INCENP_ARK-bind domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3N5_LEIMA

TriTrypDb:

LmjF.33.3010 , LMJLV39_330042700 , LMJSD75_330042000

Length:

1037

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3N5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3N5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.733
CLV_C14_Caspase3-7	138	142	PF00656	0.670
CLV_C14_Caspase3-7	365	369	PF00656	0.665
CLV_C14_Caspase3-7	550	554	PF00656	0.651
CLV_C14_Caspase3-7	689	693	PF00656	0.542
CLV_NRD_NRD_1	1005	1007	PF00675	0.526
CLV_NRD_NRD_1	147	149	PF00675	0.734
CLV_NRD_NRD_1	385	387	PF00675	0.650
CLV_NRD_NRD_1	40	42	PF00675	0.653
CLV_NRD_NRD_1	420	422	PF00675	0.609
CLV_NRD_NRD_1	430	432	PF00675	0.497
CLV_NRD_NRD_1	441	443	PF00675	0.465
CLV_NRD_NRD_1	462	464	PF00675	0.586
CLV_NRD_NRD_1	487	489	PF00675	0.534
CLV_NRD_NRD_1	511	513	PF00675	0.743
CLV_NRD_NRD_1	54	56	PF00675	0.500
CLV_NRD_NRD_1	571	573	PF00675	0.715
CLV_PCSK_FUR_1	509	513	PF00082	0.672
CLV_PCSK_KEX2_1	1005	1007	PF00082	0.476
CLV_PCSK_KEX2_1	147	149	PF00082	0.734
CLV_PCSK_KEX2_1	385	387	PF00082	0.658
CLV_PCSK_KEX2_1	40	42	PF00082	0.653
CLV_PCSK_KEX2_1	419	421	PF00082	0.564
CLV_PCSK_KEX2_1	443	445	PF00082	0.555
CLV_PCSK_KEX2_1	461	463	PF00082	0.392
CLV_PCSK_KEX2_1	468	470	PF00082	0.500
CLV_PCSK_KEX2_1	511	513	PF00082	0.743
CLV_PCSK_KEX2_1	54	56	PF00082	0.500
CLV_PCSK_KEX2_1	979	981	PF00082	0.479
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.555
CLV_PCSK_PC1ET2_1	461	463	PF00082	0.392
CLV_PCSK_PC1ET2_1	468	470	PF00082	0.500
CLV_PCSK_PC1ET2_1	979	981	PF00082	0.479
CLV_PCSK_PC7_1	381	387	PF00082	0.622
CLV_PCSK_PC7_1	457	463	PF00082	0.529
CLV_PCSK_PC7_1	507	513	PF00082	0.724
CLV_PCSK_SKI1_1	339	343	PF00082	0.591
CLV_PCSK_SKI1_1	432	436	PF00082	0.546
CLV_PCSK_SKI1_1	771	775	PF00082	0.491
CLV_PCSK_SKI1_1	803	807	PF00082	0.474
CLV_PCSK_SKI1_1	980	984	PF00082	0.491
DEG_APCC_DBOX_1	39	47	PF00400	0.652
DEG_SCF_FBW7_1	284	289	PF00400	0.592
DEG_SPOP_SBC_1	210	214	PF00917	0.690
DEG_SPOP_SBC_1	313	317	PF00917	0.695
DEG_SPOP_SBC_1	847	851	PF00917	0.507
DOC_CDC14_PxL_1	262	270	PF14671	0.737
DOC_CYCLIN_RxL_1	676	689	PF00134	0.516
DOC_CYCLIN_RxL_1	768	778	PF00134	0.484
DOC_MAPK_gen_1	979	987	PF00069	0.484
DOC_PP4_FxxP_1	758	761	PF00568	0.475
DOC_USP7_MATH_1	170	174	PF00917	0.658
DOC_USP7_MATH_1	184	188	PF00917	0.692
DOC_USP7_MATH_1	210	214	PF00917	0.690
DOC_USP7_MATH_1	234	238	PF00917	0.596
DOC_USP7_MATH_1	286	290	PF00917	0.690
DOC_USP7_MATH_1	312	316	PF00917	0.695
DOC_USP7_MATH_1	605	609	PF00917	0.759
DOC_USP7_MATH_1	632	636	PF00917	0.778
DOC_USP7_MATH_1	669	673	PF00917	0.588
DOC_USP7_MATH_1	737	741	PF00917	0.457
DOC_USP7_MATH_1	82	86	PF00917	0.715
DOC_USP7_MATH_1	903	907	PF00917	0.480
DOC_USP7_MATH_1	93	97	PF00917	0.592
DOC_USP7_MATH_2	660	666	PF00917	0.644
DOC_USP7_UBL2_3	158	162	PF12436	0.737
DOC_USP7_UBL2_3	799	803	PF12436	0.476
DOC_USP7_UBL2_3	979	983	PF12436	0.483
DOC_WW_Pin1_4	161	166	PF00397	0.691
DOC_WW_Pin1_4	220	225	PF00397	0.737
DOC_WW_Pin1_4	282	287	PF00397	0.702
DOC_WW_Pin1_4	583	588	PF00397	0.726
DOC_WW_Pin1_4	593	598	PF00397	0.606
DOC_WW_Pin1_4	610	615	PF00397	0.744
DOC_WW_Pin1_4	643	648	PF00397	0.810
DOC_WW_Pin1_4	757	762	PF00397	0.526
DOC_WW_Pin1_4	810	815	PF00397	0.520
DOC_WW_Pin1_4	820	825	PF00397	0.521
LIG_14-3-3_CanoR_1	257	265	PF00244	0.646
LIG_14-3-3_CanoR_1	347	352	PF00244	0.734
LIG_14-3-3_CanoR_1	45	52	PF00244	0.628
LIG_14-3-3_CanoR_1	572	576	PF00244	0.733
LIG_14-3-3_CanoR_1	581	587	PF00244	0.716
LIG_14-3-3_CanoR_1	591	597	PF00244	0.572
LIG_14-3-3_CanoR_1	604	614	PF00244	0.757
LIG_14-3-3_CanoR_1	768	774	PF00244	0.488
LIG_14-3-3_CanoR_1	77	86	PF00244	0.560
LIG_14-3-3_CanoR_1	854	861	PF00244	0.565
LIG_Actin_WH2_2	677	693	PF00022	0.467
LIG_Actin_WH2_2	958	976	PF00022	0.474
LIG_BIR_III_4	20	24	PF00653	0.560
LIG_BRCT_BRCA1_1	52	56	PF00533	0.650
LIG_BRCT_BRCA1_1	61	65	PF00533	0.594
LIG_Clathr_ClatBox_1	684	688	PF01394	0.483
LIG_deltaCOP1_diTrp_1	57	65	PF00928	0.635
LIG_FHA_1	257	263	PF00498	0.669
LIG_FHA_1	286	292	PF00498	0.755
LIG_FHA_1	340	346	PF00498	0.633
LIG_FHA_1	681	687	PF00498	0.485
LIG_FHA_1	708	714	PF00498	0.537
LIG_FHA_1	847	853	PF00498	0.537
LIG_FHA_1	863	869	PF00498	0.424
LIG_FHA_2	434	440	PF00498	0.539
LIG_FHA_2	538	544	PF00498	0.730
LIG_FHA_2	594	600	PF00498	0.740
LIG_FHA_2	716	722	PF00498	0.462
LIG_FHA_2	805	811	PF00498	0.544
LIG_FHA_2	894	900	PF00498	0.412
LIG_FHA_2	909	915	PF00498	0.383
LIG_LIR_Apic_2	756	761	PF02991	0.332
LIG_LIR_Gen_1	760	770	PF02991	0.454
LIG_LIR_Gen_1	812	822	PF02991	0.527
LIG_LIR_Gen_1	834	843	PF02991	0.501
LIG_LIR_Gen_1	914	923	PF02991	0.463
LIG_LIR_LC3C_4	890	894	PF02991	0.453
LIG_LIR_Nem_3	1021	1026	PF02991	0.457
LIG_LIR_Nem_3	57	63	PF02991	0.684
LIG_LIR_Nem_3	760	766	PF02991	0.451
LIG_LIR_Nem_3	812	818	PF02991	0.534
LIG_LIR_Nem_3	834	838	PF02991	0.495
LIG_LIR_Nem_3	914	918	PF02991	0.469
LIG_PCNA_yPIPBox_3	952	964	PF02747	0.430
LIG_Pex14_2	52	56	PF04695	0.650
LIG_PTB_Apo_2	829	836	PF02174	0.490
LIG_PTB_Phospho_1	829	835	PF10480	0.487
LIG_SH2_CRK	1023	1027	PF00017	0.471
LIG_SH2_CRK	835	839	PF00017	0.449
LIG_SH2_CRK	915	919	PF00017	0.461
LIG_SH2_NCK_1	16	20	PF00017	0.614
LIG_SH2_NCK_1	835	839	PF00017	0.499
LIG_SH2_NCK_1	915	919	PF00017	0.461
LIG_SH2_PTP2	984	987	PF00017	0.486
LIG_SH2_SRC	16	19	PF00017	0.540
LIG_SH2_STAP1	915	919	PF00017	0.461
LIG_SH2_STAT3	706	709	PF00017	0.534
LIG_SH2_STAT5	1011	1014	PF00017	0.498
LIG_SH2_STAT5	796	799	PF00017	0.453
LIG_SH2_STAT5	888	891	PF00017	0.469
LIG_SH2_STAT5	984	987	PF00017	0.486
LIG_SH3_1	275	281	PF00018	0.702
LIG_SH3_3	275	281	PF00018	0.707
LIG_SH3_3	288	294	PF00018	0.666
LIG_SH3_3	296	302	PF00018	0.633
LIG_SH3_3	330	336	PF00018	0.720
LIG_SH3_3	351	357	PF00018	0.674
LIG_SH3_3	523	529	PF00018	0.720
LIG_SH3_3	746	752	PF00018	0.455
LIG_SH3_3	808	814	PF00018	0.432
LIG_SH3_3	835	841	PF00018	0.451
LIG_SH3_4	158	165	PF00018	0.661
LIG_SUMO_SIM_anti_2	683	689	PF11976	0.491
LIG_SUMO_SIM_par_1	682	689	PF11976	0.494
LIG_SUMO_SIM_par_1	709	715	PF11976	0.526
LIG_SUMO_SIM_par_1	745	750	PF11976	0.453
LIG_TRAF2_1	124	127	PF00917	0.682
LIG_TRAF2_1	950	953	PF00917	0.483
LIG_TRAF2_2	526	531	PF00917	0.711
LIG_TYR_ITIM	833	838	PF00017	0.490
LIG_TYR_ITIM	982	987	PF00017	0.487
LIG_UBA3_1	434	443	PF00899	0.538
LIG_UBA3_1	86	92	PF00899	0.674
MOD_CDK_SPxxK_3	643	650	PF00069	0.593
MOD_CDK_SPxxK_3	810	817	PF00069	0.405
MOD_CK1_1	157	163	PF00069	0.837
MOD_CK1_1	177	183	PF00069	0.559
MOD_CK1_1	192	198	PF00069	0.700
MOD_CK1_1	256	262	PF00069	0.637
MOD_CK1_1	289	295	PF00069	0.664
MOD_CK1_1	297	303	PF00069	0.713
MOD_CK1_1	315	321	PF00069	0.550
MOD_CK1_1	346	352	PF00069	0.738
MOD_CK1_1	556	562	PF00069	0.694
MOD_CK1_1	608	614	PF00069	0.776
MOD_CK1_1	643	649	PF00069	0.727
MOD_CK1_1	655	661	PF00069	0.613
MOD_CK1_1	665	671	PF00069	0.587
MOD_CK1_1	672	678	PF00069	0.464
MOD_CK1_1	813	819	PF00069	0.368
MOD_CK1_1	853	859	PF00069	0.559
MOD_CK1_1	906	912	PF00069	0.552
MOD_CK1_1	96	102	PF00069	0.689
MOD_CK2_1	114	120	PF00069	0.726
MOD_CK2_1	184	190	PF00069	0.742
MOD_CK2_1	349	355	PF00069	0.692
MOD_CK2_1	593	599	PF00069	0.663
MOD_CK2_1	715	721	PF00069	0.521
MOD_CK2_1	804	810	PF00069	0.525
MOD_CK2_1	908	914	PF00069	0.511
MOD_CK2_1	947	953	PF00069	0.516
MOD_DYRK1A_RPxSP_1	610	614	PF00069	0.743
MOD_GlcNHglycan	148	151	PF01048	0.764
MOD_GlcNHglycan	159	162	PF01048	0.680
MOD_GlcNHglycan	172	175	PF01048	0.664
MOD_GlcNHglycan	176	179	PF01048	0.614
MOD_GlcNHglycan	190	194	PF01048	0.583
MOD_GlcNHglycan	200	204	PF01048	0.682
MOD_GlcNHglycan	288	291	PF01048	0.674
MOD_GlcNHglycan	47	50	PF01048	0.669
MOD_GlcNHglycan	622	625	PF01048	0.775
MOD_GlcNHglycan	628	631	PF01048	0.739
MOD_GlcNHglycan	634	637	PF01048	0.685
MOD_GlcNHglycan	667	670	PF01048	0.678
MOD_GlcNHglycan	672	675	PF01048	0.576
MOD_GlcNHglycan	739	742	PF01048	0.530
MOD_GlcNHglycan	79	82	PF01048	0.706
MOD_GlcNHglycan	807	810	PF01048	0.527
MOD_GlcNHglycan	89	92	PF01048	0.619
MOD_GlcNHglycan	905	908	PF01048	0.492
MOD_GlcNHglycan	965	968	PF01048	0.449
MOD_GlcNHglycan	974	977	PF01048	0.383
MOD_GSK3_1	157	164	PF00069	0.805
MOD_GSK3_1	170	177	PF00069	0.663
MOD_GSK3_1	182	189	PF00069	0.690
MOD_GSK3_1	195	202	PF00069	0.620
MOD_GSK3_1	210	217	PF00069	0.658
MOD_GSK3_1	251	258	PF00069	0.743
MOD_GSK3_1	282	289	PF00069	0.612
MOD_GSK3_1	31	38	PF00069	0.604
MOD_GSK3_1	312	319	PF00069	0.728
MOD_GSK3_1	335	342	PF00069	0.745
MOD_GSK3_1	343	350	PF00069	0.768
MOD_GSK3_1	503	510	PF00069	0.724
MOD_GSK3_1	512	519	PF00069	0.734
MOD_GSK3_1	55	62	PF00069	0.671
MOD_GSK3_1	626	633	PF00069	0.764
MOD_GSK3_1	665	672	PF00069	0.679
MOD_GSK3_1	67	74	PF00069	0.559
MOD_GSK3_1	707	714	PF00069	0.538
MOD_GSK3_1	753	760	PF00069	0.477
MOD_GSK3_1	846	853	PF00069	0.579
MOD_GSK3_1	888	895	PF00069	0.359
MOD_GSK3_1	96	103	PF00069	0.672
MOD_N-GLC_1	195	200	PF02516	0.758
MOD_N-GLC_1	319	324	PF02516	0.680
MOD_N-GLC_1	553	558	PF02516	0.582
MOD_N-GLC_1	652	657	PF02516	0.700
MOD_N-GLC_1	831	836	PF02516	0.498
MOD_N-GLC_1	862	867	PF02516	0.416
MOD_N-GLC_1	87	92	PF02516	0.673
MOD_N-GLC_2	654	656	PF02516	0.587
MOD_N-GLC_2	940	942	PF02516	0.397
MOD_NEK2_1	36	41	PF00069	0.548
MOD_NEK2_1	652	657	PF00069	0.571
MOD_NEK2_1	680	685	PF00069	0.462
MOD_NEK2_1	690	695	PF00069	0.437
MOD_NEK2_1	697	702	PF00069	0.359
MOD_NEK2_1	788	793	PF00069	0.444
MOD_NEK2_1	848	853	PF00069	0.499
MOD_NEK2_1	87	92	PF00069	0.648
MOD_NEK2_1	892	897	PF00069	0.292
MOD_NEK2_2	234	239	PF00069	0.596
MOD_NEK2_2	5	10	PF00069	0.680
MOD_NEK2_2	926	931	PF00069	0.477
MOD_PIKK_1	182	188	PF00454	0.643
MOD_PIKK_1	211	217	PF00454	0.742
MOD_PIKK_1	605	611	PF00454	0.742
MOD_PIKK_1	655	661	PF00454	0.658
MOD_PK_1	974	980	PF00069	0.464
MOD_PKA_1	511	517	PF00069	0.668
MOD_PKA_2	146	152	PF00069	0.763
MOD_PKA_2	256	262	PF00069	0.624
MOD_PKA_2	322	328	PF00069	0.679
MOD_PKA_2	346	352	PF00069	0.716
MOD_PKA_2	511	517	PF00069	0.726
MOD_PKA_2	571	577	PF00069	0.692
MOD_PKA_2	580	586	PF00069	0.628
MOD_PKA_2	690	696	PF00069	0.567
MOD_PKA_2	828	834	PF00069	0.489
MOD_PKA_2	853	859	PF00069	0.571
MOD_PKA_2	878	884	PF00069	0.511
MOD_PKB_1	337	345	PF00069	0.639
MOD_PKB_1	509	517	PF00069	0.670
MOD_Plk_1	662	668	PF00069	0.615
MOD_Plk_1	831	837	PF00069	0.427
MOD_Plk_1	898	904	PF00069	0.433
MOD_Plk_1	947	953	PF00069	0.491
MOD_Plk_2-3	114	120	PF00069	0.593
MOD_Plk_4	349	355	PF00069	0.810
MOD_Plk_4	5	11	PF00069	0.680
MOD_Plk_4	680	686	PF00069	0.493
MOD_Plk_4	726	732	PF00069	0.509
MOD_Plk_4	82	88	PF00069	0.662
MOD_Plk_4	888	894	PF00069	0.459
MOD_Plk_4	914	920	PF00069	0.469
MOD_ProDKin_1	161	167	PF00069	0.692
MOD_ProDKin_1	220	226	PF00069	0.741
MOD_ProDKin_1	282	288	PF00069	0.703
MOD_ProDKin_1	583	589	PF00069	0.728
MOD_ProDKin_1	593	599	PF00069	0.607
MOD_ProDKin_1	610	616	PF00069	0.742
MOD_ProDKin_1	643	649	PF00069	0.809
MOD_ProDKin_1	757	763	PF00069	0.523
MOD_ProDKin_1	810	816	PF00069	0.515
MOD_ProDKin_1	820	826	PF00069	0.517
MOD_SUMO_rev_2	213	223	PF00179	0.691
MOD_SUMO_rev_2	460	470	PF00179	0.578
MOD_SUMO_rev_2	471	476	PF00179	0.455
MOD_SUMO_rev_2	493	502	PF00179	0.590
MOD_SUMO_rev_2	658	666	PF00179	0.810
MOD_SUMO_rev_2	712	718	PF00179	0.522
MOD_SUMO_rev_2	880	885	PF00179	0.525
TRG_DiLeu_BaEn_1	1014	1019	PF01217	0.474
TRG_DiLeu_BaLyEn_6	1021	1026	PF01217	0.457
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.740
TRG_DiLeu_LyEn_5	1014	1019	PF01217	0.474
TRG_ENDOCYTIC_2	1023	1026	PF00928	0.460
TRG_ENDOCYTIC_2	835	838	PF00928	0.492
TRG_ENDOCYTIC_2	915	918	PF00928	0.464
TRG_ENDOCYTIC_2	984	987	PF00928	0.598
TRG_ER_diArg_1	146	148	PF00400	0.594
TRG_ER_diArg_1	336	339	PF00400	0.737
TRG_ER_diArg_1	419	421	PF00400	0.539
TRG_ER_diArg_1	462	464	PF00400	0.586
TRG_ER_diArg_1	509	512	PF00400	0.742
TRG_ER_diArg_1	54	56	PF00400	0.649
TRG_Pf-PMV_PEXEL_1	1010	1014	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	1017	1021	PF00026	0.395
TRG_Pf-PMV_PEXEL_1	1024	1028	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	468	472	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	488	493	PF00026	0.378
TRG_Pf-PMV_PEXEL_1	771	775	PF00026	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X763	Leishmania donovani	90%	99%
A4HM11	Leishmania braziliensis	71%	94%
A4I9E2	Leishmania infantum	90%	93%
E9B4E2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%