Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q3N4_LEIMA

TriTrypDb:

LmjF.33.3020 , LMJLV39_330042900 , LMJSD75_330042100

Length:

975

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3N4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3N4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	22	26	PF00656	0.589
CLV_C14_Caspase3-7	383	387	PF00656	0.572
CLV_C14_Caspase3-7	570	574	PF00656	0.698
CLV_C14_Caspase3-7	90	94	PF00656	0.776
CLV_C14_Caspase3-7	915	919	PF00656	0.720
CLV_NRD_NRD_1	239	241	PF00675	0.695
CLV_NRD_NRD_1	290	292	PF00675	0.615
CLV_NRD_NRD_1	356	358	PF00675	0.659
CLV_NRD_NRD_1	589	591	PF00675	0.735
CLV_NRD_NRD_1	681	683	PF00675	0.768
CLV_NRD_NRD_1	782	784	PF00675	0.716
CLV_NRD_NRD_1	798	800	PF00675	0.642
CLV_NRD_NRD_1	894	896	PF00675	0.859
CLV_PCSK_FUR_1	237	241	PF00082	0.585
CLV_PCSK_FUR_1	587	591	PF00082	0.593
CLV_PCSK_KEX2_1	239	241	PF00082	0.695
CLV_PCSK_KEX2_1	355	357	PF00082	0.756
CLV_PCSK_KEX2_1	42	44	PF00082	0.560
CLV_PCSK_KEX2_1	587	589	PF00082	0.767
CLV_PCSK_KEX2_1	660	662	PF00082	0.792
CLV_PCSK_KEX2_1	672	674	PF00082	0.692
CLV_PCSK_KEX2_1	681	683	PF00082	0.701
CLV_PCSK_KEX2_1	782	784	PF00082	0.710
CLV_PCSK_KEX2_1	894	896	PF00082	0.859
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.756
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.560
CLV_PCSK_PC1ET2_1	660	662	PF00082	0.792
CLV_PCSK_PC1ET2_1	672	674	PF00082	0.692
CLV_PCSK_SKI1_1	448	452	PF00082	0.715
CLV_PCSK_SKI1_1	821	825	PF00082	0.776
CLV_PCSK_SKI1_1	894	898	PF00082	0.852
CLV_PCSK_SKI1_1	963	967	PF00082	0.603
CLV_Separin_Metazoa	584	588	PF03568	0.690
DEG_SCF_FBW7_1	135	142	PF00400	0.716
DEG_SPOP_SBC_1	252	256	PF00917	0.764
DOC_ANK_TNKS_1	683	690	PF00023	0.607
DOC_CKS1_1	29	34	PF01111	0.697
DOC_CYCLIN_RxL_1	636	645	PF00134	0.695
DOC_PP1_RVXF_1	637	644	PF00149	0.762
DOC_PP2B_LxvP_1	830	833	PF13499	0.712
DOC_PP2B_LxvP_1	927	930	PF13499	0.616
DOC_PP4_FxxP_1	604	607	PF00568	0.575
DOC_PP4_FxxP_1	824	827	PF00568	0.735
DOC_PP4_FxxP_1	881	884	PF00568	0.610
DOC_PP4_MxPP_1	249	252	PF00568	0.730
DOC_USP7_MATH_1	139	143	PF00917	0.710
DOC_USP7_MATH_1	24	28	PF00917	0.680
DOC_USP7_MATH_1	241	245	PF00917	0.761
DOC_USP7_MATH_1	261	265	PF00917	0.511
DOC_USP7_MATH_1	408	412	PF00917	0.767
DOC_USP7_MATH_1	473	477	PF00917	0.695
DOC_USP7_MATH_1	548	552	PF00917	0.780
DOC_USP7_MATH_1	607	611	PF00917	0.684
DOC_USP7_MATH_1	627	631	PF00917	0.742
DOC_USP7_MATH_1	712	716	PF00917	0.594
DOC_USP7_MATH_1	853	857	PF00917	0.685
DOC_USP7_MATH_1	863	867	PF00917	0.647
DOC_USP7_MATH_2	607	613	PF00917	0.664
DOC_USP7_UBL2_3	444	448	PF12436	0.707
DOC_USP7_UBL2_3	660	664	PF12436	0.780
DOC_USP7_UBL2_3	665	669	PF12436	0.724
DOC_USP7_UBL2_3	671	675	PF12436	0.645
DOC_WW_Pin1_4	135	140	PF00397	0.718
DOC_WW_Pin1_4	193	198	PF00397	0.681
DOC_WW_Pin1_4	28	33	PF00397	0.753
DOC_WW_Pin1_4	328	333	PF00397	0.663
DOC_WW_Pin1_4	425	430	PF00397	0.679
DOC_WW_Pin1_4	486	491	PF00397	0.820
DOC_WW_Pin1_4	498	503	PF00397	0.620
DOC_WW_Pin1_4	646	651	PF00397	0.702
DOC_WW_Pin1_4	725	730	PF00397	0.676
DOC_WW_Pin1_4	753	758	PF00397	0.681
DOC_WW_Pin1_4	799	804	PF00397	0.718
DOC_WW_Pin1_4	885	890	PF00397	0.780
DOC_WW_Pin1_4	936	941	PF00397	0.675
LIG_14-3-3_CanoR_1	10	18	PF00244	0.574
LIG_14-3-3_CanoR_1	182	187	PF00244	0.687
LIG_14-3-3_CanoR_1	192	196	PF00244	0.590
LIG_14-3-3_CanoR_1	301	307	PF00244	0.593
LIG_14-3-3_CanoR_1	308	313	PF00244	0.538
LIG_14-3-3_CanoR_1	357	363	PF00244	0.765
LIG_14-3-3_CanoR_1	377	385	PF00244	0.523
LIG_14-3-3_CanoR_1	474	479	PF00244	0.640
LIG_14-3-3_CanoR_1	552	561	PF00244	0.650
LIG_14-3-3_CanoR_1	563	571	PF00244	0.564
LIG_14-3-3_CanoR_1	600	605	PF00244	0.720
LIG_14-3-3_CanoR_1	639	644	PF00244	0.761
LIG_14-3-3_CanoR_1	682	692	PF00244	0.629
LIG_14-3-3_CanoR_1	771	775	PF00244	0.696
LIG_14-3-3_CanoR_1	894	899	PF00244	0.789
LIG_14-3-3_CanoR_1	935	939	PF00244	0.780
LIG_14-3-3_CanoR_1	946	951	PF00244	0.607
LIG_14-3-3_CanoR_1	960	966	PF00244	0.545
LIG_Actin_WH2_2	1	17	PF00022	0.568
LIG_Actin_WH2_2	406	424	PF00022	0.695
LIG_APCC_ABBAyCdc20_2	330	336	PF00400	0.606
LIG_BRCT_BRCA1_1	184	188	PF00533	0.674
LIG_BRCT_BRCA1_1	310	314	PF00533	0.592
LIG_CtBP_PxDLS_1	287	291	PF00389	0.586
LIG_DLG_GKlike_1	308	316	PF00625	0.563
LIG_DLG_GKlike_1	946	953	PF00625	0.588
LIG_FHA_1	253	259	PF00498	0.737
LIG_FHA_1	34	40	PF00498	0.816
LIG_FHA_1	404	410	PF00498	0.689
LIG_FHA_1	467	473	PF00498	0.766
LIG_FHA_1	566	572	PF00498	0.594
LIG_FHA_1	612	618	PF00498	0.716
LIG_FHA_1	888	894	PF00498	0.600
LIG_FHA_2	131	137	PF00498	0.835
LIG_FHA_2	20	26	PF00498	0.799
LIG_FHA_2	29	35	PF00498	0.705
LIG_FHA_2	318	324	PF00498	0.562
LIG_FHA_2	534	540	PF00498	0.746
LIG_FHA_2	568	574	PF00498	0.694
LIG_FHA_2	60	66	PF00498	0.606
LIG_FHA_2	650	656	PF00498	0.784
LIG_FHA_2	820	826	PF00498	0.584
LIG_FHA_2	913	919	PF00498	0.734
LIG_FXI_DFP_1	84	88	PF00024	0.656
LIG_Integrin_isoDGR_2	942	944	PF01839	0.672
LIG_Integrin_RGD_1	510	512	PF01839	0.719
LIG_LIR_Apic_2	601	607	PF02991	0.589
LIG_LIR_Apic_2	822	827	PF02991	0.726
LIG_LIR_Apic_2	879	884	PF02991	0.606
LIG_LIR_Gen_1	117	124	PF02991	0.672
LIG_LIR_Gen_1	311	319	PF02991	0.592
LIG_LIR_Gen_1	82	90	PF02991	0.691
LIG_LIR_Gen_1	876	886	PF02991	0.774
LIG_LIR_Nem_3	117	123	PF02991	0.671
LIG_LIR_Nem_3	140	146	PF02991	0.716
LIG_LIR_Nem_3	270	275	PF02991	0.609
LIG_LIR_Nem_3	419	423	PF02991	0.706
LIG_LIR_Nem_3	82	87	PF02991	0.687
LIG_LIR_Nem_3	876	881	PF02991	0.771
LIG_LIR_Nem_3	949	953	PF02991	0.682
LIG_PCNA_yPIPBox_3	631	644	PF02747	0.666
LIG_SH2_CRK	950	954	PF00017	0.680
LIG_SH2_SRC	146	149	PF00017	0.729
LIG_SH2_SRC	423	426	PF00017	0.646
LIG_SH2_STAP1	120	124	PF00017	0.689
LIG_SH2_STAP1	152	156	PF00017	0.586
LIG_SH2_STAT5	124	127	PF00017	0.583
LIG_SH2_STAT5	253	256	PF00017	0.735
LIG_SH2_STAT5	318	321	PF00017	0.727
LIG_SH3_3	255	261	PF00018	0.602
LIG_SH3_3	579	585	PF00018	0.682
LIG_SH3_3	751	757	PF00018	0.803
LIG_SH3_3	849	855	PF00018	0.737
LIG_SH3_3	883	889	PF00018	0.721
LIG_SH3_3	935	941	PF00018	0.738
LIG_SUMO_SIM_anti_2	225	232	PF11976	0.587
LIG_SUMO_SIM_anti_2	264	270	PF11976	0.652
LIG_TRAF2_1	342	345	PF00917	0.564
LIG_WRC_WIRS_1	120	125	PF05994	0.688
LIG_WRC_WIRS_1	272	277	PF05994	0.556
LIG_WRC_WIRS_1	417	422	PF05994	0.713
LIG_WRC_WIRS_1	640	645	PF05994	0.758
MOD_CDC14_SPxK_1	728	731	PF00782	0.618
MOD_CDK_SPxK_1	725	731	PF00069	0.617
MOD_CDK_SPxxK_3	193	200	PF00069	0.627
MOD_CK1_1	113	119	PF00069	0.681
MOD_CK1_1	122	128	PF00069	0.601
MOD_CK1_1	131	137	PF00069	0.537
MOD_CK1_1	165	171	PF00069	0.714
MOD_CK1_1	174	180	PF00069	0.688
MOD_CK1_1	191	197	PF00069	0.691
MOD_CK1_1	206	212	PF00069	0.828
MOD_CK1_1	222	228	PF00069	0.563
MOD_CK1_1	244	250	PF00069	0.826
MOD_CK1_1	276	282	PF00069	0.735
MOD_CK1_1	3	9	PF00069	0.692
MOD_CK1_1	428	434	PF00069	0.672
MOD_CK1_1	440	446	PF00069	0.630
MOD_CK1_1	465	471	PF00069	0.831
MOD_CK1_1	519	525	PF00069	0.764
MOD_CK1_1	533	539	PF00069	0.624
MOD_CK1_1	567	573	PF00069	0.713
MOD_CK1_1	574	580	PF00069	0.668
MOD_CK1_1	616	622	PF00069	0.681
MOD_CK1_1	630	636	PF00069	0.665
MOD_CK1_1	733	739	PF00069	0.748
MOD_CK1_1	769	775	PF00069	0.670
MOD_CK1_1	835	841	PF00069	0.695
MOD_CK1_1	885	891	PF00069	0.666
MOD_CK1_1	900	906	PF00069	0.770
MOD_CK1_1	91	97	PF00069	0.651
MOD_CK1_1	916	922	PF00069	0.808
MOD_CK1_1	961	967	PF00069	0.633
MOD_CK2_1	139	145	PF00069	0.800
MOD_CK2_1	28	34	PF00069	0.673
MOD_CK2_1	317	323	PF00069	0.565
MOD_CK2_1	339	345	PF00069	0.696
MOD_CK2_1	376	382	PF00069	0.684
MOD_CK2_1	486	492	PF00069	0.697
MOD_CK2_1	533	539	PF00069	0.808
MOD_CK2_1	639	645	PF00069	0.760
MOD_CK2_1	649	655	PF00069	0.645
MOD_CK2_1	769	775	PF00069	0.778
MOD_CK2_1	835	841	PF00069	0.692
MOD_GlcNHglycan	105	108	PF01048	0.691
MOD_GlcNHglycan	110	115	PF01048	0.617
MOD_GlcNHglycan	208	211	PF01048	0.700
MOD_GlcNHglycan	216	219	PF01048	0.650
MOD_GlcNHglycan	243	246	PF01048	0.786
MOD_GlcNHglycan	269	272	PF01048	0.683
MOD_GlcNHglycan	279	282	PF01048	0.650
MOD_GlcNHglycan	294	297	PF01048	0.662
MOD_GlcNHglycan	532	535	PF01048	0.723
MOD_GlcNHglycan	577	580	PF01048	0.777
MOD_GlcNHglycan	590	593	PF01048	0.613
MOD_GlcNHglycan	618	621	PF01048	0.808
MOD_GlcNHglycan	714	717	PF01048	0.620
MOD_GlcNHglycan	732	735	PF01048	0.660
MOD_GlcNHglycan	838	841	PF01048	0.744
MOD_GlcNHglycan	855	858	PF01048	0.689
MOD_GlcNHglycan	865	868	PF01048	0.658
MOD_GlcNHglycan	899	902	PF01048	0.734
MOD_GlcNHglycan	920	924	PF01048	0.610
MOD_GlcNHglycan	97	100	PF01048	0.764
MOD_GSK3_1	115	122	PF00069	0.628
MOD_GSK3_1	131	138	PF00069	0.558
MOD_GSK3_1	171	178	PF00069	0.744
MOD_GSK3_1	199	206	PF00069	0.759
MOD_GSK3_1	214	221	PF00069	0.614
MOD_GSK3_1	24	31	PF00069	0.678
MOD_GSK3_1	259	266	PF00069	0.693
MOD_GSK3_1	267	274	PF00069	0.750
MOD_GSK3_1	308	315	PF00069	0.659
MOD_GSK3_1	408	415	PF00069	0.692
MOD_GSK3_1	433	440	PF00069	0.717
MOD_GSK3_1	462	469	PF00069	0.779
MOD_GSK3_1	530	537	PF00069	0.626
MOD_GSK3_1	553	560	PF00069	0.672
MOD_GSK3_1	567	574	PF00069	0.657
MOD_GSK3_1	594	601	PF00069	0.718
MOD_GSK3_1	607	614	PF00069	0.716
MOD_GSK3_1	766	773	PF00069	0.726
MOD_GSK3_1	828	835	PF00069	0.725
MOD_GSK3_1	885	892	PF00069	0.787
MOD_GSK3_1	91	98	PF00069	0.780
MOD_GSK3_1	912	919	PF00069	0.738
MOD_GSK3_1	99	106	PF00069	0.701
MOD_LATS_1	530	536	PF00433	0.799
MOD_N-GLC_1	182	187	PF02516	0.702
MOD_N-GLC_1	276	281	PF02516	0.662
MOD_N-GLC_1	308	313	PF02516	0.719
MOD_N-GLC_1	413	418	PF02516	0.599
MOD_N-GLC_1	466	471	PF02516	0.738
MOD_N-GLC_1	836	841	PF02516	0.724
MOD_N-GLC_1	913	918	PF02516	0.632
MOD_NEK2_1	123	128	PF00069	0.681
MOD_NEK2_1	14	19	PF00069	0.773
MOD_NEK2_1	188	193	PF00069	0.749
MOD_NEK2_1	214	219	PF00069	0.656
MOD_NEK2_1	229	234	PF00069	0.702
MOD_NEK2_1	263	268	PF00069	0.713
MOD_NEK2_1	312	317	PF00069	0.698
MOD_NEK2_1	35	40	PF00069	0.661
MOD_NEK2_1	413	418	PF00069	0.683
MOD_NEK2_1	611	616	PF00069	0.771
MOD_NEK2_2	119	124	PF00069	0.751
MOD_NEK2_2	819	824	PF00069	0.667
MOD_NEK2_2	889	894	PF00069	0.723
MOD_NEK2_2	958	963	PF00069	0.723
MOD_OFUCOSY	745	751	PF10250	0.686
MOD_PIKK_1	312	318	PF00454	0.750
MOD_PIKK_1	627	633	PF00454	0.740
MOD_PIKK_1	64	70	PF00454	0.759
MOD_PIKK_1	77	83	PF00454	0.570
MOD_PIKK_1	929	935	PF00454	0.618
MOD_PK_1	182	188	PF00069	0.705
MOD_PK_1	204	210	PF00069	0.581
MOD_PKA_1	588	594	PF00069	0.774
MOD_PKA_1	660	666	PF00069	0.817
MOD_PKA_1	671	677	PF00069	0.705
MOD_PKA_1	894	900	PF00069	0.786
MOD_PKA_2	191	197	PF00069	0.779
MOD_PKA_2	199	205	PF00069	0.685
MOD_PKA_2	241	247	PF00069	0.630
MOD_PKA_2	376	382	PF00069	0.706
MOD_PKA_2	473	479	PF00069	0.617
MOD_PKA_2	588	594	PF00069	0.699
MOD_PKA_2	607	613	PF00069	0.503
MOD_PKA_2	660	666	PF00069	0.755
MOD_PKA_2	683	689	PF00069	0.788
MOD_PKA_2	730	736	PF00069	0.695
MOD_PKA_2	770	776	PF00069	0.674
MOD_PKA_2	894	900	PF00069	0.786
MOD_PKA_2	9	15	PF00069	0.699
MOD_PKA_2	934	940	PF00069	0.739
MOD_PKB_1	944	952	PF00069	0.590
MOD_Plk_1	131	137	PF00069	0.777
MOD_Plk_1	165	171	PF00069	0.687
MOD_Plk_1	182	188	PF00069	0.556
MOD_Plk_1	24	30	PF00069	0.687
MOD_Plk_1	308	314	PF00069	0.691
MOD_Plk_1	381	387	PF00069	0.730
MOD_Plk_1	413	419	PF00069	0.683
MOD_Plk_1	516	522	PF00069	0.748
MOD_Plk_1	64	70	PF00069	0.759
MOD_Plk_1	789	795	PF00069	0.691
MOD_Plk_1	958	964	PF00069	0.629
MOD_Plk_2-3	397	403	PF00069	0.702
MOD_Plk_2-3	882	888	PF00069	0.589
MOD_Plk_4	119	125	PF00069	0.692
MOD_Plk_4	244	250	PF00069	0.756
MOD_Plk_4	254	260	PF00069	0.631
MOD_Plk_4	263	269	PF00069	0.523
MOD_Plk_4	308	314	PF00069	0.669
MOD_Plk_4	35	41	PF00069	0.727
MOD_Plk_4	358	364	PF00069	0.771
MOD_Plk_4	4	10	PF00069	0.566
MOD_Plk_4	416	422	PF00069	0.744
MOD_Plk_4	474	480	PF00069	0.697
MOD_Plk_4	630	636	PF00069	0.725
MOD_ProDKin_1	135	141	PF00069	0.716
MOD_ProDKin_1	193	199	PF00069	0.681
MOD_ProDKin_1	28	34	PF00069	0.751
MOD_ProDKin_1	328	334	PF00069	0.665
MOD_ProDKin_1	425	431	PF00069	0.682
MOD_ProDKin_1	486	492	PF00069	0.823
MOD_ProDKin_1	498	504	PF00069	0.617
MOD_ProDKin_1	646	652	PF00069	0.702
MOD_ProDKin_1	725	731	PF00069	0.680
MOD_ProDKin_1	753	759	PF00069	0.684
MOD_ProDKin_1	799	805	PF00069	0.719
MOD_ProDKin_1	885	891	PF00069	0.780
MOD_ProDKin_1	936	942	PF00069	0.675
MOD_SUMO_for_1	70	73	PF00179	0.643
MOD_SUMO_rev_2	395	400	PF00179	0.731
MOD_SUMO_rev_2	668	674	PF00179	0.673
TRG_DiLeu_BaEn_1	158	163	PF01217	0.603
TRG_DiLeu_BaLyEn_6	636	641	PF01217	0.761
TRG_DiLeu_BaLyEn_6	809	814	PF01217	0.585
TRG_DiLeu_BaLyEn_6	922	927	PF01217	0.592
TRG_ENDOCYTIC_2	120	123	PF00928	0.689
TRG_ENDOCYTIC_2	950	953	PF00928	0.777
TRG_ER_diArg_1	237	240	PF00400	0.701
TRG_ER_diArg_1	586	589	PF00400	0.746
TRG_ER_diArg_1	681	684	PF00400	0.709
TRG_ER_diArg_1	781	783	PF00400	0.715
TRG_ER_diArg_1	893	895	PF00400	0.851
TRG_ER_diArg_1	944	947	PF00400	0.586
TRG_NLS_Bipartite_1	660	676	PF00514	0.741
TRG_NLS_MonoExtC_3	671	676	PF00514	0.710
TRG_NLS_MonoExtN_4	661	668	PF00514	0.828
TRG_NLS_MonoExtN_4	669	676	PF00514	0.708
TRG_Pf-PMV_PEXEL_1	523	528	PF00026	0.654

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7V4	Leishmania donovani	81%	100%
A4HM12	Leishmania braziliensis	47%	100%
A4I9E3	Leishmania infantum	81%	100%
E9B4E3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%