_UBA3_1	646	655	PF00899	0.433
LIG_UBA3_1	892	900	PF00899	0.587
LIG_WRC_WIRS_1	283	288	PF05994	0.662
LIG_WRC_WIRS_1	329	334	PF05994	0.696
LIG_WW_2	188	191	PF00397	0.720
MOD_CDK_SPK_2	403	408	PF00069	0.671
MOD_CDK_SPK_2	410	415	PF00069	0.647
MOD_CK1_1	22	28	PF00069	0.777
MOD_CK1_1	282	288	PF00069	0.580
MOD_CK1_1	401	407	PF00069	0.586
MOD_CK1_1	413	419	PF00069	0.801
MOD_CK1_1	420	426	PF00069	0.792
MOD_CK1_1	447	453	PF00069	0.777
MOD_CK1_1	471	477	PF00069	0.763
MOD_CK1_1	481	487	PF00069	0.775
MOD_CK1_1	495	501	PF00069	0.549
MOD_CK1_1	619	625	PF00069	0.526
MOD_CK1_1	659	665	PF00069	0.614
MOD_CK1_1	742	748	PF00069	0.517
MOD_CK1_1	842	848	PF00069	0.546
MOD_CK1_1	857	863	PF00069	0.415
MOD_CK1_1	903	909	PF00069	0.628
MOD_CK1_1	911	917	PF00069	0.708
MOD_CK2_1	420	426	PF00069	0.733
MOD_CK2_1	578	584	PF00069	0.670
MOD_CK2_1	595	601	PF00069	0.442
MOD_CK2_1	737	743	PF00069	0.568
MOD_CK2_1	772	778	PF00069	0.530
MOD_CK2_1	796	802	PF00069	0.597
MOD_CK2_1	820	826	PF00069	0.679
MOD_CK2_1	896	902	PF00069	0.699
MOD_CK2_1	968	974	PF00069	0.438
MOD_GlcNHglycan	113	117	PF01048	0.703
MOD_GlcNHglycan	21	24	PF01048	0.807
MOD_GlcNHglycan	301	304	PF01048	0.591
MOD_GlcNHglycan	415	418	PF01048	0.776
MOD_GlcNHglycan	42	45	PF01048	0.709
MOD_GlcNHglycan	422	425	PF01048	0.779
MOD_GlcNHglycan	494	497	PF01048	0.763
MOD_GlcNHglycan	507	510	PF01048	0.586
MOD_GlcNHglycan	616	619	PF01048	0.578
MOD_GlcNHglycan	636	639	PF01048	0.274
MOD_GlcNHglycan	683	686	PF01048	0.521
MOD_GlcNHglycan	725	728	PF01048	0.364
MOD_GlcNHglycan	749	752	PF01048	0.582
MOD_GlcNHglycan	82	85	PF01048	0.754
MOD_GlcNHglycan	841	844	PF01048	0.595
MOD_GlcNHglycan	881	884	PF01048	0.498
MOD_GlcNHglycan	902	905	PF01048	0.665
MOD_GlcNHglycan	910	913	PF01048	0.675
MOD_GlcNHglycan	924	927	PF01048	0.442
MOD_GlcNHglycan	945	948	PF01048	0.625
MOD_GlcNHglycan	950	953	PF01048	0.544
MOD_GlcNHglycan	98	102	PF01048	0.728
MOD_GlcNHglycan	986	989	PF01048	0.716
MOD_GSK3_1	17	24	PF00069	0.701
MOD_GSK3_1	27	34	PF00069	0.567
MOD_GSK3_1	272	279	PF00069	0.727
MOD_GSK3_1	291	298	PF00069	0.582
MOD_GSK3_1	399	406	PF00069	0.583
MOD_GSK3_1	413	420	PF00069	0.803
MOD_GSK3_1	440	447	PF00069	0.696
MOD_GSK3_1	474	481	PF00069	0.780
MOD_GSK3_1	595	602	PF00069	0.564
MOD_GSK3_1	691	698	PF00069	0.671
MOD_GSK3_1	719	726	PF00069	0.373
MOD_GSK3_1	784	791	PF00069	0.508
MOD_GSK3_1	815	822	PF00069	0.610
MOD_GSK3_1	850	857	PF00069	0.409
MOD_GSK3_1	87	94	PF00069	0.769
MOD_GSK3_1	871	878	PF00069	0.513
MOD_GSK3_1	892	899	PF00069	0.584
MOD_GSK3_1	9	16	PF00069	0.711
MOD_GSK3_1	930	937	PF00069	0.542
MOD_GSK3_1	982	989	PF00069	0.664
MOD_LATS_1	593	599	PF00433	0.492
MOD_N-GLC_1	105	110	PF02516	0.627
MOD_N-GLC_1	247	252	PF02516	0.598
MOD_N-GLC_1	87	92	PF02516	0.634
MOD_N-GLC_1	922	927	PF02516	0.587
MOD_NEK2_1	247	252	PF00069	0.598
MOD_NEK2_1	490	495	PF00069	0.705
MOD_NEK2_1	567	572	PF00069	0.643
MOD_NEK2_1	599	604	PF00069	0.516
MOD_NEK2_1	650	655	PF00069	0.442
MOD_NEK2_1	657	662	PF00069	0.503
MOD_NEK2_1	87	92	PF00069	0.681
MOD_NEK2_1	879	884	PF00069	0.554
MOD_NEK2_1	922	927	PF00069	0.610
MOD_NEK2_1	929	934	PF00069	0.451
MOD_NEK2_1	984	989	PF00069	0.715
MOD_NEK2_2	968	973	PF00069	0.450
MOD_PIKK_1	156	162	PF00454	0.812
MOD_PIKK_1	239	245	PF00454	0.686
MOD_PIKK_1	27	33	PF00454	0.704
MOD_PIKK_1	319	325	PF00454	0.677
MOD_PIKK_1	48	54	PF00454	0.721
MOD_PIKK_1	524	530	PF00454	0.723
MOD_PIKK_1	56	62	PF00454	0.622
MOD_PIKK_1	696	702	PF00454	0.614
MOD_PIKK_1	742	748	PF00454	0.353
MOD_PIKK_1	854	860	PF00454	0.439
MOD_PIKK_1	906	912	PF00454	0.645
MOD_PK_1	321	327	PF00069	0.740
MOD_PK_1	982	988	PF00069	0.602
MOD_PKA_1	17	23	PF00069	0.652
MOD_PKA_1	56	62	PF00069	0.597
MOD_PKA_1	594	600	PF00069	0.493
MOD_PKA_1	681	687	PF00069	0.466
MOD_PKA_1	982	988	PF00069	0.602
MOD_PKA_2	156	162	PF00069	0.669
MOD_PKA_2	327	333	PF00069	0.722
MOD_PKA_2	417	423	PF00069	0.642
MOD_PKA_2	484	490	PF00069	0.725
MOD_PKA_2	56	62	PF00069	0.653
MOD_PKA_2	594	600	PF00069	0.493
MOD_PKA_2	930	936	PF00069	0.475
MOD_PKA_2	982	988	PF00069	0.635
MOD_Plk_1	558	564	PF00069	0.586
MOD_Plk_4	247	253	PF00069	0.607
MOD_Plk_4	276	282	PF00069	0.737
MOD_Plk_4	321	327	PF00069	0.740
MOD_Plk_4	533	539	PF00069	0.489
MOD_Plk_4	595	601	PF00069	0.605
MOD_Plk_4	616	622	PF00069	0.529
MOD_Plk_4	778	784	PF00069	0.551
MOD_Plk_4	875	881	PF00069	0.590
MOD_Plk_4	887	893	PF00069	0.469
MOD_Plk_4	903	909	PF00069	0.435
MOD_ProDKin_1	145	151	PF00069	0.795
MOD_ProDKin_1	192	198	PF00069	0.713
MOD_ProDKin_1	252	258	PF00069	0.731
MOD_ProDKin_1	272	278	PF00069	0.708
MOD_ProDKin_1	403	409	PF00069	0.669
MOD_ProDKin_1	410	416	PF00069	0.649
MOD_ProDKin_1	440	446	PF00069	0.696
MOD_ProDKin_1	447	453	PF00069	0.633
MOD_ProDKin_1	474	480	PF00069	0.816
MOD_ProDKin_1	531	537	PF00069	0.509
MOD_SUMO_rev_2	619	628	PF00179	0.454
MOD_SUMO_rev_2	684	694	PF00179	0.526
MOD_SUMO_rev_2	951	960	PF00179	0.468
TRG_DiLeu_BaEn_1	704	709	PF01217	0.459
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.638
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.661
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.626
TRG_DiLeu_BaLyEn_6	600	605	PF01217	0.465
TRG_DiLeu_BaLyEn_6	925	930	PF01217	0.496
TRG_ENDOCYTIC_2	283	286	PF00928	0.664
TRG_ENDOCYTIC_2	703	706	PF00928	0.536
TRG_ENDOCYTIC_2	735	738	PF00928	0.622
TRG_ENDOCYTIC_2	889	892	PF00928	0.578
TRG_ER_diArg_1	363	366	PF00400	0.688
TRG_ER_diArg_1	56	58	PF00400	0.609
TRG_ER_diArg_1	919	921	PF00400	0.671
TRG_ER_diArg_1	927	929	PF00400	0.471
TRG_ER_diArg_1	982	984	PF00400	0.580
TRG_ER_FFAT_1	667	676	PF00635	0.431
TRG_Pf-PMV_PEXEL_1	386	390	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	408	412	PF00026	0.635
TRG_Pf-PMV_PEXEL_1	736	741	PF00026	0.566
TRG_Pf-PMV_PEXEL_1	956	961	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IF45	Leishmania donovani	88%	94%
A4HM10	Leishmania braziliensis	57%	100%
A4I9E4	Leishmania infantum	88%	94%
E9B4E1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	94%