Fe2OG dioxygenase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3M6_LEIMA

TriTrypDb:

LmjF.33.3100 , LMJLV39_330044200 , LMJSD75_330043000

Length:

465

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q3M6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3M6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	379	383	PF00656	0.627
CLV_C14_Caspase3-7	401	405	PF00656	0.569
CLV_NRD_NRD_1	170	172	PF00675	0.484
CLV_NRD_NRD_1	212	214	PF00675	0.447
CLV_NRD_NRD_1	3	5	PF00675	0.666
CLV_NRD_NRD_1	444	446	PF00675	0.572
CLV_PCSK_KEX2_1	170	172	PF00082	0.550
CLV_PCSK_KEX2_1	211	213	PF00082	0.466
CLV_PCSK_KEX2_1	250	252	PF00082	0.605
CLV_PCSK_KEX2_1	258	260	PF00082	0.646
CLV_PCSK_KEX2_1	3	5	PF00082	0.672
CLV_PCSK_KEX2_1	93	95	PF00082	0.490
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.599
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.571
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.559
CLV_PCSK_SKI1_1	179	183	PF00082	0.320
CLV_PCSK_SKI1_1	307	311	PF00082	0.756
CLV_PCSK_SKI1_1	373	377	PF00082	0.577
CLV_PCSK_SKI1_1	4	8	PF00082	0.695
CLV_PCSK_SKI1_1	69	73	PF00082	0.448
CLV_PCSK_SKI1_1	83	87	PF00082	0.476
DEG_APCC_DBOX_1	2	10	PF00400	0.693
DEG_Nend_Nbox_1	1	3	PF02207	0.627
DEG_SCF_FBW7_1	278	284	PF00400	0.736
DOC_CKS1_1	278	283	PF01111	0.742
DOC_CYCLIN_RxL_1	1	8	PF00134	0.594
DOC_CYCLIN_RxL_1	176	185	PF00134	0.325
DOC_MAPK_gen_1	170	176	PF00069	0.480
DOC_MAPK_gen_1	211	220	PF00069	0.539
DOC_MAPK_gen_1	3	9	PF00069	0.667
DOC_MAPK_MEF2A_6	213	222	PF00069	0.461
DOC_MAPK_MEF2A_6	69	78	PF00069	0.483
DOC_PP2B_LxvP_1	273	276	PF13499	0.753
DOC_USP7_UBL2_3	402	406	PF12436	0.542
DOC_USP7_UBL2_3	411	415	PF12436	0.484
DOC_USP7_UBL2_3	452	456	PF12436	0.560
DOC_USP7_UBL2_3	89	93	PF12436	0.609
DOC_WW_Pin1_4	102	107	PF00397	0.391
DOC_WW_Pin1_4	277	282	PF00397	0.676
DOC_WW_Pin1_4	62	67	PF00397	0.505
LIG_14-3-3_CanoR_1	11	20	PF00244	0.552
LIG_14-3-3_CanoR_1	110	119	PF00244	0.471
LIG_14-3-3_CanoR_1	219	223	PF00244	0.384
LIG_14-3-3_CanoR_1	33	39	PF00244	0.453
LIG_14-3-3_CanoR_1	4	10	PF00244	0.636
LIG_CSL_BTD_1	103	106	PF09270	0.421
LIG_CtBP_PxDLS_1	437	441	PF00389	0.679
LIG_deltaCOP1_diTrp_1	187	194	PF00928	0.410
LIG_FHA_1	124	130	PF00498	0.414
LIG_FHA_1	146	152	PF00498	0.497
LIG_FHA_1	196	202	PF00498	0.536
LIG_FHA_1	278	284	PF00498	0.714
LIG_FHA_1	420	426	PF00498	0.687
LIG_FHA_2	157	163	PF00498	0.426
LIG_FHA_2	329	335	PF00498	0.663
LIG_FHA_2	63	69	PF00498	0.527
LIG_LIR_Gen_1	148	156	PF02991	0.421
LIG_LIR_Gen_1	397	407	PF02991	0.503
LIG_LIR_Gen_1	42	52	PF02991	0.470
LIG_LIR_Nem_3	148	153	PF02991	0.425
LIG_LIR_Nem_3	30	35	PF02991	0.496
LIG_LIR_Nem_3	338	342	PF02991	0.521
LIG_LIR_Nem_3	347	353	PF02991	0.524
LIG_LIR_Nem_3	397	403	PF02991	0.498
LIG_LIR_Nem_3	42	48	PF02991	0.428
LIG_LIR_Nem_3	82	88	PF02991	0.487
LIG_MAD2	110	118	PF02301	0.515
LIG_Pex14_1	190	194	PF04695	0.435
LIG_SH2_CRK	350	354	PF00017	0.592
LIG_SH2_GRB2like	152	155	PF00017	0.428
LIG_SH2_STAP1	137	141	PF00017	0.471
LIG_SH2_STAT3	342	345	PF00017	0.549
LIG_SH2_STAT5	152	155	PF00017	0.355
LIG_SH2_STAT5	204	207	PF00017	0.573
LIG_SH2_STAT5	75	78	PF00017	0.392
LIG_SH3_3	112	118	PF00018	0.485
LIG_SH3_3	138	144	PF00018	0.559
LIG_SH3_3	17	23	PF00018	0.414
LIG_SH3_3	171	177	PF00018	0.420
LIG_SH3_3	275	281	PF00018	0.759
LIG_SH3_3	286	292	PF00018	0.638
LIG_SUMO_SIM_par_1	34	42	PF11976	0.510
LIG_TYR_ITIM	43	48	PF00017	0.499
LIG_UBA3_1	352	357	PF00899	0.559
LIG_WRC_WIRS_1	293	298	PF05994	0.685
MOD_CDK_SPxxK_3	62	69	PF00069	0.501
MOD_CK1_1	18	24	PF00069	0.468
MOD_CK2_1	34	40	PF00069	0.445
MOD_CK2_1	391	397	PF00069	0.658
MOD_CK2_1	61	67	PF00069	0.564
MOD_Cter_Amidation	168	171	PF01082	0.576
MOD_Cter_Amidation	248	251	PF01082	0.446
MOD_GlcNHglycan	184	187	PF01048	0.394
MOD_GlcNHglycan	304	307	PF01048	0.703
MOD_GlcNHglycan	322	325	PF01048	0.736
MOD_GlcNHglycan	361	364	PF01048	0.600
MOD_GSK3_1	11	18	PF00069	0.577
MOD_GSK3_1	142	149	PF00069	0.378
MOD_GSK3_1	277	284	PF00069	0.702
MOD_GSK3_1	373	380	PF00069	0.665
MOD_GSK3_1	457	464	PF00069	0.654
MOD_N-GLC_1	207	212	PF02516	0.579
MOD_N-GLC_1	302	307	PF02516	0.740
MOD_NEK2_1	156	161	PF00069	0.392
MOD_NEK2_1	218	223	PF00069	0.387
MOD_NEK2_1	359	364	PF00069	0.590
MOD_NEK2_1	375	380	PF00069	0.634
MOD_NEK2_1	424	429	PF00069	0.668
MOD_NEK2_1	440	445	PF00069	0.350
MOD_PIKK_1	430	436	PF00454	0.713
MOD_PKA_1	373	379	PF00069	0.649
MOD_PKA_2	218	224	PF00069	0.397
MOD_PKA_2	440	446	PF00069	0.645
MOD_PKB_1	211	219	PF00069	0.545
MOD_Plk_1	15	21	PF00069	0.455
MOD_Plk_1	241	247	PF00069	0.532
MOD_Plk_1	268	274	PF00069	0.721
MOD_Plk_1	376	382	PF00069	0.659
MOD_Plk_1	46	52	PF00069	0.515
MOD_Plk_2-3	377	383	PF00069	0.680
MOD_Plk_4	104	110	PF00069	0.384
MOD_Plk_4	146	152	PF00069	0.374
MOD_Plk_4	15	21	PF00069	0.397
MOD_Plk_4	156	162	PF00069	0.389
MOD_Plk_4	200	206	PF00069	0.478
MOD_Plk_4	292	298	PF00069	0.643
MOD_Plk_4	5	11	PF00069	0.548
MOD_Plk_4	56	62	PF00069	0.526
MOD_ProDKin_1	102	108	PF00069	0.386
MOD_ProDKin_1	277	283	PF00069	0.678
MOD_ProDKin_1	62	68	PF00069	0.503
MOD_SUMO_rev_2	282	292	PF00179	0.644
MOD_SUMO_rev_2	401	407	PF00179	0.519
MOD_SUMO_rev_2	64	71	PF00179	0.558
TRG_DiLeu_BaEn_4	268	274	PF01217	0.490
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.643
TRG_ENDOCYTIC_2	152	155	PF00928	0.355
TRG_ENDOCYTIC_2	350	353	PF00928	0.583
TRG_ENDOCYTIC_2	45	48	PF00928	0.509
TRG_ENDOCYTIC_2	75	78	PF00928	0.392
TRG_ER_diArg_1	2	4	PF00400	0.681
TRG_ER_diArg_1	211	213	PF00400	0.482
TRG_NLS_MonoExtC_3	371	377	PF00514	0.542
TRG_Pf-PMV_PEXEL_1	11	16	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	50	55	PF00026	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD27	Leptomonas seymouri	76%	99%
A0A0S4JDR9	Bodo saltans	41%	75%
A0A1X0NSW5	Trypanosomatidae	54%	100%
A0A3S7X787	Leishmania donovani	95%	100%
A4HM19	Leishmania braziliensis	86%	100%
A4I9F2	Leishmania infantum	95%	100%
C9ZJS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	90%
E9B4F0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5AFA6	Trypanosoma cruzi	55%	100%