LeishMANIAdb
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Tyrosyl-DNA phosphodiesterase 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Tyrosyl-DNA phosphodiesterase 1
Gene product:
tyrosyl-DNA phosphodiesterase 1
Species:
Leishmania major
UniProt:
Q4Q3N1_LEIMA
TriTrypDb:
LmjF.33.3050 * , LMJLV39_330043200 * , LMJSD75_330042400 *
Length:
828

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 9
GO:0020023 kinetoplast 2 2
GO:0043226 organelle 2 9
GO:0043227 membrane-bounded organelle 3 9
GO:0043229 intracellular organelle 3 9
GO:0043231 intracellular membrane-bounded organelle 4 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

Q4Q3N1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3N1

Function

Biological processes
Term Name Level Count
GO:0000012 single strand break repair 6 2
GO:0006139 nucleobase-containing compound metabolic process 3 9
GO:0006259 DNA metabolic process 4 9
GO:0006281 DNA repair 5 9
GO:0006302 double-strand break repair 6 2
GO:0006725 cellular aromatic compound metabolic process 3 9
GO:0006807 nitrogen compound metabolic process 2 9
GO:0006950 response to stress 2 9
GO:0006974 DNA damage response 4 9
GO:0008152 metabolic process 1 9
GO:0009987 cellular process 1 9
GO:0033554 cellular response to stress 3 9
GO:0034641 cellular nitrogen compound metabolic process 3 9
GO:0043170 macromolecule metabolic process 3 9
GO:0044237 cellular metabolic process 2 9
GO:0044238 primary metabolic process 2 9
GO:0044260 obsolete cellular macromolecule metabolic process 3 9
GO:0046483 heterocycle metabolic process 3 9
GO:0050896 response to stimulus 1 9
GO:0051716 cellular response to stimulus 2 9
GO:0071704 organic substance metabolic process 2 9
GO:0090304 nucleic acid metabolic process 4 9
GO:1901360 organic cyclic compound metabolic process 3 9
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 2
GO:0003677 DNA binding 4 2
GO:0003690 double-stranded DNA binding 5 2
GO:0003697 single-stranded DNA binding 5 2
GO:0003824 catalytic activity 1 9
GO:0004518 nuclease activity 4 9
GO:0005488 binding 1 2
GO:0008081 phosphoric diester hydrolase activity 5 9
GO:0016787 hydrolase activity 2 9
GO:0016788 hydrolase activity, acting on ester bonds 3 9
GO:0017005 3'-tyrosyl-DNA phosphodiesterase activity 5 2
GO:0042578 phosphoric ester hydrolase activity 4 9
GO:0070259 tyrosyl-DNA phosphodiesterase activity 4 2
GO:0097159 organic cyclic compound binding 2 2
GO:0140097 catalytic activity, acting on DNA 3 2
GO:0140640 catalytic activity, acting on a nucleic acid 2 2
GO:1901363 heterocyclic compound binding 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 512 516 PF00656 0.422
CLV_C14_Caspase3-7 597 601 PF00656 0.493
CLV_NRD_NRD_1 121 123 PF00675 0.407
CLV_NRD_NRD_1 143 145 PF00675 0.451
CLV_NRD_NRD_1 244 246 PF00675 0.274
CLV_NRD_NRD_1 466 468 PF00675 0.315
CLV_NRD_NRD_1 619 621 PF00675 0.176
CLV_NRD_NRD_1 658 660 PF00675 0.309
CLV_NRD_NRD_1 821 823 PF00675 0.639
CLV_NRD_NRD_1 87 89 PF00675 0.413
CLV_PCSK_FUR_1 119 123 PF00082 0.405
CLV_PCSK_KEX2_1 121 123 PF00082 0.407
CLV_PCSK_KEX2_1 143 145 PF00082 0.451
CLV_PCSK_KEX2_1 244 246 PF00082 0.274
CLV_PCSK_KEX2_1 466 468 PF00082 0.315
CLV_PCSK_KEX2_1 574 576 PF00082 0.295
CLV_PCSK_KEX2_1 619 621 PF00082 0.176
CLV_PCSK_KEX2_1 823 825 PF00082 0.609
CLV_PCSK_KEX2_1 87 89 PF00082 0.413
CLV_PCSK_PC1ET2_1 574 576 PF00082 0.238
CLV_PCSK_PC1ET2_1 823 825 PF00082 0.645
CLV_PCSK_PC7_1 117 123 PF00082 0.407
CLV_PCSK_SKI1_1 143 147 PF00082 0.453
CLV_PCSK_SKI1_1 182 186 PF00082 0.258
CLV_PCSK_SKI1_1 188 192 PF00082 0.306
CLV_PCSK_SKI1_1 215 219 PF00082 0.349
CLV_PCSK_SKI1_1 307 311 PF00082 0.290
CLV_PCSK_SKI1_1 346 350 PF00082 0.277
CLV_PCSK_SKI1_1 467 471 PF00082 0.348
CLV_PCSK_SKI1_1 574 578 PF00082 0.238
CLV_PCSK_SKI1_1 579 583 PF00082 0.213
CLV_PCSK_SKI1_1 620 624 PF00082 0.176
CLV_PCSK_SKI1_1 640 644 PF00082 0.269
CLV_PCSK_SKI1_1 711 715 PF00082 0.290
CLV_PCSK_SKI1_1 87 91 PF00082 0.408
CLV_Separin_Metazoa 463 467 PF03568 0.490
DEG_APCC_DBOX_1 214 222 PF00400 0.443
DEG_APCC_DBOX_1 286 294 PF00400 0.469
DEG_APCC_DBOX_1 454 462 PF00400 0.490
DEG_APCC_DBOX_1 619 627 PF00400 0.376
DEG_APCC_DBOX_1 72 80 PF00400 0.388
DEG_Nend_Nbox_1 1 3 PF02207 0.393
DEG_SCF_FBW7_1 735 742 PF00400 0.392
DEG_SPOP_SBC_1 366 370 PF00917 0.435
DOC_CDC14_PxL_1 218 226 PF14671 0.447
DOC_CDC14_PxL_1 254 262 PF14671 0.376
DOC_CKS1_1 715 720 PF01111 0.474
DOC_CKS1_1 728 733 PF01111 0.422
DOC_CYCLIN_RxL_1 176 189 PF00134 0.180
DOC_CYCLIN_yCln2_LP_2 293 299 PF00134 0.454
DOC_CYCLIN_yCln2_LP_2 728 734 PF00134 0.490
DOC_MAPK_gen_1 779 788 PF00069 0.368
DOC_MAPK_MEF2A_6 541 550 PF00069 0.447
DOC_MAPK_RevD_3 74 88 PF00069 0.396
DOC_PP2B_LxvP_1 293 296 PF13499 0.433
DOC_PP2B_LxvP_1 774 777 PF13499 0.490
DOC_PP4_FxxP_1 577 580 PF00568 0.422
DOC_PP4_FxxP_1 621 624 PF00568 0.469
DOC_USP7_MATH_1 105 109 PF00917 0.395
DOC_USP7_MATH_1 132 136 PF00917 0.480
DOC_USP7_MATH_1 365 369 PF00917 0.478
DOC_USP7_MATH_1 634 638 PF00917 0.458
DOC_USP7_MATH_1 653 657 PF00917 0.490
DOC_USP7_MATH_1 707 711 PF00917 0.572
DOC_USP7_MATH_1 739 743 PF00917 0.345
DOC_USP7_MATH_1 791 795 PF00917 0.546
DOC_WW_Pin1_4 110 115 PF00397 0.396
DOC_WW_Pin1_4 249 254 PF00397 0.446
DOC_WW_Pin1_4 276 281 PF00397 0.464
DOC_WW_Pin1_4 403 408 PF00397 0.489
DOC_WW_Pin1_4 604 609 PF00397 0.390
DOC_WW_Pin1_4 714 719 PF00397 0.471
DOC_WW_Pin1_4 727 732 PF00397 0.506
DOC_WW_Pin1_4 735 740 PF00397 0.495
DOC_WW_Pin1_4 794 799 PF00397 0.421
LIG_14-3-3_CanoR_1 244 250 PF00244 0.524
LIG_14-3-3_CanoR_1 395 401 PF00244 0.376
LIG_14-3-3_CanoR_1 467 476 PF00244 0.513
LIG_14-3-3_CanoR_1 51 56 PF00244 0.424
LIG_14-3-3_CanoR_1 534 538 PF00244 0.476
LIG_14-3-3_CanoR_1 73 82 PF00244 0.389
LIG_14-3-3_CanoR_1 87 96 PF00244 0.390
LIG_Actin_WH2_2 305 320 PF00022 0.469
LIG_BIR_III_2 56 60 PF00653 0.399
LIG_BIR_III_4 782 786 PF00653 0.427
LIG_BRCT_BRCA1_1 111 115 PF00533 0.397
LIG_BRCT_BRCA1_1 375 379 PF00533 0.447
LIG_BRCT_BRCA1_1 690 694 PF00533 0.471
LIG_BRCT_BRCA1_1 77 81 PF00533 0.388
LIG_BRCT_BRCA1_2 375 381 PF00533 0.422
LIG_CtBP_PxDLS_1 608 612 PF00389 0.376
LIG_DCNL_PONY_1 1 4 PF03556 0.395
LIG_deltaCOP1_diTrp_1 328 333 PF00928 0.463
LIG_EH_1 264 268 PF12763 0.490
LIG_eIF4E_1 729 735 PF01652 0.469
LIG_FHA_1 226 232 PF00498 0.490
LIG_FHA_1 238 244 PF00498 0.497
LIG_FHA_1 27 33 PF00498 0.389
LIG_FHA_1 276 282 PF00498 0.497
LIG_FHA_1 321 327 PF00498 0.483
LIG_FHA_1 357 363 PF00498 0.390
LIG_FHA_1 420 426 PF00498 0.450
LIG_FHA_1 721 727 PF00498 0.480
LIG_FHA_1 741 747 PF00498 0.440
LIG_FHA_1 810 816 PF00498 0.692
LIG_FHA_1 91 97 PF00498 0.389
LIG_FHA_2 218 224 PF00498 0.541
LIG_FHA_2 244 250 PF00498 0.469
LIG_FHA_2 527 533 PF00498 0.447
LIG_LIR_Gen_1 200 210 PF02991 0.436
LIG_LIR_Gen_1 251 261 PF02991 0.387
LIG_LIR_Gen_1 628 634 PF02991 0.423
LIG_LIR_Gen_1 691 702 PF02991 0.469
LIG_LIR_Gen_1 730 740 PF02991 0.530
LIG_LIR_Gen_1 789 800 PF02991 0.525
LIG_LIR_Gen_1 99 105 PF02991 0.386
LIG_LIR_LC3C_4 228 233 PF02991 0.422
LIG_LIR_Nem_3 200 205 PF02991 0.436
LIG_LIR_Nem_3 251 257 PF02991 0.387
LIG_LIR_Nem_3 342 348 PF02991 0.416
LIG_LIR_Nem_3 628 632 PF02991 0.435
LIG_LIR_Nem_3 691 697 PF02991 0.493
LIG_LIR_Nem_3 730 735 PF02991 0.505
LIG_LIR_Nem_3 78 84 PF02991 0.393
LIG_LIR_Nem_3 789 795 PF02991 0.460
LIG_LIR_Nem_3 99 104 PF02991 0.389
LIG_LYPXL_yS_3 68 71 PF13949 0.383
LIG_MYND_1 134 138 PF01753 0.408
LIG_NRBOX 213 219 PF00104 0.436
LIG_Pex14_2 420 424 PF04695 0.490
LIG_PTB_Apo_2 489 496 PF02174 0.422
LIG_Rb_pABgroove_1 674 682 PF01858 0.483
LIG_SH2_CRK 254 258 PF00017 0.376
LIG_SH2_CRK 629 633 PF00017 0.461
LIG_SH2_CRK 732 736 PF00017 0.537
LIG_SH2_NCK_1 254 258 PF00017 0.422
LIG_SH2_NCK_1 629 633 PF00017 0.469
LIG_SH2_SRC 445 448 PF00017 0.422
LIG_SH2_STAP1 629 633 PF00017 0.469
LIG_SH2_STAP1 740 744 PF00017 0.394
LIG_SH2_STAP1 85 89 PF00017 0.410
LIG_SH2_STAT3 485 488 PF00017 0.447
LIG_SH2_STAT5 210 213 PF00017 0.453
LIG_SH2_STAT5 254 257 PF00017 0.490
LIG_SH2_STAT5 339 342 PF00017 0.423
LIG_SH2_STAT5 392 395 PF00017 0.449
LIG_SH2_STAT5 43 46 PF00017 0.396
LIG_SH2_STAT5 729 732 PF00017 0.531
LIG_SH2_STAT5 85 88 PF00017 0.411
LIG_SH3_3 128 134 PF00018 0.399
LIG_SH3_3 192 198 PF00018 0.422
LIG_SH3_3 247 253 PF00018 0.391
LIG_SH3_3 289 295 PF00018 0.463
LIG_SH3_3 341 347 PF00018 0.522
LIG_SH3_3 522 528 PF00018 0.447
LIG_SH3_3 56 62 PF00018 0.396
LIG_SUMO_SIM_anti_2 288 294 PF11976 0.490
LIG_SUMO_SIM_anti_2 506 513 PF11976 0.422
LIG_SUMO_SIM_par_1 230 235 PF11976 0.459
LIG_SUMO_SIM_par_1 358 364 PF11976 0.376
LIG_TRAF2_1 528 531 PF00917 0.469
LIG_WW_2 295 298 PF00397 0.447
MOD_CDK_SPxxK_3 110 117 PF00069 0.398
MOD_CK1_1 110 116 PF00069 0.395
MOD_CK1_1 169 175 PF00069 0.510
MOD_CK1_1 209 215 PF00069 0.463
MOD_CK1_1 225 231 PF00069 0.490
MOD_CK1_1 252 258 PF00069 0.458
MOD_CK1_1 276 282 PF00069 0.496
MOD_CK1_1 320 326 PF00069 0.492
MOD_CK1_1 356 362 PF00069 0.485
MOD_CK1_1 399 405 PF00069 0.433
MOD_CK1_1 468 474 PF00069 0.571
MOD_CK1_1 487 493 PF00069 0.403
MOD_CK1_1 689 695 PF00069 0.508
MOD_CK1_1 77 83 PF00069 0.484
MOD_CK1_1 794 800 PF00069 0.422
MOD_CK2_1 19 25 PF00069 0.397
MOD_CK2_1 217 223 PF00069 0.532
MOD_CK2_1 526 532 PF00069 0.447
MOD_CK2_1 697 703 PF00069 0.438
MOD_CMANNOS 537 540 PF00535 0.269
MOD_Cter_Amidation 119 122 PF01082 0.406
MOD_GlcNHglycan 171 174 PF01048 0.566
MOD_GlcNHglycan 21 24 PF01048 0.394
MOD_GlcNHglycan 223 227 PF01048 0.300
MOD_GlcNHglycan 234 237 PF01048 0.223
MOD_GlcNHglycan 275 278 PF01048 0.261
MOD_GlcNHglycan 354 358 PF01048 0.301
MOD_GlcNHglycan 401 404 PF01048 0.273
MOD_GlcNHglycan 411 414 PF01048 0.330
MOD_GlcNHglycan 467 470 PF01048 0.301
MOD_GlcNHglycan 512 515 PF01048 0.287
MOD_GlcNHglycan 645 648 PF01048 0.247
MOD_GlcNHglycan 683 686 PF01048 0.290
MOD_GlcNHglycan 688 691 PF01048 0.253
MOD_GlcNHglycan 98 101 PF01048 0.412
MOD_GSK3_1 103 110 PF00069 0.371
MOD_GSK3_1 205 212 PF00069 0.487
MOD_GSK3_1 239 246 PF00069 0.532
MOD_GSK3_1 248 255 PF00069 0.558
MOD_GSK3_1 276 283 PF00069 0.579
MOD_GSK3_1 349 356 PF00069 0.497
MOD_GSK3_1 361 368 PF00069 0.555
MOD_GSK3_1 369 376 PF00069 0.407
MOD_GSK3_1 399 406 PF00069 0.435
MOD_GSK3_1 419 426 PF00069 0.548
MOD_GSK3_1 437 444 PF00069 0.371
MOD_GSK3_1 465 472 PF00069 0.509
MOD_GSK3_1 475 482 PF00069 0.440
MOD_GSK3_1 483 490 PF00069 0.452
MOD_GSK3_1 607 614 PF00069 0.559
MOD_GSK3_1 643 650 PF00069 0.423
MOD_GSK3_1 688 695 PF00069 0.489
MOD_GSK3_1 735 742 PF00069 0.430
MOD_GSK3_1 794 801 PF00069 0.536
MOD_GSK3_1 83 90 PF00069 0.406
MOD_N-GLC_1 373 378 PF02516 0.269
MOD_N-GLC_1 647 652 PF02516 0.225
MOD_N-GLC_1 798 803 PF02516 0.489
MOD_N-GLC_2 706 708 PF02516 0.176
MOD_NEK2_1 180 185 PF00069 0.378
MOD_NEK2_1 206 211 PF00069 0.498
MOD_NEK2_1 217 222 PF00069 0.492
MOD_NEK2_1 243 248 PF00069 0.515
MOD_NEK2_1 317 322 PF00069 0.535
MOD_NEK2_1 361 366 PF00069 0.535
MOD_NEK2_1 437 442 PF00069 0.459
MOD_NEK2_1 465 470 PF00069 0.436
MOD_NEK2_1 495 500 PF00069 0.554
MOD_NEK2_1 611 616 PF00069 0.469
MOD_NEK2_1 642 647 PF00069 0.428
MOD_NEK2_1 679 684 PF00069 0.454
MOD_NEK2_1 96 101 PF00069 0.389
MOD_NEK2_2 239 244 PF00069 0.492
MOD_NEK2_2 46 51 PF00069 0.397
MOD_OFUCOSY 103 109 PF10250 0.381
MOD_PIKK_1 24 30 PF00454 0.389
MOD_PIKK_1 332 338 PF00454 0.447
MOD_PIKK_1 484 490 PF00454 0.423
MOD_PIKK_1 647 653 PF00454 0.483
MOD_PIKK_1 720 726 PF00454 0.438
MOD_PIKK_1 88 94 PF00454 0.397
MOD_PK_1 51 57 PF00069 0.411
MOD_PKA_1 244 250 PF00069 0.438
MOD_PKA_1 822 828 PF00069 0.527
MOD_PKA_1 87 93 PF00069 0.403
MOD_PKA_2 243 249 PF00069 0.469
MOD_PKA_2 317 323 PF00069 0.512
MOD_PKA_2 366 372 PF00069 0.489
MOD_PKA_2 465 471 PF00069 0.509
MOD_PKA_2 533 539 PF00069 0.476
MOD_PKA_2 72 78 PF00069 0.409
MOD_PKA_2 87 93 PF00069 0.522
MOD_Plk_1 222 228 PF00069 0.490
MOD_Plk_1 479 485 PF00069 0.439
MOD_Plk_1 634 640 PF00069 0.497
MOD_Plk_4 206 212 PF00069 0.515
MOD_Plk_4 317 323 PF00069 0.474
MOD_Plk_4 356 362 PF00069 0.439
MOD_Plk_4 689 695 PF00069 0.455
MOD_Plk_4 7 13 PF00069 0.380
MOD_Plk_4 791 797 PF00069 0.384
MOD_Plk_4 80 86 PF00069 0.506
MOD_ProDKin_1 110 116 PF00069 0.395
MOD_ProDKin_1 249 255 PF00069 0.446
MOD_ProDKin_1 276 282 PF00069 0.464
MOD_ProDKin_1 403 409 PF00069 0.489
MOD_ProDKin_1 604 610 PF00069 0.390
MOD_ProDKin_1 714 720 PF00069 0.471
MOD_ProDKin_1 727 733 PF00069 0.506
MOD_ProDKin_1 735 741 PF00069 0.495
MOD_ProDKin_1 794 800 PF00069 0.417
TRG_ENDOCYTIC_2 254 257 PF00928 0.376
TRG_ENDOCYTIC_2 618 621 PF00928 0.480
TRG_ENDOCYTIC_2 629 632 PF00928 0.444
TRG_ENDOCYTIC_2 68 71 PF00928 0.383
TRG_ENDOCYTIC_2 732 735 PF00928 0.488
TRG_ER_diArg_1 116 119 PF00400 0.405
TRG_ER_diArg_1 121 124 PF00400 0.404
TRG_ER_diArg_1 142 144 PF00400 0.450
TRG_ER_diArg_1 185 188 PF00400 0.510
TRG_ER_diArg_1 243 245 PF00400 0.474
TRG_ER_diArg_1 465 467 PF00400 0.519
TRG_ER_diArg_1 618 620 PF00400 0.376
TRG_ER_diArg_1 805 808 PF00400 0.510
TRG_ER_diArg_1 821 824 PF00400 0.658
TRG_NES_CRM1_1 223 237 PF08389 0.490
TRG_NLS_MonoExtC_3 821 826 PF00514 0.585
TRG_NLS_MonoExtN_4 821 826 PF00514 0.585

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3C9 Leptomonas seymouri 49% 100%
A0A0S4JE96 Bodo saltans 29% 100%
A0A3Q8IMS2 Leishmania donovani 90% 100%
A4HM15 Leishmania braziliensis 73% 100%
A4I9E7 Leishmania infantum 90% 100%
C9ZJR8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
E9B4E6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q8H1D9 Arabidopsis thaliana 25% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS