Importin N-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3M2_LEIMA

TriTrypDb:

LmjF.33.3140 , LMJLV39_330044600 , LMJSD75_330043400

Length:

1005

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3M2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3M2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	341	345	PF00656	0.545
CLV_C14_Caspase3-7	347	351	PF00656	0.574
CLV_NRD_NRD_1	200	202	PF00675	0.441
CLV_NRD_NRD_1	26	28	PF00675	0.445
CLV_NRD_NRD_1	501	503	PF00675	0.362
CLV_NRD_NRD_1	794	796	PF00675	0.588
CLV_NRD_NRD_1	926	928	PF00675	0.544
CLV_PCSK_KEX2_1	202	204	PF00082	0.437
CLV_PCSK_KEX2_1	501	503	PF00082	0.362
CLV_PCSK_KEX2_1	92	94	PF00082	0.507
CLV_PCSK_KEX2_1	926	928	PF00082	0.532
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.498
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.554
CLV_PCSK_PC7_1	497	503	PF00082	0.346
CLV_PCSK_SKI1_1	194	198	PF00082	0.436
CLV_PCSK_SKI1_1	264	268	PF00082	0.509
CLV_PCSK_SKI1_1	667	671	PF00082	0.503
CLV_PCSK_SKI1_1	92	96	PF00082	0.538
DEG_APCC_DBOX_1	193	201	PF00400	0.436
DEG_COP1_1	207	215	PF00400	0.485
DEG_ODPH_VHL_1	850	862	PF01847	0.508
DOC_CKS1_1	183	188	PF01111	0.374
DOC_CYCLIN_RxL_1	645	657	PF00134	0.511
DOC_CYCLIN_RxL_1	664	673	PF00134	0.246
DOC_CYCLIN_RxL_1	87	101	PF00134	0.557
DOC_CYCLIN_yCln2_LP_2	767	773	PF00134	0.532
DOC_MAPK_gen_1	27	34	PF00069	0.440
DOC_MAPK_MEF2A_6	116	124	PF00069	0.441
DOC_MAPK_MEF2A_6	189	197	PF00069	0.426
DOC_MAPK_MEF2A_6	635	643	PF00069	0.513
DOC_PP2B_LxvP_1	1001	1004	PF13499	0.435
DOC_PP4_MxPP_1	184	187	PF00568	0.390
DOC_USP7_MATH_1	204	208	PF00917	0.535
DOC_USP7_MATH_1	260	264	PF00917	0.542
DOC_USP7_MATH_1	290	294	PF00917	0.556
DOC_USP7_MATH_1	424	428	PF00917	0.476
DOC_USP7_MATH_1	622	626	PF00917	0.613
DOC_USP7_MATH_1	647	651	PF00917	0.529
DOC_USP7_MATH_1	678	682	PF00917	0.616
DOC_USP7_MATH_1	685	689	PF00917	0.352
DOC_USP7_MATH_1	722	726	PF00917	0.492
DOC_USP7_MATH_1	733	737	PF00917	0.497
DOC_USP7_MATH_1	971	975	PF00917	0.559
DOC_WW_Pin1_4	182	187	PF00397	0.388
DOC_WW_Pin1_4	407	412	PF00397	0.560
DOC_WW_Pin1_4	536	541	PF00397	0.353
DOC_WW_Pin1_4	55	60	PF00397	0.582
DOC_WW_Pin1_4	643	648	PF00397	0.460
DOC_WW_Pin1_4	811	816	PF00397	0.507
DOC_WW_Pin1_4	969	974	PF00397	0.500
LIG_14-3-3_CanoR_1	189	193	PF00244	0.488
LIG_14-3-3_CanoR_1	27	35	PF00244	0.533
LIG_14-3-3_CanoR_1	277	282	PF00244	0.422
LIG_14-3-3_CanoR_1	285	290	PF00244	0.432
LIG_14-3-3_CanoR_1	461	465	PF00244	0.491
LIG_14-3-3_CanoR_1	710	716	PF00244	0.434
LIG_14-3-3_CanoR_1	87	91	PF00244	0.470
LIG_14-3-3_CanoR_1	927	937	PF00244	0.461
LIG_Actin_WH2_2	176	191	PF00022	0.554
LIG_Actin_WH2_2	394	410	PF00022	0.560
LIG_Actin_WH2_2	448	463	PF00022	0.521
LIG_Actin_WH2_2	586	602	PF00022	0.501
LIG_APCC_ABBA_1	193	198	PF00400	0.529
LIG_APCC_ABBA_1	316	321	PF00400	0.443
LIG_APCC_ABBA_1	385	390	PF00400	0.488
LIG_APCC_ABBA_1	850	855	PF00400	0.439
LIG_BIR_III_4	554	558	PF00653	0.505
LIG_BIR_III_4	826	830	PF00653	0.628
LIG_BRCT_BRCA1_1	247	251	PF00533	0.573
LIG_BRCT_BRCA1_1	272	276	PF00533	0.451
LIG_BRCT_BRCA1_1	278	282	PF00533	0.420
LIG_Clathr_ClatBox_1	66	70	PF01394	0.517
LIG_Clathr_ClatBox_1	945	949	PF01394	0.553
LIG_deltaCOP1_diTrp_1	130	134	PF00928	0.506
LIG_deltaCOP1_diTrp_1	75	84	PF00928	0.419
LIG_EH1_1	804	812	PF00400	0.490
LIG_eIF4E_1	466	472	PF01652	0.304
LIG_eIF4E_1	519	525	PF01652	0.369
LIG_FHA_1	183	189	PF00498	0.561
LIG_FHA_1	313	319	PF00498	0.464
LIG_FHA_1	416	422	PF00498	0.451
LIG_FHA_1	487	493	PF00498	0.518
LIG_FHA_1	605	611	PF00498	0.448
LIG_FHA_1	664	670	PF00498	0.479
LIG_FHA_1	761	767	PF00498	0.420
LIG_FHA_1	864	870	PF00498	0.512
LIG_FHA_1	89	95	PF00498	0.558
LIG_FHA_1	941	947	PF00498	0.517
LIG_FHA_1	975	981	PF00498	0.492
LIG_FHA_2	265	271	PF00498	0.541
LIG_FHA_2	339	345	PF00498	0.527
LIG_GBD_Chelix_1	520	528	PF00786	0.501
LIG_Integrin_RGD_1	19	21	PF01839	0.577
LIG_Integrin_RGD_1	348	350	PF01839	0.546
LIG_Integrin_RGD_1	671	673	PF01839	0.634
LIG_KLC1_Yacidic_2	386	390	PF13176	0.519
LIG_LIR_Gen_1	31	42	PF02991	0.450
LIG_LIR_Gen_1	463	474	PF02991	0.315
LIG_LIR_Gen_1	539	550	PF02991	0.521
LIG_LIR_Gen_1	714	722	PF02991	0.503
LIG_LIR_Gen_1	949	960	PF02991	0.512
LIG_LIR_Nem_3	159	164	PF02991	0.486
LIG_LIR_Nem_3	279	284	PF02991	0.446
LIG_LIR_Nem_3	31	37	PF02991	0.458
LIG_LIR_Nem_3	463	469	PF02991	0.329
LIG_LIR_Nem_3	539	545	PF02991	0.507
LIG_LIR_Nem_3	554	559	PF02991	0.435
LIG_LIR_Nem_3	714	718	PF02991	0.492
LIG_LIR_Nem_3	949	955	PF02991	0.480
LIG_LYPXL_S_1	318	322	PF13949	0.558
LIG_LYPXL_yS_3	319	322	PF13949	0.552
LIG_MLH1_MIPbox_1	278	282	PF16413	0.466
LIG_NRBOX	229	235	PF00104	0.529
LIG_NRBOX	402	408	PF00104	0.499
LIG_NRBOX	490	496	PF00104	0.489
LIG_NRBOX	564	570	PF00104	0.473
LIG_NRBOX	62	68	PF00104	0.525
LIG_NRBOX	950	956	PF00104	0.535
LIG_PCNA_yPIPBox_3	162	170	PF02747	0.486
LIG_PCNA_yPIPBox_3	226	234	PF02747	0.533
LIG_REV1ctd_RIR_1	279	289	PF16727	0.471
LIG_SH2_CRK	515	519	PF00017	0.426
LIG_SH2_CRK	800	804	PF00017	0.477
LIG_SH2_NCK_1	515	519	PF00017	0.426
LIG_SH2_PTP2	893	896	PF00017	0.537
LIG_SH2_SRC	388	391	PF00017	0.532
LIG_SH2_SRC	466	469	PF00017	0.308
LIG_SH2_STAP1	466	470	PF00017	0.308
LIG_SH2_STAP1	515	519	PF00017	0.426
LIG_SH2_STAP1	698	702	PF00017	0.526
LIG_SH2_STAT3	480	483	PF00017	0.531
LIG_SH2_STAT3	744	747	PF00017	0.510
LIG_SH2_STAT5	164	167	PF00017	0.514
LIG_SH2_STAT5	338	341	PF00017	0.533
LIG_SH2_STAT5	361	364	PF00017	0.503
LIG_SH2_STAT5	388	391	PF00017	0.532
LIG_SH2_STAT5	519	522	PF00017	0.469
LIG_SH2_STAT5	861	864	PF00017	0.346
LIG_SH2_STAT5	893	896	PF00017	0.473
LIG_SH3_1	901	907	PF00018	0.586
LIG_SH3_3	679	685	PF00018	0.631
LIG_SH3_3	871	877	PF00018	0.499
LIG_SH3_3	901	907	PF00018	0.569
LIG_SUMO_SIM_anti_2	808	814	PF11976	0.502
LIG_SUMO_SIM_par_1	120	125	PF11976	0.469
LIG_SUMO_SIM_par_1	604	609	PF11976	0.522
LIG_SUMO_SIM_par_1	65	71	PF11976	0.523
LIG_SUMO_SIM_par_1	808	814	PF11976	0.481
LIG_SUMO_SIM_par_1	943	950	PF11976	0.513
LIG_TYR_ITIM	513	518	PF00017	0.430
LIG_UBA3_1	195	202	PF00899	0.537
LIG_UBA3_1	881	888	PF00899	0.543
LIG_WRC_WIRS_1	166	171	PF05994	0.467
LIG_WRC_WIRS_1	712	717	PF05994	0.490
LIG_WRC_WIRS_1	941	946	PF05994	0.390
MOD_CDC14_SPxK_1	648	651	PF00782	0.536
MOD_CDK_SPxK_1	645	651	PF00069	0.530
MOD_CDK_SPxxK_3	182	189	PF00069	0.372
MOD_CDK_SPxxK_3	55	62	PF00069	0.568
MOD_CK1_1	486	492	PF00069	0.518
MOD_CK1_1	560	566	PF00069	0.463
MOD_CK1_1	614	620	PF00069	0.556
MOD_CK1_1	85	91	PF00069	0.489
MOD_CK1_1	929	935	PF00069	0.633
MOD_CK1_1	947	953	PF00069	0.521
MOD_CK1_1	959	965	PF00069	0.391
MOD_CK1_1	974	980	PF00069	0.429
MOD_CK2_1	264	270	PF00069	0.506
MOD_CK2_1	502	508	PF00069	0.547
MOD_CK2_1	678	684	PF00069	0.654
MOD_CK2_1	947	953	PF00069	0.495
MOD_CK2_1	969	975	PF00069	0.498
MOD_CMANNOS	131	134	PF00535	0.494
MOD_Cter_Amidation	793	796	PF01082	0.634
MOD_GlcNHglycan	213	216	PF01048	0.634
MOD_GlcNHglycan	221	224	PF01048	0.502
MOD_GlcNHglycan	270	273	PF01048	0.493
MOD_GlcNHglycan	28	31	PF01048	0.488
MOD_GlcNHglycan	292	295	PF01048	0.589
MOD_GlcNHglycan	354	357	PF01048	0.509
MOD_GlcNHglycan	373	376	PF01048	0.344
MOD_GlcNHglycan	392	395	PF01048	0.381
MOD_GlcNHglycan	54	58	PF01048	0.562
MOD_GlcNHglycan	559	562	PF01048	0.435
MOD_GlcNHglycan	574	577	PF01048	0.449
MOD_GlcNHglycan	613	616	PF01048	0.503
MOD_GlcNHglycan	620	623	PF01048	0.611
MOD_GlcNHglycan	735	738	PF01048	0.452
MOD_GlcNHglycan	820	823	PF01048	0.544
MOD_GlcNHglycan	826	830	PF01048	0.618
MOD_GlcNHglycan	896	899	PF01048	0.582
MOD_GlcNHglycan	908	911	PF01048	0.377
MOD_GSK3_1	241	248	PF00069	0.531
MOD_GSK3_1	260	267	PF00069	0.471
MOD_GSK3_1	479	486	PF00069	0.498
MOD_GSK3_1	557	564	PF00069	0.430
MOD_GSK3_1	614	621	PF00069	0.616
MOD_GSK3_1	643	650	PF00069	0.526
MOD_GSK3_1	680	687	PF00069	0.568
MOD_GSK3_1	722	729	PF00069	0.584
MOD_GSK3_1	733	740	PF00069	0.454
MOD_GSK3_1	749	756	PF00069	0.295
MOD_GSK3_1	82	89	PF00069	0.532
MOD_GSK3_1	902	909	PF00069	0.456
MOD_GSK3_1	940	947	PF00069	0.475
MOD_GSK3_1	956	963	PF00069	0.435
MOD_GSK3_1	969	976	PF00069	0.416
MOD_N-GLC_1	483	488	PF02516	0.532
MOD_N-GLC_2	163	165	PF02516	0.533
MOD_NEK2_1	188	193	PF00069	0.481
MOD_NEK2_1	243	248	PF00069	0.570
MOD_NEK2_1	276	281	PF00069	0.390
MOD_NEK2_1	312	317	PF00069	0.483
MOD_NEK2_1	37	42	PF00069	0.360
MOD_NEK2_1	479	484	PF00069	0.456
MOD_NEK2_1	805	810	PF00069	0.435
MOD_NEK2_1	818	823	PF00069	0.526
MOD_NEK2_1	860	865	PF00069	0.476
MOD_NEK2_1	960	965	PF00069	0.492
MOD_NEK2_2	68	73	PF00069	0.516
MOD_OFUCOSY	630	637	PF10250	0.495
MOD_OFUCOSY	757	764	PF10250	0.488
MOD_PIKK_1	450	456	PF00454	0.528
MOD_PIKK_1	479	485	PF00454	0.501
MOD_PIKK_1	486	492	PF00454	0.487
MOD_PIKK_1	749	755	PF00454	0.529
MOD_PIKK_1	765	771	PF00454	0.264
MOD_PKA_1	926	932	PF00069	0.594
MOD_PKA_2	188	194	PF00069	0.487
MOD_PKA_2	204	210	PF00069	0.452
MOD_PKA_2	26	32	PF00069	0.525
MOD_PKA_2	276	282	PF00069	0.390
MOD_PKA_2	460	466	PF00069	0.530
MOD_PKA_2	86	92	PF00069	0.514
MOD_PKA_2	926	932	PF00069	0.573
MOD_Plk_1	483	489	PF00069	0.535
MOD_Plk_1	85	91	PF00069	0.495
MOD_Plk_4	100	106	PF00069	0.517
MOD_Plk_4	188	194	PF00069	0.507
MOD_Plk_4	270	276	PF00069	0.462
MOD_Plk_4	277	283	PF00069	0.422
MOD_Plk_4	564	570	PF00069	0.379
MOD_Plk_4	68	74	PF00069	0.424
MOD_Plk_4	737	743	PF00069	0.458
MOD_Plk_4	805	811	PF00069	0.379
MOD_Plk_4	940	946	PF00069	0.512
MOD_Plk_4	947	953	PF00069	0.525
MOD_ProDKin_1	182	188	PF00069	0.380
MOD_ProDKin_1	407	413	PF00069	0.557
MOD_ProDKin_1	536	542	PF00069	0.344
MOD_ProDKin_1	55	61	PF00069	0.573
MOD_ProDKin_1	643	649	PF00069	0.466
MOD_ProDKin_1	811	817	PF00069	0.510
MOD_ProDKin_1	969	975	PF00069	0.500
TRG_DiLeu_BaEn_1	224	229	PF01217	0.384
TRG_DiLeu_BaEn_2	939	945	PF01217	0.554
TRG_DiLeu_BaEn_4	238	244	PF01217	0.601
TRG_DiLeu_BaLyEn_6	90	95	PF01217	0.537
TRG_ENDOCYTIC_2	319	322	PF00928	0.552
TRG_ENDOCYTIC_2	466	469	PF00928	0.308
TRG_ENDOCYTIC_2	515	518	PF00928	0.424
TRG_ENDOCYTIC_2	800	803	PF00928	0.480
TRG_ENDOCYTIC_2	952	955	PF00928	0.448
TRG_ER_diArg_1	200	203	PF00400	0.430
TRG_ER_diArg_1	500	502	PF00400	0.355
TRG_ER_diArg_1	528	531	PF00400	0.499
TRG_ER_diArg_1	926	928	PF00400	0.560
TRG_NES_CRM1_1	306	321	PF08389	0.466
TRG_NES_CRM1_1	450	464	PF08389	0.501
TRG_NES_CRM1_1	490	504	PF08389	0.537
TRG_NES_CRM1_1	684	697	PF08389	0.503
TRG_NES_CRM1_1	935	949	PF08389	0.363
TRG_NLS_MonoCore_2	201	206	PF00514	0.574
TRG_NLS_MonoExtC_3	200	205	PF00514	0.508
TRG_NLS_MonoExtN_4	201	206	PF00514	0.574
TRG_Pf-PMV_PEXEL_1	656	660	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I500	Leptomonas seymouri	54%	100%
A0A1X0NRQ6	Trypanosomatidae	29%	98%
A0A3Q8IF54	Leishmania donovani	92%	100%
A0A3R7JX66	Trypanosoma rangeli	29%	100%
A4I9F5	Leishmania infantum	92%	100%
C9ZJS9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	93%
E9B4F3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5AVU3	Trypanosoma cruzi	28%	99%